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1. 发明授权

US4650804A Quinolizinone compounds and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents 失效
标题翻译：喹诺酮类化合物和包含其的药物组合物，可用作抗溃疡和抗过敏剂
公开(公告)号：US4650804A
公开(公告)日：1987-03-17
申请号：US712435
申请日：1985-03-18
申请人： Yoshihiko Kitaura , Teruo Oku , Hideo Hirai , Tosiyuki Yamamoto , Masashi Hashimoto
发明人： Yoshihiko Kitaura , Teruo Oku , Hideo Hirai , Tosiyuki Yamamoto , Masashi Hashimoto
IPC分类号： A61K31/435 , A61K31/47 , A61P1/04 , A61P37/08 , A61P43/00 , C07D455/00 , C07D455/02 , C07D455/03 , C07D455/04 , C07D455/06 , C07F7/18 , C07D221/06 , C07D239/02
CPC分类号： C07D455/00 , C07D455/02 , C07D455/04 , C07D455/06 , C07F7/1856 , Y02P20/55
摘要： The invention relates to novel quinolizinone compounds having inhibitory activity on allergies and ulcers, of the formula: ##STR1## wherein R.sup.1 is tetrazolylcarbamoyl;R.sup.7 is hydrogen or aryl selected from phenyl, tolyl, xylyl, cumenyl, naphthyl and biphenylyl;R.sup.2 is hydrogen, hydroxy, lower alkyl or lower alkoxy;R.sup.3 is hydrogen, hydroxy, lower alkyl, lower alkoxy, lower alkenyloxy, phenyl, napthyl, biphenylyl, phenyl having one or more substituent(s) selected from halogen, lower alkyl and lower alkoxy, arylthio selected from phenylthio, tolylthio, xylylthio, cumenylthio, naphthylthio and biphenylthio, aroyl selected from benzoyl, toluoyl and naphthoyl, ar(lower)alkyl selected from phenyl(lower)alkyl, tolyl(lower)alkyl, xylyl(lower)alkyl, cumenyl(lower)alkyl, naphthyl(lower)alkyl and biphenylyl(lower)alkyl, arenesulfonyl selected from benzenesulfonyl and p-toluenesulfonyl, arylamino selected from phenylamino, naphthylamino, biphenylylamino, phenylamino having lower alkyl on the nitrogen atom or aryloxy selected from phenoxy and tolyloxy;or pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及具有下式的过敏和溃疡抑制活性的新型喹嗪酮化合物：其中R1是四唑基氨基甲酰基; R7是氢或选自苯基，甲苯基，二甲苯基，枯烯基，萘基和联苯基的芳基; R2是氢，羟基，低级烷基或低级烷氧基; R3是氢，羟基，低级烷基，低级烷氧基，低级烯氧基，苯基，萘基，联苯基，具有一个或多个选自卤素，低级烷基和低级烷氧基的取代基的苯基，选自苯硫基，甲苯硫基，二甲苯硫基，，萘基硫基和联苯硫基，选自苯甲酰基，甲苯酰基和萘甲酰基的芳酰基，选自苯基（低级）烷基，甲苯基（低级）烷基，二甲苯基（低级）烷基，枯烯基（低级）烷基，萘基和选自苯磺酰基和对甲苯磺酰基的联苯基（低级）烷基，芳基磺酰基，选自苯基氨基，萘基氨基，联苯基氨基，在氮原子上具有低级烷基的苯基氨基或选自苯氧基和甲酰基氧基的芳氧基; 或其药学上可接受的盐。

