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1. 发明申请

US20090093414A1 Hyaluronic Acid-Methotrexate Conjugate 有权
标题翻译：透明质酸 - 甲氨蝶呤结合物
公开(公告)号：US20090093414A1
公开(公告)日：2009-04-09
申请号：US11547158
申请日：2005-04-01
申请人： Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Noriyuki Izutani , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi , Tatsuya Kato , Akie Honma
发明人： Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Noriyuki Izutani , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi , Tatsuya Kato , Akie Honma
IPC分类号： A61K31/728 , A61K38/03 , C07K2/00 , C07H3/00 , C07D475/00
CPC分类号： C08L5/08 , A61K31/519 , A61K47/61 , A61K47/65 , C07D475/08 , C08B37/0072
摘要： An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.
摘要翻译：本发明的目的是提供可用作关节病的治疗药物的透明质酸 - 甲氨蝶呤缀合物。提供了可用于治疗关节疾病的透明质酸 - 甲氨蝶呤缀合物，其中甲氨蝶呤通过含有1至8个氨基酸的肽链的接头与透明质酸的羟基缀合，并且接头与透明质酸通过氨基甲酸酯基团。

2. 发明授权

US07807675B2 Hyaluronic acid-methotrexate conjugate 有权
标题翻译：透明质酸 - 甲氨蝶呤结合物
公开(公告)号：US07807675B2
公开(公告)日：2010-10-05
申请号：US11547158
申请日：2005-04-01
申请人： Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Noriyuki Izutani , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi , Tatsuya Kato , Akie Honma
发明人： Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Noriyuki Izutani , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi , Tatsuya Kato , Akie Honma
IPC分类号： C07D475/00 , A61K31/715
CPC分类号： C08L5/08 , A61K31/519 , A61K47/61 , A61K47/65 , C07D475/08 , C08B37/0072
摘要： An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.
摘要翻译：本发明的目的是提供一种可用作关节病的治疗药物的透明质酸 - 甲氨蝶呤缀合物。提供了可用于治疗关节疾病的透明质酸 - 甲氨蝶呤缀合物，其中甲氨蝶呤通过含有1至8个氨基酸的肽链的接头与透明质酸的羟基缀合，并且接头与透明质酸通过氨基甲酸酯基团。

3. 发明授权

US08088916B2 Hyaluronic acid-methotrexate conjugate 有权
标题翻译：透明质酸 - 甲氨蝶呤结合物
公开(公告)号：US08088916B2
公开(公告)日：2012-01-03
申请号：US10591653
申请日：2005-03-04
申请人： Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi
发明人： Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi
IPC分类号： C08B37/00 , A01N43/04 , A01N43/60
CPC分类号： C08B37/0072 , A61K47/61 , A61K47/65 , C07D475/08 , C07K9/003
摘要： An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases.There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.
摘要翻译：本发明的目的是提供可用作关节疾病的治疗药物的透明质酸 - 甲氨蝶呤缀合物。提供了可用作关节疾病的治疗药物的透明质酸 - 甲氨蝶呤缀合物，其中甲氨蝶呤通过含有1至8个氨基酸的肽链的接头与透明质酸的羧基缀合。

4. 发明申请

US20070197465A1 Hyaluronic Acid-Methotrexate Conjugate 有权
标题翻译：透明质酸 - 甲氨蝶呤结合物
公开(公告)号：US20070197465A1
公开(公告)日：2007-08-23
申请号：US10591653
申请日：2005-03-04
申请人： Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi
发明人： Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi
IPC分类号： A61K31/728 , C08B37/00 , A61K31/525
CPC分类号： C08B37/0072 , A61K47/61 , A61K47/65 , C07D475/08 , C07K9/003
摘要： An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.
摘要翻译：本发明的目的是提供可用作关节疾病的治疗药物的透明质酸 - 甲氨蝶呤缀合物。提供了可用作关节疾病的治疗药物的透明质酸 - 甲氨蝶呤缀合物，其中甲氨蝶呤通过含有1至8个氨基酸的肽链的接头与透明质酸的羧基缀合。

