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1. 发明授权

US08372596B2 Asbestos detection method, asbestos detection agent, asbestos detection kit, method for screening candidate for agent aiming at preventing or treating disease for which asbestos is causative or worsening factor 有权
标题翻译：石棉检测方法，石棉检测剂，石棉检测试剂盒，筛选候选药物的方法，旨在预防或治疗石棉致病或恶化的疾病
公开(公告)号：US08372596B2
公开(公告)日：2013-02-12
申请号：US12093316
申请日：2006-11-08
申请人： Akio Kuroda , Kazutaka Nomura
发明人： Akio Kuroda , Kazutaka Nomura
IPC分类号： G01N33/00
CPC分类号： G01N33/5308 , G01N2500/02
摘要： The present invention provides a prompt and easy asbestos detection method and a method for screening a candidate for an agent aiming at preventing or treating a disease for which asbestos is a causative or worsening factor. It is possible to quickly and easily detect asbestos in a sample by finding a protein capable of binding specifically to asbestos, allowing the protein or a fusion protein of the protein and a reporter protein to bind to asbestos in the sample, and then detecting the protein or the fusion protein having been bound to asbestos. A substance inhibiting the binding of actin to asbestos, which has been found out as a protein capable of binding specifically to asbestos, is a candidate for an agent aiming at preventing or treating a disease for which asbestos is a causative or worsening factor.
摘要翻译：本发明提供一种快速且容易的石棉检测方法和筛选用于预防或治疗石棉是致病或恶化因子的疾病的试剂的候选物的方法。可以通过发现能够特异性结合石棉的蛋白质快速方便地检测样品中的石棉，使得蛋白质或蛋白质的融合蛋白质和报道蛋白质与样品中的石棉结合，然后检测蛋白质或融合蛋白已经结合到石棉上。抑制肌动蛋白与石棉结合的物质，其已被发现为能够特异性结合石棉的蛋白质，是旨在预防或治疗石棉是致病或恶化因子的疾病的药物的候选者。

2. 发明申请

US20110166348A1 NOVEL SALT OF MORPHOLINE DERIVATIVE 审中-公开
标题翻译：新型盐衍生物
公开(公告)号：US20110166348A1
公开(公告)日：2011-07-07
申请号：US13060795
申请日：2009-09-10
申请人： Kazumi Kikuchi , Akio Kuroda , Ryo Mizoguchi , Kenichirou Sakamoto , Kazuhiro Takeguchi
发明人： Kazumi Kikuchi , Akio Kuroda , Ryo Mizoguchi , Kenichirou Sakamoto , Kazuhiro Takeguchi
IPC分类号： C07D265/30
CPC分类号： C07D265/30
摘要： Provided are an acid addition salt of (+)-2-[(inden-7-yloxy)methyl]morpholine (compound A) and a novel crystal thereof, which are for use as a medicament or a drug substance, and which has high storage stability, particularly high stability against humidity and light. An acid addition salt of the compound A with an acid selected from benzenesulfonic acid and hydrobromic acid is a compound which is isolated in the form of a crystal, is a solid at room temperature, exhibits no hygroscopicity at such a level that causes a problem for use as a medicament or a drug substance, has stability against humidity and light, and is therefore extremely useful as a medicament or a drug substance.
摘要翻译：提供用作药物或药物的（+） - 2 - [（茚-7-基氧基）甲基]吗啉（化合物A）及其新结晶的酸加成盐，其具有高的储存稳定性，对湿度和光线特别高的稳定性。化合物A与选自苯磺酸和氢溴酸的酸的酸加成盐是以结晶形式分离的化合物，在室温下为固体，在这样的水平下表现出不吸湿性，导致问题的水平用作药物或药物，对湿度和光具有稳定性，因此作为药物或药物非常有用。

