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1. 发明申请

US20160354534A1 APPARATUS FOR THE EXTRACORPOREAL TREATMENT OF BLOOD 审中-公开
标题翻译：用于血液提取物治疗的装置
公开(公告)号：US20160354534A1
公开(公告)日：2016-12-08
申请号：US15242775
申请日：2016-08-22
申请人： University of Limerick
发明人： Jakki Cooney , Todd Fumio Kagawa , Edmond Magner
IPC分类号： A61M1/36 , C12N9/52 , A61M1/34 , C12N11/14
CPC分类号： A61M1/3687 , A61L33/0047 , A61M1/3496 , A61M1/3689 , C12N9/52 , C12N11/14 , C12Y304/2111
摘要： An apparatus for the extracorporeal treatment of blood comprising an extracorporeal blood circuit (2), a pump (6) configured to provide fluid displacement within the extracorporeal blood circuit, and a reaction chamber (8) connected to the extracorporeal blood circuit and configured to receive blood or plasma from the circuit and treat the blood or plasma. The reaction chamber comprises a protease enzyme immobilized to a support, in which the protease enzyme is specific for, and capable of irreversibly cleaving, a human C5a present in the blood or plasma, wherein the abundance of the human C5a in the treated blood or plasma is less than that in the untreated blood or plasma. The apparatus finds utility in the extracorporeal treatment of blood from patients with inflammatory conditions, especially auto-immune disease and sepsis.
摘要翻译：一种用于血液体外处理的装置，包括体外血液回路（2），构造成在体外血液回路内提供流体置换的泵（6）以及连接到体外血液回路并被配置为接收来自电路的血液或血浆，治疗血液或血浆。反应室包含固定在载体上的蛋白酶，其中蛋白酶对血液或血浆中存在的人C5a具有特异性，并能够不可逆地切割，其中处理的血液或血浆中的人C5a的丰度比未经处理的血液或血浆中的少。该装置可用于体外治疗患有炎症状况的患者的血液，特别是自身免疫疾病和败血症。

2. 发明申请

US20160339154A1 GRAPHENE-BASED MOLECULAR/ENZYMATIC INTEGRATED CATALYSTS 审中-公开
标题翻译：基于石墨烯的分子/酶合成催化剂
公开(公告)号：US20160339154A1
公开(公告)日：2016-11-24
申请号：US15113940
申请日：2015-01-27
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： Xiangfeng Duan , Yu Huang , Teng Xue , Mark E. Meyerhoff
IPC分类号： A61L33/02 , B01J31/18 , C12N11/14 , A61L27/54 , A61L31/08 , A61L31/16 , A61L27/30 , B01J31/00 , A61L33/00
CPC分类号： A61L33/025 , A61L27/303 , A61L27/54 , A61L31/084 , A61L31/16 , A61L33/0041 , A61L33/0047 , A61L33/0082 , B01J21/18 , B01J31/003 , B01J31/1616 , B01J31/1815 , B01J31/183 , B01J2231/70 , B01J2531/025 , C12N11/14 , C12Y101/03004
摘要： Described here is a graphene-catalysts conjugate, comprising: a graphene support; a first catalyst conjugated to the graphene support; and a second catalyst conjugated to the graphene support, and the second catalyst is different from the first catalyst. In some embodiments, the first catalyst and the second catalyst correspond to a tandem catalytic system to drive a chemical transformation.
摘要翻译：这里描述的是石墨烯 - 催化剂缀合物，其包括：石墨烯载体; 与石墨烯载体共轭的第一催化剂; 和与石墨烯载体共轭的第二催化剂，第二催化剂与第一催化剂不同。在一些实施方案中，第一催化剂和第二催化剂对应于驱动化学转化的串联催化体系。

