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1. 发明授权

US08350064B2 Fluorescent xanthenes and white light fluorophores 有权
标题翻译：荧光呫吨和白光荧光团
公开(公告)号：US08350064B2
公开(公告)日：2013-01-08
申请号：US12374111
申请日：2007-07-19
申请人： Robert M. Strongin , Isiah M. Warner , Youjun Yang , Mark Lowry , Sayo O. Fakayode , Jorge O. Escobedo Cordova , Xiangyang Xu
发明人： Robert M. Strongin , Isiah M. Warner , Youjun Yang , Mark Lowry , Sayo O. Fakayode , Jorge O. Escobedo Cordova , Xiangyang Xu
IPC分类号： C07D311/78
CPC分类号： C07D311/78 , C09B11/06 , C09B11/22 , G01N1/30
摘要： Xanthene compounds are disclosed having fluorescence at multiple wavelengths. Also disclosed are methods for their synthesis and use. Some of the compounds fluoresce at three wavelengths, emitting white light. Uses include the imaging of biological tissues, illumination, and display technologies. Many of the compounds have large Stokes shifts, and are resistant to photobleaching. The fluorescence may be readily distinguished from that of endogenous fluorophores, and from that of most existing, commercially-available fluorescent probes. The compounds are well suited for use in “multiplexing” techniques. They exhibit clear isosbestic and isoemissive points, and have broad absorption and emission ranges.
摘要翻译：公开了在多个波长具有荧光的呫吨化合物。还公开了它们的合成和使用的方法。一些化合物在三个波长发出荧光，发出白光。用途包括生物组织成像，照明和显示技术。许多化合物具有大的斯托克斯位移，并且耐光漂白。荧光可以容易地与内源性荧光团的区别，以及大多数现有的市售荧光探针的荧光。该化合物非常适用于复用技术。它们表现出清晰的同位素和等位基因，具有广泛的吸收和发射范围。

2. 发明申请

US20100051826A1 Fluorescent Xanthenes and White Light Fluorophores 有权
标题翻译：荧光Xanthenes和白光荧光团
公开(公告)号：US20100051826A1
公开(公告)日：2010-03-04
申请号：US12374111
申请日：2007-07-19
申请人： Robert M. Strongin , Isiah M. Warner , Youjun Yang , Mark Lowry , Sayo O. Fakayode , Jorge O. Escobedo Cordova , Xiangyang Xu
发明人： Robert M. Strongin , Isiah M. Warner , Youjun Yang , Mark Lowry , Sayo O. Fakayode , Jorge O. Escobedo Cordova , Xiangyang Xu
IPC分类号： B01J19/12 , C07D311/82
CPC分类号： C07D311/78 , C09B11/06 , C09B11/22 , G01N1/30
摘要： Xanthene compounds are disclosed having fluorescence at multiple wavelengths. Also disclosed are methods for their synthesis and use. Some of the compounds fluoresce at three wavelengths, emitting white light. Uses include the imaging of biological tissues, illumination, and display technologies. Many of the compounds have large Stokes shifts, and are resistant to photobleaching. The fluorescence may be readily distinguished from that of endogenous fluorophores, and from that of most existing, commercially-available fluorescent probes. The compounds are well suited for use in “multiplexing” techniques. They exhibit clear isosbestic and isoemissive points, and have broad absorption and emission ranges.
摘要翻译：公开了在多个波长具有荧光的呫吨化合物。还公开了它们的合成和使用的方法。一些化合物在三个波长发出荧光，发出白光。用途包括生物组织成像，照明和显示技术。许多化合物具有大的斯托克斯位移，并且耐光漂白。荧光可以容易地与内源性荧光团的区别，以及大多数现有的市售荧光探针的荧光。这些化合物非常适合用于“复用”技术。它们表现出清晰的同位素和等位基因，具有广泛的吸收和发射范围。

