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1. 发明申请

US20080255766A1 Methods and kits for the diagnosis of sickle cell 审中-公开
标题翻译：用于诊断镰状细胞的方法和试剂盒
公开(公告)号：US20080255766A1
公开(公告)日：2008-10-16
申请号：US12068518
申请日：2008-02-07
申请人： Michael Spain , James P. Mapes , Ralph L. McDade , Kenneth Pass
发明人： Michael Spain , James P. Mapes , Ralph L. McDade , Kenneth Pass
IPC分类号： G01N33/53 , C12Q1/00
CPC分类号： G01N33/6863 , G01N2333/52 , G01N2800/22
摘要： Provided are methods for the detection and diagnosis of sickle cell. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of sickle cell. At least two new biomarkers for sickle cell are thus disclosed, Eotaxin and Monocyte Chemotactic Protein-1. Altogether the concentrations of eleven analytes provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering from sickle cell. Other important biomarkers for sickle cell are described, including but not limited to IL-12p40, SHBG, MMP-9, Adiponectin, Haptoglobin, FGF basic, IgM, Growth Hormone, Factor VII. Kits containing reagents to assist in the analysis of fluid samples are also described.
摘要翻译：提供了镰状细胞的检测和诊断方法。这些方法是基于以下发现：患有风险的患者的样本液体（通常为血液样本）中所选分析物的异常水平支持镰状细胞的诊断。因此公开了至少两种镰状细胞的新生物标志物，即嗜酸细胞活化趋化因子和单核细胞趋化蛋白-1。总共11种分析物的浓度提供了对患者状况的敏感和选择性图像，即患者是否患有镰状细胞。描述了镰状细胞的其他重要生物标志物，包括但不限于IL-12p40，SHBG，MMP-9，脂连蛋白，海藻球蛋白，FGF碱性，IgM，生长激素，因子VII。还描述了含有辅助分析流体样品的试剂的试剂盒。

2. 发明申请

US20100197510A1 METHODS FOR RAPID DISEASE SCREENING 审中-公开
标题翻译：快速筛查筛查方法
公开(公告)号：US20100197510A1
公开(公告)日：2010-08-05
申请号：US12529840
申请日：2008-03-07
申请人： Michael Spain , Craig Benson , James P. Mapes , Ralph L. McDade
发明人： Michael Spain , Craig Benson , James P. Mapes , Ralph L. McDade
IPC分类号： C40B30/00
CPC分类号： G01N33/6803
摘要： Methods are provided for screening for the necessity for further diagnosis of one or more diseases or conditions in a subject, which methods are based on the discovery that abnormal levels of selected analytes in a sample fluid from a subject can be correlated with specific diseases or conditions. Further provided are criteria, and methods for the determine thereof, for selected analytes with respect to selected diseases or conditions. Thus, a variety of diseases or conditions can be screened in a rapid, cost-effective composite assay. The methods are useful for screening of newborn humans for a variety of diseases and conditions, whereby additional diagnostic procedures need only be conducted for those diseases or conditions indicated by the methods of the invention.
摘要翻译：提供了筛选用于进一步诊断受试者中一种或多种疾病或病症的必要性的方法，该方法基于以下发现：来自受试者的样品液体中的选定分析物的异常水平可与特定疾病或病症相关。关于所选择的疾病或病症，进一步提供了用于确定所选分析物的标准和方法。因此，可以以快速，成本有效的复合测定法筛选各种疾病或病症。该方法可用于筛选各种疾病和病症的新生儿，由此仅需对本发明方法所指出的那些疾病或病症进行额外的诊断程序。

