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1. 发明授权

US5360896A Glycosylated FGF 失效
标题翻译：糖基化FGF
公开(公告)号：US5360896A
公开(公告)日：1994-11-01
申请号：US7089
申请日：1993-01-19
申请人： Masaharu Senoo , Reiko Sasada , Koichi Igarashi
发明人： Masaharu Senoo , Reiko Sasada , Koichi Igarashi
IPC分类号： G06F1/28 , A61K38/00 , C07K14/50 , C07K13/00
CPC分类号： C07K14/50 , A61K38/00 , C07K2319/036 , C07K2319/75
摘要： Disclosed are (1) a mutein of a fibroblast growth factor (FGF), the DNA having introduced therein at least one nucleotide sequence coding for a glycosylation site, (2) a DNA coding for the mutein of (1), (3) a vector containing the DNA of (2), (4) a transformant transformed with the vector of (3), and (5) a process for producing the mutein which comprises cultivating in a culture medium the transformant of a yeast or animal cell transformed with a vector of (3), and producing and accumulating the mutein of (1) in the culture medium, whereby the FGF mutein into which at least one glycosylation site has been introduced is improved in productivity, stability and activities, and advantageously used as medicine.
摘要翻译：公开了（1）成纤维细胞生长因子（FGF）的突变蛋白，其中引入了至少一个编码糖基化位点的核苷酸序列的DNA，（2）编码（1），（3）的突变蛋白的DNA 含有（2）的DNA的载体，（4）用（3）的载体转化的转化体，和（5）一种产生突变蛋白的方法，其包括在培养基中培养转化了酵母或动物细胞的转化体（3）的载体，并且在培养基中产生和积累（1）的突变蛋白，从而提高了其中引入至少一个糖基化位点的FGF突变蛋白的生产力，稳定性和活性，并且有利地用作药物。

2. 发明授权

US5852177A Basic fibroblast growth factor (bFGF) muteins 失效
标题翻译：碱性成纤维细胞生长因子（bFGF）突变蛋白
公开(公告)号：US5852177A
公开(公告)日：1998-12-22
申请号：US301460
申请日：1989-01-24
申请人： Masaharu Senoo , Reiko Sasada , Tsutomu Kurokawa , Koichi Igarashi
发明人： Masaharu Senoo , Reiko Sasada , Tsutomu Kurokawa , Koichi Igarashi
IPC分类号： A61K38/00 , C07K14/50 , C07K14/55 , C07K16/22
CPC分类号： C07K16/22 , C07K14/503 , C07K14/55 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/75
摘要： A mutein of basic fibroblast growth factors (bFGF) possesses fibroblast growth promoting activity, growth stimulating activity of capillary endothelial cells and angiogenic activity, has high stability and is low toxicity. And therefore, the present mutein is advantageously used as a healing accelerator for burns etc., a therapeutic drug for thrombosis etc., and a cell cultivation promoter.
摘要翻译：碱性成纤维细胞生长因子（bFGF）的突变蛋白具有成纤维细胞生长促进活性，毛细血管内皮细胞生长刺激活性和血管生成活性，稳定性高，毒性低。因此，本发明的突变蛋白有利地用作燃烧等的愈合促进剂，血栓形成治疗药等，以及细胞培养促进剂。

3. 发明授权

US5464943A DNA encoding glycosylated FGF and production thereof 失效
标题翻译：编码糖基化FGF的DNA及其生产
公开(公告)号：US5464943A
公开(公告)日：1995-11-07
申请号：US275635
申请日：1994-07-15
申请人： Masaharu Senoo , Reiko Sasada , Koichi Igarashi
发明人： Masaharu Senoo , Reiko Sasada , Koichi Igarashi
IPC分类号： A61K38/00 , C07K14/50 , C12N15/62 , C07H21/00 , C12N15/18 , C12N15/63
CPC分类号： C07K14/503 , C07K14/50 , C12N15/625 , A61K38/00 , C07K2319/036 , C07K2319/75 , C07K2319/91
摘要： Disclosed are (1) a mutein of a fibroblast growth factor (FGF), the DNA having introduced therein at least one nucleotide sequence coding for a glycosylation site, (2) a DNA coding for the mutein of (1), (3) a vector containing the DNA of (2), (4) a transformant transformed with the vector of (3), and (5) a process for producing the mutein which comprises cultivating in a culture medium the transformant of a yeast or animal cell transformed with a vector of (3), and producing and accumulating the mutein of (1) in the culture medium, whereby the FGF mutein into which at least one glycosylation site has been introduced is improved in productivity, stability and activities, and advantageously used as medicine.
摘要翻译：公开了（1）成纤维细胞生长因子（FGF）的突变蛋白，其中引入了至少一个编码糖基化位点的核苷酸序列的DNA，（2）编码（1），（3）的突变蛋白的DNA 含有（2）的DNA的载体，（4）用（3）的载体转化的转化体，和（5）一种产生突变蛋白的方法，其包括在培养基中培养转化了酵母或动物细胞的转化体（3）的载体，并且在培养基中产生和积累（1）的突变蛋白，从而提高了其中引入至少一个糖基化位点的FGF突变蛋白的生产力，稳定性和活性，并且有利地用作药物。

