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1. 发明申请

US20060011602A1 Ceramic heater, glow plug, and ceramic heater manufacturing method 有权
标题翻译：陶瓷加热器，电热塞和陶瓷加热器制造方法
公开(公告)号：US20060011602A1
公开(公告)日：2006-01-19
申请号：US11168534
申请日：2005-06-29
申请人： Masahiro Konishi , Haruhiko Sato , Tetsuya Suzuki , Takahiro Matsui
发明人： Masahiro Konishi , Haruhiko Sato , Tetsuya Suzuki , Takahiro Matsui
IPC分类号： F23Q7/22
CPC分类号： F23Q7/00 , F23Q7/001 , F23Q2007/004 , H05B3/141 , H05B2203/027
摘要： A ceramic heater which includes: a cylindrical substrate including an insulator; a resistor provided in one end side of the substrate; a pair of lead parts provided in the substrate, connected to the resistor and extending to an opposite end side of the substrate; and a pair of electrode parts exposed to a surface at an opposite end side of the substrate and connected respectively to the lead parts. Both lead parts are made of the same material as both electrode parts. An axial cross-sectional area of the electrode part is equal to or larger than a cross-sectional area of the lead part in a direction perpendicular to an axis of the ceramic heater.
摘要翻译：一种陶瓷加热器，包括：包括绝缘体的圆柱形基板; 设置在所述基板的一端侧的电阻器; 一对引线部分，设置在所述基板中，连接到所述电阻器并延伸到所述基板的相对端侧; 以及一对电极部件，其暴露于基板的相对端侧的表面并分别连接到引线部分。两个引线部分由与两个电极部分相同的材料制成。电极部分的轴向截面积等于或大于引线部件在垂直于陶瓷加热器的轴线的方向上的横截面面积。

2. 发明授权

US07223942B2 Ceramic heater, glow plug, and ceramic heater manufacturing method 有权
标题翻译：陶瓷加热器，电热塞和陶瓷加热器制造方法
公开(公告)号：US07223942B2
公开(公告)日：2007-05-29
申请号：US11168534
申请日：2005-06-29
申请人： Masahiro Konishi , Haruhiko Sato , Tetsuya Suzuki , Takahiro Matsui
发明人： Masahiro Konishi , Haruhiko Sato , Tetsuya Suzuki , Takahiro Matsui
IPC分类号： F23Q7/22 , F02N17/00
CPC分类号： F23Q7/00 , F23Q7/001 , F23Q2007/004 , H05B3/141 , H05B2203/027
摘要： A ceramic heater which includes: a cylindrical substrate including an insulator; a resistor provided in one end side of the substrate; a pair of lead parts provided in the substrate, connected to the resistor and extending to an opposite end side of the substrate; and a pair of electrode parts exposed to a surface at an opposite end side of the substrate and connected respectively to the lead parts. Both lead parts are made of the same material as both electrode parts. An axial cross-sectional area of the electrode part is equal to or larger than a cross-sectional area of the lead part in a direction perpendicular to an axis of the ceramic heater.
摘要翻译：一种陶瓷加热器，包括：包括绝缘体的圆柱形基板; 设置在所述基板的一端侧的电阻器; 一对引线部分，设置在所述基板中，连接到所述电阻器并延伸到所述基板的相对端侧; 以及一对电极部件，其暴露于基板的相对端侧的表面并分别连接到引线部分。两个引线部分由与两个电极部分相同的材料制成。电极部分的轴向截面积等于或大于引线部分在垂直于陶瓷加热器的轴线的方向上的横截面面积。