3. 发明申请

US20090118142A1 METHOD AND AGENT FOR IMMOBILIZING PROTEIN VIA PROTEIN BOUND TO SILICON OXIDE-CONTAINING SUBSTANCE 有权
标题翻译：用于通过蛋白质固定蛋白质与含氧化硅物质固定的方法和试剂
公开(公告)号：US20090118142A1
公开(公告)日：2009-05-07
申请号：US12093313
申请日：2006-11-09
申请人： Akio Kuroda , Kazutaka Momura
发明人： Akio Kuroda , Kazutaka Momura
IPC分类号： C40B50/18 , C07K14/00 , C12N15/11 , C12N15/00
CPC分类号： G01N33/552 , C07K14/21 , C07K14/245 , C07K14/31 , C07K2319/00 , C07K2319/20 , C07K2319/705 , C07K2319/74
摘要： Disclosed is a method for immobilizing a target protein to the surface of silicon oxide-containing substance such as glass without modifying the surface of silicon oxide-containing substance by using a protein binding strongly to silicon oxide-containing substance. A protein capable binding strongly to silicon oxide-containing substance such as glass has been found, and thus a target protein can be directly bound and immobilized to the surface of silicon oxide-containing substance via the found protein. In addition, a fusion protein of the found protein and a target protein can be bound and immobilized to silicon oxide-containing substance.
摘要翻译：公开了通过使用与含氧化硅的物质强烈结合的蛋白质，将目标蛋白质固定在含氧化硅的物质如玻璃的表面上而不改变含氧化硅物质的表面的方法。已经发现能够与含氧化硅的物质如玻璃强烈结合的蛋白质，因此可以通过发现的蛋白质将靶蛋白直接结合固定在含氧化硅物质的表面上。此外，所发现的蛋白质和靶蛋白质的融合蛋白质可以结合并固定在含氧化硅的物质上。

4. 发明授权

US07438652B2 Golf ball marker 失效
标题翻译：高尔夫球标记
公开(公告)号：US07438652B2
公开(公告)日：2008-10-21
申请号：US11397630
申请日：2006-04-05
申请人： Akio Kuroda
发明人： Akio Kuroda
IPC分类号： A63B57/00
CPC分类号： A63B57/353 , A63B57/207
摘要： A ball marker is provided with a pivotal member (2) that is constituted by a hinged portion (5), a shaft piercing portion (6) and an insertion portion (7) and allowed to pivot, and a main body (3) that allows the pivotal member (2) to be inserted therein and shaft-engaged thereto, and in this structure, when the hinged portion (5) is raised upright on the surface of the main body (3), the insertion portion (7) is also raised upright on the back surface of the main body (3) cooperatively, and when the hinged portion (5) is laid down on the surface of the main body (3), the insertion portion (7) is also laid down on the back surface of the main body (3) cooperatively, so that a housing section used for housing the insertion portion (7) is formed on the back surface of the main body (3); thus, the insertion portion (7) is made virtually flush with the back surface of the main body, with the hinged portion (5) and the insertion (7) portion being laid down. The objective of the present invention is to provide a golf ball marker that can be visually recognized easily even from a distant location when it is placed on the green face and used, and is superior in portability.
摘要翻译：球标记器具有由铰链部分（5），轴穿刺部分（6）和插入部分（7）构成并被允许枢转的枢转构件（2）和主体（3），主体允许枢转构件（2）插入其中并与其轴接合，并且在该结构中，当铰链部分（5）在主体（3）的表面上竖起时，插入部分（7）是同时也在主体（3）的后表面上直立地竖立，并且当铰链部分（5）放置在主体（3）的表面上时，插入部分（7）也被放置在配合主体（3）的背面，使得用于容纳插入部（7）的收纳部形成在主体（3）的背面上。因此，插入部分（7）实际上与主体的后表面齐平，铰链部分（5）和插入部分（7）部分被放下。本发明的目的是提供一种高尔夫球标记器，即使在被放置在绿色面上并且使用时也能从远处位置容易地视觉识别，并且便携性优异。

5. 发明授权

US07186731B2 2-cyanopyrrolidinecarboxamide compound 失效
标题翻译： 2-氰基吡咯烷甲酰胺化合物
公开(公告)号：US07186731B2
公开(公告)日：2007-03-06
申请号：US10975524
申请日：2004-10-29
申请人： Ichiro Shima , Akio Kuroda , Takehiko Ohkawa , Toshio Kurosaki , Yuki Sawada , Aiko Wada
发明人： Ichiro Shima , Akio Kuroda , Takehiko Ohkawa , Toshio Kurosaki , Yuki Sawada , Aiko Wada
IPC分类号： A61K31/4439 , C07D451/00
CPC分类号： C07D453/02 , C07D451/04 , C07D471/08
摘要： A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X1 and X2 each is independently lower alkylene; X3 is ═CH2, ═CHF or ═CF2; R1 is substituent, R2 and R3 each is independently H or lower alkyl; n is 0, 1, 2, 3 or 4.] having the activity inhibiting DPP-IV activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as NIDDM.
摘要翻译：式（I）化合物或其药学上可接受的盐：其中X 1和X 2各自独立地为低级亚烷基; X 3是-CH 2，-CHF或-CF 2; R 1是取代基，R 2和R 3各自独立地是H或低级烷基; n为0,1,2,3或4]具有抑制DPP-IV活性的活性。因此，它们可用于治疗DPP-IV介导的病症，例如NIDDM。

