专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US11572475B2 Carbocyanines for G-quadruplex DNA stabilization and telomerase inhibition 有权
公开(公告)号：US11572475B2
公开(公告)日：2023-02-07
申请号：US14233044
申请日：2012-07-18
申请人： Maged Henary , W. David Wilson
发明人： Maged Henary , W. David Wilson
IPC分类号： C09B23/06 , C07D209/14 , C07D403/06 , C07D213/73 , C07D209/49 , C07D403/12 , C07D407/12 , C07D249/10 , C07D231/14 , C07D413/14 , C07D239/34 , C07D231/20 , C07D401/14 , C07D401/04 , C07D403/10 , C07D209/18 , C07D235/24 , C07D417/12 , C07D213/64
摘要： Cyanines which selectively bind to G-quadruplex DNA complexes, particularly quadruplexes expressed in cancer cells, and methods of making and using thereof are described herein. The cyanine can be a symmetrical or unsymmetrical streptocyanine, hemicyanine, closed chain cyanine, or combinations thereof. The cyanine is preferably substituted with one or more groups that minimize or prevent aggregation of the cyanine and/or inhibit binding of the cyanine to duplex DNA. One or more of the cyanines can be formulated with one or more pharmaceutical excipients and/or carrier to prepare pharmaceutical compositions suitable for administration to a patient, particular a human patient. The compounds and compositions described herein can be used to treat diseases or disorders characterized by the expression of G-quadruplex DNA, such as cancer.

2. 发明授权

US10030036B2 Method and dyes for detecting and destroying cancer cells 有权
公开(公告)号：US10030036B2
公开(公告)日：2018-07-24
申请号：US12778569
申请日：2010-05-12
申请人： James J. Krutak , Lyle Small , Maged Henary , Gabor Patonay
发明人： James J. Krutak , Lyle Small , Maged Henary , Gabor Patonay
IPC分类号： A61N1/40 , C07F1/00 , A61K49/00 , A61K41/00 , C09B23/01 , C09B23/08
摘要： This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.

3. 发明申请

US20110262354A1 CYANINE-CONTAINING COMPOUNDS FOR CANCER IMAGING AND TREATMENT 审中-公开
标题翻译：用于癌症成像和治疗的含氰胺的化合物
公开(公告)号：US20110262354A1
公开(公告)日：2011-10-27
申请号：US12668460
申请日：2008-07-10
申请人： Leland W. K. Chung , Ruoxiang Wang , Haiyen E. Zhau , Lucjan Strekowski , Maged Henary , Gabor Patonay , James J. Krutak , Xiaojian Yang , Guodong Zhu
发明人： Leland W. K. Chung , Ruoxiang Wang , Haiyen E. Zhau , Lucjan Strekowski , Maged Henary , Gabor Patonay , James J. Krutak , Xiaojian Yang , Guodong Zhu
IPC分类号： A61K49/00 , A61P35/00 , C12N5/00 , A61K31/404 , C07D403/08 , C12Q1/02
CPC分类号： A61K49/00 , A61K31/404 , C07D209/10 , C07D209/60 , C07D209/92 , G01N33/5008
摘要： This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields.
摘要翻译：本发明一般涉及含花青化合物; 包含含花青化合物的药物组合物; 以及使用含花青素化合物进行癌细胞成像，癌细胞生长抑制，以及检测癌细胞的方法等。与正常细胞相比，本发明的化合物优先被癌细胞吸收。这可以在癌症治疗，诊断，跟踪和成像领域的许多用途。