3. 发明申请

US20090275623A1 ALPHA-AMINO ACID DERIVATIVES AND MEDICAMENTS CONTAINING THE SAME AS AN ACTIVE INGREDIENT 有权
标题翻译： ALPHA-氨基酸衍生物和含有其作为活性成分的药物
公开(公告)号：US20090275623A1
公开(公告)日：2009-11-05
申请号：US12306901
申请日：2007-06-29
申请人： Kazuhiko Ohrai , Michiaki Adachi , Koji Toyama , Takanori Shimizu , Keishi Hayashi , Masataka Minami , Yoshiyuki Suzuki , Masakazu Sugiyama , Masateru Ohta , Shojiro Kadono , Takuya Shiraishi , Haruhiko Sato , Yoshiaki Watanabe , Nobuya Ishii , Masahiro Sakaitani , Masami Hasegawa
发明人： Kazuhiko Ohrai , Michiaki Adachi , Koji Toyama , Takanori Shimizu , Keishi Hayashi , Masataka Minami , Yoshiyuki Suzuki , Masakazu Sugiyama , Masateru Ohta , Shojiro Kadono , Takuya Shiraishi , Haruhiko Sato , Yoshiaki Watanabe , Nobuya Ishii , Masahiro Sakaitani , Masami Hasegawa
IPC分类号： A61K31/429 , C07D513/04 , A61P9/04 , A61P35/00
CPC分类号： C07D513/04
摘要： The present invention provides novel α-amino acid derivatives of formula (1): (wherein, R1, R2, R3, R4, X and Y are as defined in the claims) or pharmaceutically acceptable salts, prodrugs or solvates thereof. The derivatives of formula (1) have βARK1 inhibitory activity and are useful for preventing or treating heart failure. Moreover, the derivatives of formula (1) also have antitumor activity, particularly dual inhibitory activity on Aurora kinase and CDK, and are useful for cell proliferative diseases such as cancer.
摘要翻译：本发明提供新的式（1）的α-氨基酸衍生物：（其中，R 1，R 2，R 3，R 4，X和Y如权利要求中所定义）或其药学上可接受的盐，前药或溶剂合物。式（1）的衍生物具有βARK1抑制活性，可用于预防或治疗心力衰竭。此外，式（1）的衍生物还具有抗肿瘤活性，特别是对Aurora激酶和CDK的双重抑制活性，并且可用于细胞增殖性疾病如癌症。

4. 发明申请

US20090093414A1 Hyaluronic Acid-Methotrexate Conjugate 有权
标题翻译：透明质酸 - 甲氨蝶呤结合物
公开(公告)号：US20090093414A1
公开(公告)日：2009-04-09
申请号：US11547158
申请日：2005-04-01
申请人： Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Noriyuki Izutani , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi , Tatsuya Kato , Akie Honma
发明人： Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Noriyuki Izutani , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi , Tatsuya Kato , Akie Honma
IPC分类号： A61K31/728 , A61K38/03 , C07K2/00 , C07H3/00 , C07D475/00
CPC分类号： C08L5/08 , A61K31/519 , A61K47/61 , A61K47/65 , C07D475/08 , C08B37/0072
摘要： An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.
摘要翻译：本发明的目的是提供可用作关节病的治疗药物的透明质酸 - 甲氨蝶呤缀合物。提供了可用于治疗关节疾病的透明质酸 - 甲氨蝶呤缀合物，其中甲氨蝶呤通过含有1至8个氨基酸的肽链的接头与透明质酸的羟基缀合，并且接头与透明质酸通过氨基甲酸酯基团。

5. 发明授权

US06653601B2 Ceramic heater, glow plug using the same, and method for manufacturing the same 有权
公开(公告)号：US06653601B2
公开(公告)日：2003-11-25
申请号：US10135770
申请日：2002-05-01
申请人： Masato Taniguchi , Nobuyuki Hotta , Haruhiko Sato
发明人： Masato Taniguchi , Nobuyuki Hotta , Haruhiko Sato
IPC分类号： F23Q700
CPC分类号： F23Q7/001 , F23Q2007/004 , H05B3/141 , H05B3/48 , H05B2203/027
摘要： A ceramic heater 1 is configured such that a ceramic resistor 10 includes a first resistor portion 11, which is disposed at a front end portion of a heater body 2, and which is formed of a first electrically conductive ceramic, and a pair of second resistor portions 12, which are disposed on the rear side of the first resistor portion 11 so as to extend along the direction of the axis O of the heater body 2. The front end parts of the second resistor portions 12 are joined to corresponding end parts of the first resistor portion 11 as viewed along the direction of electricity supply. The second resistor portions are formed of a second electrically conductive ceramic having an electrical resistivity that is lower than that of the first electrically conductive ceramic. At least a portion of a joint interface 15 between the first resistor portion 11 and each of the second resistor portions 12 deviates from a transverse plane P that perpendicularly intersects the axis O of the heater body 2. The joint interface 15 is formed of planes that perpendicularly intersect a reference plane K including the respective axes J of the second resistor portions 12.

