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1. 发明授权

US6099562A Drug coating with topcoat 失效
公开(公告)号：US6099562A
公开(公告)日：2000-08-08
申请号：US996410
申请日：1997-12-22
申请人： Ni Ding , Michael N. Helmus
发明人： Ni Ding , Michael N. Helmus
IPC分类号： A61F2/00 , A61F2/82 , A61F2/86 , A61F2/90 , A61K9/00 , A61K47/32 , A61K47/34 , A61L27/00 , A61L27/22 , A61L31/08 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , A61L33/10 , A61M37/00 , A61F2/06 , B05D3/00
CPC分类号： A61L33/0011 , A61F2/82 , A61F2/86 , A61F2/90 , A61L27/227 , A61L31/08 , A61L31/10 , A61L31/141 , A61L31/16 , A61F2210/0014 , A61F2250/0067 , A61L2300/236 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08
摘要： A coating and method for a coating an implantable device or prostheses are disclosed. The coating includes an undercoat of polymeric material containing an amount of biologically active material, particularly heparin, dispersed therein. The coating further includes a topcoat which covers less than the entire surface of the undercoat and wherein the topcoat comprises a polymeric material substantially free of pores and porosigens. The polymeric material of the topcoat can be a biostable, biocompatible material which provides long term non-thrombogenicity to the device portion during and after release of the biologically active material.

2. 发明授权

US5849368A Process for hydrophilicization of hydrophobic polymers 失效
标题翻译：疏水聚合物亲水化方法
公开(公告)号：US5849368A
公开(公告)日：1998-12-15
申请号：US851052
申请日：1997-05-05
申请人： Fritz Hostettler , Michael N. Helmus , Ni Ding
发明人： Fritz Hostettler , Michael N. Helmus , Ni Ding
IPC分类号： A61L29/00 , A61L31/00 , C08F8/06 , C08F8/30 , C08J3/28 , C08J7/00 , C08J7/04 , C08J7/12 , B05D3/00 , C23C16/00 , H05H1/00
CPC分类号： C08J7/123 , C08J7/04 , C08J7/047 , C08J7/12 , C08J2315/00 , C08J2475/00
摘要： A process for rendering the surfaces of polymeric plastic or rubber materials, which are intrinsically non-polar or only slightly polar, and hydrophobic, polar or more polar, and hydrophilic, so that amine-containing functional groups, and ultimately, a durable tenaciously adhering, slippery polyurethane or polyurethane-urea hydrogel coating may subsequently be applied to the polymer surface, is disclosed. The process involves dual plasma-treatment of a polymeric plastic or rubber substrate material; the first treatment being with an oxygen-containing plasma gas, to affix hydroxyl, carboxyl and carbonyl groups to the substrate surface, thereby rendering the surface more polar and activated; and the second treatment being with a nitrogen-containing plasma gas, to affix amine and amino groups to the substrate surface to make it more hydrophilic and reactive toward terminal isocyanate groups of a polyurethane or polyurethane/urea prepolymer adduct intermediate tie-coat which is subsequently applied to the substrate surface and then converted to a tenaciously adhering, slippery hydrogel coating. The process is especially suited to the hydrophilicization of intrinsically non-polar and hydrophobic polymeric plastic materials, such as polyethylenes, nylons-11 and nylons-12.
摘要翻译：使本体非极性或仅极微小的聚合物塑料或橡胶材料表面的方法，以及疏水，极性或更极性和亲水性的方法，使得含胺官能团，最终持久坚固地粘附，可以随后将湿滑的聚氨酯或聚氨酯 - 尿素水凝胶涂层施加到聚合物表面。该方法涉及聚合物塑料或橡胶基材材料的双等离子体处理; 用含氧等离子体气体进行第一次处理，将羟基，羧基和羰基粘合到基材表面，从而使表面更加极性和活化; 并且第二次处理是用含氮等离子体气体，以将胺和氨基固定在基材表面上，使其对聚氨酯或聚氨酯/脲预聚物加合物中间粘结层的末端异氰酸酯基团更亲水并具有反应性施加到基材表面，然后转化成坚固粘附，滑滑的水凝胶涂层。该方法特别适用于本征非极性和疏水性聚合物塑料材料如聚乙烯，尼龙-11和尼龙-12的亲水化。

