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1. 发明授权

US07709439B2 Biomaterials for enhanced healing 有权
标题翻译：生物材料增强愈合
公开(公告)号：US07709439B2
公开(公告)日：2010-05-04
申请号：US10781932
申请日：2004-02-20
申请人： Michael N. Helmus , Robert Richard , Melissa Dixon
发明人： Michael N. Helmus , Robert Richard , Melissa Dixon
IPC分类号： A61K38/00 , C07K14/00 , A61F2/02 , A61F13/00
CPC分类号： A61L27/22 , A61L27/20
摘要： The present invention relates to novel biomaterials and methods of using these new biomaterials to facilitate wound healing. The novel biomaterial may be a biocompatible polymer to which at least one bioactive polymer is covalently bonded by graft polymerization, copolymerization or cross-linking. Alternatively, the novel biomaterial may be a polymer blend comprising at least one biocompatible polymer and at least one bioactive polymer.
摘要翻译：本发明涉及使用这些新生物材料以促进伤口愈合的新型生物材料和方法。新型生物材料可以是生物相容性聚合物，至少一种生物活性聚合物通过接枝聚合，共聚或交联共价键合到该聚合物上。或者，新型生物材料可以是包含至少一种生物相容性聚合物和至少一种生物活性聚合物的聚合物共混物。

2. 发明授权

US08574615B2 Medical devices having nanoporous coatings for controlled therapeutic agent delivery 有权
标题翻译：具有用于受控治疗剂递送的纳米多孔涂层的医疗装置
公开(公告)号：US08574615B2
公开(公告)日：2013-11-05
申请号：US12787209
申请日：2010-05-25
申请人： Barron Tenney , Yixin Xu , Michael N. Helmus
发明人： Barron Tenney , Yixin Xu , Michael N. Helmus
IPC分类号： A61F2/02
CPC分类号： A61F2/02 , A61F2/30767 , A61F2/82 , A61F2/91 , A61F2002/30677 , A61F2002/3068 , A61F2002/3084 , A61F2210/0076 , A61F2250/0068 , A61L29/146 , A61L29/16 , A61L31/146 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61N1/375 , B82Y30/00
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided which contain (a) one or more depressions that contain at least one therapeutic agent, and (b) a nanoporous coating, disposed over the therapeutic-agent-containing depressions, which regulate transport of species between the therapeutic-agent-containing depressions and the exterior of the device. The implantable or insertable devices are configured to preform a role beyond mere drug delivery, for example, providing mechanical and/or electrical functions within the body, among other functions. An advantage of the present invention is that medical devices may be provided, which release therapeutic agents in quantities far exceeding the void volume within the nanoporous coating, while at the same time providing functionality that extends beyond drug delivery. Such release may further approach or achieve a zero order kinetic drug release profile.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含（a）含有至少一种治疗剂的一种或多种凹陷，和（b）在含治疗剂的凹陷上设置的纳米多孔涂层，其调节物质在含治疗剂的凹陷和装置的外部之间的运输。可植入或可插入的装置被配置为预防仅仅药物递送的作用，例如在体内提供机械和/或电功能等功能。本发明的一个优点是可以提供医疗装置，其释放的量远远超过纳米多孔涂层内的空隙体积，同时提供延伸超出药物递送的功能。这种释放可以进一步接近或实现零级动力学药物释放曲线。