5. 发明授权

US09433542B2 Absorbent article and production method thereof 有权
标题翻译：吸收性物品及其制造方法
公开(公告)号：US09433542B2
公开(公告)日：2016-09-06
申请号：US14002762
申请日：2012-02-27
申请人： Nobuyuki Kato , Tatsuya Tamura , Toshihisa Hayashi , Masashi Kitagawa
发明人： Nobuyuki Kato , Tatsuya Tamura , Toshihisa Hayashi , Masashi Kitagawa
IPC分类号： A61F13/475 , A61F13/533 , A61F13/537 , A61F13/15 , A61F13/535 , A61F13/539 , A61F13/47
CPC分类号： A61F13/537 , A61F13/15617 , A61F13/15731 , A61F13/4704 , A61F13/4756 , A61F13/535 , A61F13/539 , Y10T156/1041
摘要： The absorbent article of the present invention comprises: a liquid-pervious surface sheet, a liquid-impervious backside sheet provided at the position opposing said surface sheet, and an absorption body provided between said surface sheet and said backside sheet, wherein the absorbent article comprises an endless compressed groove, surrounding a central part of said absorbent article, which is formed in said surface sheet and said absorption body in the thickness direction, and a plurality of concave parts, provided inside and outside said compressed groove, which are formed in said surface sheet and said absorption body in the thickness direction, and an uncompressed region bordering inner and outer edges of the compressed groove, wherein the closest distance between said compressed groove and the nearest concave parts is greater than the distance between adjacent ones of those same concave parts.
摘要翻译：本发明的吸收性物品包括：透液性表面片，设置在与所述表面片相对的位置处的不透液性背面片，以及设置在所述表面片和所述背面片之间的吸收体，其中，所述吸收性物品包含围绕形成在所述表面片和所述吸收体的厚度方向的所述吸收性物品的中心部分的无端压缩槽，以及设置在所述压缩槽的内部和外部的多个凹部，表面片和所述吸收体在厚度方向上，以及与所述压缩槽的内边缘和外边缘接合的未压缩区域，其中所述压缩槽和最近的凹入部分之间的最近距离大于相邻的相同凹部部分。

6. 发明申请

US20130317470A1 ABSORBENT ARTICLE PACKAGE AND METHOD OF FOLDING THE SAME 有权
标题翻译：吸收性物品包装及其折叠方法
公开(公告)号：US20130317470A1
公开(公告)日：2013-11-28
申请号：US13976233
申请日：2011-12-27
申请人： Nobuyuki Kato , Masahiro Kashiwagi , Tatsuya Tamura , Masashi Kitagawa
发明人： Nobuyuki Kato , Masahiro Kashiwagi , Tatsuya Tamura , Masashi Kitagawa
IPC分类号： A61F13/551 , A61F13/15
CPC分类号： A61F13/5514 , A61F13/15577 , A61F13/15747
摘要： An absorbent article package is individually packaged by folding a packaging sheet and an absorbent article in a state where the absorbent article is arranged on the packaging sheet. In a state where the individually-packaged absorbent article is opened, in the packaging sheet and the absorbent article, a first folding line based on which the absorbent article and the packaging sheet are folded towards the topsheet side, and a second folding line based on which the absorbent article and the packaging sheet are folded towards the backsheet side are formed adjacent to each other in the longitudinal direction.
摘要翻译：通过在吸收性物品配置在包装片上的状态下折叠包装片和吸收性物品，分别包装吸收性物品包装。在打开单独包装的吸收性物品的状态下，在包装用片材和吸收性物品中，将吸收性物品和包装用片材朝向顶片侧折叠的第一折叠线和基于所述吸收性物品和所述包装用薄片朝向所述背面侧折叠而形成为在长度方向上彼此相邻地形成。

