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1. 发明授权

US4939241A Amino acid derivatives of antitumor activity 失效
标题翻译：抗肿瘤活性的氨基酸衍生物
公开(公告)号：US4939241A
公开(公告)日：1990-07-03
申请号：US173294
申请日：1988-03-25
申请人： Masakuni Okuhara , Toshio Goto , Masami Ezaki , Miho Tanaka , Shigehiro Takase , Hidenori Nakajima , Hideo Hirai , Akira Katayama
发明人： Masakuni Okuhara , Toshio Goto , Masami Ezaki , Miho Tanaka , Shigehiro Takase , Hidenori Nakajima , Hideo Hirai , Akira Katayama
IPC分类号： A61K31/22 , A61P35/00 , C07C67/00 , C07C241/00 , C07C245/18 , C12P13/00 , C12R1/465
CPC分类号： C12P13/04 , C07C245/18 , C12P13/00 , Y10S435/886
摘要： The invention relates to compounds of antitumor activity of the formula: ##STR1## ps in which R.sup.1 is hydrogen, lower allkyl, halo(lower)alkyl or aryl,R.sup.2 is hydrogen, hydroxy or protected hydroxy,R.sup.3 is hydrogen,R.sup.4 is aminocarboxy(lower)alkyl, protected amino(lower)alkyl or protected aminocarboxy(lower)alkyl, andR.sup.5 is hydrogen or lower alkyl, or its pharmaceutical acceptable salt.

2. 发明授权

US06177458B1 Isochroman compounds and their production process 失效
标题翻译：异色素化合物及其制备方法
公开(公告)号：US06177458B1
公开(公告)日：2001-01-23
申请号：US09468770
申请日：1999-12-21
申请人： Hideo Hirai , Toshio Ichiba , Hiroko Tonai
发明人： Hideo Hirai , Toshio Ichiba , Hiroko Tonai
IPC分类号： A61K3135
CPC分类号： C12R1/80 , C07D311/76 , C12P17/06
摘要： This invention relates to the isochroman compound of formula (I) and its pharmaceutically acceptable salts, which are useful as an amyloid aggregation inhibitor and for treating Alzheimer's disease. This invention also relates to processes for producing the isochroman compound, which comprises cultivating Penicillium simplicissimum FERM BP-6357 and then isolating the isochroman compound from the fermentation broth. The present invention also relates to a pharmaceutical composition comprising the isochroman compound.
摘要翻译：本发明涉及式（I）的异苯并二氢吡喃化合物及其药学上可接受的盐，其可用作淀粉样聚集抑制剂并用于治疗阿尔茨海默氏病。本发明还涉及异苯并二氢吡喃化合物的制备方法，该方法包括培养简单微生物FERM BP-6357的青霉菌，然后从发酵液中分离异色素化合物。本发明还涉及包含异色满化合物的药物组合物。

3. 发明授权

US5885959A Cyclic peptide compounds and their production process 失效
标题翻译：环肽化合物及其制备方法
公开(公告)号：US5885959A
公开(公告)日：1999-03-23
申请号：US999627
申请日：1997-12-03
申请人： Hideo Hirai , Nakao Kojima , Hiroyuki Nishida , Toshiyuki Saito , Nobuji Yoshikawa
发明人： Hideo Hirai , Nakao Kojima , Hiroyuki Nishida , Toshiyuki Saito , Nobuji Yoshikawa
IPC分类号： C12P21/04 , A61K38/00 , A61P25/04 , A61P25/30 , A61P39/02 , C07K5/12 , C12P21/02 , C12R1/645 , A61K38/12 , C07K5/00 , C07K7/00 , C07K16/00
CPC分类号： C07K5/126 , C12P21/02 , A61K38/00
摘要： This invention provides processes for producing novel cyclic peptide compounds, which comprise cultivating Ctenomyces serratus FERM BP-5731 and then isolating the cyclic peptide compounds from the fermentation broth. The compounds produced by these processes include a cyclic peptide compound of the following formula (I): ##STR1## The present invention also relates to a pharmaceutical composition comprising the same, which is useful in the treatment of severe pain, detoxication of narcotics dependency or acute narcotics intoxication or the like.
摘要翻译：本发明提供了生产新型环肽化合物的方法，其包括培养C ivating atus ERM FERM BP-5731，然后从发酵液中分离出环状肽化合物。通过这些方法制备的化合物包括下式（I）的环肽化合物：（I）本发明还涉及包含其的药物组合物，其可用于治疗严重疼痛，解毒麻醉品依赖或急性毒品中毒等。

