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1. 发明授权

US5994413A Process for the production of fruit polyphenols from unripe rosaceae fruit 失效
标题翻译：从未成熟的玫瑰果科果实生产水果多酚的方法
公开(公告)号：US5994413A
公开(公告)日：1999-11-30
申请号：US784546
申请日：1997-01-21
申请人： Masayuki Tanabe , Tomomasa Kanda , Akio Yanagida
发明人： Masayuki Tanabe , Tomomasa Kanda , Akio Yanagida
IPC分类号： A61K36/73 , A23L1/30 , A61K31/35 , A61K131/00 , A61P37/00 , A61P39/06 , C07D311/62 , A01N31/08
CPC分类号： C07D311/62 , A23L33/105
摘要： The present invention provides a fruit polyphenol obtained by subjecting unripe fruits of Rosaceae to pressing and/or extraction and then purifying the resulting juice or extract. The present invention further provides an antioxidant, a hypotensive agent, an antimutagenic agent, an antiallergic agent and an anticariogenic agent each comprising, as an effective component, a fruit polyphenol obtained by subjecting unripe fruits of Rosaceae to pressing and/or extraction and then purifying the resulting juice or extract. The fruit polyphenol of the present invention has various physiological activities, for example, an antioxidative activity, an ACE-inhibiting activity, an antimutagenic activity, a hyalulonidase-inhibiting activity and a GTase-inhibiting activity.
摘要翻译：本发明提供一种水果多酚，其通过使蔷薇科的未成熟果实压制和/或提取，然后纯化得到的果汁或提取物而获得。本发明还提供抗氧化剂，降血压剂，抗诱变剂，抗过敏剂和抗龋剂，其各自包含通过使蔷薇科的未成熟果实压制和/或提取然后纯化而获得的水果多酚作为有效成分所得的果汁或提取物。本发明的果实多酚具有各种生理活性，例如抗氧化活性，ACE抑制活性，抗诱变活性，透明质酸酶抑制活性和GTase抑制活性。

2. 发明授权

US5932623A Process for the production of fruit polyphenols from unripe rosaceae fruit 失效
公开(公告)号：US5932623A
公开(公告)日：1999-08-03
申请号：US555729
申请日：1995-11-09
申请人： Masayuki Tanabe , Tomomasa Kanda , Akio Yanagida
发明人： Masayuki Tanabe , Tomomasa Kanda , Akio Yanagida
IPC分类号： A61K36/73 , A23L1/30 , A61K31/35 , A61K131/00 , A61P37/00 , A61P39/06 , C07D311/62 , A01N31/08
CPC分类号： C07D311/62 , A23L33/105
摘要： The present invention provides a fruit polyphenol obtained by subjecting unripe fruits of Rosaceae to pressing and/or extraction and then purifying the resulting juice or extract. The present invention further provides an antioxidant, a hypotensive agent, an antimutagenic agent, an antiallergic agent and an anticariogenic agent each comprising, as an effective component, a fruit polyphenol obtained by subjecting unripe fruits of Rosaceae to pressing and/or extraction and then purifying the resulting juice or extract. The fruit polyphenol of the present invention has various physiological activities, for example, an antioxidative activity, an ACE-inhibiting activity, an antimutagenic activity, a hyalulonidase-inhibiting activity and a GTase-inhibiting activity.

