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1. 发明申请

US20110262354A1 CYANINE-CONTAINING COMPOUNDS FOR CANCER IMAGING AND TREATMENT 审中-公开
标题翻译：用于癌症成像和治疗的含氰胺的化合物
公开(公告)号：US20110262354A1
公开(公告)日：2011-10-27
申请号：US12668460
申请日：2008-07-10
申请人： Leland W. K. Chung , Ruoxiang Wang , Haiyen E. Zhau , Lucjan Strekowski , Maged Henary , Gabor Patonay , James J. Krutak , Xiaojian Yang , Guodong Zhu
发明人： Leland W. K. Chung , Ruoxiang Wang , Haiyen E. Zhau , Lucjan Strekowski , Maged Henary , Gabor Patonay , James J. Krutak , Xiaojian Yang , Guodong Zhu
IPC分类号： A61K49/00 , A61P35/00 , C12N5/00 , A61K31/404 , C07D403/08 , C12Q1/02
CPC分类号： A61K49/00 , A61K31/404 , C07D209/10 , C07D209/60 , C07D209/92 , G01N33/5008
摘要： This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields.
摘要翻译：本发明一般涉及含花青化合物; 包含含花青化合物的药物组合物; 以及使用含花青素化合物进行癌细胞成像，癌细胞生长抑制，以及检测癌细胞的方法等。与正常细胞相比，本发明的化合物优先被癌细胞吸收。这可以在癌症治疗，诊断，跟踪和成像领域的许多用途。

2. 发明申请

US20130101513A1 METHOD OF USING NEAR INFRARED FLUORESCENT DYES FOR IMAGING AND TARGETING CANCERS 审中-公开
标题翻译：使用近红外荧光染料成像和靶向癌症的方法
公开(公告)号：US20130101513A1
公开(公告)日：2013-04-25
申请号：US13634677
申请日：2011-03-16
申请人： Xiaojian Yang , Haiyen E. Zhau , Ruoxiang Wang , Leland W.K. Chung
发明人： Xiaojian Yang , Haiyen E. Zhau , Ruoxiang Wang , Leland W.K. Chung
IPC分类号： C12Q1/04 , A61K49/00
CPC分类号： C12Q1/04 , A61B5/0059 , A61B5/417 , A61B2503/40 , A61K49/006 , C09B23/0016 , C09B23/0033 , C09B23/0066 , C09B23/086 , G01N21/6428 , G01N33/5091 , G01N33/574
摘要： The present invention describes methods of identifying, detecting, imaging, isolating and locating cancer cells in a subject. The method invokes the use of near-infrared (NIR) organic carbocyanine dyes, particularly, near infrared heptamethine cyanine dyes and the detection of the fluorescence of these NIR dyes. The uptake of these dyes by cancer cells and not by normal cells, as well as their high intensity, among other things, allow for the detection of cancerous cells in a subject and facilitate their subsequent isolation. Further, detection of many tumor types and tumor cell populations under cell culture and in vivo conditions are described.
摘要翻译：本发明描述了鉴定，检测，成像，分离和定位受试者中的癌细胞的方法。该方法调用了使用近红外（NIR）有机碳菁染料，特别是近红外七甲基氰花青染料和这些NIR染料的荧光检测。由癌细胞而不是正常细胞摄取这些染料，以及其高强度等可以检测受试者中的癌细胞，并促进其随后的分离。此外，描述了在细胞培养和体内条件下检测许多肿瘤类型和肿瘤细胞群体。