4. 发明授权

US4929639A Oxygen-containing heterocyclic compound 失效
标题翻译：含氧杂环化合物
公开(公告)号：US4929639A
公开(公告)日：1990-05-29
申请号：US208665
申请日：1988-06-20
申请人： Hiroyuki Setoi , Akio Kuroda , Hirokazu Tanaka , Hideo Hirai , Hiroshi Marusawa , Masashi Hashimoto
发明人： Hiroyuki Setoi , Akio Kuroda , Hirokazu Tanaka , Hideo Hirai , Hiroshi Marusawa , Masashi Hashimoto
IPC分类号： A61K31/357 , A61P7/02 , C07D309/06 , C07D319/06 , C07D405/12 , C07D409/12
CPC分类号： C07D405/12 , C07D309/06 , C07D319/06 , C07D409/12
摘要： The invention relates to treatment of diseases caused by thromboxane A.sub.2 comprising administering a compound ##STR1## wherein R.sup.1 is hydrogen or lower alkyl,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl andR.sup.3 is --CH.dbd.N--R.sup.4 in which R.sup.4 is arylureido or arylthioureido andX is --O--,or a pharmaceutically acceptable salt thereof.

5. 发明申请

US20100177859A1 NUCLEAR REACTOR BUILDING AND CONSTRUCTION METHOD THEREOF 有权
标题翻译：核反应堆建筑及其施工方法
公开(公告)号：US20100177859A1
公开(公告)日：2010-07-15
申请号：US12652976
申请日：2010-01-06
申请人： Shigeki Yokoyama , Makoto Ukai , Munetaka Takahashi , Hideo Hirai , Takuya Miyagawa , Masashi Tanabe
发明人： Shigeki Yokoyama , Makoto Ukai , Munetaka Takahashi , Hideo Hirai , Takuya Miyagawa , Masashi Tanabe
IPC分类号： G21C13/00 , E04B1/00
CPC分类号： G21C13/02 , Y02E30/40
摘要： In a nuclear reactor building of a steel plate concrete structure that houses a pressure containment vessel formed with a plurality of penetration ports penetrating the pressure containment vessel on the periphery thereof and includes a biological shielding wall disposed outside the pressure containment vessel. The pressure containment vessel is vertically divided into a plurality of blocks so that each of the blocks has one or more pressure containment vessel penetration ports arranged on a same horizontal plane, and the reactor building including the biological shielding wall is divided into a plurality of modules by the horizontal plane.
摘要翻译：在钢板混凝土结构的核反应堆建筑物中，其容纳形成有贯穿其外围的压力容器的多个穿透口的压力容器，并且包括设置在压力容器外部的生物屏蔽壁。压力容器垂直地分成多个块，使得每个块具有设置在同一水平面上的一个或多个压力容器渗透口，并且包括生物屏蔽壁的反应堆建筑物被分成多个模块由水平面。

6. 发明授权

US5083983A Belt tensioner 失效
标题翻译：皮带张力器
公开(公告)号：US5083983A
公开(公告)日：1992-01-28
申请号：US601313
申请日：1990-10-19
申请人： Hideo Hirai , Yasuhiro Hashimoto , Norikazu Tanaka
发明人： Hideo Hirai , Yasuhiro Hashimoto , Norikazu Tanaka
IPC分类号： F16H7/08 , F16H7/12
CPC分类号： F16H7/1218 , F02B2275/06 , F16H2007/081
摘要： An apparatus for tensioning a drive belt and having a tensioner arm with structure thereon for engaging a surface of the drive belt, structure for mounting the tensioner arm to a support for pivoting movement about a first axis in first and second opposite directions relative to the support including a roller bearing for guiding relative movement between the tensioner arm and support, and structure for normally biasing the belt in one of the first and second opposite directions relative to the support.

