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1. 发明授权

US09730883B2 Prophylactic or therapeutic agent for oral diseases 有权
公开(公告)号：US09730883B2
公开(公告)日：2017-08-15
申请号：US14236849
申请日：2012-08-03
申请人： Takekazu Okumura , Tomohiko Terai , Masumi Nakao , Kimiyuki Kaneko , Masahiko Ito , Kouji Miyazaki , Kazuaki Yamaji , Kaoru Tochiya , Nobuhiro Hanada , Susumu Imai , Yoshiaki Nomura , Shunsuke Baba
发明人： Takekazu Okumura , Tomohiko Terai , Masumi Nakao , Kimiyuki Kaneko , Masahiko Ito , Kouji Miyazaki , Kazuaki Yamaji , Kaoru Tochiya , Nobuhiro Hanada , Susumu Imai , Yoshiaki Nomura , Shunsuke Baba
IPC分类号： A61K39/07 , A61K8/99 , C12R1/225 , C12R1/46 , C12N1/20 , A61K35/744 , A61K35/747 , A61Q11/00 , C12Q1/68 , A23L2/52 , A61K9/20 , A23L29/00 , A23L33/135
CPC分类号： A61K8/99 , A23L2/52 , A23L29/065 , A23L33/135 , A61K9/2018 , A61K35/744 , A61K35/747 , A61Q11/00 , C12N1/20 , C12Q1/68 , C12R1/225 , C12R1/46
摘要： Provided is a novel lactic acid bacterium strain which is capable of suppressing production of volatile sulfur compounds by oral bacteria, has no cariogenicity and no causative role in infective endocarditis, and is safe in an oral cavity, and provided is an agent for preventing, improving and/or treating oral diseases and discomforts by use of the bacterial strain.An agent for preventing and/or treating an oral disease, containing, as an active ingredient, at least one lactic acid bacterium selected from Lactobacillus crispatus, Lactobacillus fermentum, Lactobacillus gasseri, and Streptococcus mitis and having all of the following properties (1) to (6): (1) having no ability to produce a volatile sulfur compound (VSC); (2) having no ability to produce water-insoluble glucan; (3) having adhesiveness to a tooth surface and/or an oral cell; (4) having a growth inhibitory effect on a bad breath-causing bacterium and/or a periodontal pathogen; (5) having no causative role in infective endocarditis; and (6) having no cariogenicity.

2. 发明申请

US20140178313A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR ORAL DISEASES 有权
标题翻译：用于口腔疾病的预防或治疗药物
公开(公告)号：US20140178313A1
公开(公告)日：2014-06-26
申请号：US14236849
申请日：2012-08-03
申请人： Takekazu Okumura , Tomohiko Terai , Masumi Nakao , Kimiyuki Kaneko , Masahiko Ito , Kouji Miyazaki , Kazuaki Yamaji , Kaoru Tochiya , Nobuhiro Hanada , Susumu Imai , Yoshiaki Nomura , Shunsuke Baba
发明人： Takekazu Okumura , Tomohiko Terai , Masumi Nakao , Kimiyuki Kaneko , Masahiko Ito , Kouji Miyazaki , Kazuaki Yamaji , Kaoru Tochiya , Nobuhiro Hanada , Susumu Imai , Yoshiaki Nomura , Shunsuke Baba
IPC分类号： A61K8/99 , C12Q1/68 , A61Q11/00
CPC分类号： A61K8/99 , A23L2/52 , A23L29/065 , A23L33/135 , A61K9/2018 , A61K35/744 , A61K35/747 , A61Q11/00 , C12N1/20 , C12Q1/68 , C12R1/225 , C12R1/46
摘要： Provided is a novel lactic acid bacterium strain which is capable of suppressing production of volatile sulfur compounds by oral bacteria, has no cariogenicity and no causative role in infective endocarditis, and is safe in an oral cavity, and provided is an agent for preventing, improving and/or treating oral diseases and discomforts by use of the bacterial strain.An agent for preventing and/or treating an oral disease, containing, as an active ingredient, at least one lactic acid bacterium selected from Lactobacillus crispatus, Lactobacillus fermentum, Lactobacillus gasseri, and Streptococcus mitis and having all of the following properties (1) to (6): (1) having no ability to produce a volatile sulfur compound (VSC); (2) having no ability to produce water-insoluble glucan; (3) having adhesiveness to a tooth surface and/or an oral cell; (4) having a growth inhibitory effect on a bad breath-causing bacterium and/or a periodontal pathogen; (5) having no causative role in infective endocarditis; and (6) having no cariogenicity.
摘要翻译：本发明提供能够抑制口腔细菌产生挥发性硫化合物的新型乳酸菌株，在感染性心内膜炎中不具有致龋性，无致病作用，并且在口腔中是安全的，作为预防，改善和/或通过使用细菌菌株治疗口腔疾病和不适。用于预防和/或治疗口腔疾病的药剂，其含有至少一种选自干酪乳杆菌，发酵乳杆菌，加氏乳杆菌和链球菌的至少一种乳酸菌，并具有以下所有性质（1）至（6）：（1）不具有产生挥发性硫化合物（VSC）的能力; （2）不具有产生水不溶性葡聚糖的能力; （3）对牙齿表面和/或口腔具有粘附性; （4）对不良呼吸细菌和/或牙周病原体具有生长抑制作用; （5）感染性心内膜炎无致病作用; 和（6）没有致龋性。