4. 发明申请

US20150376209A1 METHOD AND DYES FOR DETECTING AND DESTROYING CANCER CELLS 审中-公开
标题翻译：用于检测和破坏癌细胞的方法和方法
公开(公告)号：US20150376209A1
公开(公告)日：2015-12-31
申请号：US12778569
申请日：2010-05-12
申请人： JAMES J. KRUTAK , Lyle Small , Maged Henary , Gabor Patonay
发明人： JAMES J. KRUTAK , Lyle Small , Maged Henary , Gabor Patonay
IPC分类号： C07F1/00 , A61N1/40 , C09B23/01 , A61K49/00 , A61K41/00
CPC分类号： C07F1/00 , A61K41/0052 , A61K41/0057 , A61K49/0032 , A61K49/0093 , A61N1/406 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/086
摘要： This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.
摘要翻译：本发明涉及新的碳菁染料组合物，包含这种组合物的药物组合物，通过近红外荧光成像检测初始癌细胞的方法和通过施用这种药物组合物鉴定的癌细胞的选择性破坏。一种检测和破坏癌细胞的方法包括将金染料引入怀疑具有癌细胞的生物体中。金染料是共价连接到金纳米颗粒上的碳菁染料。近红外光照射在怀疑患有癌细胞的区域。检测到来自金色染料的荧光。射频能量束被引导到该区域以诱导癌细胞中的高热。碳菁染料具有MHI-148和结构6和22的最基本结构，在赋予癌细胞活性的环己烯环上具有Aun- [CH 2（CH 2）9 CH 2 - （OCH 2 CH 2）4 O] COCH 2 CH 2 - 苯基-O基团绑定和销毁过程。

5. 发明申请

US20140142147A1 Carbocyanines for G-Quadruplex DNA Stabilization and Telomerase Inhibition 审中-公开
标题翻译：用于G-Quadruplex DNA稳定化和端粒酶抑制的花青素
公开(公告)号：US20140142147A1
公开(公告)日：2014-05-22
申请号：US14233044
申请日：2012-07-18
申请人： Maged Henary , W. David Wilson
发明人： Maged Henary , W. David Wilson
IPC分类号： C09B23/06
CPC分类号： C09B23/06 , C07D209/14 , C07D209/18 , C07D209/49 , C07D213/64 , C07D213/73 , C07D231/14 , C07D231/20 , C07D235/24 , C07D239/34 , C07D249/10 , C07D401/04 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12
摘要： Cyanines which selectively bind to G-quadruplex DNA complexes, particularly quadruplexes expressed in cancer cells, and methods of making and using thereof are described herein. The cyanine can be a symmetrical or unsymmetrical streptocyanine, hemicyanine, closed chain cyanine, or combinations thereof. The cyanine is preferably substituted with one or more groups that minimize or prevent aggregation of the cyanine and/or inhibit binding of the cyanine to duplex DNA. One or more of the cyanines can be formulated with one or more pharmaceutical excipients and/or carrier to prepare pharmaceutical compositions suitable for administration to a patient, particular a human patient. The compounds and compositions described herein can be used to treat diseases or disorders characterized by the expression of G-quadruplex DNA, such as cancer.
摘要翻译：在本文中描述了选择性结合G-四链体DNA复合物，特别是在癌细胞中表达的四链体的花青苷及其制备和使用方法。花青可以是对称或不对称的链花青，半花青，闭链花青或其组合。花青优选被一个或多个使花青聚集和/或抑制花青与双链DNA结合的聚合作用的基团取代。一种或多种花青可以与一种或多种药物赋形剂和/或载体一起配制，以制备适于给予患者，特别是人类患者的药物组合物。本文所述的化合物和组合物可用于治疗特征在于表达G-四链体DNA例如癌症的疾病或病症。

6. 发明申请

US20130075675A1 Thermochromic Compositions From Trisubstituted Pyridine Leuco Dyes 审中-公开
标题翻译：三取代吡啶无色染料的热变色组合物
公开(公告)号：US20130075675A1
公开(公告)日：2013-03-28
申请号：US13627916
申请日：2012-09-26
申请人： James J. Krutak , Maged Henary , Timothy J. Owen , Chromatic Technologies, Inc.
发明人： James J. Krutak , Maged Henary , Timothy J. Owen , Chromatic Technologies, Inc.
IPC分类号： C09K9/02
CPC分类号： C09B9/00 , B41M5/284 , C09D11/037
摘要： A thermochromic leuco dye composition contains a leuco dye moiety including one or more tri-aryl substituted pyridines, a UVA developer moiety including at least one UVA developer selected from the group consisting of salicylic acid and derivatives thereof, and biphenyls and derivatives thereof, and a carrier selected from the group consisting of a fatty ester, fatty alcohol, fatty amide, and combinations thereof.
摘要翻译：热致变色无色染料组合物含有包含一个或多个三芳基取代吡啶的无色染料部分，包含至少一种选自水杨酸及其衍生物的UVA显影剂的UVA显影剂部分及其联苯及其衍生物，以及选自脂肪酯，脂肪醇，脂肪酰胺及其组合的载体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式