3. 发明申请

US20130303402A1 Detection and Molecular Weight Determination of Organic Vapors 有权
标题翻译：有机蒸汽的检测和分子量测定
公开(公告)号：US20130303402A1
公开(公告)日：2013-11-14
申请号：US13980068
申请日：2012-01-19
申请人： Isiah M. Warner , Bishnu P. Regmi , Bilal El-Zahab , Daniel J. Hayes
发明人： Isiah M. Warner , Bishnu P. Regmi , Bilal El-Zahab , Daniel J. Hayes
IPC分类号： B01J20/22
CPC分类号： B01J20/22 , G01N29/022 , G01N29/036 , G01N33/0047 , G01N2291/021 , G01N2291/0426
摘要： Composite films comprising an organic salt (or GUMBOS) such as 1-n-butyl-2,3-dimethylimidazolium hexafluoro-phosphate and a polymer such as cellulose acetate are prepared. These films are useful in detecting vapors of volatile organic compounds, and in determining their molecular weights. A quartz crystal microbalance-based sensor was designed by depositing a thin film of this composite material on the gold electrode surface of a quartz crystal resonator. The sensor exhibited rapid response toward a variety of volatile organic compounds, and complete regeneration, high sensitivity, low detection limits, and wide dynamic ranges. The ratio of the change in frequency to the change in motional resistance is a concentration-independent quantity that is proportional to the molecular weight of the absorbed chemical species. These properties facilitate the easy identification and molecular weight determination of a broad range of organic vapors.
摘要翻译：制备包含有机盐（或GUMBOS）如1-正丁基-2,3-二甲基咪唑鎓六氟磷酸盐和聚合物如乙酸纤维素的复合膜。这些膜可用于检测挥发性有机化合物的蒸气，以及确定其分子量。通过在石英晶体谐振器的金电极表面上沉积该复合材料的薄膜来设计石英晶体微量天平传感器。传感器对各种挥发性有机化合物表现出快速反应，完全再生，灵敏度高，检测限低，动态范围广。频率变化与运动阻力变化的比率是与吸收的化学物质的分子量成比例的浓度非依赖性量。这些性质有助于容易地鉴定和分子量测定范围广泛的有机蒸气。

4. 发明授权

US06013738A Composition and method for chiral separations 失效
标题翻译：手性分离的组成和方法
公开(公告)号：US06013738A
公开(公告)日：2000-01-11
申请号：US154377
申请日：1998-09-16
申请人： William H. Daly , Drew S. Poche , Stefan J. Thibodeaux , Isiah M. Warner
发明人： William H. Daly , Drew S. Poche , Stefan J. Thibodeaux , Isiah M. Warner
IPC分类号： B01D61/16 , B01D61/38 , C08G69/10 , C08F283/04
CPC分类号： B01D61/16 , B01D61/007 , B01D61/145 , B01D61/38 , C08G69/10 , B01D2311/04
摘要： Polymers are disclosed that are useful in performing chiral separations. A synthetic scheme for producing the novel polymers is also disclosed. The alkyl side chains of poly(.gamma.-alkyl-.alpha.,L-glutamates) have been altered, allowing the facile substitution of the side chains with pendent functional groups. The compounds may be used as a stationary-phase or pseudo-stationary phase in separation techniques such as high performance liquid chromatography, or electrokinetic capillary chromatography. The novel compounds are water-soluble or water-swellable, and are particularly useful in separations of stereoisomers.
摘要翻译：公开了可用于进行手性分离的聚合物。还公开了用于生产新型聚合物的合成方案。聚（γ-烷基-α，L-谷氨酸）的烷基侧链已被改变，允许用侧链官能团容易地取代侧链。在高效液相色谱法或电动毛细管色谱法等分离技术中，化合物可用作固定相或假固定相。新型化合物是水溶性或水溶胀性的，并且在立体异构体的分离中特别有用。