3. 发明申请

US20130121931A1 METHOD FOR CONTROLLING CONTINUOUSNESS OF DEODORANT EFFECT AFTER CONSUMPTION OF CHEWING GUM COMPOSITION AND A CHEWING GUM COMPOSITION 审中-公开
标题翻译：用于控制切割胶组合物消耗后的去污效果连续性的方法和一种芝麻组合物
公开(公告)号：US20130121931A1
公开(公告)日：2013-05-16
申请号：US13312137
申请日：2011-12-06
申请人： Masafumi YAMAI , Kenichiro YANAGI , Yoshiaki ADACHI , Samantha HOLME , Nobuhiro HANADA , Susumu IMAI
发明人： Masafumi YAMAI , Kenichiro YANAGI , Yoshiaki ADACHI , Samantha HOLME , Nobuhiro HANADA , Susumu IMAI
IPC分类号： A61K9/68 , A61Q11/00
CPC分类号： A61Q11/00 , A23G4/06 , A23G4/068 , A23G4/123 , A61K8/66 , A61K8/97 , A61K36/49 , A61K36/53 , A61K38/44 , C12Y111/01 , A61K2300/00
摘要： An object of the present invention is to provide a method for controlling the continuousness of deodorant effect after consumption of a chewing gum composition, and a chewing gum composition having excellent continuousness of the deodorant effect after consumption of the chewing gum composition. The method for controlling continuousness of the deodorant effect after consumption of the chewing gum composition, in which the chewing gum composition contains a biphenyl compounds-containing extract and a tannins-containing extract, includes the step of controlling the ratio of a blending amount of the tannins-containing extract to a blending amount of biphenyl compounds-containing extract. The chewing gum composition contains a biphenyl compounds-containing extract and a tannins-containing extract, in which the ratio by mass of the blending amount of the tannins-containing extract to the blending amount of the biphenyl compounds-containing extract is greater than 5.0.
摘要翻译：本发明的目的是提供一种控制口香糖组合物消毒后除臭效果的连续性的方法，以及在口香糖组合物消耗后具有优异的除臭效果连续性的口香糖组合物。在口香糖组合物含有含联苯化合物的提取物和含有单宁的提取物的口香糖组合物消费后的除臭效果的连续性的方法包括以下步骤：控制所述口香糖组合物的混合量含单宁提取物至含联苯化合物的提取物的混合量。所述口香糖组合物含有含联苯化合物的提取物和含有单宁的提取物，其中所述含单宁提取物的配合量与所述含联苯化合物的提取物的配合量的比例大于5.0。