3. 发明申请

US20080102194A1 METHOD AND APPARATUS FOR COATING A MEDICAL DEVICE BY ELECTROLESS PLATING 审中-公开
标题翻译：通过电镀法涂敷医疗器械的方法和装置
公开(公告)号：US20080102194A1
公开(公告)日：2008-05-01
申请号：US11860866
申请日：2007-09-25
申请人： Michael N. Helmus , Yixin Xu , John Benco
发明人： Michael N. Helmus , Yixin Xu , John Benco
IPC分类号： B05D1/18 , A61F2/06
CPC分类号： A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/606 , A61L2420/02 , C23C18/1644 , C23C18/1662 , C23C18/44
摘要： Methods and apparatus for coating surfaces of medical devices by electroless plating are disclosed. In one embodiment, the invention includes a coating method in which a therapeutic agent and a plating material are plated onto the surface of the medical device by an electroless plating chemical reaction. In another embodiment, a coating method is disclosed in which the coating is formed by suspending a therapeutic agent in a soluble plating solution and plating a plating material onto the medical device by electroless plating wherein the plated material contains the suspended therapeutic agent. In another embodiment, a coating method is provided wherein the coating is formed by initially bonding a therapeutic agent to a plating material, and then plating the bonded therapeutic agent/plating material onto the medical device by electroless plating. In another embodiment, an additive is introduced to the soluble plating solution to regulate the chemical reaction of electroless plating. In another embodiment, a coating method is provided wherein the surface of the medical device is treated, e.g. creating a porous surface layer, to increase the amount of the therapeutic agent that may be plated onto the medical device by electroless plating. The coating is formed by plating a therapeutic agent into and/or onto the porous surface layer. These methods and apparatus are used to apply one or more coating materials, simultaneously or in sequence. In certain embodiments of the invention, the coating materials include therapeutic agents and cationic drugs.
摘要翻译：公开了通过化学镀涂覆医疗器械表面的方法和装置。在一个实施方案中，本发明包括通过化学镀化学反应将治疗剂和电镀材料镀在医疗装置的表面上的涂布方法。在另一个实施方案中，公开了一种涂覆方法，其中通过将治疗剂悬浮在可溶性电镀溶液中并通过化学镀将电镀材料镀覆到医疗装置上而形成涂层，其中电镀材料含有悬浮治疗剂。在另一个实施方案中，提供了涂覆方法，其中通过首先将治疗剂粘合到电镀材料上形成所述涂层，然后通过无电镀将所述结合的治疗剂/电镀材料电镀到所述医疗装置上。在另一个实施方案中，将添加剂引入到可溶性电镀溶液中以调节化学镀的化学反应。在另一个实施例中，提供一种涂覆方法，其中治疗医疗装置的表面，例如，产生多孔表面层，以通过无电镀来增加可镀在医疗装置上的治疗剂的量。通过将治疗剂镀在多孔表面层中和/或之上而形成涂层。这些方法和装置用于同时或按顺序施加一种或多种涂层材料。在本发明的某些实施方案中，涂层材料包括治疗剂和阳离子药物。

4. 发明授权

US06991804B2 Delivery systems for periadventitial delivery for treatment of restenosis and anastomotic intimal hyperplasia 有权
公开(公告)号：US06991804B2
公开(公告)日：2006-01-31
申请号：US10816680
申请日：2004-04-02
申请人： Michael N. Helmus , Crystal M. Cunanan , Patrice Tremble
发明人： Michael N. Helmus , Crystal M. Cunanan , Patrice Tremble
IPC分类号： A61F2/02 , A61K9/50
CPC分类号： A61L27/52 , A61L27/225 , A61L27/54 , A61L31/04 , A61L31/145 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/622
摘要： The invention provides methods for treating injuries to one or more internal structures of a subject by administering a drug delivery vehicle to an external surface of the injured structure. The drug delivery vehicle substantially adheres to the site of administration and provides for the release of a bioactive agent that reduces or prevents further injury to the internal structure by disease processes, such as hyperplasia.

5. 发明授权

US6099562A Drug coating with topcoat 失效
公开(公告)号：US6099562A
公开(公告)日：2000-08-08
申请号：US996410
申请日：1997-12-22
申请人： Ni Ding , Michael N. Helmus
发明人： Ni Ding , Michael N. Helmus
IPC分类号： A61F2/00 , A61F2/82 , A61F2/86 , A61F2/90 , A61K9/00 , A61K47/32 , A61K47/34 , A61L27/00 , A61L27/22 , A61L31/08 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , A61L33/10 , A61M37/00 , A61F2/06 , B05D3/00
CPC分类号： A61L33/0011 , A61F2/82 , A61F2/86 , A61F2/90 , A61L27/227 , A61L31/08 , A61L31/10 , A61L31/141 , A61L31/16 , A61F2210/0014 , A61F2250/0067 , A61L2300/236 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08
摘要： A coating and method for a coating an implantable device or prostheses are disclosed. The coating includes an undercoat of polymeric material containing an amount of biologically active material, particularly heparin, dispersed therein. The coating further includes a topcoat which covers less than the entire surface of the undercoat and wherein the topcoat comprises a polymeric material substantially free of pores and porosigens. The polymeric material of the topcoat can be a biostable, biocompatible material which provides long term non-thrombogenicity to the device portion during and after release of the biologically active material.