2. 发明授权

US4698349A Quinolizinone compounds, and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents 失效
标题翻译：喹诺酮酮化合物和包含其的药物组合物，其可用作抗溃疡和抗过敏剂
公开(公告)号：US4698349A
公开(公告)日：1987-10-06
申请号：US770953
申请日：1985-08-30
申请人： Yoshihiko Kitaura , Teruo Oku , Hideo Hirai , Tosiyuki Yamamoto , Masashi Hashimoto
发明人： Yoshihiko Kitaura , Teruo Oku , Hideo Hirai , Tosiyuki Yamamoto , Masashi Hashimoto
IPC分类号： A61K31/435 , A61K31/47 , A61P1/04 , A61P37/08 , A61P43/00 , C07D455/00 , C07D455/02 , C07D455/03 , C07D455/04 , C07D455/06 , C07F7/18 , A61K31/345
CPC分类号： C07D455/00 , C07D455/02 , C07D455/04 , C07D455/06 , C07F7/1856 , Y02P20/55
摘要： The invention relates to novel quinolizinone compounds, of inhibitory activity on allergies and ulcers, of the formula: ##STR1## wherein R.sup.1 is carboxy, carbamoyl Y.sup.1, phenylcarbamoyl which may have hydroxy, cyano or thiocarbamoyl,R.sup.7 is hydrogen or aryl selected from phenyl, tolyl, xylyl, cumenyl, naphthyl and biphenylyl;R.sup.2 is hydrogen, hydroxy, lower alkyl or lower alkoxy; andR.sup.3 is hydrogen, hydroxy, lower alkyl, lower alkoxy, lower alkenyloxy, phenyl, naphthyl, biphenylyl, phenyl having one or more substituent(s) selected from halogen, lower alkyl and lower alkoxy, arylthio selected from phenylthio, tolylthio, xylylthio, cumenylthio, naphthylthio and biphenylylthio, aroyl selected from benzoyl, toluoyl and naphthoyl, ar(lower)alkyl selected from phenyl(lower)alkyl, tolyl(lower)alkyl, xylyl(lower)alkyl, cumenyl(lower)alkyl, naphthyl(lower)alkyl and biphenylyl(lower)alkyl, arenesulfonyl selected from benzenesulfonyl and p-toluenesulfonyl, arylamino selected from phenylamino, naphthylamino, biphenylylamino, phenylamino having lower alkyl on the nitrogen atom or aryloxy selected from phenoxy and tolyloxy; or pharmaceutically acceptable salts thereof.

3. 再颁专利

USRE32992E Peptide process for preparation thereof and use thereof 失效
标题翻译：其制备方法及其用途
公开(公告)号：USRE32992E
公开(公告)日：1989-07-18
申请号：US611733
申请日：1984-05-18
申请人： Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka , Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
发明人： Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka , Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
IPC分类号： A61K38/00 , C07K5/02 , C07K5/06 , C07K5/062 , C07K5/072 , C07K9/00
CPC分类号： C07C243/00 , C07K5/0215 , C07K5/06026 , C07K5/06052 , C07K5/06069 , C07K5/06078 , C07K9/005 , C12R1/465 , A61K38/00 , Y02P20/55
摘要： The invention deals with novel peptides useful for the therapeutic treatment of infectious diseases caused by pathogenic microorganisms. Included is the peptide FR900156 having the structure: ##STR1## as well as the peptides of the structure ##STR2## wherein R.sup.1 is acyl;R.sub.b.sup.1 is hydrogen, methyl, isopropyl, hydroxymethyl, protected hydroxymethyl or benzyl;R.sup.2 is hydrogen, carboxy, protected carboxy, or a group of the formula: ##STR3## wherein R.sub.a.sup.2 is mono- or di-carboxy lower alkyl or ar(carboxy) lower alkyl whose aryl moiety may be substituted by hydroxy,R.sub.b.sup.2 is hydrogen or lower alkyl;R.sup.p and R.sup.q are each hydrogen, carboxy, protected carboxy, with proviso that when one of R.sup.2 and R.sup.q is hydrogen, then the other is carboxy or protected carboxy;R.sup.r is hydrogen or amino protective group; m is an integer 1 to 3, and n is 1 .Iadd.provided that when R.sup.1 is benzyloxycarbonyl R.sub.5.sup.1 is methyl, m is an integer 2 and n is an integer 1, then R.sup.2 is not protected carboxy, and .Iaddend.provided that when R.sup.1 is .[.hydrogen,.]. t-butoxycarbonyl or N-acetylmuramyl, R.sub.b.sup.1 is methyl, m is an integer 2 and n is an integer 1, then R.sup.2 is hydrogen, protected carboxy or a group of the formula: ##STR4## wherein R.sub.a.sup.2 is mono- or di-carboxy lower alkyl having 1 and 3 to 6, carbon atoms, .[..alpha.-carboxyethyl,.]. .Iadd.--CH.sub.2 --CH.sub.2 --COOH, .Iaddend.ar(carboxy) lower alkyl whose aryl moiety may be substituted by hydroxy and R.sub.b.sup.2 is as defined above, or its pharmaceutically acceptable salt.