7. 发明授权

US4568315A Speed-shifting pulley with clutch mechanism 失效
标题翻译：带离合器机构的换档滑轮
公开(公告)号：US4568315A
公开(公告)日：1986-02-04
申请号：US575027
申请日：1984-01-30
申请人： Takashi Tomiyori , Hideo Hirai
发明人： Takashi Tomiyori , Hideo Hirai
IPC分类号： F16H9/12 , F16H7/08 , F16H55/56 , F16H11/06
CPC分类号： F16H55/56 , F16H7/0827
摘要： A variable speed pulley mounted to a torque transmission shaft having an idler structure arranged to maintain the power transmission belt centered between the pulley sheaves when the sheaves are spaced apart sufficiently to permit the belt to ride on the idler as in a stopped or idling condition of the pulley system. A tension roller may be utilized in the system for urging the belt against the outer surface of the idler, which, in the illustrated embodiment, is crowned. Structure is provided for affording facilitated adjustable movement of the adjustable sheave on the shaft, and in one embodiment, provision is made for providing lubrication therebetween.
摘要翻译：一种安装在转矩传动轴上的变速传动轴，其具有惰轮结构，其布置成当滑轮间隔开时将动力传递带保持在滑轮滑轮之间的中心位置，以允许皮带骑行在惰轮上，如在停止或空转状态滑轮系统。可以在系统中使用张紧辊来将带子推压到惰轮的外表面，在所示的实施例中，凸轮被加冠。提供了用于提供可调节滑轮在轴上的便利的可调节运动的结构，并且在一个实施例中，提供用于在它们之间提供润滑。

8. 发明授权

US08712002B2 Nuclear reactor building and construction method thereof 有权
标题翻译：核反应堆建设及其施工方法
公开(公告)号：US08712002B2
公开(公告)日：2014-04-29
申请号：US12652976
申请日：2010-01-06
申请人： Shigeki Yokoyama , Makoto Ukai , Munetaka Takahashi , Hideo Hirai , Takuya Miyagawa , Masashi Tanabe
发明人： Shigeki Yokoyama , Makoto Ukai , Munetaka Takahashi , Hideo Hirai , Takuya Miyagawa , Masashi Tanabe
IPC分类号： G21C1/01 , G21C11/02 , G21C13/02 , G21C1/00 , G21C11/00 , G21C13/00
CPC分类号： G21C13/02 , Y02E30/40
摘要： In a nuclear reactor building of a steel plate concrete structure that houses a pressure containment vessel formed with a plurality of penetration ports penetrating the pressure containment vessel on the periphery thereof and includes a biological shielding wall disposed outside the pressure containment vessel. The pressure containment vessel is vertically divided into a plurality of blocks so that each of the blocks has one or more pressure containment vessel penetration ports arranged on a same horizontal plane, and the reactor building including the biological shielding wall is divided into a plurality of modules by the horizontal plane.
摘要翻译：在钢板混凝土结构的核反应堆建筑物中，其容纳形成有贯穿其外围的压力容器的多个穿透口的压力容器，并且包括设置在压力容器外部的生物屏蔽壁。压力容器垂直地分成多个块，使得每个块具有设置在同一水平面上的一个或多个压力容器渗透口，并且包括生物屏蔽壁的反应堆建筑物被分成多个模块由水平面。