4. 发明申请

US20080003186A1 MATERIAL FOR INHIBITING ENAMEL DEMINERALIZATION 审中-公开
标题翻译：阻止ENAMEL DEMINERAL化的材料
公开(公告)号：US20080003186A1
公开(公告)日：2008-01-03
申请号：US11773240
申请日：2007-07-03
申请人： Susumu IMAI , Motoyuki Tagashira , Tomomasa Kanda , Toshiki Nishizawa , Nobuhiro Hanada
发明人： Susumu IMAI , Motoyuki Tagashira , Tomomasa Kanda , Toshiki Nishizawa , Nobuhiro Hanada
IPC分类号： A61K8/30 , A61P43/00 , A61Q11/00
CPC分类号： A23G3/36 , A23G3/48 , A61K8/97 , A61Q11/00
摘要： It is intended to provide an effective cariostatic material which inhibits dental plaque formation as well as onset of dental carries. A material for inhibiting enamel demineralization containing, as the active ingredient, a proanthocyanidin-like polyphenol originating in hop bract or immature apple, which effectively inhibits not only dental plaque formation but also the dental caries process including proliferation of bacteria, formation of acids by the bacteria and enamel demineralization. Also, foods, drinks and oral care goods with the use of the above substance as an enamel demineralization inhibitor are provided.
摘要翻译：旨在提供抑制牙菌斑形成以及牙齿携带物发生的有效的抑菌材料。用于抑制釉质脱矿质的材料，其含有起源于苞片或未成熟苹果的原花色素苷多酚作为活性成分，其不仅有效抑制牙菌斑形成，而且还有效地抑制龋齿过程，包括细菌的增殖，由细菌和搪瓷脱矿质。此外，提供了使用上述物质作为釉质脱矿质化抑制剂的食品，饮料和口腔护理用品。

5. 发明申请

US20050052956A1 Method for determining reproducing light beam intensity and recording and reproducing apparatus 审中-公开
标题翻译：用于确定再现光束强度的方法和记录和再现装置
公开(公告)号：US20050052956A1
公开(公告)日：2005-03-10
申请号：US10895910
申请日：2004-07-22
申请人： Hiroshi Ido , Hiroyuki Awano , Manabu Tani , Susumu Imai
发明人： Hiroshi Ido , Hiroyuki Awano , Manabu Tani , Susumu Imai
IPC分类号： G11B11/00 , G11B11/105
CPC分类号： G11B11/10515 , G11B11/10595
摘要： A means is provided to determine, accurately in a shorter period of time, an optimum reproducing laser beam intensity for reproducing user data or various management data on a magneto-optical recording medium based on the magnetic amplifying magneto-optical transfer system. In a method for determining the reproducing laser beam intensity of the present invention, a test reproduction area, which is formed of maze magnetic domains having random sizes not subjected to any recording process and provided on a magneto-optical recording medium based on Zero-Field MAMMOS, is irradiated with a laser beam before reproducing user information while changing the laser beam intensity to detect a magneto-optical signal. Subsequently, the reproducing laser beam intensity is determined for user information on the basis of the magneto-optical signal obtained from the test reproduction area.
摘要翻译：提供了一种装置，用于在更短的时间内精确地确定用于基于磁放大磁光转移系统在磁光记录介质上再现用户数据或各种管理数据的最佳再现激光束强度。在本发明的再生激光强度的确定方法中，由具有不经历任何记录处理的随机大小的迷宫磁畴形成的测试再现区域，其设置在基于零场的磁光记录介质上 MAMMOS在再现用户信息之前用激光束照射，同时改变激光束强度以检测磁光信号。随后，基于从测试再现区域获得的磁光信号，确定用户信息的再现激光束强度。