6. 发明授权

US5185229A Dry toner for high speed electrophotography 失效
标题翻译：用于高速电子照相的干粉
公开(公告)号：US5185229A
公开(公告)日：1993-02-09
申请号：US643935
申请日：1991-01-22
申请人： Haruhiko Sato , Katsuaki Kida , Akio Kashihara
发明人： Haruhiko Sato , Katsuaki Kida , Akio Kashihara
IPC分类号： G03G9/08 , G03G9/087
CPC分类号： G03G9/08795 , G03G9/0825 , G03G9/08797
摘要： Dry toner for electrophotography in the form of colored particles, each particle being composed of a colored core portion having an average diameter of 5 to 20.mu. and comprising as main ingredients, a coloring material and heat-meltable resin having a flow initiation temperature of 120.degree. C. to 160.degree. C., and a covering shell portion of a vinyl resin mixture of a comparatively low molecular weight component and a high molecular weight component, each having the maximum value in the molecular weight distribution curve obtained by gel-permeation chromatography of 8.times.10.sup.3 to 3.times.10.sup.4 and 8.times.10.sup.4 to 5.times.10.sup.5, respectively, and present in a ratio of Mw/Mn=5.0 or more; the weight ratio of said vinyl resins to the total weight of said core and shell portions being 8 to 25% by weight. The present dry toner is particularly useful for use in a high speed electrography.
摘要翻译：用于电子照相的干燥调色剂为有色颗粒的形式，每个颗粒由平均直径为5至20μm的着色芯部分组成，并且包含作为主要成分的着色材料和热熔树脂，其流动起始温度为120 ℃至160℃，以及通过凝胶渗透色谱法获得的分子量分布曲线中具有最大值的较低分子量组分和高分子量组分的乙烯基树脂混合物的覆盖壳部分分别为8×10 3〜3×10 4和8×10 4〜5×10 5，以Mw / Mn = 5.0以上的比率存在。所述乙烯基树脂与所述核和壳部分的总重量的重量比为8至25重量％。本发明的干燥调色剂特别适用于高速电摄影。

7. 发明授权

US07803826B2 Imidazolidine derivatives 有权
标题翻译：咪唑烷衍生物
公开(公告)号：US07803826B2
公开(公告)日：2010-09-28
申请号：US11659369
申请日：2005-08-03
申请人： Kazutaka Tachibana , Haruhiko Sato , Masateru Ohta , Mitsuaki Nakamura , Takuya Shiraishi , Ikuhiro Imaoka , Hitoshi Yoshino , Masahiro Nagamuta , Hiromitsu Kawata
发明人： Kazutaka Tachibana , Haruhiko Sato , Masateru Ohta , Mitsuaki Nakamura , Takuya Shiraishi , Ikuhiro Imaoka , Hitoshi Yoshino , Masahiro Nagamuta , Hiromitsu Kawata
IPC分类号： A61K31/4166 , C07D233/40
CPC分类号： C07D233/86 , C07D233/76
摘要： The present invention provides a compound represented by formula (I): wherein n is an integer selected from 1 to 20, Q is A is cyano or the like; B is hydrogen, halogen, or the like; X1 and X2 are each independently selected from O and S; E is a C1-4 alkyl group; and R1, R2, R3 and R4 are each independently selected from a hydrogen atom and a C1-C6 alkyl group, and a drug, a pharmaceutical composition containing the compound, and the like.
摘要翻译：本发明提供由式（I）表示的化合物：其中n是选自1至20的整数，Q是A是氰基等; B是氢，卤素等; X1和X2各自独立地选自O和S; E是C 1-4烷基; R 1，R 2，R 3和R 4各自独立地选自氢原子和C 1 -C 6烷基，以及药物，含有该化合物的药物组合物等。