6. 发明授权

US5849368A Process for hydrophilicization of hydrophobic polymers 失效
标题翻译：疏水聚合物亲水化方法
公开(公告)号：US5849368A
公开(公告)日：1998-12-15
申请号：US851052
申请日：1997-05-05
申请人： Fritz Hostettler , Michael N. Helmus , Ni Ding
发明人： Fritz Hostettler , Michael N. Helmus , Ni Ding
IPC分类号： A61L29/00 , A61L31/00 , C08F8/06 , C08F8/30 , C08J3/28 , C08J7/00 , C08J7/04 , C08J7/12 , B05D3/00 , C23C16/00 , H05H1/00
CPC分类号： C08J7/123 , C08J7/04 , C08J7/047 , C08J7/12 , C08J2315/00 , C08J2475/00
摘要： A process for rendering the surfaces of polymeric plastic or rubber materials, which are intrinsically non-polar or only slightly polar, and hydrophobic, polar or more polar, and hydrophilic, so that amine-containing functional groups, and ultimately, a durable tenaciously adhering, slippery polyurethane or polyurethane-urea hydrogel coating may subsequently be applied to the polymer surface, is disclosed. The process involves dual plasma-treatment of a polymeric plastic or rubber substrate material; the first treatment being with an oxygen-containing plasma gas, to affix hydroxyl, carboxyl and carbonyl groups to the substrate surface, thereby rendering the surface more polar and activated; and the second treatment being with a nitrogen-containing plasma gas, to affix amine and amino groups to the substrate surface to make it more hydrophilic and reactive toward terminal isocyanate groups of a polyurethane or polyurethane/urea prepolymer adduct intermediate tie-coat which is subsequently applied to the substrate surface and then converted to a tenaciously adhering, slippery hydrogel coating. The process is especially suited to the hydrophilicization of intrinsically non-polar and hydrophobic polymeric plastic materials, such as polyethylenes, nylons-11 and nylons-12.
摘要翻译：使本体非极性或仅极微小的聚合物塑料或橡胶材料表面的方法，以及疏水，极性或更极性和亲水性的方法，使得含胺官能团，最终持久坚固地粘附，可以随后将湿滑的聚氨酯或聚氨酯 - 尿素水凝胶涂层施加到聚合物表面。该方法涉及聚合物塑料或橡胶基材材料的双等离子体处理; 用含氧等离子体气体进行第一次处理，将羟基，羧基和羰基粘合到基材表面，从而使表面更加极性和活化; 并且第二次处理是用含氮等离子体气体，以将胺和氨基固定在基材表面上，使其对聚氨酯或聚氨酯/脲预聚物加合物中间粘结层的末端异氰酸酯基团更亲水并具有反应性施加到基材表面，然后转化成坚固粘附，滑滑的水凝胶涂层。该方法特别适用于本征非极性和疏水性聚合物塑料材料如聚乙烯，尼龙-11和尼龙-12的亲水化。

7. 发明授权

US5837313A Drug release stent coating process 失效
标题翻译：药物释放支架涂层工艺
公开(公告)号：US5837313A
公开(公告)日：1998-11-17
申请号：US663490
申请日：1996-06-13
申请人： Ni Ding , Michael N. Helmus
发明人： Ni Ding , Michael N. Helmus
IPC分类号： A61F20060101 , A61F2/00 , A61F2/82 , A61F2/86 , A61F2/90 , A61K9/00 , A61L20060101 , A61L27/22 , A61L31/00 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , B05D3/00 , A61L27/00
CPC分类号： A61L31/16 , A61F2/82 , A61F2/86 , A61F2/90 , A61L27/227 , A61L31/10 , A61L31/141 , A61L33/0011 , A61F2210/0014 , A61F2250/0067 , A61L2300/222 , A61L2300/236 , A61L2300/406 , A61L2300/42 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2300/622 , A61L2420/02
摘要： A method of coating implantable open lattice metallic stent prosthesis is disclosed which includes sequentially applying a plurality of relatively thin outer layers of a coating composition comprising a solvent mixture of uncured polymeric silicone material and crosslinker and finely divided biologically active species, possibly of controlled average particle size, to form a coating on each stent surface. The coatings are cured in situ and the coated, cured prosthesis are sterilized in a step that includes preferred pretreatment with argon gas plasma and exposure to gamma radiation electron beam, ethylene oxide, steam.
摘要翻译：公开了一种涂覆可植入的开放格子金属支架假体的方法，其包括依次施加多个相对较薄的涂层组合物的外层，所述涂层组合物包含未固化的聚合物硅氧烷材料和交联剂的溶剂混合物以及细分的生物活性物质，可能是受控的平均颗粒尺寸，以在每个支架表面上形成涂层。涂层在原位固化，并且涂覆的固化假体在包括优选的氩气等离子体预处理和暴露于γ射线电子束，环氧乙烷，蒸汽的步骤中被灭菌。