9. 发明授权

US06833517B2 Multiple switch device 失效
标题翻译：多开关装置
公开(公告)号：US06833517B2
公开(公告)日：2004-12-21
申请号：US09739686
申请日：2000-12-20
申请人： Tsuyoshi Sotome , Osamu Furukawa , Hiroshi Seki , Hideo Hirai
发明人： Tsuyoshi Sotome , Osamu Furukawa , Hiroshi Seki , Hideo Hirai
IPC分类号： H01H900
CPC分类号： H01H25/00 , H01H13/562 , H01H21/22 , H01H23/164 , H01H25/008 , H01H25/06 , H01H2021/225 , H01H2300/01
摘要： A low cost automotive power window switch having few window operating switches uses a single switch to select which of the four windows to operate, and to control the window locks. The power window switch has a window operating switch 3 for raising and lowering each of the car windows, and a mode selector switch 2 for switching between the windows. The mode selector switch 2 also has a window lock switch function for locking and unlocking the windows.
摘要翻译：具有少量窗口操作开关的低成本汽车电动车窗开关使用单个开关来选择要操作的四个窗口中的哪一个，并且控制窗口锁。电动车窗开关具有用于升高和降低每个车窗的窗口操作开关3和用于在窗户之间切换的模式选择器开关2。模式选择开关2还具有用于锁定和解锁窗口的窗口锁定开关功能。

10. 发明授权

US4698349A Quinolizinone compounds, and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents 失效
标题翻译：喹诺酮酮化合物和包含其的药物组合物，其可用作抗溃疡和抗过敏剂
公开(公告)号：US4698349A
公开(公告)日：1987-10-06
申请号：US770953
申请日：1985-08-30
申请人： Yoshihiko Kitaura , Teruo Oku , Hideo Hirai , Tosiyuki Yamamoto , Masashi Hashimoto
发明人： Yoshihiko Kitaura , Teruo Oku , Hideo Hirai , Tosiyuki Yamamoto , Masashi Hashimoto
IPC分类号： A61K31/435 , A61K31/47 , A61P1/04 , A61P37/08 , A61P43/00 , C07D455/00 , C07D455/02 , C07D455/03 , C07D455/04 , C07D455/06 , C07F7/18 , A61K31/345
CPC分类号： C07D455/00 , C07D455/02 , C07D455/04 , C07D455/06 , C07F7/1856 , Y02P20/55
摘要： The invention relates to novel quinolizinone compounds, of inhibitory activity on allergies and ulcers, of the formula: ##STR1## wherein R.sup.1 is carboxy, carbamoyl Y.sup.1, phenylcarbamoyl which may have hydroxy, cyano or thiocarbamoyl,R.sup.7 is hydrogen or aryl selected from phenyl, tolyl, xylyl, cumenyl, naphthyl and biphenylyl;R.sup.2 is hydrogen, hydroxy, lower alkyl or lower alkoxy; andR.sup.3 is hydrogen, hydroxy, lower alkyl, lower alkoxy, lower alkenyloxy, phenyl, naphthyl, biphenylyl, phenyl having one or more substituent(s) selected from halogen, lower alkyl and lower alkoxy, arylthio selected from phenylthio, tolylthio, xylylthio, cumenylthio, naphthylthio and biphenylylthio, aroyl selected from benzoyl, toluoyl and naphthoyl, ar(lower)alkyl selected from phenyl(lower)alkyl, tolyl(lower)alkyl, xylyl(lower)alkyl, cumenyl(lower)alkyl, naphthyl(lower)alkyl and biphenylyl(lower)alkyl, arenesulfonyl selected from benzenesulfonyl and p-toluenesulfonyl, arylamino selected from phenylamino, naphthylamino, biphenylylamino, phenylamino having lower alkyl on the nitrogen atom or aryloxy selected from phenoxy and tolyloxy; or pharmaceutically acceptable salts thereof.

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