3. 发明授权

US09486559B2 Methods of treatment with a bioresorbable scaffold for neurologic drug delivery 有权
标题翻译：用生物可吸收支架治疗神经系统药物递送的方法
公开(公告)号：US09486559B2
公开(公告)日：2016-11-08
申请号：US13889259
申请日：2013-05-07
申请人： Abbott Cardiovascular Systems Inc.
发明人： Terry B. Mazer , Stephen D. Pacetti , Brenna H. Lord
IPC分类号： A61F2/06 , A61L31/14 , A61L33/00 , A61L31/06 , A61L31/16
CPC分类号： A61L31/148 , A61L31/06 , A61L31/146 , A61L31/16 , A61L33/0011 , A61L33/0047 , A61L2300/254 , A61L2300/256 , A61L2300/416 , A61L2300/45 , A61L2300/604 , C08L67/04
摘要： Bioresorbable scaffolds and methods of treatment with such scaffolds for neurologic disorders including Parkinson's disease, Huntington's disease, Alzheimer's disease, and brain neoplasms are disclosed. The bioresorbable scaffold includes a bioresorbable body and an active agent or drug associated with the body for treating or ameliorating the neurological disorder. The bioresorbable scaffold is implanted in the neurological vasculature brain or brain tissue to provide localized delivery of the drug or active agent. Embodiments of the invention include scaffolds that are partially bioresorbable or completely bioresorbable.
摘要翻译：公开了生物可吸收支架和用这种支架治疗包括帕金森病，亨廷顿病，阿尔茨海默氏病和脑肿瘤的神经障碍的方法。生物可吸收支架包括生物可吸收体和与身体相关联的用于治疗或改善神经障碍的活性剂或药物。将生物可吸收的支架植入神经系统的脉管系统脑或脑组织中以提供药物或活性剂的局部递送。本发明的实施方案包括部分生物可再吸收或完全生物可再吸收的支架。

4. 发明授权

US09333280B2 Stabilized enzyme compositions 有权
标题翻译：稳定的酶组合物
公开(公告)号：US09333280B2
公开(公告)日：2016-05-10
申请号：US14041947
申请日：2013-09-30
申请人： Teleflex Medical Incorporated
发明人： Nisha Gupta
IPC分类号： A61L33/06 , A61L33/04 , A61L29/04 , A61L29/08 , A61L29/16 , A61L33/00
CPC分类号： A61L33/062 , A61L29/048 , A61L29/085 , A61L29/16 , A61L33/0047 , A61L2300/206 , A61L2300/254 , A61L2300/404 , A61L2300/42 , A61L2300/45 , C08L5/02
摘要： A medical device includes a base material having an immobilized enzyme and dextran sulfate. The dextran sulfate has a molecular weight that is less than 40 kilo dalton (kDa). The medical device is formed from at least a base material. An enzyme is immobilized on the base material. The enzyme is stabilized with a dextran sulfate having a molecular weight of less than 40 (kDa).
摘要翻译：医疗装置包括具有固定化酶和硫酸葡聚糖的基材。硫酸葡聚糖的分子量小于40千道尔顿（kDa）。医疗装置至少由基材形成。酶固定在基材上。该酶用分子量小于40（kDa）的硫酸葡聚糖稳定。

5. 发明申请

US20150166978A1 APPARATUS FOR THE EXTRACORPOREAL TREATMENT OF BLOOD 有权
标题翻译：用于血液提取物治疗的装置
公开(公告)号：US20150166978A1
公开(公告)日：2015-06-18
申请号：US14314387
申请日：2014-06-25
申请人： University of Limerick
发明人： Jakki Cooney , Todd Fumio Kagawa , Edmond Magner
IPC分类号： C12N11/14 , A61L33/00 , C12N9/52
CPC分类号： A61M1/3687 , A61L33/0047 , A61M1/3496 , A61M1/3689 , C12N9/52 , C12N11/14 , C12Y304/2111
摘要： An apparatus for the extracorporeal treatment of blood comprising an extracorporeal blood circuit (2), a pump (6) configured to provide fluid displacement within the extracorporeal blood circuit, and a reaction chamber (8) connected to the extracorporeal blood circuit and configured to receive blood or plasma from the circuit and treat the blood or plasma. The reaction chamber comprises an protease enzyme immobilized to a support, in which the protease enzyme is specific for, and capable of irreversibly cleaving, a human C5a present in the blood or plasma, wherein the abundance of the human C5a in the treated blood or plasma is less than that in the untreated blood or plasma. The apparatus finds utility in the extracorporeal treatment of blood from patients with inflammatory conditions, especially auto-immune disease and sepsis.
摘要翻译：一种用于血液体外处理的装置，包括体外血液回路（2），构造成在体外血液回路内提供流体置换的泵（6）以及连接到体外血液回路并被配置为接收来自电路的血液或血浆，治疗血液或血浆。反应室包含固定在载体上的蛋白酶，其中蛋白酶对血液或血浆中存在的人C5a具有特异性，并能够不可逆地裂解，其中处理的血液或血浆中的人C5a的丰度比未经处理的血液或血浆中的少。该装置可用于体外治疗患有炎症状况的患者的血液，特别是自身免疫疾病和败血症。