3. 发明授权

US5837313A Drug release stent coating process 失效
标题翻译：药物释放支架涂层工艺
公开(公告)号：US5837313A
公开(公告)日：1998-11-17
申请号：US663490
申请日：1996-06-13
申请人： Ni Ding , Michael N. Helmus
发明人： Ni Ding , Michael N. Helmus
IPC分类号： A61F20060101 , A61F2/00 , A61F2/82 , A61F2/86 , A61F2/90 , A61K9/00 , A61L20060101 , A61L27/22 , A61L31/00 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , B05D3/00 , A61L27/00
CPC分类号： A61L31/16 , A61F2/82 , A61F2/86 , A61F2/90 , A61L27/227 , A61L31/10 , A61L31/141 , A61L33/0011 , A61F2210/0014 , A61F2250/0067 , A61L2300/222 , A61L2300/236 , A61L2300/406 , A61L2300/42 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2300/622 , A61L2420/02
摘要： A method of coating implantable open lattice metallic stent prosthesis is disclosed which includes sequentially applying a plurality of relatively thin outer layers of a coating composition comprising a solvent mixture of uncured polymeric silicone material and crosslinker and finely divided biologically active species, possibly of controlled average particle size, to form a coating on each stent surface. The coatings are cured in situ and the coated, cured prosthesis are sterilized in a step that includes preferred pretreatment with argon gas plasma and exposure to gamma radiation electron beam, ethylene oxide, steam.
摘要翻译：公开了一种涂覆可植入的开放格子金属支架假体的方法，其包括依次施加多个相对较薄的涂层组合物的外层，所述涂层组合物包含未固化的聚合物硅氧烷材料和交联剂的溶剂混合物以及细分的生物活性物质，可能是受控的平均颗粒尺寸，以在每个支架表面上形成涂层。涂层在原位固化，并且涂覆的固化假体在包括优选的氩气等离子体预处理和暴露于γ射线电子束，环氧乙烷，蒸汽的步骤中被灭菌。

4. 发明授权

US06358556B1 Drug release stent coating 失效
公开(公告)号：US06358556B1
公开(公告)日：2002-03-19
申请号：US09012443
申请日：1998-01-23
申请人： Ni Ding , Michael N. Helmus
发明人： Ni Ding , Michael N. Helmus
IPC分类号： B05D304
CPC分类号： A61L31/16 , A61F2/82 , A61F2/86 , A61F2/90 , A61F2210/0014 , A61F2250/0067 , A61L27/227 , A61L31/10 , A61L31/141 , A61L33/0011 , A61L2300/222 , A61L2300/236 , A61L2300/406 , A61L2300/42 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2300/622 , A61L2420/02 , C08L71/02 , C08L83/04 , C08L83/00 , C08L83/08 , C08L5/00 , C08L75/04
摘要： A method of coating implantable open lattice metallic stent prosthesis is disclosed which includes sequentially applying a plurality of relatively thin outer layers of a coating composition comprising a solvent mixture of uncured polymeric silicone material and crosslinker and finely divided biologically active species, possibly of controlled average particle size, to form a coating on each stent surface. The coatings are cured in situ and the coated, cured prosthesis are sterilized in a step that includes preferred pretreatment with argon gas plasma and exposure to gamma radiation electron beam, ethylene oxide, steam.

5. 发明授权

US06017577A Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated polymer substrate materials, and coated medical devices 失效
标题翻译：滑溜，强力粘附亲水性聚氨酯水凝胶涂层，涂层聚合物基材和涂层医疗器械
公开(公告)号：US06017577A
公开(公告)日：2000-01-25
申请号：US382478
申请日：1995-02-01
申请人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
发明人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
IPC分类号： A61L29/08 , A61L31/10 , C08G18/10 , C08G18/28 , C08J7/04 , B05D3/06 , B05D1/36
CPC分类号： C08J7/047 , A61L29/085 , A61L31/10 , C08G18/10 , C08G18/283 , C08J7/04 , C08G2230/00 , C08J2475/00 , Y10T428/31554 , Y10T428/31562 , Y10T428/31565 , Y10T428/31569 , Y10T428/31587 , Y10T428/31678
摘要： A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coating compositions are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.
摘要翻译：用于制备光滑的亲水性聚氨酯水凝胶涂料组合物的方法，以及由聚合物塑料或橡胶基材或金属基材组成的材料，其上具有光滑的亲水性聚氨酯水凝胶涂层，使得涂料组合物顽固地粘附于基材，被披露。涂料组合物和涂层材料是无毒的和生物相容的，并且理想地适用于医疗装置，特别是导管，导管气囊和支架。涂层组合物，涂覆材料和涂覆的装置表现出与体液，特别是血液接触的低摩擦系数，以及在长时间使用该装置时高度的磨损持久性。水凝胶涂料组合物能够被干燥以促进其已被施加到其上的装置的储存，并且可以立即重新活化以便随后通过暴露于水中使用。