4. 发明授权

US4725582A Peptide, process for preparation thereof and use thereof 失效
标题翻译：肽，其制备方法及其用途
公开(公告)号：US4725582A
公开(公告)日：1988-02-16
申请号：US377836
申请日：1982-05-13
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Takeno Hidekazu , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Takeno Hidekazu , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
IPC分类号： A61K38/00 , C07K5/02 , C07K5/06 , C07K5/062 , C07K5/072 , C07K9/00 , A61K37/02 , C07C103/52
CPC分类号： C07C243/00 , C07K5/0215 , C07K5/06026 , C07K5/06052 , C07K5/06069 , C07K5/06078 , C07K9/005 , C12R1/465 , A61K38/00 , Y02P20/55
摘要： The invention concerns peptides, having the pharmaceutical property of enhancing the immune response, having the structure: ##STR1## wherein R.sup.1 is alkanoyl,R.sub.b.sup.1 is hydrogen, methyl, isopropyl, hydroxymethyl, protected hydroxymethyl or benzyl,R.sup.2 is hydrogen, carboxy, protected carboxy or a group of the formula: ##STR2## wherein R.sub.a.sup.2 is mono- or di-carboxy (or protected carboxy) lower alkyl or ar(carboxy or protected carboxy) lower alkyl whose aryl moiety is substituted by hydroxy or not substituted,R.sub.b.sup.2 is hydrogen or lower alkyl,R.sup.p is hydrogen, carboxy or protected carboxy,R.sup.q is carboxy, protected carboxy or a group of the formula ##STR3## wherein R.sub.a.sup.2 and R.sub.b.sup.2 are each as defined above, R.sup.r is hydrogen or amino protective group,m is an integer 1 to 3, andn is an integer 1.
摘要翻译：本发明涉及具有以下结构的具有增强免疫应答的药学性质的肽：其中R 1是烷酰基，R 1b是氢，甲基，异丙基，羟甲基，被保护的羟甲基或苄基，R 2是氢，羧基，被保护的羧基或下式的基团：其中R 2a是其芳基部分被羟基或未取代的单或二羧基（或保护的羧基）低级烷基或芳（羧基或被保护的羧基）低级烷基，R 2b是氢或低级烷基，Rp是氢，羧基或受保护的羧基，Rq是羧基，被保护的羧基或下式的基团：其中Ra2和Rb2各自如上定义，Rr是氢或氨基保护基，m是整数 1〜3，n为整数1。