6. 发明申请

US20070048352A1 Method for attachment of biomolecules to medical device surfaces 审中-公开
标题翻译：将生物分子附着到医疗器械表面的方法
公开(公告)号：US20070048352A1
公开(公告)日：2007-03-01
申请号：US11507172
申请日：2006-08-21
申请人： James Keogh , Paul Trescony
发明人： James Keogh , Paul Trescony
IPC分类号： B05D3/00
CPC分类号： A61L27/28 , A61L27/22 , A61L27/24 , A61L27/34 , A61L27/3625 , A61L27/3641 , A61L27/3645 , A61L27/54 , A61L29/085 , A61L31/08 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L33/0029 , A61L33/0047 , A61L33/0082 , A61L33/12 , A61L33/128 , A61L33/18 , A61L2300/606 , C08L89/00 , C12N11/02 , C12N11/14 , Y10S530/81 , Y10S530/811 , Y10S530/815 , Y10S530/816
摘要： A method for making a medical device having at least one biomolecule immobilized on a substrate surface is provided. One method of the present invention includes immobilizing a biomolecule comprising an unsubstituted amide moiety on a biomaterial surface. Another method of the present invention includes immobilizing a biomolecule on a biomaterial surface comprising an unsubstituted amide moiety. Still another method of the present invention may be employed to crosslink biomolecules comprising unsubstituted amide moieties immobilized on medical device surfaces. Additionally, one method of the present invention may be employed to crosslink biomolecules comprising unsubstituted amide moieties in solution, thereby forming a crosslinked biomaterial or a crosslinked medical device coating.
摘要翻译：提供一种制造具有固定在基材表面上的至少一种生物分子的医疗装置的方法。本发明的一种方法包括将包含未取代的酰胺部分的生物分子固定在生物材料表面上。本发明的另一种方法包括将生物分子固定在包含未取代的酰胺部分的生物材料表面上。可以使用本发明的另一种方法来交联包含固定在医疗器械表面上的未取代酰胺部分的生物分子。此外，本发明的一种方法可用于交联包含未溶解的酰胺部分的生物分子，由此形成交联的生物材料或交联的医疗器械涂层。

7. 发明授权

US06890339B2 Stent lining 失效
标题翻译：支架内衬
公开(公告)号：US06890339B2
公开(公告)日：2005-05-10
申请号：US10059420
申请日：2002-01-31
申请人： Ronald A. Sahatjian , James J. Barry , Maria Palasis
发明人： Ronald A. Sahatjian , James J. Barry , Maria Palasis
IPC分类号： A61F2/00 , A61F2/90 , A61K9/00 , A61K38/49 , A61K48/00 , A61L27/00 , A61L29/00 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , A61M16/04 , A61M25/00 , A61M29/02 , A61M29/00
CPC分类号： A61F2/90 , A61F2/0077 , A61F2/958 , A61F2230/0013 , A61F2250/0067 , A61K9/0024 , A61K38/49 , A61K48/00 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/10 , A61L31/145 , A61L31/16 , A61L33/0011 , A61L33/0023 , A61L33/0029 , A61L33/0047 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61M25/0045 , A61M25/104 , A61M2025/0046 , A61M2025/0057 , A61M2025/09183 , A61M2025/1013 , A61M2025/105 , A61M2025/1086 , A61M2025/1093 , A61M2205/0266 , C08L33/02 , C08L35/00
摘要： The invention features a catheter assembly and methods for delivering a hydrogel-lined stent to a body lumen, and methods for lining a stent with a hydrogel. The assembly includes a catheter which has a balloon at least a portion of which is coated with a hydrogel and an expansible stent mounted on the balloon in a contracted condition for passage with the catheter to a site of a body. Expansion of the balloon lodges the stent in the body with hydrogel coated on the inner surfaces of the stent as a lining.
摘要翻译：本发明的特征在于导管组件和用于将水凝胶衬里的支架输送到体腔的方法以及用水凝胶衬里支架的方法。该组件包括导管，其具有气囊，其至少一部分涂覆有水凝胶，并且在收缩条件下安装在气囊上的可膨胀支架，用于将导管通过至身体部位。气囊的扩张将支架置于体内，水凝胶涂覆在支架的内表面作为衬里。