3. 发明授权

US5853728A Polyphenolic cosmetic composition 失效
标题翻译：多酚化妆品组合物
公开(公告)号：US5853728A
公开(公告)日：1998-12-29
申请号：US773596
申请日：1996-12-27
申请人： Masayuki Tanabe , Tomomasa Kanda , Akio Yanagida , Toshihiko Shoji
发明人： Masayuki Tanabe , Tomomasa Kanda , Akio Yanagida , Toshihiko Shoji
IPC分类号： A61K8/30 , A61K8/00 , A61K8/33 , A61K8/96 , A61K8/97 , A61Q5/00 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A01N65/00
CPC分类号： A61Q19/00 , A61K8/97 , A61Q17/00 , A61Q17/04 , Y10S514/846 , Y10S514/847
摘要： Cosmetics are herein disclosed which contain a polyphenol derived from the fruits of Rosaceae, and the polyphenol is obtainable by purifying a pressed juice or an extract of the unripe fruits of the Rosaceae, for example, apples, pears or peaches. The cosmetics have many useful functions such as an ultraviolet light absorbing activity and a free radical erasing activity.
摘要翻译：本文公开了含有衍生自蔷薇科果实的多酚的化妆品，并且多酚可通过纯化蔷薇科的未成熟果实的压榨汁或提取物获得，例如苹果，梨或桃。化妆品具有许多有用的功能，例如紫外光吸收活性和自由基擦除活性。

4. 发明授权

US06800433B1 Process for purification of proanthocyanidin oligomer 失效
标题翻译：纯化原花青素低聚物的方法
公开(公告)号：US06800433B1
公开(公告)日：2004-10-05
申请号：US09959274
申请日：2001-10-19
申请人： Shinkichi Honda , Tomoya Takahashi , Ayako Kamimura , Takako Matsuoka , Tomomasa Kanda , Akio Yanagida , Kazuo Hieda
发明人： Shinkichi Honda , Tomoya Takahashi , Ayako Kamimura , Takako Matsuoka , Tomomasa Kanda , Akio Yanagida , Kazuo Hieda
IPC分类号： C12Q100
CPC分类号： C07D311/62 , C07D311/60
摘要： The present invention relates to a process for purifying dimeric to pentameric proanthocyanidin oligomers which comprises extracting the proanthocyanidin oligomers from raw materials containing the proanthocyanidin oligomers or crude purification products therefrom by solid-liquid extraction using methyl acetate as a liquid phase; a process for purifying dimeric to pentameric proanthocyanidin oligomers which comprises pretreating with an enzyme for hydrolysis raw materials containing the proanthocyanidin oligomers, crude purification products therefrom, or a solution containing one of these; and a process for purifying dimeric to pentameric proanthocyanidin oligomers with a uniform polymerization degree which comprises separating and purifying the proanthocyanidin oligomers by polymerization degree from raw materials containing the proanthocyanidin oligomers or crude purification products there from by normal phase silica gel liquid chromatography using as a mobile phase a single solvent or a mixed solvent of two or more solvents selected from the group consisting of an ester solvent, a ketone solvent, a hydrocarbon solvent, an ether solvent and an alcohol solvent.
摘要翻译：本发明涉及一种纯化二聚至五聚原花青素低聚物的方法，该方法包括通过使用乙酸甲酯作为液相通过固液萃取从原料中提取原花青素低聚物或粗提纯产物; 用于纯化二聚体至五聚原花青素低聚物的方法，其包括用酶预处理含有原花青素低聚物的水解原料，其粗提纯产物或含有这些之一的溶液; 以及具有均匀聚合度的二聚至五聚原花青素低聚物的纯化方法，该方法包括通过使用作为流动相的正相硅胶液相色谱法从含有原花青素低聚物或粗纯化产物的原料中分离纯化原花青素低聚物将溶剂选自酯溶剂，酮溶剂，烃溶剂，醚溶剂和醇溶剂中的两种或更多种溶剂的单一溶剂或混合溶剂。