3. 发明申请

US20110065137A1 Methods and Devices for Detecting Obstructive Uropathy and Associated Disorders 有权
标题翻译：用于检测阻塞性尿路疾病和相关疾病的方法和装置
公开(公告)号：US20110065137A1
公开(公告)日：2011-03-17
申请号：US12852236
申请日：2010-08-06
申请人： Samuel T. LaBrie , James P. Mapes , Ralph L. McDade , Dominic Eisinger , Karri L. Ballard , Michael D. Spain
发明人： Samuel T. LaBrie , James P. Mapes , Ralph L. McDade , Dominic Eisinger , Karri L. Ballard , Michael D. Spain
IPC分类号： C12Q1/48 , G01N33/70 , G01N33/68
CPC分类号： G01N33/6893 , G01N33/5302 , G01N33/566 , G01N2333/47 , G01N2333/4703 , G01N2333/4706 , G01N2333/4725 , G01N2333/4727 , G01N2333/475 , G01N2333/52 , G01N2333/70503 , G01N2333/70539 , G01N2333/765 , G01N2333/775 , G01N2333/8139 , G01N2333/8146 , G01N2333/82 , G01N2333/91177 , G01N2800/34 , G01N2800/347 , G01N2800/52 , G01N2800/56 , G01N2800/60 , Y10T436/147777
摘要： Methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
摘要翻译：描述了用于诊断，监测或确定哺乳动物的阻塞性尿病或相关疾病的方法和装置。具体地，描述了使用从哺乳动物取得的测试样品中测量浓度的三种或更多种分析物的组合来诊断，监测或确定阻塞性尿病或相关疾病的方法和装置。

4. 发明申请

US20110065598A1 Methods and Devices for Detecting Diabetic Nephropathy and Associated Disorders 审中-公开
标题翻译：检测糖尿病肾病和相关疾病的方法和装置
公开(公告)号：US20110065598A1
公开(公告)日：2011-03-17
申请号：US12852282
申请日：2010-08-06
申请人： Samuel T. Labrie , James P. Mapes , Ralph L. McDade , Dominic Eisinger , Karri L. Ballard
发明人： Samuel T. Labrie , James P. Mapes , Ralph L. McDade , Dominic Eisinger , Karri L. Ballard
IPC分类号： C40B30/04
CPC分类号： G01N33/6893 , G01N33/5302 , G01N33/566 , G01N2333/47 , G01N2333/4703 , G01N2333/4706 , G01N2333/4725 , G01N2333/4727 , G01N2333/475 , G01N2333/52 , G01N2333/70503 , G01N2333/70539 , G01N2333/765 , G01N2333/775 , G01N2333/8139 , G01N2333/8146 , G01N2333/82 , G01N2333/91177 , G01N2800/34 , G01N2800/347 , G01N2800/52 , G01N2800/56 , G01N2800/60 , Y10T436/147777
摘要： Methods and devices for diagnosing, monitoring, or determining diabetic nephropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining diabetic nephropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
摘要翻译：描述了用于诊断，监测或确定哺乳动物中的糖尿病性肾病或相关疾病的方法和装置。具体地，描述了使用从哺乳动物获取的测试样品中测量的三种或更多种分析物的组合的测量浓度来诊断，监测或确定糖尿病性肾病或相关疾病的方法和装置。

5. 发明申请

US20110177959A1 Methods and Devices for Detecting Kidney Transplant Rejection 审中-公开
标题翻译：检测肾移植排斥的方法和装置
公开(公告)号：US20110177959A1
公开(公告)日：2011-07-21
申请号：US12852322
申请日：2010-08-06
申请人： Michael D. Spain , James P. Mapes , Samuel T. Labrie , Ralph L. McDade , Dominic P. Eisinger , Karri L. Ballard , Daniel R. Salomon , Michael Abecassis
发明人： Michael D. Spain , James P. Mapes , Samuel T. Labrie , Ralph L. McDade , Dominic P. Eisinger , Karri L. Ballard , Daniel R. Salomon , Michael Abecassis
IPC分类号： C40B30/02
CPC分类号： G01N33/6893 , G01N33/5302 , G01N33/566 , G01N2333/47 , G01N2333/4703 , G01N2333/4706 , G01N2333/4725 , G01N2333/4727 , G01N2333/475 , G01N2333/52 , G01N2333/70503 , G01N2333/70539 , G01N2333/765 , G01N2333/775 , G01N2333/8139 , G01N2333/8146 , G01N2333/82 , G01N2333/91177 , G01N2800/34 , G01N2800/347 , G01N2800/52 , G01N2800/56 , G01N2800/60 , Y10T436/147777
摘要： Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
摘要翻译：描述了用于诊断，监测或确定哺乳动物的肾移植排斥或相关病症的方法和装置。具体地，描述了使用从哺乳动物获取的测试样品中测量浓度的三种或更多种分析物的组合来诊断，监测或确定肾移植排斥或相关疾病的方法和装置。