6. 发明授权

US6044041A Recording and reproducing apparatus having a magneto-optical head with an objective lens and laser-beam-permeable member 失效
公开(公告)号：US6044041A
公开(公告)日：2000-03-28
申请号：US946066
申请日：1997-10-07
申请人： Osamu Ishizaki , Katsusuke Shimazaki , Toshinori Sugiyama , Masafumi Yoshihiro , Susumu Imai
发明人： Osamu Ishizaki , Katsusuke Shimazaki , Toshinori Sugiyama , Masafumi Yoshihiro , Susumu Imai
IPC分类号： G11B7/085 , G11B5/127 , G11B5/17 , G11B7/135 , G11B11/105 , G11B17/04 , G11B11/00
CPC分类号： B82Y10/00 , G11B11/10532 , G11B11/10554 , G11B11/10569 , G11B11/10578 , G11B11/1058 , G11B7/1372 , G11B11/10565 , G11B11/10571 , G11B17/0436 , G11B5/127 , G11B5/17
摘要： A compact recording and reproducing apparatus includes a floating-type head movable in a fan shape in parallel with the surface of a disk recording medium in order to make faster access to the tracks and to record information at a higher density. A slider and a head are secured to the tip of a swing arm capable of fan-shaped swing movement, and a solid immersion lens is used for the head, so that the light beam can be passed along the arm from the fulcrum at the rotating pivot of the swing arm member.

7. 发明授权

US4117586A Machine tool with automatic tool changer 失效
标题翻译：机床带自动换刀装置
公开(公告)号：US4117586A
公开(公告)日：1978-10-03
申请号：US675897
申请日：1976-04-12
申请人： Yoshiro Uchida , Toshihiko Mizuno , Isao Higuchi , Susumu Imai , Shyoichiro Usui
发明人： Yoshiro Uchida , Toshihiko Mizuno , Isao Higuchi , Susumu Imai , Shyoichiro Usui
IPC分类号： B23B31/20 , B23Q3/157
CPC分类号： B23B31/207 , B23Q3/15773 , Y10S483/902 , Y10T409/30 , Y10T483/1736 , Y10T483/176 , Y10T483/1767 , Y10T483/1864 , Y10T483/1891
摘要： A machine tool with an automatic tool changer having a tool storage magazine accommodating tools having the same shank configuration as that of the first shank, tools having the same configuration as that of the second shank, and a tool adaptor which has the same configuration as the larger of the first shank or second shank and which incorporate the smaller shank sections of the tools of the first shank or second shank configuration.
摘要翻译：一种具有自动换刀器的机床，具有一个具有与第一柄相同柄柄构型的工具存放盒，其具有与第二柄相同的构形的工具，以及具有与第二杆相同构造的工具适配器较大的第一柄或第二柄，并且其包括第一柄或第二柄构型的工具的较小柄部。

8. 发明授权

US08183215B2 Method of administering oral flora-improving agent, antibacterial agent and growth promoter 有权
标题翻译：口服植物改良剂，抗菌剂和生长促进剂的施用方法
公开(公告)号：US08183215B2
公开(公告)日：2012-05-22
申请号：US12610896
申请日：2009-11-02
申请人： Hiroshi Kawakami , Nobuhiro Hanada , Susumu Imai
发明人： Hiroshi Kawakami , Nobuhiro Hanada , Susumu Imai
IPC分类号： A01N43/04 , A61K31/70 , A61K8/02
CPC分类号： A23K20/195 , A23K20/121 , A23L33/10 , A61K31/7028 , A61Q11/00
摘要： It is intended to provide an oral flora-improving agent capable of forming a favorable flora in the oral cavity and a food or a drink for improving the oral flora. An oral flora-improving agent containing as an active ingredient a ganglioside and a food, a drink, or a feed for improving the oral flora containing the ganglioside exhibit an antibacterial effect on harmful bacteria in the oral cavity, which are undesirable from the viewpoint of decay and diseases such as periodontal disease, and a growth-improving effect on useful bacteria to be preserved in the oral cavity. Further, the ganglioside is efficaciously used as an active ingredient in an antibacterial agent or an antibacterial drink, food, or feed, a growth promoter, or a food, a drink, or a feed for promoting growth.
摘要翻译：旨在提供能够在口腔中形成有利菌群的口腔植物改良剂和用于改善口腔菌群的食品或饮料。含有作为活性成分的神经节苷脂的口腔内植物改善剂和用于改善含有神经节苷脂的口腔菌群的食品，饮料或饲料，对口腔内的有害细菌表现出抗菌作用，从对衰老和疾病如牙周病，以及对在口腔中保留的有用细菌的生长改善作用。此外，神经节苷脂有效地用作抗菌剂或抗菌饮料，食品或饲料，生长促进剂或用于促进生长的食品，饮料或饲料中的活性成分。