7. 发明申请

US20110100489A1 SUBSTRATE PROCESS APPARATUS, SUBSTRATE PROCESS METHOD, AND COMPUTER READABLE STORAGE MEDIUM 有权
标题翻译：基板工艺设备，基板工艺方法和计算机可读存储介质
公开(公告)号：US20110100489A1
公开(公告)日：2011-05-05
申请号：US12916667
申请日：2010-11-01
申请人： Kohichi Orito , Manabu Honma , Tatsuya Tamura
发明人： Kohichi Orito , Manabu Honma , Tatsuya Tamura
IPC分类号： F17D1/00
CPC分类号： H01L21/67253 , C23C16/45502 , C23C16/45551 , C23C16/45557 , C23C16/45587 , H01L21/68764 , H01L21/68771 , Y10T137/8376
摘要： A vacuum chamber is evacuated through a first evacuation passage provided with a first valve and a second evacuation passage provided with a second valve. An opening degree of the first valve is adjusted so that a pressure in the vacuum chamber becomes substantially equal to a process pressure P; an opening degree of a butterfly valve further provided in the second evacuation passage is adjusted to substantially equal to a set value determined by a table in order to set flow rates of gases to be evacuated through the first evacuation passage and the second evacuation passage to be substantially equal to corresponding set values determined by the recipe; and an opening degree of the second valve is adjusted so that a measurement value of a differential pressure gauge further provided in the second evacuation passage becomes substantially equal to a differential pressure written in the table.
摘要翻译：通过设置有第一阀的第一抽空通道和设置有第二阀的第二抽空通道抽真空室。调节第一阀的开度，使得真空室中的压力基本上等于处理压力P; 进一步设置在第二排气通道中的蝶阀的开度被调整为基本上等于由工作台确定的设定值，以便将通过第一抽空通道和第二抽空通道排出的气体的流量设定为基本上等于由配方确定的相应设定值; 并且调节第二阀的开度，使得进一步设置在第二排气通道中的差压计的测量值变得基本上等于写在工作台中的压差。

8. 发明授权

US07727456B2 Method of manufacturing composite molded article and manufacturing apparatus of composite molded article 有权
标题翻译：复合成形品的制造方法和复合成形品的制造装置
公开(公告)号：US07727456B2
公开(公告)日：2010-06-01
申请号：US11498178
申请日：2006-08-03
申请人： Katsuyuki Amano , Naoko Amano, legal representative , Akihiro Suzuki , Yukiko Tsuya , Tatsuya Tamura
发明人： Katsuyuki Amano , Akihiro Suzuki , Yukiko Tsuya , Tatsuya Tamura
IPC分类号： B29D22/00 , B28B5/00 , B29C45/14 , B29C45/22 , B29C45/18
CPC分类号： B29C45/14344 , B29C45/14836 , B29C45/1676 , B29C45/1704 , B29C2045/0027 , B29C2045/14459 , B29L2031/26 , B29L2031/302 , B60J10/16 , B60J10/265 , B60J10/70
摘要： A method of manufacturing a composite molded member, which includes the steps of: setting the main body inside an injection mold; closing the injection mold to fix the main body inside the injection mold; and forming the cushion members on the edges of the main body through heat and pressure of the injected elastic polymer material. The elastic polymer material is injected from an injection gate into one of the first and second edges at the back surface side of the main body of the molding cavities to flow the elastic polymer material into one of the molding cavities. The elastic polymer material flows into the other of the molding cavities through the connecting flow path, and fills the molding cavities with the elastic polymer material.
摘要翻译：一种制造复合模制构件的方法，包括以下步骤：将主体设置在注射模具内; 关闭注射模具将主体固定在注射模具内; 以及通过所注射的弹性聚合物材料的热和压力在所述主体的边缘上形成所述缓冲构件。将弹性聚合物材料从注射浇口注入到模腔主体的后表面侧的第一和第二边缘之一中，以将弹性聚合物材料流入其中一个模腔。弹性聚合物材料通过连接流路流入另一个模腔，并用弹性聚合物材料填充模腔。