5. 发明授权

US5770084A Polymerized chiral micelles for chiral separations 失效
标题翻译：用于手性分离的聚合手性胶束
公开(公告)号：US5770084A
公开(公告)日：1998-06-23
申请号：US698351
申请日：1996-08-15
申请人： Isiah M. Warner , Jian Wang
发明人： Isiah M. Warner , Jian Wang
IPC分类号： B01D15/04 , C07B57/00 , B01D15/08
CPC分类号： C07B57/00
摘要： Chiral separations can be enhanced through the use of polymerized chiral micelles. Because polymerized micelles eliminate much of the complex dynamic behavior associated with conventional micelles, polymerized chiral micelles have stronger chiral recognition properties than do otherwise-identical, "conventional" or non-polymerized chiral micelles. Recovery of chiral ligands from polymerized chiral micelles is often easier, as the chiral ligands may typically be recovered by simple extraction with an appropriate organic solvent. By contrast, recovering the solute from a conventional, non-polymerized micellar medium by extraction with an organic solvent frequently results in the formation of troublesome emulsion systems. Polymerized chiral micelle systems are therefore beneficial in both preparative-scale and process-scale separations. Polymerized chiral micelles have no critical micelle concentration, allowing lower concentrations to be used in micellar electrokinetic capillary chromatography, which in turn reduces the otherwise deleterious heat that can be generated.
摘要翻译：通过使用聚合的手性胶束可以增强手性分离。由于聚合的胶束消除了与常规胶束相关的大量复杂的动态行为，聚合的手性胶束具有比其他相同的“常规”或非聚合手性胶束更强的手性识别性能。手性配体从聚合手性胶束的回收通常更容易，因为手性配体通常可以通过用合适的有机溶剂简单萃取来回收。相比之下，通过用有机溶剂萃取从常规的非聚合胶束介质中回收溶质常常导致形成麻烦的乳液体系。因此，聚合的手性胶束体系在制备规模和工艺规模分离中都是有益的。聚合的手性胶束没有临界胶束浓度，允许较低的浓度用于胶束电动毛细管色谱，这反过来又减少了可能产生的其他有害的热量。

6. 发明授权

US06849722B2 Polymerized oligopeptide-surfactant chiral micelles 失效
标题翻译：聚合寡肽 - 表面活性剂手性胶束
公开(公告)号：US06849722B2
公开(公告)日：2005-02-01
申请号：US09876304
申请日：2001-06-07
申请人： Isiah M. Warner , Eugene J. Billiot , Shahab A. Shamsi , Stefan J. Thibodeaux
发明人： Isiah M. Warner , Eugene J. Billiot , Shahab A. Shamsi , Stefan J. Thibodeaux
IPC分类号： B01D15/38 , G01N27/447 , G01N30/02 , A61K38/00
CPC分类号： G01N27/44747 , B01D15/3833 , B01D15/3842 , G01N30/02
摘要： Chiral separations can be enhanced through the use of polymerized dipeptide-surfactant or oligopeptide-surfactant chiral micelles. Because polymerized micelles eliminate much of the complex dynamic behavior associated with conventional micelles, polymerized chiral micelles have stronger chiral recognition properties than do otherwise-identical, “conventional” or non-polymerized chiral micelles. Recovery of chiral ligands from polymerized chiral micelles is often easier, as the chiral ligands may typically be recovered by simple extraction with an appropriate organic solvent. By contrast, recovering the solute from a conventional, non-polymerized micellar medium by extraction with an organic solvent frequently results in the formation of troublesome emulsion systems. Polymerized chiral micelle systems are therefore beneficial in both preparative-scale and process-scale separations. Polymerized chiral micelles have no critical micelle concentration, allowing lower concentrations to be used in micellar electrokinetic capillary chromatography, which in turn reduces the otherwise deleterious heat that can be generated. Many polymerized dipeptide-surfactant or oligopeptide-surfactant chiral micelles have superior separation properties as compared to polymerized amino acid-surfactant chiral micelles.
摘要翻译：可以通过使用聚合的二肽 - 表面活性剂或寡肽 - 表面活性剂手性胶束来增强手性分离。由于聚合的胶束消除了与常规胶束相关的大量复杂的动态行为，聚合的手性胶束具有比其他相同的“常规”或非聚合手性胶束更强的手性识别性能。手性配体从聚合手性胶束的回收通常更容易，因为手性配体通常可以通过用合适的有机溶剂简单萃取来回收。相比之下，通过用有机溶剂萃取从常规的非聚合胶束介质中回收溶质常常导致形成麻烦的乳液体系。因此，聚合的手性胶束体系在制备规模和工艺规模分离中都是有益的。聚合的手性胶束没有临界胶束浓度，允许较低的浓度用于胶束电动毛细管色谱，这又降低了可产生的另外有害的热量。与聚合的氨基酸 - 表面活性剂手性胶束相比，许多聚合的二肽 - 表面活性剂或寡肽 - 表面活性剂手性胶束具有优异的分离性能。