6. 发明授权

US08735080B2 Methods and devices for detecting obstructive uropathy and associated disorders 有权
标题翻译：用于检测阻塞性病变和相关疾病的方法和装置
公开(公告)号：US08735080B2
公开(公告)日：2014-05-27
申请号：US12852236
申请日：2010-08-06
申请人： Samuel T. Labrie , James P. Mapes , Ralph L. McDade , Dominic Eisinger , Karri L. Ballard , Michael D. Spain
发明人： Samuel T. Labrie , James P. Mapes , Ralph L. McDade , Dominic Eisinger , Karri L. Ballard , Michael D. Spain
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N33/5302 , G01N33/566 , G01N2333/47 , G01N2333/4703 , G01N2333/4706 , G01N2333/4725 , G01N2333/4727 , G01N2333/475 , G01N2333/52 , G01N2333/70503 , G01N2333/70539 , G01N2333/765 , G01N2333/775 , G01N2333/8139 , G01N2333/8146 , G01N2333/82 , G01N2333/91177 , G01N2800/34 , G01N2800/347 , G01N2800/52 , G01N2800/56 , G01N2800/60 , Y10T436/147777
摘要： Methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
摘要翻译：描述了用于诊断，监测或确定哺乳动物中的阻塞性尿病或相关疾病的方法和装置。具体地，描述了使用从哺乳动物取得的测试样品中测量浓度的三种或更多种分析物的组合来诊断，监测或确定阻塞性尿病或相关疾病的方法和装置。

7. 发明申请

US20110065608A1 Devices for Detecting Renal Disorders 审中-公开
标题翻译：肾脏疾病检测装置
公开(公告)号：US20110065608A1
公开(公告)日：2011-03-17
申请号：US12852312
申请日：2010-08-06
申请人： Samuel T. LaBrie , James P. Mapes , Ralph L. McDade , Dominic P. Eisinger , Karri L. Ballard , Michael D. Spain
发明人： Samuel T. LaBrie , James P. Mapes , Ralph L. McDade , Dominic P. Eisinger , Karri L. Ballard , Michael D. Spain
IPC分类号： C40B40/10
CPC分类号： G01N33/6893 , G01N33/5302 , G01N33/566 , G01N2333/47 , G01N2333/4703 , G01N2333/4706 , G01N2333/4725 , G01N2333/4727 , G01N2333/475 , G01N2333/52 , G01N2333/70503 , G01N2333/70539 , G01N2333/765 , G01N2333/775 , G01N2333/8139 , G01N2333/8146 , G01N2333/82 , G01N2333/91177 , G01N2800/34 , G01N2800/347 , G01N2800/52 , G01N2800/56 , G01N2800/60 , Y10T436/147777
摘要： Devices for diagnosing, monitoring, or determining a renal disorder in a mammal are described. In particular, devices for diagnosing, monitoring, or determining a renal disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
摘要翻译：描述了用于诊断，监测或确定哺乳动物肾脏疾病的装置。特别地，描述了从哺乳动物取得的测试样品中使用测量浓度的三种或更多种分析物的组合来诊断，监测或确定肾脏疾病的装置。

8. 发明申请

US20110065599A1 Methods and Devices for Detecting Kidney Damage 审中-公开
标题翻译：检测肾损伤的方法和装置
公开(公告)号：US20110065599A1
公开(公告)日：2011-03-17
申请号：US12852295
申请日：2010-08-06
申请人： Samuel T. LaBrie , James P. Mapes , Ralph L. McDade , Dominic Eisinger , Karri L. Ballard , Michael D. Spain
发明人： Samuel T. LaBrie , James P. Mapes , Ralph L. McDade , Dominic Eisinger , Karri L. Ballard , Michael D. Spain
IPC分类号： C40B30/04
CPC分类号： G01N33/6893 , G01N33/5302 , G01N33/566 , G01N2333/47 , G01N2333/4703 , G01N2333/4706 , G01N2333/4725 , G01N2333/4727 , G01N2333/475 , G01N2333/52 , G01N2333/70503 , G01N2333/70539 , G01N2333/765 , G01N2333/775 , G01N2333/8139 , G01N2333/8146 , G01N2333/82 , G01N2333/91177 , G01N2800/34 , G01N2800/347 , G01N2800/52 , G01N2800/56 , G01N2800/60 , Y10T436/147777
摘要： Methods and devices for diagnosing, monitoring, or determining kidney damage in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney damage using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
摘要翻译：描述了用于诊断，监测或确定哺乳动物肾损伤的方法和装置。具体地说，描述了从哺乳动物取得的测试样品中使用测量浓度的三种或更多种分析物的组合来诊断，监测或确定肾损伤的方法和装置。