5. 发明申请

US20090053384A1 Method for Preparation of Plant Extract 审中-公开
标题翻译：植物提取物的制备方法
公开(公告)号：US20090053384A1
公开(公告)日：2009-02-26
申请号：US11887777
申请日：2006-03-16
申请人： Takehiro Watanabe , Rumi Fujita , Motoyuki Tagashira , Tomomasa Kanda , Seiichi Higuchi , Masayuki Tanabe
发明人： Takehiro Watanabe , Rumi Fujita , Motoyuki Tagashira , Tomomasa Kanda , Seiichi Higuchi , Masayuki Tanabe
IPC分类号： C12C3/00 , A23L1/28 , A23L1/025
CPC分类号： C07G17/00 , A23L33/105 , C12F3/06
摘要： It is intended to develop a technique for producing a water-soluble polyphenol at high purity and with high efficiency in a short time from hop bract or the like which is a by-product in the beer brewing. A method for preparation of a purified plant extract comprising steps of treating a plant extract with a clay mineral such as bentonite and removing any divalent cations from the resulting product; a method for producing a polyphenol comprising steps of passing the purified plant extract through a column to adsorb polyphenols onto the column and passing a solvent though the column to elute a water-soluble polyphenol from the column; and a method for producing a water-soluble hop bract polyphenol comprising steps of adding bentonite to a hop bract extract and allowing the resulting mixture to stand under acidic conditions, performing solid-liquid separation to produce a supernatant, purifying the supernatant through a column to give a pholyphenol-containing fraction, cooling the fraction and allowing the cooled fraction to stand to cause the precipitation of water-insoluble ingredients and performing solid-liquid separation to give the desired water-soluble hop bract polyphenol.
摘要翻译：旨在开发一种在啤酒酿造中作为副产物的啤酒花苞等在高纯度和高效率的短时间内生产水溶性多酚的技术。一种纯化植物提取物的制备方法，其包括用粘土矿物如膨润土处理植物提取物并从所得产物中除去任何二价阳离子的步骤; 一种生产多酚的方法包括以下步骤：使纯化的植物提取物通过柱，以将多酚吸附到柱上并使溶剂通过柱，以从柱中洗脱水溶性多酚; 以及制造水溶性跳苞片多酚的方法，其特征在于，包括以下步骤：将膨润土加入到鞭毛提取物中，使所得混合物在酸性条件下放置，进行固液分离，制成上清液，通过柱纯化上清液至得到含苯酚的级分，冷却该级分并使冷却的级分静置以引起水不溶性成分的沉淀并进行固液分离，得到所需的水溶性鞭毛多酚。

6. 发明申请

US20080003186A1 MATERIAL FOR INHIBITING ENAMEL DEMINERALIZATION 审中-公开
标题翻译：阻止ENAMEL DEMINERAL化的材料
公开(公告)号：US20080003186A1
公开(公告)日：2008-01-03
申请号：US11773240
申请日：2007-07-03
申请人： Susumu IMAI , Motoyuki Tagashira , Tomomasa Kanda , Toshiki Nishizawa , Nobuhiro Hanada
发明人： Susumu IMAI , Motoyuki Tagashira , Tomomasa Kanda , Toshiki Nishizawa , Nobuhiro Hanada
IPC分类号： A61K8/30 , A61P43/00 , A61Q11/00
CPC分类号： A23G3/36 , A23G3/48 , A61K8/97 , A61Q11/00
摘要： It is intended to provide an effective cariostatic material which inhibits dental plaque formation as well as onset of dental carries. A material for inhibiting enamel demineralization containing, as the active ingredient, a proanthocyanidin-like polyphenol originating in hop bract or immature apple, which effectively inhibits not only dental plaque formation but also the dental caries process including proliferation of bacteria, formation of acids by the bacteria and enamel demineralization. Also, foods, drinks and oral care goods with the use of the above substance as an enamel demineralization inhibitor are provided.
摘要翻译：旨在提供抑制牙菌斑形成以及牙齿携带物发生的有效的抑菌材料。用于抑制釉质脱矿质的材料，其含有起源于苞片或未成熟苹果的原花色素苷多酚作为活性成分，其不仅有效抑制牙菌斑形成，而且还有效地抑制龋齿过程，包括细菌的增殖，由细菌和搪瓷脱矿质。此外，提供了使用上述物质作为釉质脱矿质化抑制剂的食品，饮料和口腔护理用品。

