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1. 发明授权

US5959296A Scanners for reading near infrared fluorescent marks 失效
标题翻译：用于阅读近红外荧光标记的扫描仪
公开(公告)号：US5959296A
公开(公告)日：1999-09-28
申请号：US880037
申请日：1997-06-20
申请人： Michael John Cyr , James John Krutak, Sr. , Horst Clauberg , Randy Barnett Meade , James Edward Moore , Gabor Patonay
发明人： Michael John Cyr , James John Krutak, Sr. , Horst Clauberg , Randy Barnett Meade , James Edward Moore , Gabor Patonay
IPC分类号： G02B6/38 , G06K7/12 , G06K7/10
CPC分类号： G06K7/12 , G02B6/3861 , G02B6/3862 , G02B6/3887
摘要： An apparatus for detecting an invisible, near infrared fluorescing mark disposed on a background comprises: includes an excitation source for exciting the mark, having sufficient power to excite the mark and provide a fluorescent signal the mark from a; a signal detector for detecting the fluorescent signal from the mark; a and power modulator means for varying the power if the excitation source between zero and the maximum power level to produce a decodable fluorescent signal from the mark disposed on the background. A process for decoding an invisible mark having a near infrared fluorescing material includes the steps of: providing at least one invisible, near infrared fluorescing mark disposed on at least one portion of a background; exciting the mark with a laser having a maximum power level sufficient to provide a fluorescent signal from the mark; detecting the fluorescent signal and concurrently varying the power of the laser between zero and its maximum power, to obtain a decodable fluorescent signal.
摘要翻译：用于检测设置在背景上的不可见的近红外荧光标记的装置包括：包括用于激发标记的激励源，具有足够的功率来激发标记并从a提供标记的荧光信号; 用于从标记检测荧光信号的信号检测器; a和功率调制器装置，用于如果激励源在零和最大功率水平之间改变功率，以从设置在背景上的标记产生可解码的荧光信号。用于解码具有近红外荧光材料的不可见标记的方法包括以下步骤：提供设置在背景的至少一部分上的至少一个不可见的近红外荧光标记; 使用具有足以提供来自标记的荧光信号的最大功率电平的激光器来激发标记; 检测荧光信号并同时改变激光器在0和最大功率之间的功率，以获得可解码的荧光信号。

2. 发明申请

US20150376209A1 METHOD AND DYES FOR DETECTING AND DESTROYING CANCER CELLS 审中-公开
标题翻译：用于检测和破坏癌细胞的方法和方法
公开(公告)号：US20150376209A1
公开(公告)日：2015-12-31
申请号：US12778569
申请日：2010-05-12
申请人： JAMES J. KRUTAK , Lyle Small , Maged Henary , Gabor Patonay
发明人： JAMES J. KRUTAK , Lyle Small , Maged Henary , Gabor Patonay
IPC分类号： C07F1/00 , A61N1/40 , C09B23/01 , A61K49/00 , A61K41/00
CPC分类号： C07F1/00 , A61K41/0052 , A61K41/0057 , A61K49/0032 , A61K49/0093 , A61N1/406 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/086
摘要： This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.
摘要翻译：本发明涉及新的碳菁染料组合物，包含这种组合物的药物组合物，通过近红外荧光成像检测初始癌细胞的方法和通过施用这种药物组合物鉴定的癌细胞的选择性破坏。一种检测和破坏癌细胞的方法包括将金染料引入怀疑具有癌细胞的生物体中。金染料是共价连接到金纳米颗粒上的碳菁染料。近红外光照射在怀疑患有癌细胞的区域。检测到来自金色染料的荧光。射频能量束被引导到该区域以诱导癌细胞中的高热。碳菁染料具有MHI-148和结构6和22的最基本结构，在赋予癌细胞活性的环己烯环上具有Aun- [CH 2（CH 2）9 CH 2 - （OCH 2 CH 2）4 O] COCH 2 CH 2 - 苯基-O基团绑定和销毁过程。