6. 发明授权

US06120904A Medical device coated with interpenetrating network of hydrogel polymers 有权
标题翻译：涂有水凝胶聚合物互穿网络的医疗器械
公开(公告)号：US06120904A
公开(公告)日：2000-09-19
申请号：US317531
申请日：1999-05-24
申请人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
发明人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
IPC分类号： A61L29/00 , A61L29/08 , A61L31/00 , A61L31/10 , B05D1/36 , B05D7/00 , B05D7/02 , B05D7/16 , B05D7/24 , C08G18/10 , C08G18/48 , C08G18/75 , C08J7/00 , C08J7/04 , C09D175/12 , B32B27/40
CPC分类号： B05D7/52 , A61L29/085 , A61L31/10 , B05D7/02 , B05D7/16 , C08G18/10 , C08G18/4833 , C08G18/755 , C08G18/758 , C09D175/12 , C08G2210/00 , C08G2270/00 , Y10T428/31551 , Y10T428/31554 , Y10T428/31562 , Y10T428/31565 , Y10T428/31587 , Y10T428/31605
摘要： A medical device comprising an organic polymer substrate material having a coating thereon, the coating comprising an interpenetrating network of two different hydrogel polymers, one of which is a polyurethane/polyurea hydrogel polymer, the polyurethane/polyurea hydrogel polymer being linked to the substrate material by covalent urea linkages.
摘要翻译：一种包括其上具有涂层的有机聚合物基底材料的医疗装置，所述涂层包含两种不同的水凝胶聚合物的互穿网络，其中一种是聚氨酯/聚脲水凝胶聚合物，所述聚氨酯/聚脲水凝胶聚合物通过共价尿素键。

7. 发明授权

US6080488A Process for preparation of slippery, tenaciously adhering, hydrophilic polyurethane hydrogel coating, coated polymer and metal substrate materials, and coated medical devices 失效
公开(公告)号：US6080488A
公开(公告)日：2000-06-27
申请号：US126376
申请日：1998-03-24
申请人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
发明人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
IPC分类号： A61L29/08 , A61L31/10 , C08G18/10 , C08G18/28 , C08J7/04 , B05D1/36 , B32B27/00
CPC分类号： C08J7/047 , A61L29/085 , A61L31/10 , C08G18/10 , C08G18/283 , C08J7/04 , C08G2230/00 , C08J2475/00 , Y10T428/31554 , Y10T428/31562 , Y10T428/31565 , Y10T428/31569 , Y10T428/31587 , Y10T428/31678
摘要： A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coating compositions are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

8. 发明授权

US5919570A Slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly(N-vinylpyrrolidone) polymer hydrogel, coated polymer and metal substrate materials, and coated medical devices 失效
标题翻译：含有聚（N-乙烯基吡咯烷酮）聚合物水凝胶，涂覆聚合物和金属基底材料的聚氨酯 - 脲聚合物水凝胶和涂覆医疗器械的粘性水凝胶涂层
公开(公告)号：US5919570A
公开(公告)日：1999-07-06
申请号：US382318
申请日：1995-02-01
申请人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
发明人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
IPC分类号： A61L29/00 , A61L29/08 , A61L31/00 , A61L31/10 , B05D1/36 , B05D7/00 , B05D7/02 , B05D7/16 , B05D7/24 , C08G18/10 , C08G18/48 , C08G18/75 , C08J7/00 , C08J7/04 , C09D175/12 , B32B27/00
CPC分类号： B05D7/52 , A61L29/085 , A61L31/10 , B05D7/02 , B05D7/16 , C08G18/10 , C08G18/4833 , C08G18/755 , C08G18/758 , C09D175/12 , C08G2210/00 , C08G2270/00 , Y10T428/31551 , Y10T428/31554 , Y10T428/31562 , Y10T428/31565 , Y10T428/31587 , Y10T428/31605
摘要： Slippery, hydrophilic coating compositions of a polyurethane/urea prepolymer adduct intermediate commingled with at least one dissimilar hydrogel polymer precursor, and materials composed of a polymeric plastic or rubber substrate or a metallic substrate with a slippery hydrogel coating of a polyurethane/urea prepolymer adduct intermediate and at least one dissimilar hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coatings are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.
摘要翻译：与至少一种不同的水凝胶聚合物前体混合的聚氨酯/脲预聚合物加合物中间体的滑爽的亲水涂料组合物，以及由聚合物塑料或橡胶基材或具有聚氨酯/脲预聚物加合物中间体的光滑水凝胶涂层的金属基材组成的材料和其上的至少一种不相似的水凝胶，使得涂层组合物顽固地粘附到基底上。涂料组合物和涂层材料是无毒的和生物相容的，并且理想地适用于医疗装置，特别是导管，导管气囊和支架。涂层组合物，涂覆材料和涂覆的装置表现出与体液，特别是血液接触的低摩擦系数，以及在长时间使用该装置时高度的磨损持久性。水凝胶涂层能够被干燥以促进其已经被施加到的装置的储存，并且可以立即重新激活以供以后通过暴露于水中使用。