8. 发明授权

US6153252A Process for coating stents 有权
标题翻译：涂敷支架的方法
公开(公告)号：US6153252A
公开(公告)日：2000-11-28
申请号：US294164
申请日：1999-04-19
申请人： Syed F. A. Hossainy , Mark B. Roller , Gerard H. Llanos , Gregory A. Kopia
发明人： Syed F. A. Hossainy , Mark B. Roller , Gerard H. Llanos , Gregory A. Kopia
IPC分类号： A61F2/00 , A61F2/82 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , A61L33/10 , A61L33/14 , A61L33/16 , A61L27/00 , B05D7/22
CPC分类号： A61F2/82 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L33/0047 , A61F2250/0067 , A61L2300/606 , A61L2420/02
摘要： A process is provided for coating stents having a first and second surface with passages there between to avoid blockage and bridging of the passages. The process comprises contacting the stent with a liquid coating solution containing a film forming biocompatible polymer under conditions suitable to allow the film forming biocompatible polymer to coat at least one surface of the stent while maintaining a fluid flow through said passages sufficient prevent the film forming biocompatible polymer from substantially blocking said passages. Also described are stents coated by this process.
摘要翻译：提供了一种用于涂覆具有第一和第二表面的支架的过程，其间具有通道，以避免通道的阻塞和桥接。该方法包括使支架与含有成膜生物相容性聚合物的液体涂布溶液接触，所述液体涂覆溶液在适于允许成膜生物相容性聚合物涂覆支架的至少一个表面的条件下同时保持流经所述通道的流体足以防止膜形成生物相容性聚合物基本上阻挡所述通道。还描述了通过该方法涂覆的支架。

9. 发明授权

US5945457A Process for preparing biologically compatible polymers and their use in medical devices 失效
标题翻译：制备生物相容性聚合物的方法及其在医疗器械中的应用
公开(公告)号：US5945457A
公开(公告)日：1999-08-31
申请号：US942571
申请日：1997-10-01
申请人： Nicolai A. Plate , Lev I. Valuev , Lubov D. Uzhinova , Vladimir A. Sinani
发明人： Nicolai A. Plate , Lev I. Valuev , Lubov D. Uzhinova , Vladimir A. Sinani
IPC分类号： A61L33/00 , A61L33/06 , A01N1/00 , A01N1/02
CPC分类号： A61L33/0047 , A61L33/0005 , A61L33/0041 , A61L33/06 , Y10S524/916
摘要： A hemocompatible composition comprising a polymer containing at least one pharmacologic material chemically bonded to a polymer backbone. Such compositions may be obtained by reacting a pharmacologic material with a compound containing a polymerizable group (e.g., an acyl halide) and thereafter either copolymerizing the acylated material with one or more copolymerizable monomers or first irradiating a backbone polymer and thereafter grafting the acylated pharmacologic material onto the irradiated polymer. The resulting products are hemocompatible and may be used in the manufacture of medical devices which come in contact with blood or other bodily fluids. The advantage of chemically bonded pharmacologic materials is that they are not leached out and retain their pharmaceutical effectiveness for a long period of time. The compositions may contain one or more additional pharmacologic materials which are physically admixed with polymers containing bonded pharmacologic materials.
摘要翻译：一种血液相容性组合物，其包含含有至少一种与聚合物主链化学键合的药理学材料的聚合物。这样的组合物可以通过使药物材料与含有可聚合基团的化合物（例如酰基卤）反应，然后将酰化物质与一种或多种可共聚单体共聚，或者首先辐照骨架聚合物，然后将酰化药理学材料到被照射的聚合物上。所得产品是血液相容性的并且可用于制造与血液或其它体液接触的医疗装置。化学结合的药理学材料的优点是它们不会被浸出并长期保持其药物有效性。组合物可以含有一种或多种另外的药物物质，其与含有结合的药理学材料的聚合物物理混合。