3. 发明授权

US5553714A Method for detecting and separating thermoplastic containers with near infrared fluorosphores 失效
标题翻译：用近红外荧光团检测和分离热塑性容器的方法
公开(公告)号：US5553714A
公开(公告)日：1996-09-10
申请号：US339318
申请日：1994-11-14
申请人： Michael R. Cushman , James J. Krutak , William W. Parham , Clarence A. Coates , Max A. Weaver , Gabor Patonay
发明人： Michael R. Cushman , James J. Krutak , William W. Parham , Clarence A. Coates , Max A. Weaver , Gabor Patonay
IPC分类号： C07D487/22 , B07C5/342 , C07D209/60 , C07F5/06 , C07F7/02 , C07F7/08 , C08K5/00 , C08K5/34 , C08K5/3412 , C08K5/3415 , C08L67/00 , C08L101/00 , C09B47/06 , C09B47/067 , C09B47/073 , C09B47/08 , C09B47/18 , C09B57/00 , C09B67/20 , C09K11/06 , B07C5/10
CPC分类号： C09B47/063 , B07C5/342 , B07C5/365 , C07D209/60 , C07F5/069 , C07F7/025 , C07F7/0858 , C08K5/0008 , C08K5/0041 , C08K5/34 , C09B47/0675 , C09B47/0676 , C09B47/073 , C09B47/08 , C09B47/18 , C09B57/007 , C09B67/0061 , B29B2017/0279 , Y02W30/622
摘要： Provided is a method for tagging thermoplastic containers using near infrared fluorescing compounds or copolymerized residues readily capable of detection. Also provided is a method for identifying a thermoplastic container. Also provided are thermoplastic polymer compositions comprised of the near infrared fluorescing compounds or residues and articles comprised of such compositions.
摘要翻译：提供了使用近红外荧光化合物或易于检测的共聚残基来标记热塑性容器的方法。还提供了一种用于识别热塑性容器的方法。还提供了由近红外荧光化合物或由这些组合物组成的残余物和制品组成的热塑性聚合物组合物。

4. 发明授权

US4602193A Method and apparatus for the stabilization of direct current arc lamps 失效
标题翻译：用于稳定直流电弧灯的方法和装置
公开(公告)号：US4602193A
公开(公告)日：1986-07-22
申请号：US639383
申请日：1984-08-10
申请人： Gabor Patonay , Isiah M. Warner , Philip B. Oldham
发明人： Gabor Patonay , Isiah M. Warner , Philip B. Oldham
IPC分类号： G01J3/10 , H05B41/34 , H05B37/00 , H05B39/00
CPC分类号： H05B41/34 , Y10T307/50
摘要： A system for stabilizing the arc in a DC arc lamp. An AC signal is superimposed on the DC power source of the lamp to cause small regular fluctuations in the arc. The small fluctuations prevent large fluctuations while the small regular fluctuations may be averaged to obtain a constant average value. The average is taken over 5 to 10 periods of the AC signal to produce a constant average signal with a very small standard deviation.
摘要翻译：用于稳定直流弧光灯中的电弧的系统。交流信号叠加在灯的直流电源上，导致电弧的小规则波动。小的波动防止大的波动，而小的正常波动可以被平均以获得恒定的平均值。平均值为5到10个周期的交流信号，以产生具有非常小的标准偏差的恒定平均信号。

5. 发明授权

US06086737A Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor 失效
标题翻译：测量近红外和红外荧光标记的DNA用于检测使用激光二极管和适合的标签
公开(公告)号：US06086737A
公开(公告)日：2000-07-11
申请号：US500691
申请日：1995-07-11
申请人： Gabor Patonay , Narasimhachari Narayanan , John A. Brumbaugh , Lyle Richard Middendorf
发明人： Gabor Patonay , Narasimhachari Narayanan , John A. Brumbaugh , Lyle Richard Middendorf
IPC分类号： C12N15/09 , C07D209/12 , C07D209/60 , C07D209/62 , C09B23/01 , C12Q1/68 , G01N21/64 , G01N27/447 , G01N27/26
CPC分类号： G01N21/6458 , C07D209/12 , C07D209/62 , C09B23/0025 , C09B23/0066 , C12Q1/6816 , C12Q1/6869 , G01N21/6428 , G01N27/447 , G01N27/44721 , G01N27/44726 , Y10S435/968 , Y10S436/80
摘要： To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.
摘要翻译：为了自动序列DNA，用远红外线，近红外或红外荧光染料标记的DNA通过凝胶电泳板或毛细管在多个通道中进行电泳，其中根据凝胶中DNA片段的大小来分离DNA样品电泳板或毛细管进入荧光标记的DNA条带。分离的样品用激光二极管和传感器进行光电扫描，其中激光扫描具有在所述荧光标记的DNA样品的吸收光谱内的波长的扫描光，并且在标记的DNA的发射波长处感测光。

