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1. 发明授权

US4565781A Antibiotic, Spicamycin 失效
标题翻译：抗生素，Spicamycin
公开(公告)号：US4565781A
公开(公告)日：1986-01-21
申请号：US583108
申请日：1984-02-24
申请人： Noboru Otake , Yoichi Hayakawa , Hiroyuki Kawai , Masaya Nakagawa , Kozo Tanabe , Junichiro Mochizuki
发明人： Noboru Otake , Yoichi Hayakawa , Hiroyuki Kawai , Masaya Nakagawa , Kozo Tanabe , Junichiro Mochizuki
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61P31/04 , A61P35/00 , C07H17/02 , C12P1/06 , C12P19/28 , C12P19/32 , C12R1/465 , C12P19/40 , C07H19/06
CPC分类号： C07H17/02
摘要： An antibiotic, Spicamycin, having the physicochemical properties set forth below is produced by aerobically cultivating a Spicamycin-producing Streptomyces strain in a suitable culture medium, and recovering from the culture the antibiotic, Spicamycin.(1) Color and properties: Weakly acidic white powder(2) Melting point: 215.degree. to 220.degree. C. (decomposed)(3) Specific rotatory power: [.alpha.].sub.D.sup.25 =+15.degree. (C: 0.15, in methanol)(4) Elementary analysis (Found): C: 57.4%, H: 8.3%; N: 15.7%, O: 18.6%(5) Ultraviolet absorption spectrum (maximum):______________________________________ CH.sub.3 OH 264 nm (E.sub.1cm.sup.1% 257) 0.01N NaOH + CH.sub.3 OH 272 nm (E.sub.1cm.sup.1% 226) 0.01N HCl + CH.sub.3 OH 273 nm (E.sub.1cm.sup.1% 258) ______________________________________ (6) Infrared absorption spectrum (as measured by the potassium bromide method): As shown in FIG. 2.(7) Solubility in Solvent: Soluble in basic water, dimethyl sulfoxide, methanol, ethanol, n-propanol, and n-butanol. Sparingly soluble in water, acetone, ethyl acetate, and chloroform. Insoluble in benzene, ethyl ether, and hexane.(8) Thin layer chromatography (using "Silica Gel 60F.sub.254 " plate supplied by Merck & Co., Inc.):______________________________________ Developing solvent Rf value ______________________________________ Chloroform:Methanol (1:1) 0.34 ______________________________________ (9) NMR spectrum (400 MHz, in deuteromethanol): As shown in FIG. 3.
摘要翻译：具有下述物理化学性质的抗生素Spicamycin通过在合适的培养基中有条不紊地培养产生Spicamycin的链霉菌菌株产生，并从培养物中回收抗生素Spicamycin。（1）颜色和性质：弱酸性白色粉末（2）熔点：215〜220℃（分解）（3）比旋光度：αD25= + 15℃（甲醇中C：0.15）（4）元素分析（实测值）：C：57.4％，H：8.3％ N：15.7％，O：18.6％（5）紫外吸收光谱（最大）：-CH 3 OH 264nm（E1cm1％257）-0.01N NaOH + CH3OH 272nm（E1cm1％226）-0.01N HCl + CH3OH 273nm E1cm1％258） - （6）红外吸收光谱（通过溴化钾法测定）：如图1所示。（7）溶剂中的溶解度：溶于碱性水，二甲基亚砜，甲醇，乙醇，正丙醇和正丁醇。微溶于水，丙酮，乙酸乙酯和氯仿。不溶于苯，乙醚和己烷。（8）薄层色谱法（使用由Merck＆Co.，Inc。提供的“Silica Gel 60F254”板）：显影溶剂Rf值 - 氯仿：甲醇（1：1）0.34 - （9）NMR谱（400MHz，在氘甲醇中）： 3。

