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1. 发明授权

US4929639A Oxygen-containing heterocyclic compound 失效
标题翻译：含氧杂环化合物
公开(公告)号：US4929639A
公开(公告)日：1990-05-29
申请号：US208665
申请日：1988-06-20
申请人： Hiroyuki Setoi , Akio Kuroda , Hirokazu Tanaka , Hideo Hirai , Hiroshi Marusawa , Masashi Hashimoto
发明人： Hiroyuki Setoi , Akio Kuroda , Hirokazu Tanaka , Hideo Hirai , Hiroshi Marusawa , Masashi Hashimoto
IPC分类号： A61K31/357 , A61P7/02 , C07D309/06 , C07D319/06 , C07D405/12 , C07D409/12
CPC分类号： C07D405/12 , C07D309/06 , C07D319/06 , C07D409/12
摘要： The invention relates to treatment of diseases caused by thromboxane A.sub.2 comprising administering a compound ##STR1## wherein R.sup.1 is hydrogen or lower alkyl,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl andR.sup.3 is --CH.dbd.N--R.sup.4 in which R.sup.4 is arylureido or arylthioureido andX is --O--,or a pharmaceutically acceptable salt thereof.

2. 发明授权

US4916152A Pyrrolidine derivatives as antiasthmatics 失效
标题翻译：吡咯烷衍生物作为抗哮喘药
公开(公告)号：US4916152A
公开(公告)日：1990-04-10
申请号：US187240
申请日：1988-04-28
申请人： Hiroyuki Setoi , Hideo Hirai , Hiroshi Marusawa , Akio Kuroda , Hirokazu Tanaka , Masashi Hashimoto
发明人： Hiroyuki Setoi , Hideo Hirai , Hiroshi Marusawa , Akio Kuroda , Hirokazu Tanaka , Masashi Hashimoto
IPC分类号： A61K31/40 , A61K31/4025 , A61K31/66 , A61P7/00 , A61P7/02 , A61P11/00 , A61P13/02 , A61P15/00 , C07D207/12 , C07D207/14 , C07D207/16 , C07D409/12 , C07F9/572
CPC分类号： C07D207/16 , C07D207/12 , C07D207/14
摘要： The invention relates to novel compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkoxycarbonyl, phenylsulfonyl, phenylsulfonyl substituted with 1 to 3 substituent(s) selected from the group consisting of halogen, nitro, lower alkoxy, mono (or di or tri)halo(lower)alkyl and lower alkyl, phenylcarbamoyl, lower alkylsulfonyl, benzoyl or thienylsulfonyl;R.sup.2 is phenylsulfonyl or phenylsulfonyl substituted with 1 to 3 substituent(s) selected from the group consisting of halogen, lower alkyl, lower alkoxy and mono(or di or tri)halo(lower)alkyl,R.sup.3 is carboxy(lower)alkyl, lower alkyl substituted with carboxy and 1 to 3 halogen atom(s), esterified carboxy(lower)alkyl, carbamoyl(lower)alkyl, lower alkylsulfonylcarbamoyl(lower)alkyl, phenylsulfonylcarbamoyl(lower)alkyl, carboxyphenyl, esterified carboxyphenyl, carboxy, esterified carboxy, hydroxy(lower)alkyl, sulfino(lower)alkyl, phosphono(lower)alkyl, di(lower)alkoxyphosphoryl(lower)alkyl or halo(lower)alkyl,R.sup.7 is hydrogen or lower alkyl, andA is ##STR2## in which R.sup.8 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof, useful as therapeutic agents for thrombosis, asthma and nephritis.

3. 发明授权

US5210092A Angiotensin II antagonizing heterocyclic derivatives 失效
标题翻译： ANGIOTENSIN II拮抗杂环衍生物
公开(公告)号：US5210092A
公开(公告)日：1993-05-11
申请号：US748954
申请日：1991-08-23
申请人： Teruo Oku , Hiroyuki Setoi , Hiroshi Kayakiri , Shigeki Satoh , Takayuki Inoue , Yuki Saitoh , Akio Kuroda , Hirokazu Tanaka
发明人： Teruo Oku , Hiroyuki Setoi , Hiroshi Kayakiri , Shigeki Satoh , Takayuki Inoue , Yuki Saitoh , Akio Kuroda , Hirokazu Tanaka
IPC分类号： A61K31/415 , A61K31/435 , A61K31/52 , A61P9/00 , A61P9/12 , A61P43/00 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D487/04 , C07D495/04
CPC分类号： C07D403/14 , C07D471/04 , C07D495/04 , Y02P20/55
摘要： The invention concerns compounds of the formula ##STR1## represents a condensed or uncondensed imidazolyl ring and the rest of the variables are defined in the specification. They are angiotensin II antagonists useful for treating hypertension, etc.

