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1. 发明申请

US20060121022A1 Apc non-neutralizing anti-body 有权
标题翻译： Apc非中和抗体
公开(公告)号：US20060121022A1
公开(公告)日：2006-06-08
申请号：US10522086
申请日：2003-07-17
申请人： Takaki Koga , Tsukasa Suzuki , Hiroyuki Saito
发明人： Takaki Koga , Tsukasa Suzuki , Hiroyuki Saito
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/565 , C07K2317/76
摘要： The present invention provides anti-aPC antibodies that suppress the inactivation of activated protein C (aPC), and uses thereof. The present inventors screened anti-aPC antibodies, and succeeded in isolating anti-aPC antibodies comprising the activity of suppressing aPC inactivation in blood. The antibodies of the present invention can be used to maintain aPC activity by suppressing aPC inactivation, and can thus be used to sustain aPC bioactivities, such as the activity of suppressing activation of the blood coagulation system, and anti-inflammatory activity. In addition, the present invention provides uses of the antibodies of the present invention in aPC therapy for diseases such as thrombosis and sepsis. The therapeutic effect of aPC can be prolonged in treatment that uses aPC administration by allowing an antibody of the present invention to bind with aPC. The antibodies of the present invention can be used in the treatment and prevention of diseases such as thrombosis and sepsis.
摘要翻译：本发明提供抑制活化蛋白C（aPC）失活的抗-APC抗体及其用途。本发明人筛选了抗-APC抗体，并成功地分离了包含抑制血液中的aPC失活活性的抗-APC抗体。本发明的抗体可用于通过抑制aPC灭活来维持PCPC活性，因此可用于维持aPC生物活性，例如抑制血液凝固系统活化的活性和抗炎活性。此外，本发明提供本发明的抗体在aPC治疗中用于血栓形成和败血症等疾病的用途。通过使本发明的抗体与aPC结合，可以延长使用aPC施用的治疗中aPC的治疗效果。本发明的抗体可用于治疗和预防诸如血栓形成和败血症等疾病。

2. 发明授权

US07517965B2 Non-neutralizing anti-aPC antibodies 有权
标题翻译：非中和抗APC抗体
公开(公告)号：US07517965B2
公开(公告)日：2009-04-14
申请号：US10522086
申请日：2003-07-17
申请人： Takaki Koga , Tsukasa Suzuki , Hiroyuki Saito
发明人： Takaki Koga , Tsukasa Suzuki , Hiroyuki Saito
IPC分类号： C07K16/00
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/565 , C07K2317/76
摘要： The present invention provides anti-aPC antibodies that suppress the inactivation of activated protein C (aPC), and uses thereof. The present inventors screened anti-aPC antibodies, and succeeded in isolating anti-aPC antibodies comprising the activity of suppressing aPC inactivation in blood. The antibodies of the present invention can be used to maintain aPC activity by suppressing aPC inactivation, and can thus be used to sustain aPC bioactivities, such as the activity of suppressing activation of the blood coagulation system, and anti-inflammatory activity. In addition, the present invention provides uses of the antibodies of the present invention in aPC therapy for diseases such as thrombosis and sepsis. The therapeutic effect of aPC can be prolonged in treatment that uses aPC administration by allowing an antibody of the present invention to bind with aPC. The antibodies of the present invention can be used in the treatment and prevention of diseases such as thrombosis and sepsis.
摘要翻译：本发明提供抑制活化蛋白C（aPC）失活的抗-APC抗体及其用途。本发明人筛选了抗-APC抗体，并成功地分离了包含抑制血液中的aPC失活活性的抗-APC抗体。本发明的抗体可用于通过抑制aPC灭活来维持PCPC活性，因此可用于维持aPC生物活性，例如抑制血液凝固系统活化的活性和抗炎活性。此外，本发明提供本发明的抗体在aPC治疗中用于血栓形成和败血症等疾病的用途。通过使本发明的抗体与aPC结合，可以延长使用aPC施用的治疗中aPC的治疗效果。本发明的抗体可用于治疗和预防诸如血栓形成和败血症等疾病。