9. 发明申请

US20110065593A1 Computer Methods and Devices for Detecting Kidney Damage 审中-公开
标题翻译：用于检测肾损伤的计算机方法和装置
公开(公告)号：US20110065593A1
公开(公告)日：2011-03-17
申请号：US12852202
申请日：2010-08-06
申请人： Samuel T. Labrie , James P. Mapes , Ralph L. McDade , Dominic Eisinger , Karri L. Ballard , Michael D. Spain
发明人： Samuel T. Labrie , James P. Mapes , Ralph L. McDade , Dominic Eisinger , Karri L. Ballard , Michael D. Spain
IPC分类号： C40B30/02 , C40B60/12 , C40B40/00
CPC分类号： G01N33/6893 , G01N33/5302 , G01N33/566 , G01N2333/47 , G01N2333/4703 , G01N2333/4706 , G01N2333/4725 , G01N2333/4727 , G01N2333/475 , G01N2333/52 , G01N2333/70503 , G01N2333/70539 , G01N2333/765 , G01N2333/775 , G01N2333/8139 , G01N2333/8146 , G01N2333/82 , G01N2333/91177 , G01N2800/34 , G01N2800/347 , G01N2800/52 , G01N2800/56 , G01N2800/60 , Y10T436/147777
摘要： Methods and devices for diagnosing, monitoring, or determining a renal disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining a renal disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
摘要翻译：描述了用于诊断，监测或确定哺乳动物肾脏疾病的方法和装置。具体地，描述了使用从哺乳动物取得的测试样品中使用测量浓度的三种或更多种分析物的组合来诊断，监测或确定肾脏疾病的方法和装置。

10. 发明申请

US20110065136A1 Methods and Devices for Detecting Glomerulonephritis and Associated Disorders 审中-公开
标题翻译：检测肾小球肾炎和相关疾病的方法和装置
公开(公告)号：US20110065136A1
公开(公告)日：2011-03-17
申请号：US12852152
申请日：2010-08-06
申请人： Samuel T. Labrie , James P. Mapes , Ralph L. McDade , Dominic P. Eisinger , Karri L. Ballard , Michael D. Spain
发明人： Samuel T. Labrie , James P. Mapes , Ralph L. McDade , Dominic P. Eisinger , Karri L. Ballard , Michael D. Spain
IPC分类号： C12Q1/48 , G01N33/70 , G01N33/68
CPC分类号： G01N33/6893 , G01N33/5302 , G01N33/566 , G01N2333/47 , G01N2333/4703 , G01N2333/4706 , G01N2333/4725 , G01N2333/4727 , G01N2333/475 , G01N2333/52 , G01N2333/70503 , G01N2333/70539 , G01N2333/765 , G01N2333/775 , G01N2333/8139 , G01N2333/8146 , G01N2333/82 , G01N2333/91177 , G01N2800/34 , G01N2800/347 , G01N2800/52 , G01N2800/56 , G01N2800/60 , Y10T436/147777
摘要： Methods and devices for diagnosing, monitoring, or determining glomerulonephritis or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining glomerulonephritis or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
摘要翻译：描述了用于诊断，监测或测定哺乳动物中的肾小球性肾炎或相关病症的方法和装置。具体地说，描述了从哺乳动物取得的测试样品中使用测量浓度的三种或更多种分析物的组合来诊断，监测或测定肾小球肾炎或相关疾病的方法和装置。

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