7. 发明授权

US09782744B2 Detection and molecular weight determination of organic vapors 有权
公开(公告)号：US09782744B2
公开(公告)日：2017-10-10
申请号：US13980068
申请日：2012-01-19
申请人： Isiah M. Warner , Bishnu P. Regmi , Bilal El-Zahab , Daniel J. Hayes
发明人： Isiah M. Warner , Bishnu P. Regmi , Bilal El-Zahab , Daniel J. Hayes
IPC分类号： B01J20/22 , G01N33/00 , G01N29/02 , G01N29/036
CPC分类号： B01J20/22 , G01N29/022 , G01N29/036 , G01N33/0047 , G01N2291/021 , G01N2291/0426
摘要： Composite films comprising an organic salt (or GUMBOS) such as 1-n-butyl-2,3-dimethylimidazolium hexafluorophosphate and a polymer such as cellulose acetate are prepared. These films are useful in detecting vapors of volatile organic compounds, and in determining their molecular weights. A quartz crystal microbalance-based sensor was designed by depositing a thin film of this composite material on the gold electrode surface of a quartz crystal resonator. The sensor exhibited rapid response toward a variety of volatile organic compounds, and complete regeneration, high sensitivity, low detection limits, and wide dynamic ranges. The ratio of the change in frequency to the change in motional resistance is a concentration-independent quantity that is proportional to the molecular weight of the absorbed chemical species. These properties facilitate the easy identification and molecular weight determination of a broad range of organic vapors.

8. 发明申请

US20110217553A1 Frozen Ionic Liquid Microparticles and Nanoparticles, and Methods for their Synthesis and Use 审中-公开
标题翻译：冷冻离子液体微粒和纳米颗粒及其合成和使用方法
公开(公告)号：US20110217553A1
公开(公告)日：2011-09-08
申请号：US12808782
申请日：2008-12-09
申请人： Isiah M. Warner , Aaron Tesfai , Bilal M. El-Zahab , David Bwambok , Gary A. Baker , Sayo O. Fakayode , Mark Lowa , Michael P. Tolocka , Sergio De Rooy
发明人： Isiah M. Warner , Aaron Tesfai , Bilal M. El-Zahab , David Bwambok , Gary A. Baker , Sayo O. Fakayode , Mark Lowa , Michael P. Tolocka , Sergio De Rooy
IPC分类号： B32B9/00 , B29B9/06 , C08K5/3445 , B82Y5/00 , B82Y30/00 , B82Y15/00
CPC分类号： B82Y30/00 , D01D5/003 , Y10T428/2982 , Y10T428/2989
摘要： “Frozen ionic liquid” microparticles and nanoparticles are disclosed, as are alternative methods of making the particles. The particles may be monodisperse or polydisperse, with spherical or other shapes. The particles may be prepared without specialized equipment, and without harsh conditions. The microparticles and nanoparticles have uses in biomedical, materials, analytical, and other fields.
摘要翻译：公开了“冷冻离子液体”微粒和纳米颗粒，以及制备颗粒的替代方法。颗粒可以是单分散的或多分散的，具有球形或其它形状。颗粒可以在没有专门设备的情况下制备，并且在恶劣条件下。微粒和纳米颗粒在生物医学，材料，分析和其他领域都有应用。