8. 发明授权

US5569463A Medical device polymer 失效
公开(公告)号：US5569463A
公开(公告)日：1996-10-29
申请号：US479513
申请日：1995-06-07
申请人： Michael N. Helmus , M. Joshua Tolkoff , Carol L. Raleigh
发明人： Michael N. Helmus , M. Joshua Tolkoff , Carol L. Raleigh
IPC分类号： A61L27/54 , A61L33/00 , A61M5/142 , A61M31/00 , A61F2/04 , A01N1/02 , A61M5/32
CPC分类号： A61L33/0047 , A61L27/54 , A61L33/0011 , A61L33/007 , A61M31/002 , A61L2300/22 , A61L2300/222 , A61L2300/236 , A61L2300/404 , A61L2300/412 , A61L2300/414 , A61L2300/416 , A61L2300/42 , A61L2300/608 , A61M5/14276 , Y10S514/822
摘要： A medical device and a method for its manufacture. The function of the medical device requires exposure of the device to the tissue of a patient. The device has a tissue-exposed portion constructed to release an agent that inhibits adverse reaction to the presence of the device defined by a polymeric surface-layer overlying in a supported manner a polymer defining a reservoir. The reservoir incorporates the agent in a manner that permits substantially free outward release of the agent from the reservoir and the overlying layer defines metering outward passages constructed to control the outward migration of the agent to enable prolonged release of the agent from the surface of the medical device to prevent the adverse reaction due to the presence of the device.

9. 发明授权

US08221783B2 Medical devices with triggerable bioadhesive material 有权
标题翻译：具有可触发生物粘附材料的医疗设备
公开(公告)号：US08221783B2
公开(公告)日：2012-07-17
申请号：US12207839
申请日：2008-09-10
申请人： Michael N. Helmus , Yixin Xu , Barron W. Tenney , Paul L. Valint , Shrirang V. Ranade
发明人： Michael N. Helmus , Yixin Xu , Barron W. Tenney , Paul L. Valint , Shrirang V. Ranade
IPC分类号： C08B37/08 , C08L71/02 , A61K47/36 , A61K47/42 , A61K9/70 , A61K9/00 , A61K31/337 , A61K31/436 , A61K47/38 , A61F2/02 , C07K14/78 , C08F210/00 , C08G63/06 , C08G67/00 , C08G73/00 , C08G73/10
CPC分类号： A61L31/145 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/416
摘要： Described herein are implantable medical devices comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue. The triggerable bioadhesive property of the polymer can be triggered or activated by exposure to a stimulus. Also, the present invention pertains to methods of making an implantable medical device comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue.
摘要翻译：本文描述的是可植入医疗装置，其包括生物相容性聚合物，其包含可触发的生物粘合性质，其允许该装置粘附于身体组织。可以通过暴露于刺激物来触发或激活聚合物的可触发生物粘合性质。此外，本发明涉及制造包括生物相容性聚合物的可植入医疗装置的方法，所述生物相容性聚合物包含允许装置粘附于身体组织的可触发的生物粘合性质。

10. 发明授权

US07666179B2 Medical devices having porous regions for controlled therapeutic agent exposure or delivery 有权
标题翻译：具有用于受控治疗剂暴露或递送的多孔区域的医疗装置
公开(公告)号：US07666179B2
公开(公告)日：2010-02-23
申请号：US11545439
申请日：2006-10-10
申请人： Barron Tenney , Michael N. Helmus , Yixin Xu
发明人： Barron Tenney , Michael N. Helmus , Yixin Xu
IPC分类号： A61K9/22
CPC分类号： A61M25/00 , A61F2250/0068 , A61L27/54 , A61L27/56 , A61L29/146 , A61L29/16 , A61L31/146 , A61L31/16 , A61L2300/602 , A61M31/002 , A61M37/00 , A61M2025/0057
摘要： According to an aspect of the invention, implantable or insertable medical devices are provided which contain the following: (a) one or more porous regions comprising pores and (b) one or more therapeutic agents which are (i) contained within the porous region, (ii) disposed beneath the porous region, or (iii) both. Moreover, the porous regions are capable of undergoing a change in configuration, such that the pores undergo a change in configuration, upon subjecting the porous regions to activating stimuli.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含以下内容：（a）一个或多个包含孔的多孔区域和（b）一种或多种治疗剂，其（i）包含在多孔区域内，（ii）设置在多孔区域下方，或（iii）两者。此外，多孔区域能够经受构型变化，使得当多孔区域激活激活时，孔经历构型变化。

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