7. 发明申请

US20060165609A1 Periodontal ligament-protecting agent 审中-公开
标题翻译：牙周韧带保护剂
公开(公告)号：US20060165609A1
公开(公告)日：2006-07-27
申请号：US10545412
申请日：2005-02-25
申请人： Hiroaki Inaba , Motoyuki Tagashira , Tomomasa Kanda , Atsuo Amano
发明人： Hiroaki Inaba , Motoyuki Tagashira , Tomomasa Kanda , Atsuo Amano
IPC分类号： A61K8/49 , A61K36/185
CPC分类号： A61K8/97 , A23L33/11 , A61K8/347 , A61K31/352 , A61Q11/00 , A61Q17/005 , C07D311/62
摘要： The present invention provides a protectant of periodontal membranes for inhibiting the destruction of periodontal tissues, particularly periodontal membranes by participation of Porphyromonas gingivalis. Further, it provides an agent for oral cavity or food and drinks containing the protectant of periodontal membranes having effects of prevention and therapy of diseases involving damage of periodontal membranes. A protectant of periodontal membranes is proanthocyanidins, particularly proanthocyanidins derived from apple premature fruits or hop bracts having an effect decreasing the damage to periodontal membranes caused by Porphyromonas gingivalis, and an eating and drinking product containing the protectant of periodontal membranes as an effective component.
摘要翻译：本发明提供了牙周膜保护剂，其通过参与牙龈卟啉单胞菌来抑制牙周组织，特别是牙周膜的破坏。此外，它提供含有牙周膜保护剂的口腔或食物和饮料的药剂，其具有预防和治疗涉及牙周膜损伤的疾病的作用。牙周膜的保护剂是原花青素，特别是源自苹果过早果实的原花青素或具有降低由牙龈卟啉单胞菌引起的牙周膜损伤作用的跳虱，以及含有牙周膜保护剂作为有效成分的饮食品。

8. 发明申请

US20070092456A1 Protectant of periodontal membranes 审中-公开
标题翻译：牙周膜保护剂
公开(公告)号：US20070092456A1
公开(公告)日：2007-04-26
申请号：US11640301
申请日：2006-12-18
申请人： Hiroaki Inaba , Motoyuki Tagashira , Tomomasa Kanda , Atsuo Amano
发明人： Hiroaki Inaba , Motoyuki Tagashira , Tomomasa Kanda , Atsuo Amano
IPC分类号： A61K8/49
CPC分类号： A61K8/97 , A23L33/11 , A61K8/347 , A61K31/352 , A61Q11/00 , A61Q17/005 , C07D311/62
摘要： The present invention provides a protectant of periodontal membranes for inhibiting the destruction of periodontal tissues, particularly periodontal membranes by participation of Porphyromonas gingivalis. Further, it provides an agent for oral cavity or food and drinks containing the protectant of periodontal membranes having effects of prevention and therapy of diseases involving damage of periodontal membranes. A protectant of periodontal membranes is proanthocyanidins, particularly proanthocyanidins derived from apple premature fruits or hop bracts having an effect decreasing the damage to periodontal membranes caused by Porphyromonas gingivalis, and an eating and drinking product containing the protectant of periodontal membranes as an effective component.
摘要翻译：本发明提供了牙周膜保护剂，其通过参与牙龈卟啉单胞菌来抑制牙周组织，特别是牙周膜的破坏。此外，它提供含有牙周膜保护剂的口腔或食物和饮料的药剂，其具有预防和治疗涉及牙周膜损伤的疾病的作用。牙周膜的保护剂是原花青素，特别是源自苹果过早果实的原花青素或具有降低由牙龈卟啉单胞菌引起的牙周膜损伤作用的跳虱，以及含有牙周膜保护剂作为有效成分的饮食品。