9. 发明申请

US20100291689A1 Lanthanide Complexes as Fluorescent Indicators for Neutral Sugars and Cancer Diagnosis 审中-公开
标题翻译：镧系复合物作为中性糖和癌症诊断的荧光指示剂
公开(公告)号：US20100291689A1
公开(公告)日：2010-11-18
申请号：US12293483
申请日：2007-03-14
申请人： Robert M. Strongin , Onur Alptürk , Oleksandr Rusin , Sayo O. Fakayode , Jorge O. Escobedo Cordova , Weihua Wang , Isiah M. Warner , William E. Crowe , Vladimir Král
发明人： Robert M. Strongin , Onur Alptürk , Oleksandr Rusin , Sayo O. Fakayode , Jorge O. Escobedo Cordova , Weihua Wang , Isiah M. Warner , William E. Crowe , Vladimir Král
IPC分类号： G01N33/48 , G01N33/92 , G01N33/574 , C07F5/00 , C07C251/00
CPC分类号： G01N33/57449 , Y10T436/143333
摘要： A group of water-soluble salophene-lanthanide complexes and other salophene-metal complexes are useful for purposes including: (i) detecting neutral carbohydrates at physiologically-relevant pH, (ii) the selective detection of gangliosides, and (iii) the selective detection of lysophosphatidic acid (LPA) in the presence of phosphatidic acid. The selective detection of LPA is useful in diagnosing ovarian and other cancers.
摘要翻译：一组水溶性樟脑磺酸镧系元素配合物和其他的三环素金属络合物可用于：（i）在生理相关pH下检测中性碳水化合物，（ii）选择性检测神经节苷脂，和（iii）选择性检测的磷脂酸存在下的溶血磷脂酸（LPA）。 LPA的选择性检测可用于诊断卵巢癌和其他癌症。

10. 发明授权

US07314550B2 Analytical separations with polyelectrolyte layers, molecular micelles, or zwitterionic polymers 有权
标题翻译：用聚电解质层，分子胶束或两性离子聚合物进行分析分离
公开(公告)号：US07314550B2
公开(公告)日：2008-01-01
申请号：US10283471
申请日：2002-10-30
申请人： Isiah M. Warner , Joseph B. Schlenoff , Constantina P. Kapnissi
发明人： Isiah M. Warner , Joseph B. Schlenoff , Constantina P. Kapnissi
IPC分类号： B01D15/08
CPC分类号： G01N27/44752
摘要： Polymeric surfactants (molecular micelles) are disclosed for use in open tubular capillary electrochromatography or in high performance liquid chromatography. For example, fused silica capillaries are coated with thin films of charged polymers in a polyelectrolyte multilayer (PEM). A PEM coating may be formed in situ by alternate rinses with positive and negative polyelectrolytes. At least the innermost of the negatively charged polymer layers is a molecular micelle. Prototype embodiments have successfully separated seven benzodiazepines from one another. The run-to-run, day-to-day, week-to-week and capillary-to-capillary reproducibilities were very good, with relative standard deviation values less than 0.01. The PEM-coated capillary was very robust over at least 200 runs. Stability against high and low pH values was also observed. Using chiral polymerized micelles, chiral separations may be achieved, as was demonstrated with a separation of the enantiomers of 1,1′-binaphthyl-2,2′-dihydrogenphosphate. Alternatively, layers for use in this invention may be formed from zwitterionic polymers in lieu of separate cationic and anionic layers. Zwitterionic polymer layers may be used either with or without molecular micelles.
摘要翻译：公开了用于开放式管状毛细管电色谱法或高效液相色谱法中的聚合物表面活性剂（分子胶束）。例如，熔融二氧化硅毛细管在聚电解质多层（PEM）中用带电聚合物的薄膜涂覆。可以通过用正和负聚电解质的交替漂洗来原位形成PEM涂层。至少最内层的带负电荷的聚合物层是分子胶束。原型实施方案已成功地将七种苯并二氮杂相互分离。运行中的日常生活，周到周和毛细血管与毛细血管的重复性非常好，相对标准偏差值小于0.01。 PEM涂层的毛细管在至少200次运行中非常坚固。也观察到高和低pH值的稳定性。使用手性聚合的胶束，可以实现手性分离，如通过分离1,1'-联萘-2,2'-二氢磷酸盐的对映异构体所证明的。或者，用于本发明的层可以由两性离子聚合物代替单独的阳离子和阴离子层形成。两性离子聚合物层可以使用或不使用分子胶束。

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