5. 发明授权

US4493794A Peptide, process for preparation thereof and use thereof 失效
标题翻译：肽，其制备方法及其用途
公开(公告)号：US4493794A
公开(公告)日：1985-01-15
申请号：US328997
申请日：1981-12-09
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Satoshi Yonishi , Hidekazu Takeno , Satoshi Okada , Masashi Hashimoto
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Satoshi Yonishi , Hidekazu Takeno , Satoshi Okada , Masashi Hashimoto
IPC分类号： C07D263/44 , A61K31/195 , A61K31/22 , A61K31/27 , A61K38/00 , A61P31/04 , A61P35/00 , A61P37/04 , C07C231/02 , C07C237/10 , C07C237/12 , C07C237/22 , C07C271/22 , C07K5/02 , C07C103/52
CPC分类号： C07K5/0215 , A61K38/00 , Y02P20/55
摘要： The invention deals with novel peptides useful for the therapeutic treatment of infectious diseases caused by pathogenic microorganisms, having the structure: ##STR1## wherein R.sup.1 is hydrogen, substituted or unsubstituted alkanoyl, or substituted or unsubstituted aralkanoyl,R.sup.2 is carboxy or protected carboxy,R.sup.3 is carboxy, protected carboxy, carbamoyl, or carboxy or protected carboxy(lower)alkylcarbamoyl,R.sup.4 is carboxy, protected carboxy or carbamoyl, andR.sup.5 is hydrogen or an amino protective group, with proviso that at least one of R.sup.3 and R.sup.4 is always carbamoyl and their pharmaceutically acceptable salts.
摘要翻译：本发明涉及可用于治疗由病原微生物引起的感染性疾病的新型肽，其具有以下结构：其中R 1为氢，取代或未取代的烷酰基或取代或未取代的芳烷酰基，R 2为羧基或被保护的羧基，R 3 羧基，保护的羧基，氨基甲酰基或羧基或受保护的羧基（低级）烷基氨基甲酰基，R4是羧基，保护的羧基或氨基甲酰基，R5是氢或氨基保护基，条件是R3和R4中的至少一个总是氨基甲酰基及其药学上可接受的盐。

6. 发明授权

US4476050A Peptide, process for preparation thereof and use thereof 失效
标题翻译：肽，其制备方法及其用途
公开(公告)号：US4476050A
公开(公告)日：1984-10-09
申请号：US341057
申请日：1982-01-20
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Satoshi Yonishi , Hidekazu Takeno , Satoshi Okada , Masashi Hashimoto
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Satoshi Yonishi , Hidekazu Takeno , Satoshi Okada , Masashi Hashimoto
IPC分类号： C07K1/113 , A61K38/00 , A61P31/04 , A61P37/04 , C07K5/02 , C07C103/52
CPC分类号： C07K5/0215 , A61K38/00 , Y02P20/55
摘要： The invention deals with novel peptides useful in the therapeutic treatment of infectious diseases caused by pathogenic microorganisms having the structure: ##STR1## wherein, R.sup.1 is hydrogen or acyl,R.sup.2 is lower alkyl,R.sup.3 is carboxy or protected carboxy,R.sup.4 is hydrogen or lower alkyl,R.sup.5 is hydrogen, alkyl or ar(lower)alkyl,R.sup.6 is carboxy or protected carboxy, andR.sup.7 is hydrogen or an amino protective group,and their pharmaceutically acceptable salts.
摘要翻译：本发明涉及用于治疗由具有以下结构的病原微生物引起的感染性疾病的新型肽：其中R1为氢或酰基，R2为低级烷基，R3为羧基或被保护的羧基，R4为氢或低级烷基，R 5为氢，烷基或芳（低级）烷基，R 6为羧基或被保护的羧基，R 7为氢或氨基保护基，及其药学上可接受的盐。