9. 发明申请

US20090166366A1 Container having handling hole for transportation and opening and closing member for handling hole and manufacturing method for the same 审中-公开
标题翻译：具有用于运输的处理孔和用于处理孔的打开和关闭构件的容器及其制造方法
公开(公告)号：US20090166366A1
公开(公告)日：2009-07-02
申请号：US12318328
申请日：2008-12-24
申请人： Shinji Kaneko , Tatsuya Tamura , Ryozo Kuwata
发明人： Shinji Kaneko , Tatsuya Tamura , Ryozo Kuwata
IPC分类号： B65D90/02 , B31B1/14
CPC分类号： B65D25/30 , B29C48/0022 , B29C48/06 , B29C48/13 , B29L2031/7126
摘要： A main body of an opening and closing member is arranged so as to cover a handling hole from one side of a wall, such as a container wall. The opening and closing member is mounted to the container by engaging an engagement portion with a flange formed at the periphery of the handling hole. When a user inserts a hand into the handling hole and pushes the main body, the main body moves away from the wall, and the handling hole is uncovered. By so doing, the user can insert his or her hand into the handling hole and carry the container or other object. Then, when the user removes his or her hand from the handling hole, the main body moves toward the wall, and an outer periphery of the main body contacts the wall at the periphery of the handling hole and returns to the original position. Thus, the handling hole is covered from one side of the wall. By so doing, dirt, water and/or the like can be suppressed from passing through the handling hole. Thus, the container or other object can easily be carried by using the handling hole, and dirt, water and/or the like can be suppressed from passing through the handling hole without requiring a special operation or task.
摘要翻译：打开和关闭构件的主体被布置成从诸如容器壁的壁的一侧覆盖操作孔。通过将接合部与形成在操作孔的周边处的凸缘接合而将开闭部件安装到容器。当用户将手插入处理孔并推动主体时，主体远离壁移动，并且操作孔未被覆盖。通过这样做，用户可以将他或她的手插入处理孔并携带容器或其他物体。然后，当使用者将他或她的手从处理孔中取出时，主体朝向壁移动，并且主体的外周与操作孔的周边处的壁接触并返回原来的位置。因此，处理孔从壁的一侧被覆盖。通过这样做，可以抑制污物，水和/或类似物通过处理孔。因此，容器或其他物体可以容易地通过使用处理孔来承载，并且可以防止污垢，水和/或类似物通过操作孔而不需要特别的操作或任务。

10. 发明申请

US20090133335A1 BELT MOLDING FOR VEHICLES 有权
标题翻译：用于车辆的皮带模制
公开(公告)号：US20090133335A1
公开(公告)日：2009-05-28
申请号：US12276008
申请日：2008-11-21
申请人： Tatsuya Tamura
发明人： Tatsuya Tamura
IPC分类号： E06B7/16
CPC分类号： B60J10/75 , B60J10/18 , B60J10/30
摘要： A vehicle belt molding includes an attaching member and a seal lip. An elastic repulsive member is disposed between the engage wall portion and the seal lip and integrally provided with a fixed piece portion, a shifting piece portion, and a connecting piece portion. The seal lip is always urged toward the window pane by an elastic restoring force of the connecting piece portion itself or by a cooperative function of the elastic restoring force and an elastic restoring force of the elastic polymer material. When the attaching member is mounted to the mounting member, the seal lip causes the contacting portion to be elastically restored by the elastic restoring force toward a thickness direction of the window pane at a speed exceeding a restoring speed obtained only by the elastic polymer material.
摘要翻译：车辆用带束成型体包括安装构件和密封唇。弹性排斥构件设置在接合壁部分和密封唇之间，并且一体地设置有固定片部分，移动片部分和连接片部分。密封唇总是通过连接片部分本身的弹性恢复力或弹性恢复力的协同作用和弹性聚合物材料的弹性恢复力一直被推向窗玻璃。当安装构件安装到安装构件上时，密封唇使得接触部分以超过仅由弹性聚合物材料获得的恢复速度的速度通过弹性恢复力朝向窗玻璃的厚度方向弹性恢复。

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