6. 发明申请

US20060234813A1 Golf ball marker 失效
标题翻译：高尔夫球标记
公开(公告)号：US20060234813A1
公开(公告)日：2006-10-19
申请号：US11397630
申请日：2006-04-05
申请人： Akio Kuroda
发明人： Akio Kuroda
IPC分类号： A63B57/00
CPC分类号： A63B57/353 , A63B57/207
摘要： A ball marker is provided with a pivotal member (2) that is constituted by a hinged portion (5), a shaft piercing portion (6) and an insertion portion (7) and allowed to pivot, and a main body (3) that allows the pivotal member (2) to be inserted therein and shaft-engaged thereto, and in this structure, when the hinged portion (5) is raised upright on the surface of the main body (3), the insertion portion (7) is also raised upright on the back surface of the main body (3) cooperatively, and when the hinged portion (5) is laid down on the surface of the main body (3), the insertion portion (7) is also laid down on the back surface of the main body (3) cooperatively, so that a housing section used for housing the insertion portion (7) is formed on the back surface of the main body (3); thus, the insertion portion (7) is made virtually flush with the back surface of the main body, with the hinged portion (5) and the insertion (7) portion being laid down. The objective of the present invention is to provide a golf ball marker that can be visually recognized easily even from a distant location when it is placed on the green face and used, and is superior in portability.
摘要翻译：球标记器具有由铰链部分（5），轴穿刺部分（6）和插入部分（7）构成并被允许枢转的枢转构件（2）和主体（3），主体允许枢转构件（2）插入其中并与其轴接合，并且在该结构中，当铰链部分（5）在主体（3）的表面上竖起时，插入部分（7）是同时也在主体（3）的后表面上直立地竖立，并且当铰链部分（5）放置在主体（3）的表面上时，插入部分（7）也被放置在配合主体（3）的背面，使得用于容纳插入部（7）的收纳部形成在主体（3）的背面上。因此，插入部分（7）实际上与主体的后表面齐平，铰链部分（5）和插入部分（7）部分被放下。本发明的目的是提供一种高尔夫球标记器，即使在被放置在绿色面上并且使用时也能从远处位置容易地视觉识别，并且便携性优异。

7. 发明授权

US6069156A Indole derivatives as cGMP-PDE inhibitors 失效
标题翻译：吲哚衍生物作为cGMP-PDE抑制剂
公开(公告)号：US6069156A
公开(公告)日：2000-05-30
申请号：US930597
申请日：1997-12-10
申请人： Teruo Oku , Kozo Sawada , Akio Kuroda , Kazuhiko Ohne , Atsushi Nomoto , Naomi Hosogai , Yoshimitsu Nakajima , Akira Nagashima , Keizo Sogabe , Kouichi Tamura , Masakazu Kobayashi
发明人： Teruo Oku , Kozo Sawada , Akio Kuroda , Kazuhiko Ohne , Atsushi Nomoto , Naomi Hosogai , Yoshimitsu Nakajima , Akira Nagashima , Keizo Sogabe , Kouichi Tamura , Masakazu Kobayashi
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/535 , A61P3/08 , A61P3/10 , A61P9/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P27/02 , A61P27/14 , A61P37/08 , A61P43/00 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/30 , C07D209/42 , C07D209/52 , C07D209/88 , C07D209/94 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D417/06 , A01N43/40 , C07D209/04
CPC分类号： C07D401/06 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/30 , C07D209/42 , C07D209/52 , C07D209/88 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D417/06
摘要： Compounds of the formula (I): ##STR1## and their pharmaceutically acceptable compositions are useful in inhibiting the activity of cyclic guanosine 3',5'-monophosphate phosphodiesterase.
摘要翻译： PCT No.PCT / JP96 / 00892 Sec。 371 1997年12月10日第 102（e）日期1997年12月10日PCT提交1996年4月2日PCT公布。公开号WO96 / 32379 日期：1996年10月17日式（I）化合物及其药学上可接受的组合物可用于抑制环鸟苷3'，5'-单磷酸磷酸二酯酶的活性。