3. 发明申请

US20170314056A1 METHOD OF USING NEAR INFRARED FLUORESCENT DYES FOR IMAGING AND TARGETING CANCERS 审中-公开
公开(公告)号：US20170314056A1
公开(公告)日：2017-11-02
申请号：US15487320
申请日：2017-04-13
申请人： Xiaojian Yang , Haiyen E. Zhau , Ruoxiang Wang , Leland W.K. Chung
发明人： Xiaojian Yang , Haiyen E. Zhau , Ruoxiang Wang , Leland W.K. Chung
IPC分类号： C12Q1/04 , G01N33/50 , G01N21/64 , C09B23/08 , A61B5/00 , C09B23/01 , A61K49/00 , G01N33/574
CPC分类号： C12Q1/04 , A61B5/0059 , A61B5/417 , A61B2503/40 , A61K49/006 , C09B23/0016 , C09B23/0033 , C09B23/0066 , C09B23/086 , G01N21/6428 , G01N33/5091 , G01N33/574
摘要： The present invention describes methods of identifying, detecting, imaging, isolating and locating cancer cells in a subject. The method involves the use of near-infrared (NIR) organic carbocyanine dyes, particularly, near infrared heptamethine cyanine dyes and the detection of the fluorescence of these NIR dyes. The uptake of these dyes by cancer cells and not by normal cells, as well as their high intensity, among other things, allow for the detection of cancerous cells in a subject and facilitate their subsequent isolation. Further, detection of many tumor types and tumor cell populations under cell culture and in vivo conditions are described.

4. 发明授权

US5874305A Androgen-repressed metastatic human prostate cancer cell line 失效
标题翻译：雄激素抑制转移性人前列腺癌细胞系
公开(公告)号：US5874305A
公开(公告)日：1999-02-23
申请号：US593807
申请日：1996-01-30
申请人： Leland W.K. Chung , Haiyen E. Zhau , Shi-ming Chang
发明人： Leland W.K. Chung , Haiyen E. Zhau , Shi-ming Chang
IPC分类号： C12Q1/02 , A61K49/00 , C12N5/09 , G01N33/15 , G01N33/50 , C12N5/00
CPC分类号： A61K49/0008 , A61K49/0004 , C12N5/0693 , G01N33/5011
摘要： A new prostate cancer cell line is a continuous line of androgen-repressed metastatic prostate cancer cells. Androgen-repressed prostate cancer cells are linked with aggressive, malignant prostate cancer, in the identification and establishment of androgen-repressed prostate cancer cell lines, which are stable and continuous, allows the examination of therapeutic agents therefor, as well as identification of biological markers for the same.
摘要翻译：一种新的前列腺癌细胞系是一种连续的雄激素抑制转移性前列腺癌细胞系。雄激素抑制的前列腺癌细胞与侵袭性恶性前列腺癌相关，在鉴定和建立雄激素受抑制的前列腺癌细胞系中，其稳定和连续，允许检查其治疗剂，以及鉴定生物标志物相同的

5. 发明申请

US20090028832A1 Compositions and methods for targeted tumor therapy 审中-公开
标题翻译：用于靶向肿瘤治疗的组合物和方法
公开(公告)号：US20090028832A1
公开(公告)日：2009-01-29
申请号：US11891361
申请日：2007-08-10
申请人： Leland F. Chung , Haiyen E. Zhau
发明人： Leland F. Chung , Haiyen E. Zhau
IPC分类号： A61K35/12 , A61P35/00
CPC分类号： A61K35/48
摘要： The present invention relates to a method of treating a human patient having one or more tumor cells. In one embodiment, the method comprises the step of implanting at or around the site of one or more tumor cells in the patient a cell population comprising one or more prostate cancer cells characterized in that the one or more prostate cancer cells have the propensity of metastasizing to skeleton and soft tissues which represent one or more lethal phenotypes of human prostate cancer.
摘要翻译：本发明涉及治疗患有一种或多种肿瘤细胞的人类患者的方法。在一个实施方案中，该方法包括在患者体内的一个或多个肿瘤细胞的位点处或周围植入包含一种或多种前列腺癌细胞的细胞群的步骤，其特征在于所述一种或多种前列腺癌细胞具有转移倾向涉及表示人前列腺癌的一种或多种致死表型的骨骼和软组织。