6. 发明授权

US5703229A Method for tagging thermoplastic materials with near infrared fluorophores 失效
标题翻译：用近红外荧光团标记热塑性材料的方法
公开(公告)号：US5703229A
公开(公告)日：1997-12-30
申请号：US609011
申请日：1996-02-29
申请人： James J. Krutak , Michael R. Cushman , Clarence A. Coates , William W. Parham , Max A. Weaver , Gabor Patonay
发明人： James J. Krutak , Michael R. Cushman , Clarence A. Coates , William W. Parham , Max A. Weaver , Gabor Patonay
IPC分类号： C07D487/22 , B07C5/342 , C07D209/60 , C07F5/06 , C07F7/02 , C07F7/08 , C08K5/00 , C08K5/34 , C08K5/3412 , C08K5/3415 , C08L67/00 , C08L101/00 , C09B47/06 , C09B47/067 , C09B47/073 , C09B47/08 , C09B47/18 , C09B57/00 , C09B67/20 , C09K11/06 , C07B47/24
CPC分类号： C09B47/063 , B07C5/342 , B07C5/365 , C07D209/60 , C07F5/069 , C07F7/025 , C07F7/0858 , C08K5/0008 , C08K5/0041 , C08K5/34 , C09B47/0675 , C09B47/0676 , C09B47/073 , C09B47/08 , C09B47/18 , C09B57/007 , C09B67/0061 , B29B2017/0279 , Y02W30/622
摘要： Provided are new compounds useful as near infrared fluorophoric markers. In the practice of this invention a method is also provided for tagging thermoplastic containers using near infrared fluorescing compounds or copolymerized residues readily capable of detection. The new compounds are phthalocyanine and naphthalocyanine derivatives which are covalently bonded to substituted silicon and aluminum compounds. The methods, compositions, and compounds described herein thus provide a total system useful for marking, for identification purposes, the various classes of thermoplastic wastes, so that they can be identified, sorted, and subsequently recycled.
摘要翻译：提供用作近红外荧光标记的新化合物。在本发明的实践中，还提供了使用近红外荧光化合物或易于检测的共聚残基来标记热塑性容器的方法。新化合物是与取代的硅和铝化合物共价键合的酞菁和萘酞菁衍生物。因此，本文所述的方法，组合物和化合物提供了用于标识目的的各种类型的热塑性废物的总体系统，以便可以鉴定，分类和随后再循环。

7. 发明授权

US5423432A Water-dissipatable polyesters and amides containing near infrared fluorescent compounds copolymerized therein 失效
标题翻译：含有其中共聚的近红外荧光化合物的可水分散的聚酯和酰胺
公开(公告)号：US5423432A
公开(公告)日：1995-06-13
申请号：US238300
申请日：1994-05-05
申请人： James J. Krutak , Michael R. Cushman , William W. Parham , Clarence A. Coates , Max A. Weaver , Gabor Patonay
发明人： James J. Krutak , Michael R. Cushman , William W. Parham , Clarence A. Coates , Max A. Weaver , Gabor Patonay
IPC分类号： C08G63/68 , C08G69/04 , G06K7/12 , G06K19/06 , B07C5/00 , C08G73/06
CPC分类号： G06K7/12 , C08G63/68 , C08G69/04 , G06K19/06009 , Y10T428/31786 , Y10T428/3179
摘要： Provided are water-dissipatable, sulfo-containing polyesters and polyester-amides having copolymerized therein thermally stable near infrared flourophoric compounds. The polymers are useful in coating or ink compositions, which are in turn useful for marking articles for identification/authentication purposes. Also provided is a method for invisibly marking such articles and a method for detecting and sorting articles by utilizing the near infrared flourophoric ink or coating compositions.
摘要翻译：提供了在其中共聚有热稳定性近红外光滑化合物的可水分散的含磺基聚酯和聚酯酰胺。聚合物可用于涂料或油墨组合物，这些组合物又用于标记物品以用于鉴定/认证目的。还提供了一种用于不可见地标记这种物品的方法，以及通过利用近红外荧光墨水或涂料组合物来检测和分选物品的方法。