3. 发明申请

US20060167230A1 Anti-pci neutralizing antibody 审中-公开
标题翻译：抗pci中和抗体
公开(公告)号：US20060167230A1
公开(公告)日：2006-07-27
申请号：US10542682
申请日：2004-01-20
申请人： Takaki Koga , Naoki Kimura , Takeshi Yoshino , Koichiro Ono
发明人： Takaki Koga , Naoki Kimura , Takeshi Yoshino , Koichiro Ono
IPC分类号： C07K16/44 , C07K16/40
CPC分类号： C07K16/38 , C07K14/8121 , C07K2317/50 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention provides anti-PCI antibodies having Protein C inhibitor (PCI)-neutralizing activity, and the uses thereof. Through the generation and screening of anti-PCI antibodies, the inventors successfully isolated anti-PCI antibodies which inhibit PCI's inhibitory effect on the production and activity of activated Protein C (aPC). The antibodies of the present invention suppress PCI's inhibitory effect on aPC production and/or the aPC inactivation by PCI, and thus can be used to maintain aPC activity and sustain the effects of aPC physiological activities, such as suppression of the activation of blood coagulation system and anti-inflammatory functions. The present invention also provides uses of the antibodies of the present invention in treating diseases such as thrombosis and sepsis using aPC. In treatments by aPC administration, the therapeutic effect of aPC can be sustained by administering an antibody of the present invention. The antibodies of the present invention can be used in the treatment and prevention of diseases such as thrombosis and sepsis.
摘要翻译：本发明提供具有蛋白C抑制剂（PCI） - 中和活性的抗PCI抗体及其用途。通过抗PCI抗体的产生和筛选，本发明人成功地分离了抗PCI抗体，其抑制PCI对活化蛋白C（aPC）的产生和活性的抑制作用。本发明的抗体抑制PCI对aPC生成的抑制作用和/或PCI的aPC失活，因此可用于维持aPC活性并维持aPC生理活性的作用，例如抑制血液凝固系统的活化和抗炎功能。本发明还提供了本发明的抗体在使用aPC治疗诸如血栓形成和败血症的疾病中的用途。在通过aPC施用的治疗中，通过施用本发明的抗体可以维持aPC的治疗效果。本发明的抗体可用于治疗和预防诸如血栓形成和败血症等疾病。

4. 发明授权

US06395953B1 Process for preparing purified conjugated diene 有权
标题翻译：制备纯化的共轭二烯的方法
公开(公告)号：US06395953B1
公开(公告)日：2002-05-28
申请号：US09380003
申请日：1999-08-24
申请人： Takaki Koga , Nobumasa Shimomura , Masanobu Kanauchi
发明人： Takaki Koga , Nobumasa Shimomura , Masanobu Kanauchi
IPC分类号： C10G2128
CPC分类号： C10G7/08
摘要： Processes for producing a purified conjugated diene comprise feeding a petroleum fraction containing the conjugated diene to an extractive distillation column, feeding an extraction solvent to the extractive distillation column, and extractive-distilling the conjugated diene from the petroleum fraction containing the conjugated diene in the extractive distillation column. The extraction solvent comprises an amide compound, and a heterocyclic aldehyde, aromatic nitro compound or aromatic aldehyde is contained in the extraction solvent within a range of 0.01 to 10 wt. % based on the weight of the extractive solvent. An oxygen concentration in a gas phase of a distillate discharged from the top of the extraction distillation column is controlled to 10 ppm or lower. The processes further comprise recovering the extraction solvent, purifying the recovered extraction solvent to adjust the content of water in the recovered extraction solvent to within a range of 50 to 500 ppm based on the weight of the extraction solvent, and recovering the isolated conjugated diene. The extraction solvent fed to the extractive distillation column is the purified recovered extraction solvent.
摘要翻译：用于生产纯化的共轭二烯的方法包括将含有共轭二烯的石油馏分进料到萃取蒸馏塔中，将萃取溶剂进料到萃取蒸馏塔中，并从提取物中含有共轭二烯的石油馏分萃取 - 蒸馏共轭二烯蒸馏塔。提取溶剂含有酰胺化合物，提取溶剂中含有杂环醛，芳香族硝基化合物或芳香醛，为0.01〜10重量％。基于萃取溶剂的重量％。将从提取蒸馏塔顶部排出的馏出物的气相中的氧浓度控制在10ppm以下。所述方法还包括回收提取溶剂，纯化回收的萃取溶剂以将回收的萃取溶剂中的水含量调节至基于萃取溶剂重量的50至500ppm的范围内，并回收分离的共轭二烯。进料到萃取蒸馏塔的萃取溶剂是纯化的回收提取溶剂。

5. 发明授权

US07001887B2 Peptide derivatives 失效
标题翻译：肽衍生物
公开(公告)号：US07001887B2
公开(公告)日：2006-02-21
申请号：US10470801
申请日：2002-02-04
申请人： Takuya Shiraishi , Shojiro Kadono , Masayuki Haramura , Haruhiko Sato , Toshiro Kozono , Takaki Koga , Akihisa Sakamoto
发明人： Takuya Shiraishi , Shojiro Kadono , Masayuki Haramura , Haruhiko Sato , Toshiro Kozono , Takaki Koga , Akihisa Sakamoto
IPC分类号： C07K5/06 , C07D213/02 , C07D235/04 , C07D239/86 , C07D401/04
CPC分类号： G06F19/16 , A61K38/00 , C07K5/06078 , C07K5/06139 , C07K5/06156 , G01N33/68
摘要： A compound of Formula (1): wherein R1 represents an amidinophenyl group, etc.; R2 represents a hydrogen atom, etc.; R3 represents a carbamoylalkyl group, etc.; R4 represents a hydrogen atom, etc.; R5 represents a benzyl group, etc.; R6 represents a hydrogen atom, etc.; and R7 represents an alkylsulfonyl group, etc. A crystal of a complex between factor VIIa/human soluble tissue factor and a low-molecular weight reversible factor VIIa inhibitor. A medium carrying a part or all of structure coordinate data of a complex between human factor VIIa/human soluble tissue factor and a low-molecular weight reversible factor VIIa inhibitor, obtainable by X-ray crystal structure analysis of the crystal. A method for computationally designing a low-molecular weight reversible factor VIIa inhibitor using the coordinate data.
摘要翻译：式的化合物

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