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    • 8. 发明授权
    • Antibiotic, Spicamycin
    • 抗生素,Spicamycin
    • US4565781A
    • 1986-01-21
    • US583108
    • 1984-02-24
    • Noboru OtakeYoichi HayakawaHiroyuki KawaiMasaya NakagawaKozo TanabeJunichiro Mochizuki
    • Noboru OtakeYoichi HayakawaHiroyuki KawaiMasaya NakagawaKozo TanabeJunichiro Mochizuki
    • A61K31/70A61K31/7042A61K31/7052A61P31/04A61P35/00C07H17/02C12P1/06C12P19/28C12P19/32C12R1/465C12P19/40C07H19/06
    • C07H17/02
    • An antibiotic, Spicamycin, having the physicochemical properties set forth below is produced by aerobically cultivating a Spicamycin-producing Streptomyces strain in a suitable culture medium, and recovering from the culture the antibiotic, Spicamycin.(1) Color and properties: Weakly acidic white powder(2) Melting point: 215.degree. to 220.degree. C. (decomposed)(3) Specific rotatory power: [.alpha.].sub.D.sup.25 =+15.degree. (C: 0.15, in methanol)(4) Elementary analysis (Found): C: 57.4%, H: 8.3%; N: 15.7%, O: 18.6%(5) Ultraviolet absorption spectrum (maximum):______________________________________ CH.sub.3 OH 264 nm (E.sub.1cm.sup.1% 257) 0.01N NaOH + CH.sub.3 OH 272 nm (E.sub.1cm.sup.1% 226) 0.01N HCl + CH.sub.3 OH 273 nm (E.sub.1cm.sup.1% 258) ______________________________________ (6) Infrared absorption spectrum (as measured by the potassium bromide method): As shown in FIG. 2.(7) Solubility in Solvent: Soluble in basic water, dimethyl sulfoxide, methanol, ethanol, n-propanol, and n-butanol. Sparingly soluble in water, acetone, ethyl acetate, and chloroform. Insoluble in benzene, ethyl ether, and hexane.(8) Thin layer chromatography (using "Silica Gel 60F.sub.254 " plate supplied by Merck & Co., Inc.):______________________________________ Developing solvent Rf value ______________________________________ Chloroform:Methanol (1:1) 0.34 ______________________________________ (9) NMR spectrum (400 MHz, in deuteromethanol): As shown in FIG. 3.
    • 具有下述物理化学性质的抗生素Spicamycin通过在合适的培养基中有条不紊地培养产生Spicamycin的链霉菌菌株产生,并从培养物中回收抗生素Spicamycin。 (1)颜色和性质:弱酸性白色粉末(2)熔点:215〜220℃(分解)(3)比旋光度:αD25= + 15℃(甲醇中C:0.15) (4)元素分析(实测值):C:57.4%,H:8.3% N:15.7%,O:18.6%(5)紫外吸收光谱(最大):-CH 3 OH 264nm(E1cm1%257)-0.01N NaOH + CH3OH 272nm(E1cm1%226)-0.01N HCl + CH3OH 273nm E1cm1%258) - (6)红外吸收光谱(通过溴化钾法测定):如图1所示。 (7)溶剂中的溶解度:溶于碱性水,二甲基亚砜,甲醇,乙醇,正丙醇和正丁醇。 微溶于水,丙酮,乙酸乙酯和氯仿。 不溶于苯,乙醚和己烷。 (8)薄层色谱法(使用由Merck&Co.,Inc。提供的“Silica Gel 60F254”板):显影溶剂Rf值 - 氯仿:甲醇(1:1)0.34 - (9)NMR谱(400MHz, 在氘甲醇中): 3。