9. 发明申请

US20060216248A1 Material for inhibiting enamel decalcification 审中-公开
标题翻译：用于抑制釉质脱钙的材料
公开(公告)号：US20060216248A1
公开(公告)日：2006-09-28
申请号：US10554932
申请日：2004-04-30
申请人： Susumu Imai , Motoyuki Tagashira , Tomomasa Kanda , Toshiki Nishizawa , Nobuhiro Hanada
发明人： Susumu Imai , Motoyuki Tagashira , Tomomasa Kanda , Toshiki Nishizawa , Nobuhiro Hanada
IPC分类号： A61K36/185 , A61K8/97 , A61K36/73
CPC分类号： A23G3/36 , A23G3/48 , A61K8/97 , A61Q11/00
摘要： It is intended to provide an effective cariostatic material which inhibits dental plaque formation as well as onset of dental carries. A material for inhibiting enamel demineralization containing, as the active ingredient, a proanthocyanidin-like polyphenol originating in hop bract or immature apple, which effectively inhibits not only dental plaque formation but also the dental caries process including proliferation of bacteria, formation of acids by the bacteria and enamel demineralization. Also, foods, drinks and oral care goods with the use of the above substance as an enamel demineralization inhibitor are provided.
摘要翻译：旨在提供抑制牙菌斑形成以及牙齿携带物发生的有效的抑菌材料。用于抑制釉质脱矿质的材料，其含有起源于苞片或未成熟苹果的原花色素苷多酚作为活性成分，其不仅有效抑制牙菌斑形成，而且还有效地抑制龋齿过程，包括细菌的增殖，由细菌和搪瓷脱矿质。此外，提供了使用上述物质作为釉质脱矿质化抑制剂的食品，饮料和口腔护理用品。

10. 发明授权

US06434088B1 Recording and reproducing apparatus having a magneto-optical head with an objective lens and laser-beam-permeable member 失效
标题翻译：具有具有物镜的磁光头和激光束可透过构件的记录和再现装置
公开(公告)号：US06434088B1
公开(公告)日：2002-08-13
申请号：US09482463
申请日：2000-01-13
申请人： Osamu Ishizaki , Katsusuke Shimazaki , Toshinori Sugiyama , Masafumi Yoshihiro , Susumu Imai
发明人： Osamu Ishizaki , Katsusuke Shimazaki , Toshinori Sugiyama , Masafumi Yoshihiro , Susumu Imai
IPC分类号： G11B1100
CPC分类号： B82Y10/00 , G11B5/127 , G11B5/17 , G11B7/1372 , G11B11/10532 , G11B11/10554 , G11B11/10565 , G11B11/10569 , G11B11/10571 , G11B11/10578 , G11B11/1058 , G11B17/0436
摘要： A compact recording and reproducing apparatus includes a floating-type head movable in a fan shape in parallel with the surface of a disk recording medium in order to make faster access to the tracks and to record information at a higher density. A slider and a head are secured to the tip of a swing arm capable of fan-shaped swing movement, and a solid immersion lens is used for the head, so that the light beam can be passed along the arm from the fulcrum at the rotating pivot of the swing arm member.
摘要翻译：一种紧凑的记录和再现装置包括浮动型头部，其可与盘记录介质的表面平行地移动为扇形，以便更快地访问轨道并以更高的密度记录信息。滑块和头部被固定到能够进行扇形摆动的摆臂的尖端，并且头部使用固体浸没透镜，使得光束可以沿着旋转的支点从支臂通过摆臂构件的枢轴。

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