6. 发明申请

US20110142848A1 ANTI-BETA-2-MICROGLOBULIN AGENTS AND THE USE THEREOF 审中-公开
标题翻译：抗β-2-微粒蛋白剂及其用途
公开(公告)号：US20110142848A1
公开(公告)日：2011-06-16
申请号：US13056926
申请日：2009-08-07
申请人： Leland W.K. Chung , Sajni Josson , Wen-Chin Huang , Haiyen E. Zhau
发明人： Leland W.K. Chung , Sajni Josson , Wen-Chin Huang , Haiyen E. Zhau
IPC分类号： A61K39/395 , A61K31/7088 , A61K31/69 , A61K31/7068 , A61K33/24 , A61K31/704 , A61K31/337 , A61K31/7048 , A61K31/395 , A61P35/00 , A61M37/00
CPC分类号： C07K16/2833 , A61K31/7105 , A61K39/39558 , A61K45/06 , A61K2300/00
摘要： A method for treating cancer includes treating a subject with an agent against beta-2-microglobulin; and treating the subject with radiation or a cancer therapeutic agent. The agent against beta-2-microglobulin includes anti-b2-M antibodies and miRNAs.
摘要翻译：用于治疗癌症的方法包括用针对β-2-微球蛋白的药剂治疗受试者; 并用辐射或癌症治疗剂治疗受试者。针对β-2-微球蛋白的药物包括抗b2-M抗体和miRNA。

7. 发明授权

US5221612A Unique protein marker for bladder cancer 失效
标题翻译：独特的蛋白质标记为乳腺癌
公开(公告)号：US5221612A
公开(公告)日：1993-06-22
申请号：US318790
申请日：1989-03-03
申请人： Haiyen E. Zhau , Richard J. Babaian
发明人： Haiyen E. Zhau , Richard J. Babaian
IPC分类号： G01N33/50 , C07K16/30 , G01N33/53 , G01N33/574 , G01N33/577
CPC分类号： C07K16/3038 , G01N33/57446 , Y10S436/813 , Y10S436/825 , Y10S436/828 , Y10S530/806 , Y10S530/828 , Y10S530/834 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： The present invention involves a method for detecting bladder cancer in a subject. The method preferably comprises first collecting a urine sample from the subject. The presence of a proteinaceous substance having a molecular weight of about 180 kDa according to its relative electrophoretic migration rate through detergent-containing polyacrylamide gel is then measured. This substance reversibly binds concanavalin A and is complexed with gamma globulin while in the urine. The gamma globulin complex binds to Staphlococcal protein A. Said proteinaceous substance, when present in detectable amount, is an indicator of bladder cancer.The method of the present invention for diagnosing bladder cancer in a subject may also be described as comprising detection in a urine sample from said subject of a proteinaceous substance having a molecular weight of about 180 kDa and being unreactive with antibodies specifically binding to carcinoembryonic antigen or epidermal growth factor receptor. When an antibody is used for the present method of diagnosis, an initial step for preparing an antibody specifically binding a urinary 180 kDa antigen present in urine of bladder cancer victims is carried out. This antibody of course may be prepared by others and merely obtained by commercial purchase. In any case said antibody may be used to detect the bladder cancer-specific 180 kDa antigen of the present invention in patient urine. This antibody is most preferably monoclonal or may be polyclonal.
摘要翻译：本发明涉及用于检测受试者膀胱癌的方法。该方法优选地包括首先从受试者收集尿液样品。然后测量根据其通过含有去污剂的聚丙烯酰胺凝胶的相对电泳迁移速率，分子量为约180kDa的蛋白质物质的存在。该物质可逆地结合刀豆蛋白A，并与尿球中的γ球蛋白复合。 γ球蛋白复合物与葡萄球菌蛋白A结合。所述蛋白质物质以可检测的量存在时，是膀胱癌的指标。用于诊断受试者的膀胱癌的本发明的方法还可以被描述为包括在来自所述受试者的尿液样品中检测分子量为约180kDa的蛋白质物质，并且与特异性结合癌胚抗原的抗体不反应或表皮生长因子受体当本发明的诊断方法使用抗体时，进行制备特异性结合膀胱癌患者尿中存在的尿180kDa抗原的抗体的初始步骤。这种抗体当然可以由他人制备，只能通过商业购买获得。在任何情况下，所述抗体可用于在患者尿液中检测本发明的膀胱癌特异性180kDa抗原。该抗体最优选是单克隆抗体或可以是多克隆的。