8. 发明申请

US20070249697A1 Novel Imidazolidine Derivatives 有权
标题翻译：新型咪唑烷衍生物
公开(公告)号：US20070249697A1
公开(公告)日：2007-10-25
申请号：US11659369
申请日：2005-08-03
申请人： Kazutaka Tachibana , Haruhiko Sato , Masateru Ohta , Mitsuaki Nakamura , Takuya Shiraishi , Ikuhiro Imaoka , Hitoshi Yoshino , Masahiro Nagamuta , Hiromitsu Kawata
发明人： Kazutaka Tachibana , Haruhiko Sato , Masateru Ohta , Mitsuaki Nakamura , Takuya Shiraishi , Ikuhiro Imaoka , Hitoshi Yoshino , Masahiro Nagamuta , Hiromitsu Kawata
IPC分类号： A61K31/4164 , A61P5/26 , C07D233/00
CPC分类号： C07D233/86 , C07D233/76
摘要： The present invention provides a compound represented by formula (I): wherein n is an integer selected from 1 to 20, Q is A is cyano or the like; B is hydrogen, halogen, or the like; X1 and X2 are each independently selected from O and S; E is a C1-4 alkyl group; and R1, R2, R3 and R4 are each independently selected from a hydrogen atom and a C1-C6 alkyl group, and a drug, a pharmaceutical composition containing the compound, and the like.
摘要翻译：本发明提供由式（I）表示的化合物：其中n是选自1至20的整数，Q是A是氰基等; B是氢，卤素等; X 1和X 2各自独立地选自O和S; E是C 1-4烷基; 且R 1，R 2，R 3和R 4各自独立地选自氢原子和 C 1 -C 6烷基，以及药物，含有该化合物的药物组合物等。

9. 发明授权

US07001887B2 Peptide derivatives 失效
标题翻译：肽衍生物
公开(公告)号：US07001887B2
公开(公告)日：2006-02-21
申请号：US10470801
申请日：2002-02-04
申请人： Takuya Shiraishi , Shojiro Kadono , Masayuki Haramura , Haruhiko Sato , Toshiro Kozono , Takaki Koga , Akihisa Sakamoto
发明人： Takuya Shiraishi , Shojiro Kadono , Masayuki Haramura , Haruhiko Sato , Toshiro Kozono , Takaki Koga , Akihisa Sakamoto
IPC分类号： C07K5/06 , C07D213/02 , C07D235/04 , C07D239/86 , C07D401/04
CPC分类号： G06F19/16 , A61K38/00 , C07K5/06078 , C07K5/06139 , C07K5/06156 , G01N33/68
摘要： A compound of Formula (1): wherein R1 represents an amidinophenyl group, etc.; R2 represents a hydrogen atom, etc.; R3 represents a carbamoylalkyl group, etc.; R4 represents a hydrogen atom, etc.; R5 represents a benzyl group, etc.; R6 represents a hydrogen atom, etc.; and R7 represents an alkylsulfonyl group, etc. A crystal of a complex between factor VIIa/human soluble tissue factor and a low-molecular weight reversible factor VIIa inhibitor. A medium carrying a part or all of structure coordinate data of a complex between human factor VIIa/human soluble tissue factor and a low-molecular weight reversible factor VIIa inhibitor, obtainable by X-ray crystal structure analysis of the crystal. A method for computationally designing a low-molecular weight reversible factor VIIa inhibitor using the coordinate data.
摘要翻译：式的化合物

10. 发明授权

US5418109A Production of toner 失效
标题翻译：生产墨粉
公开(公告)号：US5418109A
公开(公告)日：1995-05-23
申请号：US233446
申请日：1994-04-26
申请人： Akihiro Kanakura , Yutaka Harada , Takehiro Ojima , Shinji Seo , Haruhiko Sato
发明人： Akihiro Kanakura , Yutaka Harada , Takehiro Ojima , Shinji Seo , Haruhiko Sato
IPC分类号： G03G9/08 , G03G9/087 , G03G9/093 , G03G9/097
CPC分类号： G03G9/0804 , G03G9/0808
摘要： Disclosed is a preparation method of a toner comprising steps of:(a) preparing a dispersion mixture containing colored polymer particles, a charge controlling agent and organic resin fine particles, in an aqueous medium;(b) allowing said charge controlling agent and organic resin fine particles to be adhered on the surface of said colored polymer particles by salting-out;(c) drying said colored polymer particles having thereon said charge controlling agent and organic resin fine particles; and(d) applying mechanical impact to said colored polymer particles to effect a conversion of said organic resin fine particles into a film on the surfaces of said colored polymer particles.
摘要翻译：公开了一种调色剂的制备方法，其包括以下步骤：（a）在含水介质中制备含有着色聚合物颗粒，电荷控制剂和有机树脂细颗粒的分散混合物; （b）使所述电荷控制剂和有机树脂微粒通过盐析粘附在所述着色聚合物颗粒的表面上; （c）干燥其上具有所述电荷控制剂的有色聚合物颗粒和有机树脂细颗粒; 和（d）对所述有色聚合物颗粒施加机械冲击以使所述有机树脂微粒转化成所述着色聚合物颗粒表面上的膜。

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