7. 发明授权

US4512980A Peptide, process for preparation thereof and use thereof 失效
标题翻译：肽，其制备方法及其用途
公开(公告)号：US4512980A
公开(公告)日：1985-04-23
申请号：US402438
申请日：1982-07-28
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
IPC分类号： A61K38/00 , A61P31/04 , A61P37/00 , A61P37/04 , C07C237/22 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/04 , C07K7/02 , C07K9/00 , C07C103/52 , A61K37/02
CPC分类号： C07C243/00 , C07K5/0215 , C07K9/005 , C12R1/465 , A61K38/00
摘要： The invention relates to novel peptides of pharmacological activity, of the formula ##STR1## wherein R.sup.1 is hydrogen or acyl;R.sup.2 is carboxy or protected carboxy or a group of the formula: --COHN--R.sub.a.sup.2 wherein R.sub.a.sup.2 is carboxy (lower) alkyl or protected carboxy (lower) alkyl;R.sup.3 is carboxy, protected carboxy, lower alkyl, hydroxyphenyl, carbamoyl or a group of the formula: ##STR2## wherein R.sub.a.sup.3 is hydrogen, amino, protected amino or acylamino, R.sub.b.sup.3 is carboxy or protected carboxy;R.sup.p is carboxy, protected carboxy, carbamoyl, carboxy (lower) alkyl or protected carboxy (lower) alkyl;l is an integer 0;m is an interger 3; andn is an integer 1, provided that when R.sup.1 is hydrogen or acyl,R.sup.2 is carboxy, protected carboxy or a group of the formula:--CONHR.sub.a.sup.2 wherein R.sub.a.sup.2 is carboxy (lower) alkyl or protected carboxy (lower) alkyl,R.sup.p is carboxy, or protected carboxy,R.sup.3 is carbamoyl, lower alkyl or hydroxyphenyl or a group of the formula: ##STR3## wherein R.sub.a.sup.3 is hydrogen or acylamino and R.sub.b.sup.3 is carboxy or protected carboxy, andwhen R.sup.p is carbamoyl, thenR.sup.1 is acyl.

8. 发明授权

US4504584A Cultures of novel strains of Streptomyces 失效
标题翻译：链霉菌新菌株的培养
公开(公告)号：US4504584A
公开(公告)日：1985-03-12
申请号：US379851
申请日：1982-05-19
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
IPC分类号： A61K38/00 , C07K5/02 , C07K5/06 , C07K5/062 , C07K5/072 , C07K9/00 , C12N1/20 , C12R1/465
CPC分类号： C07C243/00 , C07K5/0215 , C07K5/06026 , C07K5/06104 , C07K9/005 , C12R1/465 , A61K38/00 , Y10S435/886 , Y10S930/19
摘要： The invention relates to a biologically pure culture of new strains of the microorganism Streptomyces which are capable upon fermentation of producing a peptide of pharmacological activity.
摘要翻译：本发明涉及生物学纯培养的新型菌株的微生物链霉菌，其能够在发酵时产生药理活性肽。

9. 发明授权

US4354966A Peptides, process for preparation thereof and use thereof 失效
标题翻译：肽，其制备方法和用途
公开(公告)号：US4354966A
公开(公告)日：1982-10-19
申请号：US193453
申请日：1980-10-03
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
IPC分类号： A61K38/00 , C07K5/02 , C07K9/00 , C07C103/52
CPC分类号： C07C243/00 , C07K5/0215 , C07K9/005 , C12R1/465 , A61K38/00
摘要： The invention relates to novel peptides and their pharmaceutically acceptable salts, particularly useful for pharmaceutical purposes such as in the therapeutic treatment of infectious diseases caused by pathogenic microorganisms. The compounds have the structure ##STR1## wherein R.sup.1 is hydrogen or acyl;R.sup.2 is carboxy or protected carboxy or a group of the formula: --COHN--R.sub.a.sup.2 wherein R.sub.a.sup.2 is carboxy (lower) alkyl or protected carboxy (lower) alkyl;R.sup.3 is carboxy, protected carboxy, lower alkyl, hydroxyphenyl, carbamoyl or a group of the formula: ##STR2## wherein R.sub.a.sup.3 is hydrogen, amino, protected amino or acylamino, R.sub.b.sup.3 is carboxy or protected carboxy;R.sup.p is carboxy, protected carboxy, carbamoyl, carboxy (lower) alkyl or protected carboxy (lower) alkyl;l is an integer 2,m is an integer 0 to 2 andn is an integer 1,provided that,whenR.sup.1 is hydrogen or acyl,R.sup.2 is carboxy, protected carboxy or a group of the formula: --CONHR.sub.a.sup.2 wherein R.sub.a.sup.2 is carboxy (lower) alkyl or protected carboxy (lower) alkyl,R.sup.p is carboxy, or protected carboxy, m is an integer 2, thenR.sup.3 is carbamoyl, lower alkyl or hydroxyphenyl or a group of the formula: ##STR3## wherein R.sub.a.sup.3 is hydrogen or acylamino and R.sub.b.sup.3 is carboxy or protected caboxy, andwhenR.sup.p is carbamoyl, thenR.sup.1 is acyl.
摘要翻译：本发明涉及新型肽及其药学上可接受的盐，特别可用于药物目的，例如由病原微生物引起的感染性疾病的治疗性治疗。这些化合物具有结构，其中R 1是氢或酰基; R2是羧基或保护的羧基或下式基团-COHN-Ra2，其中Ra2是羧基（低级）烷基或被保护的羧基（低级）烷基; R 3是羧基，保护的羧基，低级烷基，羟基苯基，氨基甲酰基或下式的基团：其中R 3a是氢，氨基，被保护的氨基或酰氨基，R 3b是羧基或被保护的羧基; Rp是羧基，保护的羧基，氨基甲酰基，羧基（低级）烷基或被保护的羧基（低级）烷基; l为整数2，m为整数0〜2，n为整数1，条件是当R 1为氢或酰基时，R 2为羧基，被保护的羧基或式-CONHRa 2基团，其中Ra 2为羧基（低级）烷基或受保护的羧基（低级）烷基，Rp是羧基或受保护的羧基，m是整数2，则R3是氨基甲酰基，低级烷基或羟基苯基或下式的基团：其中R 3a是氢或酰基氨基并且R 3b是羧基或被保护的环氧基，当Rp是氨基甲酰基时，则R1是酰基。

