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1. 发明授权

US5932623A Process for the production of fruit polyphenols from unripe rosaceae fruit 失效
公开(公告)号：US5932623A
公开(公告)日：1999-08-03
申请号：US555729
申请日：1995-11-09
申请人： Masayuki Tanabe , Tomomasa Kanda , Akio Yanagida
发明人： Masayuki Tanabe , Tomomasa Kanda , Akio Yanagida
IPC分类号： A61K36/73 , A23L1/30 , A61K31/35 , A61K131/00 , A61P37/00 , A61P39/06 , C07D311/62 , A01N31/08
CPC分类号： C07D311/62 , A23L33/105
摘要： The present invention provides a fruit polyphenol obtained by subjecting unripe fruits of Rosaceae to pressing and/or extraction and then purifying the resulting juice or extract. The present invention further provides an antioxidant, a hypotensive agent, an antimutagenic agent, an antiallergic agent and an anticariogenic agent each comprising, as an effective component, a fruit polyphenol obtained by subjecting unripe fruits of Rosaceae to pressing and/or extraction and then purifying the resulting juice or extract. The fruit polyphenol of the present invention has various physiological activities, for example, an antioxidative activity, an ACE-inhibiting activity, an antimutagenic activity, a hyalulonidase-inhibiting activity and a GTase-inhibiting activity.

2. 发明授权

US5994413A Process for the production of fruit polyphenols from unripe rosaceae fruit 失效
标题翻译：从未成熟的玫瑰果科果实生产水果多酚的方法
公开(公告)号：US5994413A
公开(公告)日：1999-11-30
申请号：US784546
申请日：1997-01-21
申请人： Masayuki Tanabe , Tomomasa Kanda , Akio Yanagida
发明人： Masayuki Tanabe , Tomomasa Kanda , Akio Yanagida
IPC分类号： A61K36/73 , A23L1/30 , A61K31/35 , A61K131/00 , A61P37/00 , A61P39/06 , C07D311/62 , A01N31/08
CPC分类号： C07D311/62 , A23L33/105
摘要： The present invention provides a fruit polyphenol obtained by subjecting unripe fruits of Rosaceae to pressing and/or extraction and then purifying the resulting juice or extract. The present invention further provides an antioxidant, a hypotensive agent, an antimutagenic agent, an antiallergic agent and an anticariogenic agent each comprising, as an effective component, a fruit polyphenol obtained by subjecting unripe fruits of Rosaceae to pressing and/or extraction and then purifying the resulting juice or extract. The fruit polyphenol of the present invention has various physiological activities, for example, an antioxidative activity, an ACE-inhibiting activity, an antimutagenic activity, a hyalulonidase-inhibiting activity and a GTase-inhibiting activity.
摘要翻译：本发明提供一种水果多酚，其通过使蔷薇科的未成熟果实压制和/或提取，然后纯化得到的果汁或提取物而获得。本发明还提供抗氧化剂，降血压剂，抗诱变剂，抗过敏剂和抗龋剂，其各自包含通过使蔷薇科的未成熟果实压制和/或提取然后纯化而获得的水果多酚作为有效成分所得的果汁或提取物。本发明的果实多酚具有各种生理活性，例如抗氧化活性，ACE抑制活性，抗诱变活性，透明质酸酶抑制活性和GTase抑制活性。

3. 发明授权

US5853728A Polyphenolic cosmetic composition 失效
标题翻译：多酚化妆品组合物
公开(公告)号：US5853728A
公开(公告)日：1998-12-29
申请号：US773596
申请日：1996-12-27
申请人： Masayuki Tanabe , Tomomasa Kanda , Akio Yanagida , Toshihiko Shoji
发明人： Masayuki Tanabe , Tomomasa Kanda , Akio Yanagida , Toshihiko Shoji
IPC分类号： A61K8/30 , A61K8/00 , A61K8/33 , A61K8/96 , A61K8/97 , A61Q5/00 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A01N65/00
CPC分类号： A61Q19/00 , A61K8/97 , A61Q17/00 , A61Q17/04 , Y10S514/846 , Y10S514/847
摘要： Cosmetics are herein disclosed which contain a polyphenol derived from the fruits of Rosaceae, and the polyphenol is obtainable by purifying a pressed juice or an extract of the unripe fruits of the Rosaceae, for example, apples, pears or peaches. The cosmetics have many useful functions such as an ultraviolet light absorbing activity and a free radical erasing activity.
摘要翻译：本文公开了含有衍生自蔷薇科果实的多酚的化妆品，并且多酚可通过纯化蔷薇科的未成熟果实的压榨汁或提取物获得，例如苹果，梨或桃。化妆品具有许多有用的功能，例如紫外光吸收活性和自由基擦除活性。

4. 发明授权

US06800433B1 Process for purification of proanthocyanidin oligomer 失效
标题翻译：纯化原花青素低聚物的方法
公开(公告)号：US06800433B1
公开(公告)日：2004-10-05
申请号：US09959274
申请日：2001-10-19
申请人： Shinkichi Honda , Tomoya Takahashi , Ayako Kamimura , Takako Matsuoka , Tomomasa Kanda , Akio Yanagida , Kazuo Hieda
发明人： Shinkichi Honda , Tomoya Takahashi , Ayako Kamimura , Takako Matsuoka , Tomomasa Kanda , Akio Yanagida , Kazuo Hieda
IPC分类号： C12Q100
CPC分类号： C07D311/62 , C07D311/60
摘要： The present invention relates to a process for purifying dimeric to pentameric proanthocyanidin oligomers which comprises extracting the proanthocyanidin oligomers from raw materials containing the proanthocyanidin oligomers or crude purification products therefrom by solid-liquid extraction using methyl acetate as a liquid phase; a process for purifying dimeric to pentameric proanthocyanidin oligomers which comprises pretreating with an enzyme for hydrolysis raw materials containing the proanthocyanidin oligomers, crude purification products therefrom, or a solution containing one of these; and a process for purifying dimeric to pentameric proanthocyanidin oligomers with a uniform polymerization degree which comprises separating and purifying the proanthocyanidin oligomers by polymerization degree from raw materials containing the proanthocyanidin oligomers or crude purification products there from by normal phase silica gel liquid chromatography using as a mobile phase a single solvent or a mixed solvent of two or more solvents selected from the group consisting of an ester solvent, a ketone solvent, a hydrocarbon solvent, an ether solvent and an alcohol solvent.
摘要翻译：本发明涉及一种纯化二聚至五聚原花青素低聚物的方法，该方法包括通过使用乙酸甲酯作为液相通过固液萃取从原料中提取原花青素低聚物或粗提纯产物; 用于纯化二聚体至五聚原花青素低聚物的方法，其包括用酶预处理含有原花青素低聚物的水解原料，其粗提纯产物或含有这些之一的溶液; 以及具有均匀聚合度的二聚至五聚原花青素低聚物的纯化方法，该方法包括通过使用作为流动相的正相硅胶液相色谱法从含有原花青素低聚物或粗纯化产物的原料中分离纯化原花青素低聚物将溶剂选自酯溶剂，酮溶剂，烃溶剂，醚溶剂和醇溶剂中的两种或更多种溶剂的单一溶剂或混合溶剂。

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