2. 发明授权

US4598146A Compound, arugomycin 失效
标题翻译：化合物，阿鲁木霉素
公开(公告)号：US4598146A
公开(公告)日：1986-07-01
申请号：US583180
申请日：1984-02-24
申请人： Noboru Otake , Hiroyuki Kawai , Yoichi Hayakawa , Masaya Nakagawa , Kanji Imamura , Kozo Tanabe
发明人： Noboru Otake , Hiroyuki Kawai , Yoichi Hayakawa , Masaya Nakagawa , Kanji Imamura , Kozo Tanabe
IPC分类号： C07G11/00 , A61K35/74 , A61P35/00 , C07H15/252 , C12P1/06 , C12P19/56 , C12R1/465 , C07H15/24
CPC分类号： C07H15/252 , C12P19/56 , C12R1/465
摘要： An anthracycline compound, Arugomycin, having the physicochemical properties set forth below is produced by aerobically cultivating an Arugomycin-producing Streptomyces strain in a suitable culture medium, and recovering from the culture the anthracycline compound, Arugomycin.(1) Color and form:Orange powder(2) Melting point:207.degree. to 213.degree. C. (decomposed)(3) Specific rotatory power:[.alpha.].sub.D.sup.25 =+112.degree.(C: 0.1, chloroform:methanol=9:1)(4) Elementary analysis (%):______________________________________ C H O N ______________________________________ Found 56.2 6.9 35.1 1.8 Calcd. 56.7 6.7 34.9 1.7 ______________________________________ (5) Ultraviolet and visible absorption spectrum: as shown in FIG. 1.______________________________________ .lambda..sub.max (E.sup.1% .sub.1cm) ______________________________________ CH.sub.3 OH 235(363), 258(167), 292(61), 476(104) 0.1N HCl + CH.sub.3 OH 235(387), 258(159), 292(61), 468(110) 0.1N NaOH + CH.sub.3 OH 239(302), 294(41), 543(88) ______________________________________ (6) Infrared absorption spectrum (as measured by the potassium bromide method): as shown in FIG. 2.(7) Solubility in solvent:Easily soluble in a chloroform-methanol mixture, dimethyl sulfoxide, pyridine, and basic water.Soluble in chloroform, methanol, ethyl acetate, methyl ethyl ketone, butanol, butyl acetate, ethanol, acetone, and acidic water.Sparingly soluble in water.(8) Thin layer chromatography (using "Silica Gel 60F.sub.254 " plate supplied by Merck & Co., Inc.):______________________________________ Developing solvent Rf value ______________________________________ Chloroform:Methanol (8:1) 0.20 Chloroform:Methanol:29% Aqueous 0.25 ammonia (8:1:0.1) Chloroform:Methanol:Acetic acid 0.30 (8:1:0.1) Chloroform:Benzene:Methanol 0.26 (7:2:2) ______________________________________ (9) NMR spectrum (400 MHz, in deuterochloroform-deuteromethanol): as shown in FIG. 3.(10) Molecular weight (SIMS):m/z 1694 (M+H).
摘要翻译：具有下述物理化学性质的蒽环霉素化合物阿鲁木霉是通过在合适的培养基中有条不紊地培养产阿霉素霉素链霉菌菌株产生的，并从培养物中回收蒽环类化合物阿鲁霉素。（1）颜色和形式：橙色粉末（2）熔点：207〜213℃（分解）（3）比旋光度：αD25= + 112°（C：0.1，氯仿：甲醇= 9 ：1）（4）元素分析（％）：-CHON-发现56.2 6.9 35.1 1.8 - 56.7 6.7 34.9 1.7 - （5）紫外和可见吸收光谱：如图1所示。 - λmax（E1％1cm）-CH 3 OH 235（363），258（167），292（61）， - 476（104）-0.1N HCl + CH3OH 235（387），258（159） 61）， - 468（110）-0.1N NaOH + CH3OH 239（302），294（41），543（88） - （6）红外吸收光谱（通过溴化钾法测量）：（7）溶剂中的溶解性：易溶于氯仿 - 甲醇混合物，二甲基亚砜，吡啶和碱性水。溶于氯仿，甲醇，乙酸乙酯，甲基乙基酮，丁醇，乙酸丁酯，乙醇，丙酮和酸性水。微溶于水。（8）薄层色谱法（使用由Merck＆Co.，Inc。提供的“Silica Gel 60F254”板）： - 显影溶剂Rf值 - 氯仿：甲醇（8:1）0.20-氯仿：甲醇：29％氨（8：1：0.1） - 氯仿：甲醇：乙酸0.30 - （8：1：0.1） - 氯仿：苯：甲醇0.26 - （7：2：2） - （9）NMR谱（400MHz，氘氯仿 - 氘代甲醇）：如图1所示。（10）分子量（SIMS）：m / z 1694（M + H）。

3. 发明授权

US4313934A Physiologically active polysaccharides, production and uses thereof 失效
标题翻译：生理活性多糖，其生产和用途
公开(公告)号：US4313934A
公开(公告)日：1982-02-02
申请号：US141232
申请日：1980-04-17
申请人： Kumpei Kitamura , Shigeru Matsuki , Kozo Tanabe
发明人： Kumpei Kitamura , Shigeru Matsuki , Kozo Tanabe
IPC分类号： A61K36/064 , A61K36/07 , A61K38/00 , C07K14/395 , C12P1/02 , C12P21/00 , A61K39/00 , A61K37/00 , C07G7/00
CPC分类号： C12P21/005 , A61K36/064 , A61K36/07 , C07K14/395 , C12P1/02 , A61K38/00 , Y10S514/889
摘要： A physiologically active polysaccharide is prepared by treating autolysis-insoluble matters of yeasts of Saccharomyces with a yeast cell wall-lytic enzyme and obtaining a water-soluble physiologically active substance in the resulting solution-fraction. The novel polysaccharide possesses specific physical and chemical properties, and provides a chemotherapeutic agent such as a carcinostatic agent which can be used in the treatment of implanted tumors in mice and rats and an interferon inducer.
摘要翻译：通过用酵母细胞裂解酶处理酵母菌的自溶不溶性物质并在所得溶液馏分中获得水溶性生理活性物质来制备生理活性多糖。该新型多糖具有特定的物理和化学性质，并提供可用于治疗小鼠和大鼠和干扰素诱导剂中植入的肿瘤的化学治疗剂，例如制癌剂。

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