4. 发明授权

US5354759A Angiotenin II antagonizing heterocyclic compounds 失效
标题翻译：血管紧张素II拮抗杂环化合物
公开(公告)号：US5354759A
公开(公告)日：1994-10-11
申请号：US8646
申请日：1993-01-25
申请人： Teruo Oku , Hiroyuki Setoi , Hiroshi Kayakiri , Shigeki Satoh , Takayuki Inoue , Yuki Sawada , Akio Kuroda , Hirokazu Tanaka
发明人： Teruo Oku , Hiroyuki Setoi , Hiroshi Kayakiri , Shigeki Satoh , Takayuki Inoue , Yuki Sawada , Akio Kuroda , Hirokazu Tanaka
IPC分类号： A61K31/435 , C07D471/04
CPC分类号： A61K31/435 , C07D471/04
摘要： This invention related to compounds of the formula ##STR1## wherein the radicals are as defined in the claims. The compounds are angiotensin II antagonists useful in treating hypertension, etc.
摘要翻译：本发明涉及式IMA的化合物，其中基团如权利要求中所定义。这些化合物是可用于治疗高血压等的血管紧张素II拮抗剂

5. 发明授权

US5215994A Angiotenin II antagonizing heterocyclic derivatives 失效
标题翻译：血管紧张素II拮抗杂环衍生物
公开(公告)号：US5215994A
公开(公告)日：1993-06-01
申请号：US758688
申请日：1991-09-12
申请人： Teruo Oku , Hiroyuki Setoi , Hiroshi Kayakiri , Shigeki Satoh , Takayuji Inoue , Yuki Saitoh , Akio Kuroda , Hirokazu Tanaka
发明人： Teruo Oku , Hiroyuki Setoi , Hiroshi Kayakiri , Shigeki Satoh , Takayuji Inoue , Yuki Saitoh , Akio Kuroda , Hirokazu Tanaka
IPC分类号： C07D403/14 , C07D471/04 , C07D495/04
CPC分类号： C07D403/14 , C07D471/04 , C07D495/04
摘要： The invention relates to compounds of the formula ##STR1## wherein ##STR2## represents a condensed or uncondensed imidazolyl ring and the rest of the variables are as defined in the specification. They are angiotensin II antagonists useful for treating hypertension, etc..
摘要翻译：本发明涉及式“IMAGE”的化合物，其中“IMAGE”表示缩合或未缩合的咪唑基环，其余变量如说明书中所定义。它们是可用于治疗高血压等的血管紧张素II拮抗剂。

6. 发明授权

US5780633A Process for the preparation of indolizine derivatives 失效
标题翻译：中和衍生物的制备方法
公开(公告)号：US5780633A
公开(公告)日：1998-07-14
申请号：US592309
申请日：1996-05-06
申请人： Satoshi Okada , Kozo Sawada , Akio Kuroda , Shinya Watanabe , Hirokazu Tanaka
发明人： Satoshi Okada , Kozo Sawada , Akio Kuroda , Shinya Watanabe , Hirokazu Tanaka
IPC分类号： A61K31/435 , A61P43/00 , C07D213/50 , C07D213/61 , C07D471/04 , C07D221/04 , C07D209/02
CPC分类号： C07D471/04 , C07D213/50
摘要： A new process for preparing a compound of the formula: ##STR1##
摘要翻译： PCT No.PCT / JP94 / 01465 Sec。 371日期：1996年5月6日 102（e）日期1996年5月6日PCT 1994年9月6日PCT公布。公开号WO95 / 07279 日期1995年3月16日一种制备下式化合物的新方法：

7. 发明授权

US5530019A Indole derivatives useful as testosterone 5.alpha.-reductase inhibitors 失效
标题翻译：吲哚衍生物可用作睾丸激素5α-还原酶抑制剂
公开(公告)号：US5530019A
公开(公告)日：1996-06-25
申请号：US338533
申请日：1995-03-08
申请人： Satoshi Okada , Kozo Sawada , Akio Kuroda , Shinya Watanabe , Hirokazu Tanaka
发明人： Satoshi Okada , Kozo Sawada , Akio Kuroda , Shinya Watanabe , Hirokazu Tanaka
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61P13/02 , A61P15/00 , A61P17/00 , A61P43/00 , C07D209/12 , C07D209/18 , C07D209/42
CPC分类号： C07D209/12 , C07D209/18 , C07D209/42
摘要： A compound of the formula (I): ##STR1## wherein R.sup.1 is an optionally protected carboxy(lower)alkyl, R.sup.2 is a hydrogen, an optionally substituted aryl or a carboxy,X is a bond, --0--, --NH-- or a cycloalkylene, andY is an alkylene which may be interrupted by an oxygen atom, an alkenylene or an alkadienylene,or a pharmaceutically acceptable salt thereof. The compound of the present invention is useful as a testosterone 5.alpha.-reductase inhibitor and effective against testosterone 5.alpha.-reductase-mediated diseases such as prostatism, prostatic hypertrophy, prostatic cancer, alopecia, hirsutism (e.g. female hirsutism), androgenic alopecia (or male-pattern baldness), acne (e.g. acne vulgaris, pimple), and other hyperandrogenisms.
摘要翻译： PCT No.PCT / JP94 / 00406 Sec。 371日期：1995年3月8日 102（e）日期1995年3月8日PCT 1994年3月14日PCT公布。第WO94 / 22821号公报（I）化合物：其中R 1为任选保护的羧基（低级）烷基，R 2为氢，任选取代的芳基或羧基，X为键，-O - ， - NH-或亚环烷基，Y是可被氧原子，亚烯基或链二烯基或其可药用盐间隔的亚烷基。本发明的化合物可用作睾丸激素5α-还原酶抑制剂，并且有效地抵抗睾酮5α-还原酶介导的疾病，例如前列腺炎，前列腺肥大，前列腺癌，脱发，多毛症（例如雌性多毛症），雄激素性脱发（或男性型秃发），痤疮（例如寻常痤疮，疙瘩）和其他雄激素过多。