10. 发明授权

US5945319A Periodate oxidative method for attachment of biomolecules to medical device surfaces 失效
标题翻译：用于将生物分子附着到医疗器械表面的高碘酸氧化法
公开(公告)号：US5945319A
公开(公告)日：1999-08-31
申请号：US1994
申请日：1997-12-31
申请人： James R. Keogh
发明人： James R. Keogh
IPC分类号： A61L27/24 , A61L27/28 , A61L27/34 , A61L29/08 , A61L31/08 , A61L31/10 , A61L33/00 , A61L33/12 , A61L33/18 , C12N11/00 , G01N33/543 , C07K1/00 , A61K38/43
CPC分类号： A61L33/128 , A61L27/24 , A61L27/28 , A61L27/34 , A61L29/085 , A61L31/08 , A61L31/10 , A61L33/0011 , A61L33/0029 , A61L33/0047 , A61L33/0082 , A61L33/12 , A61L33/18 , Y10S530/81 , Y10S530/811 , Y10S530/815 , Y10S530/816
摘要： Methods are provided for forming a coating of an immobilized biomolecule on a surface of a medical device to impart improved biocompatibility for contacting tissue and bodily fluids. A 2-aminoalcohol moiety of a biomolecule is oxidized with a periodate to an aldehyde moiety which is reacted with an amine moiety on the surface of a medical device to form an imine moiety, and the imine moiety is reduced to form an amine linkage immobilizing a coating of the biomolecule on the surface. In another method, a biomolecule coating containing an amine moiety and a 2-aminoalcohol moiety is immobilized on the surface of a medical device, the 2-aminoalcohol moiety is oxidized with a periodate to an aldehyde moiety which is reacted with the amine moiety to form an imine moiety, and the imine moiety is reduced to form a secondary amine and crosslink the coating. Each biomolecule may contain an amine moiety and a 2-aminoalcohol moiety, and the aldehyde moiety of one biomolecule resulting from periodate oxidation may react with the amine moiety of another biomolecule. In a further embodiment, a 2-aminoalcohol moiety on the surface of a medical device is oxidized with a periodate to an aldehyde moiety, and an amine moiety of a biomolecule is reacted with the aldehyde moiety to form an imine moiety which is reduced to form an amine linkage immobilizing the biomolecule on the surface.
摘要翻译：提供了用于在医疗装置的表面上形成固定的生物分子的涂层的方法，以提高用于接触组织和体液的生物相容性。生物分子的2-氨基醇部分用高碘酸酯氧化成醛部分，其与医疗器械表面上的胺部分反应以形成亚胺部分，并且亚胺部分被还原以形成胺连接，在表面上涂覆生物分子。在另一种方法中，将包含胺部分和2-氨基醇部分的生物分子包被固定在医疗装置的表面上，2-氨基醇部分被高碘酸酯氧化成醛部分，其与胺部分反应形成亚胺部分，并且亚胺部分被还原以形成仲胺并交联涂层。每个生物分子可以含有胺部分和2-氨基醇部分，并且由高碘酸氧化产生的一个生物分子的醛部分可能与另一种生物分子的胺部分反应。在另一个实施方案中，医疗器械表面上的2-氨基醇部分被高碘酸酯氧化成醛部分，并且生物分子的胺部分与醛部分反应以形成亚胺部分，其被还原形成将生物分子固定在表面上的胺键。

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