8. 发明授权

US10030036B2 Method and dyes for detecting and destroying cancer cells 有权
公开(公告)号：US10030036B2
公开(公告)日：2018-07-24
申请号：US12778569
申请日：2010-05-12
申请人： James J. Krutak , Lyle Small , Maged Henary , Gabor Patonay
发明人： James J. Krutak , Lyle Small , Maged Henary , Gabor Patonay
IPC分类号： A61N1/40 , C07F1/00 , A61K49/00 , A61K41/00 , C09B23/01 , C09B23/08
摘要： This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.

9. 发明申请

US20110262354A1 CYANINE-CONTAINING COMPOUNDS FOR CANCER IMAGING AND TREATMENT 审中-公开
标题翻译：用于癌症成像和治疗的含氰胺的化合物
公开(公告)号：US20110262354A1
公开(公告)日：2011-10-27
申请号：US12668460
申请日：2008-07-10
申请人： Leland W. K. Chung , Ruoxiang Wang , Haiyen E. Zhau , Lucjan Strekowski , Maged Henary , Gabor Patonay , James J. Krutak , Xiaojian Yang , Guodong Zhu
发明人： Leland W. K. Chung , Ruoxiang Wang , Haiyen E. Zhau , Lucjan Strekowski , Maged Henary , Gabor Patonay , James J. Krutak , Xiaojian Yang , Guodong Zhu
IPC分类号： A61K49/00 , A61P35/00 , C12N5/00 , A61K31/404 , C07D403/08 , C12Q1/02
CPC分类号： A61K49/00 , A61K31/404 , C07D209/10 , C07D209/60 , C07D209/92 , G01N33/5008
摘要： This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields.
摘要翻译：本发明一般涉及含花青化合物; 包含含花青化合物的药物组合物; 以及使用含花青素化合物进行癌细胞成像，癌细胞生长抑制，以及检测癌细胞的方法等。与正常细胞相比，本发明的化合物优先被癌细胞吸收。这可以在癌症治疗，诊断，跟踪和成像领域的许多用途。

10. 发明授权

US5336714A Water-dissipatable polyesters and amides containing near infrared fluorescent compounds copolymerized therein 失效
公开(公告)号：US5336714A
公开(公告)日：1994-08-09
申请号：US175447
申请日：1993-12-30
申请人： James J. Krutak , Michael R. Cushman , William W. Parham , Clarence A. Coates , Max A. Weaver , Gabor Patonay
发明人： James J. Krutak , Michael R. Cushman , William W. Parham , Clarence A. Coates , Max A. Weaver , Gabor Patonay
IPC分类号： C09K11/06 , C08G63/68 , C08G69/44 , C09B69/10 , C09D5/22 , C09D11/10 , C09D167/00 , C09D167/02 , C09D177/00 , C09D177/12 , C08K3/20
CPC分类号： C09D11/102 , C08G63/68 , C08G69/44 , C09B69/10 , Y10T428/29 , Y10T428/3179
摘要： Provided are water-dissipatable, sulfo-containing polyesters and polyester-amides having copolymerized therein thermally stable near infrared flourophoric compounds. The polymers are useful in coating or ink compositions, which are in turn useful for marking articles for identification/authentication purposes. Also provided is a method for invisibly marking such articles and a method for detecting and sorting articles by utilizing the near infrared flourophoric ink or coating compositions.

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