8. 发明授权

US5334716A Heterocyclic derivatives 失效
标题翻译：杂环衍生物
公开(公告)号：US5334716A
公开(公告)日：1994-08-02
申请号：US892453
申请日：1992-06-02
申请人： Satoshi Okada , Kozo Sawada , Akio Kuroda , Shinya Watanabe , Hirokazu Tanaka
发明人： Satoshi Okada , Kozo Sawada , Akio Kuroda , Shinya Watanabe , Hirokazu Tanaka
IPC分类号： A61K31/435 , A61P13/02 , A61P15/00 , A61P17/00 , A61P43/00 , C07D471/04 , C07D417/07 , A61K31/41 , C07D405/14
CPC分类号： C07D471/04 , Y02P20/55
摘要： This invention relates to heterocyclic derivatives useful for treating or preventing testosteron 5.alpha.-reductase mediated diseases such as alopecia, ache, prostatism and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to uses thereof.
摘要翻译：本发明涉及可用于治疗或预防睾丸激素5α-还原酶介导的疾病如脱发，疼痛，前列腺等的杂环衍生物，其可以由下式表示：（1）其制备方法涉及含有该组合物的药物组合物及其用途。

9. 发明申请

US20140051134A1 METHOD FOR PRODUCING PHOSPHITE DEHYDROGENASE PROTEIN AND USE THEREOF 有权
标题翻译：生产磷酸脱氢蛋白的方法及其用途
公开(公告)号：US20140051134A1
公开(公告)日：2014-02-20
申请号：US14113346
申请日：2012-04-16
申请人： Akio Kuroda , Ryuichi Hirota
发明人： Akio Kuroda , Ryuichi Hirota
IPC分类号： C12N9/04
CPC分类号： C12N9/0006 , C12N9/0004 , C12P17/182 , C12Y120/01001
摘要： In order to provide: a phosphite dehydrogenase protein having both improved solubility and improved heat stability; a method for producing a gene encoding the phosphite dehydrogenase protein; a method for producing the phosphite dehydrogenase protein; and use of the phosphite dehydrogenase protein, (i) a phosphite dehydrogenase protein having a specific amino acid sequence and (ii) a gene encoding the phosphite dehydrogenase protein are used.
摘要翻译：为了提供：具有改善的溶解度和改善的热稳定性的亚磷酸酯脱氢酶蛋白质; 生产编码亚磷酸脱氢酶蛋白质的基因的方法; 一种生产亚磷酸脱氢酶蛋白的方法; 和使用亚磷酸酯脱氢酶蛋白质，（i）具有特定氨基酸序列的亚磷酸脱氢酶蛋白质和（ii）编码亚磷酸酯脱氢酶蛋白质的基因。

10. 发明授权

US08394602B2 Luminescent method for measuring endotoxin 有权
标题翻译：用于测量内毒素的发光方法
公开(公告)号：US08394602B2
公开(公告)日：2013-03-12
申请号：US12734485
申请日：2008-11-11
申请人： Akio Kuroda , Kenichi Noda
发明人： Akio Kuroda , Kenichi Noda
IPC分类号： C12Q1/56
CPC分类号： G01N21/763 , C12Q1/66 , G01N33/56911 , G01N33/579
摘要： The present invention provides a method comprising allowing a reaction of a sample, a reagent containing Factor C, which can be activated by binding with endotoxin, and a synthetic luminescent substrate comprising a luminescent substrate bound to a peptide, for release of the luminescent substrate from the synthetic luminescent substrate, allowing a luminescent enzyme to act on the luminescent substrate released in the luminescent substrate release step, for measurement of the luminescence intensity, and quantifying the level of endotoxin in the sample based on a measured value obtained in the luminescence measuring step, the method enabling endotoxin to be simply and quickly measured at a level that cannot be detected in conventional methods for endotoxin measurement, without use of any dedicated measuring device.
摘要翻译：本发明提供了一种方法，其包括使样品，可通过与内毒素结合而活化的因子C的试剂与包含与肽结合的发光底物的合成发光底物反应，从而将发光底物从所述合成发光基板允许发光酶作用于在所述发光底物释放步骤中释放的所述发光基板，用于测量所述发光强度，并且基于在所述发光测量步骤中获得的测量值来定量所述样品中的内毒素水平，在不使用任何专用测量装置的情况下，能够以常规的内毒素测量方法无法检测的水平简单且快速地测量内毒素的方法。

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