10. 发明授权

US4487763A Peptide, process for preparation thereof and use thereof 失效
标题翻译：肽，其制备方法及其用途
公开(公告)号：US4487763A
公开(公告)日：1984-12-11
申请号：US402440
申请日：1982-07-28
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
IPC分类号： A61K38/00 , A61P31/04 , A61P37/00 , A61P37/04 , C07C237/22 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/04 , C07K7/02 , C07K9/00 , C07C103/52 , A61K37/02
CPC分类号： C07C243/00 , C07K5/0215 , C07K9/005 , C12R1/465 , A61K38/00
摘要： The invention relates to novel peptides and their pharmaceutically acceptable salts, particularly useful for pharmaceutical purposes such as in the therapeutic treatment of infectious diseases caused by pathogenic microorganisms. The compounds have the structure ##STR1## wherein R.sup.1 is hydrogen or acyl;R.sup.2 is carboxy or protected carboxy or a group of the formula: --COHN--R.sub.a.sup.2 wherein R.sub.a.sup.2 is carboxy (lower) alkyl or protected carboxy (lower) alkyl;R.sup.3 is carboxy, protected carboxy, lower alkyl, hydroxyphenyl, carbamoyl or a group of the formula: ##STR2## wherein R.sub.a.sup.3 is hydrogen, amino, protected amino or acylamino, R.sub.b.sup.3 is carboxy or protected carboxy,R.sup. is carboxy, protected carboxy, carbamoyl, carboxy (lower) alkyl or protected carboxy (lower) alkyl;l is an integer 2,m is an integer 0 to 2 andn is an integer 1, provided that, whenR.sup.1 is hydrogen or acyl,R.sup.2 is carboxy, protected carboxy or a group of the formula: --CONHR.sub.a.sup.2 wherein R.sub.a.sup.2 is carboxy (lower) alkyl or protected carboxy (lower) alkyl,R.sup.P is carboxy, or protected carboxy, m is an integer 2, thenR.sup.3 is carbamoyl, lower alkyl or hydroxyphenyl or a group of the formula: ##STR3## wherein R.sub.a.sup.3 is hydrogen or acylamino and R.sub.b.sup.3 is carboxy or protected carboxy, and whenR.sup.P is carbamoyl, thenR.sup.1 is acyl.

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