9. 发明申请

US20060251760A1 Process for producing hop glume polyphenol 审中-公开
标题翻译：啤酒花多酚生产工艺
公开(公告)号：US20060251760A1
公开(公告)日：2006-11-09
申请号：US10538790
申请日：2003-12-12
申请人： Motoyuki Tagashira , Tomomasa Kanda
发明人： Motoyuki Tagashira , Tomomasa Kanda
IPC分类号： C12G1/00
CPC分类号： A61K8/97 , A61Q11/00 , C07D311/30 , C07G17/00
摘要： It is intended to provide a process for efficiently producing highly purified hop bract polyphenol using hop bract as the starting material, and foods, drinks, cosmetics and drugs with the use of the highly purified hop bract polyphenol. Namely, a process for producing hop polyphenol which comprises extracting hop bract with an aqueous alcohol solution, concentrating the extract to give a residual alcohol concentration of 0.5 to 2% and then centrifuging and/or filtering the concentrate. This polyphenol is usable in foods, drinks, cosmetics, drugs, etc.
摘要翻译：本发明旨在提供一种利用高效提纯啤酒花苞片多酚作为起始原料的高纯度啤酒花苞多酚的方法，以及食品，饮料，化妆品和药物。即，生产啤酒花多酚的方法，其包括用醇水溶液萃取啤酒花苞，浓缩提取物，得到残留的酒精浓度为0.5〜2％，然后离心和/或过滤浓缩物。该多酚可用于食品，饮料，化妆品，药物等。

10. 发明申请

US20100179227A1 Production method of hop preparation, hop preparation, anti-inflammatory agent, food product and beverage, and oral product 审中-公开
标题翻译：啤酒花制备，啤酒花制备，消炎剂，食品和饮料以及口服产品的生产方法
公开(公告)号：US20100179227A1
公开(公告)日：2010-07-15
申请号：US12310559
申请日：2007-08-21
申请人： Hiroaki Inaba , Daiki Honma , Motoyuki Tagashira , Tomomasa Kanda , Atsuo Amano
发明人： Hiroaki Inaba , Daiki Honma , Motoyuki Tagashira , Tomomasa Kanda , Atsuo Amano
IPC分类号： A61K31/05 , A61P29/00 , A61P1/02
CPC分类号： A61Q11/00 , A23L2/02 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K8/97 , A61K36/18 , A61K36/185 , A23V2200/312 , A23V2200/324 , A23V2250/032 , A23V2250/21168 , A23V2250/2132 , A23V2250/606
摘要： A method for producing a preparation that can be used in the prevention and treatment of inflammatory diseases, including periodontitis caused by P. gingivalis. Specifically, the invention provides a method for producing a hop preparation comprising the following steps (1) to (3): (1) adjusting the pH of a polyphenol-containing liquid prepared from hop bracts to 6 to 7 and passing the liquid through a gel-type synthetic resin to allow components including useful substances to be adsorbed onto the resin; (2) washing the resin obtained in the step (1) with a 30 to 60% aqueous ethanol solution to elute unwanted substances, leaving the useful substances adsorbed to the resin; and (3) washing the resin obtained in the step (2) with a 70% or higher aqueous ethanol solution or ethanol to elute the components including the useful substances and forming the preparation from the eluted fraction.
摘要翻译：一种可用于预防和治疗由牙龈卟啉菌引起的牙周炎的炎性疾病的制剂的制备方法。具体地说，本发明提供一种制备包含以下步骤（1）至（3）的啤酒花制备方法：（1）将由跳虱制备的含多酚液体的pH调节至6至7，并使液体通过凝胶型合成树脂，使包含有用物质的成分吸附在树脂上; （2）用30〜60％乙醇水溶液洗涤工序（1）得到的树脂，洗脱不需要的物质，留下有用物质吸附在树脂上; 和（3）用70％或更高的乙醇水溶液或乙醇洗涤步骤（2）中得到的树脂，以洗脱含有有用物质的组分并从洗脱级分形成制剂。

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