8. 发明授权

US09771625B2 Monoamine oxidase inhibitors and methods for treatment and diagnosis of prostate cancer 有权
公开(公告)号：US09771625B2
公开(公告)日：2017-09-26
申请号：US13559431
申请日：2012-07-26
申请人： Jean C. Shih , Leland Chung , Haiyen E. Zhau , Boyang Jason Wu , Bogdan Z. Olenyuk
发明人： Jean C. Shih , Leland Chung , Haiyen E. Zhau , Boyang Jason Wu , Bogdan Z. Olenyuk
IPC分类号： A61K31/405 , A61K31/352 , A61K31/357 , A61K31/381 , C12N15/113 , A61K31/366 , A61K31/5375 , A61K31/713 , A61K47/48 , A61K49/00
CPC分类号： A61K31/137 , A61K31/352 , A61K31/357 , A61K31/366 , A61K31/381 , A61K31/405 , A61K31/5375 , A61K31/713 , A61K47/545 , A61K47/55 , A61K47/6929 , A61K49/0032 , C12N15/1137 , C12N2310/14 , C12N2310/531 , C12Y104/03004
摘要： A mechanism of monoamine oxidases (MAOs) driven epithelium-to-mesenchymal transition (EMT) is disclosed. Also disclosed are methods for treating cancer by inhibiting or suppressing MAOs in cancer cells. Novel MAOs inhibitors, such as small molecules, siRNA, shRNA, antisense oligonucleotides, aptamers, decoys, and pharmaceutical compositions useful for treating cancer by disrupting the workings of MAOs are provided. In particular, a class of conjugates formed by covalently conjugating near infrared dye 783, IR-780, and MHI-148 to a MAO inhibitor, such as clorgyline, with and without encapsulation it in a nanoparticle is provided. Other aspects of the invention include methods for forming the nano-conjugates, method for monitoring treatment progress in a cancer patient by monitoring the changes in MAO activity, methods for screening patients who are at risk of cancer or differentiating different forms of cancer by assaying the level and location of MAO activity.

9. 发明授权

US5359031A Unique protein marker for bladder cancer 失效
标题翻译：独特的膀胱癌蛋白标记物
公开(公告)号：US5359031A
公开(公告)日：1994-10-25
申请号：US875626
申请日：1992-04-28
申请人： Haiyen E. Zhau , Richard J. Babaian
发明人： Haiyen E. Zhau , Richard J. Babaian
IPC分类号： G01N33/50 , C07K16/30 , G01N33/53 , G01N33/574 , G01N33/577 , C07K15/00
CPC分类号： C07K16/3038 , G01N33/57446 , Y10S436/813 , Y10S436/825 , Y10S436/828 , Y10S530/806 , Y10S530/828 , Y10S530/834 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： The present invention involves a method for detecting bladder cancer in a subject. The method preferably comprises first collecting a urine sample from the subject. The presence of a proteinaceous substance having a molecular weight of about 180 kDa according to its relative electrophoretic migration rate through detergent-containing polyacrylamide gel is then measured. This substance reversibly binds concanavalin A and is complexed with gamma globulin while in the urine. The gamma globulin complex binds to Staphlococcal protein A. Said proteinaceous substance, when present in detectable amount, is an indicator of bladder cancer.
摘要翻译：本发明涉及用于检测受试者膀胱癌的方法。该方法优选地包括首先从受试者收集尿液样品。然后测量根据其通过含有去污剂的聚丙烯酰胺凝胶的相对电泳迁移速率，分子量为约180kDa的蛋白质物质的存在。该物质可逆地结合刀豆蛋白A，并与尿球中的γ球蛋白复合。 γ球蛋白复合物与葡萄球菌蛋白A结合。所述蛋白质物质以可检测的量存在时，是膀胱癌的指标。

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