8. 发明授权

US6037575A Method and apparatus for removing a defect in joined metal blocks 失效
标题翻译：用于去除接合的金属块中的缺陷的方法和装置
公开(公告)号：US6037575A
公开(公告)日：2000-03-14
申请号：US946756
申请日：1997-10-07
申请人： Shigeru Isoyama , Takeshi Hirabayashi , Hideyuki Nikaido , Hirosuke Yamada , Toshiaki Amagasa , Toshisada Takechi , Kunio Miyamoto , Akio Kuroda , Yoshiki Mito
发明人： Shigeru Isoyama , Takeshi Hirabayashi , Hideyuki Nikaido , Hirosuke Yamada , Toshiaki Amagasa , Toshisada Takechi , Kunio Miyamoto , Akio Kuroda , Yoshiki Mito
IPC分类号： B21B1/26 , B21B15/00 , B23K13/00 , B23K13/01 , B23K37/047
CPC分类号： B23K13/00 , B21B15/0085 , B23K13/015 , B23K37/047 , B21B1/26 , B23K2201/16
摘要： A post continuous hot rolling method where a rear end portion of a preced metal block and a fore end portion of a succeeding metal block are cut and the metal blocks joined to each other by heating and pressing followed by a finish rolling, wherein a poorly joined portion is removed by shaving the defective portion through application of rotating cutters prior to a final finish rolling of the joined blocks.
摘要翻译：一种后连续热轧方法，其中先前金属块的后端部分和后面的金属块的前端部分被切割，并且通过加热和压制接着进行精轧而彼此接合的金属块，其中接合不良通过在连接的块的最终精轧之前通过施加旋转刀具来剃刮缺陷部分来去除部分。

9. 发明授权

US5210092A Angiotensin II antagonizing heterocyclic derivatives 失效
标题翻译： ANGIOTENSIN II拮抗杂环衍生物
公开(公告)号：US5210092A
公开(公告)日：1993-05-11
申请号：US748954
申请日：1991-08-23
申请人： Teruo Oku , Hiroyuki Setoi , Hiroshi Kayakiri , Shigeki Satoh , Takayuki Inoue , Yuki Saitoh , Akio Kuroda , Hirokazu Tanaka
发明人： Teruo Oku , Hiroyuki Setoi , Hiroshi Kayakiri , Shigeki Satoh , Takayuki Inoue , Yuki Saitoh , Akio Kuroda , Hirokazu Tanaka
IPC分类号： A61K31/415 , A61K31/435 , A61K31/52 , A61P9/00 , A61P9/12 , A61P43/00 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D487/04 , C07D495/04
CPC分类号： C07D403/14 , C07D471/04 , C07D495/04 , Y02P20/55
摘要： The invention concerns compounds of the formula ##STR1## represents a condensed or uncondensed imidazolyl ring and the rest of the variables are defined in the specification. They are angiotensin II antagonists useful for treating hypertension, etc.

10. 发明授权

US4646284A High density information record medium using carbon black particles surface-treated with silicone oil 失效
标题翻译：高密度信息记录介质，采用硅油表面处理的炭黑颗粒
公开(公告)号：US4646284A
公开(公告)日：1987-02-24
申请号：US774800
申请日：1985-09-11
申请人： Toshiaki Hamaguchi , Kazuhira Namikawa , Mutsuaki Nakamura , Akio Kuroda , Toshio Akai
发明人： Toshiaki Hamaguchi , Kazuhira Namikawa , Mutsuaki Nakamura , Akio Kuroda , Toshio Akai
IPC分类号： G11B9/06 , C09C1/56 , H01B1/06
CPC分类号： G11B9/065 , G11B9/068
摘要： High density information signal recording media of an electrostatic capacitance type, in which an information signal is recorded as geometric variations. The medium consists of a conductive resin composition which comprises a vinyl chloride resin, carbon black particles and a silicone oil lubricant. The carbon black particles are treated with a silicone oil to have the oil coated thereon.
摘要翻译：静电电容式的高密度信息信号记录介质，其中信息信号被记录为几何变化。介质由包含氯乙烯树脂，炭黑颗粒和硅油润滑剂的导电树脂组合物组成。炭黑颗粒用硅油处理以涂覆油。

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