9. 发明授权

US5576072A Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with at least one other, dissimilar polymer hydrogel 失效
标题翻译：含有聚氨酯 - 尿素聚合物水凝胶的湿滑粘结水凝胶涂层的方法，该水凝胶与至少一种其它不同的聚合物水凝胶
公开(公告)号：US5576072A
公开(公告)日：1996-11-19
申请号：US382459
申请日：1995-02-01
申请人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
发明人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
IPC分类号： A61L29/04 , A61L29/08 , B05D7/00 , B05D7/02 , C08G18/10 , C08G18/48 , C08G18/75 , C09D175/04 , B05D3/00 , B29C71/02 , C04B41/00 , H05H1/00
CPC分类号： B05D7/54 , A61L29/049 , A61L29/085 , B05D7/02 , C08G18/10 , C08G18/4833 , C08G18/4837 , C08G18/755 , C08G18/758 , C09D175/04 , C08G2210/00 , Y10T428/31551
摘要： A process for preparing coating compositions of a commingled hydrogel of a polyurethane-polyurea polymer hydrogel and at least one other polymer hydrogel of a polymer different from polyurethane-polyurea; a process for making materials composed of a polymeric plastic or rubber substrate or a metallic substrate, with a coating of the commingled hydrogel thereon; and a process for making medical devices with a coating of the commingled hydrogel thereon, are disclosed. The coating compositions tenaciously adhere to the substrate materials and medical devices to which they are applied due to bonding of a tie coat to a reactive substrate surface and due to the commingling of the two hydrogel components. The coating compositions and coated materials and medical devices are non-toxic and biocompatible, making them ideally suited for use in applications such as for catheters, catheter balloons and stents. In such applications, the coating compositions, coated materials, and coated medical devices made therefrom demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use. The commingled hydrogel coatings are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.
摘要翻译：制备聚氨酯 - 聚脲聚合物水凝胶的混合水凝胶和不同于聚氨酯 - 聚脲的聚合物的至少一种其它聚合物水凝胶的涂料组合物的方法; 制造由聚合物塑料或橡胶基材或金属基材组成的材料的方法，其上混合水凝胶的涂层; 并公开了在其上制造混合水凝胶涂层的医疗装置的方法。涂层组合物由于粘结涂层与反应性基底表面的结合以及由于两种水凝胶组分的混合而顽固地粘附到其所施加的基底材料和医疗装置上。涂料组合物和涂覆材料和医疗装置是无毒的和生物相容的，使得它们非常适用于诸如导管，导管气囊和支架的应用。在这样的应用中，由其制成的涂料组合物，涂覆的材料和涂覆的医疗装置显示出与体液，特别是血液接触的低摩擦系数，以及长期使用时的高度的耐磨性。混合的水凝胶涂层能够被干燥以便于其已被施加到的装置的储存，并且可以立即重新激活以供将来通过暴露于水中使用。

10. 发明授权

US06620194B2 Drug coating with topcoat 失效
公开(公告)号：US06620194B2
公开(公告)日：2003-09-16
申请号：US09942716
申请日：2001-08-30
申请人： Ni Ding , Michael N. Helmus
发明人： Ni Ding , Michael N. Helmus
IPC分类号： A61F206
CPC分类号： A61L33/0011 , A61F2/82 , A61F2/86 , A61F2/90 , A61F2210/0014 , A61F2250/0067 , A61L27/227 , A61L31/08 , A61L31/10 , A61L31/141 , A61L31/16 , A61L2300/236 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , C08L83/08 , C08L71/02 , C08L5/00 , C08L83/00 , C08L83/04
摘要： A coating and method for a coating an implantable device or prostheses are disclosed. The coating includes an undercoat of polymeric material containing an amount of biologically active material, particularly heparin, dispersed therein. The coating further includes a topcoat which covers less than the entire surface of the undercoat and wherein the topcoat comprises a polymeric material substantially free of pores and porosigens. The polymeric material of the topcoat can be a biostable, biocompatible material which provides long term non-thrombogenicity to the device portion during and after release of the biologically active material.

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