4. 发明授权

US4935352A Expression vector for animal cell line and use thereof 失效
标题翻译：动物细胞系的表达载体及其用途
公开(公告)号：US4935352A
公开(公告)日：1990-06-19
申请号：US919798
申请日：1986-10-16
申请人： Koichi Igarashi , Reiko Sasada , Tomoko Fujii , Ryuji Marumoto
发明人： Koichi Igarashi , Reiko Sasada , Tomoko Fujii , Ryuji Marumoto
IPC分类号： C07K14/485 , C07K14/55 , C07K16/00 , C12N15/85
CPC分类号： C12N15/85 , C07K14/485 , C07K14/55 , C07K16/00 , C07K2319/02
摘要： An animal cell line transformed with an expression vector for an animal cell, the expression vector which contains a DNA segment comprising:(a) a DNA sequence coding for a signal peptide of an animal cell-derived protein,(b) a second DNA sequence coding for a different protein from the signal protein joined downstream of said signal peptide encoding DNA sequence without causing any reading frame shift, and(c) a promoter DNA sequence capable of functioning in an animal cell, wherein the promoter sequence is positioned upstream of the signal peptide encoding DNA sequence, can produce glycosylated proteins advantageously as secretable proteins.
摘要翻译：用动物细胞表达载体转化的动物细胞系，含有DNA片段的表达载体包含：（a）编码动物细胞来源的蛋白质的信号肽的DNA序列，（b）第二DNA序列编码来自所述信号肽编码DNA序列下游的信号蛋白的不同蛋白质，而不引起任何阅读框移动，和（c）能够在动物细胞中起作用的启动子DNA序列，其中启动子序列位于信号肽编码DNA序列，可以有利地产生糖基化的蛋白质作为可分泌的蛋白质。

5. 发明授权

US06825165B1 Betacellulin modification 失效
标题翻译：白细胞素修饰
公开(公告)号：US06825165B1
公开(公告)日：2004-11-30
申请号：US09857815
申请日：2001-06-08
申请人： Takashi Ito , Mitsuyo Kondo , Yoko Tanaka , Masayuki Kobayashi , Koichi Igarashi , Reiko Sasada , Osamu Nishimura
发明人： Takashi Ito , Mitsuyo Kondo , Yoko Tanaka , Masayuki Kobayashi , Koichi Igarashi , Reiko Sasada , Osamu Nishimura
IPC分类号： C07K1400
CPC分类号： C07K14/475 , A61K38/00 , C07K14/485
摘要： The betacellulin mutein or its salt of the present invention is useful for better therapeutic drug for diabetes. Since they have intact BTC activity and reduced EGF activity, and no antigenicity-related problems.
摘要翻译：本发明的细胞素突变蛋白或其盐可用于更好的治疗药物用于糖尿病。因为它们具有完整的BTC活性和降低的EGF活性，并且没有抗原性相关的问题。

6. 发明授权

US5750371A Water-soluble mutein of FGF receptor, DNA and production thereof 失效
标题翻译： FGF受体的水溶性突变蛋白，DNA及其生产
公开(公告)号：US5750371A
公开(公告)日：1998-05-12
申请号：US471570
申请日：1995-06-06
申请人： Masaharu Senoo , Tatsuya Watanabe , Koichi Igarashi
发明人： Masaharu Senoo , Tatsuya Watanabe , Koichi Igarashi
IPC分类号： A61K38/00 , C07K14/71 , C12N15/12 , C07H21/00 , C12N15/63
CPC分类号： C07K14/71 , A61K38/00
摘要： Disclosed are (1) a water-soluble mutein of an animal protein having activity as a receptor for a fibroblast growth factor (FGF) protein, (2) a recombinant DNA having a nucleotide sequence coding for the above water-soluble mutein, (3) a vector containing the above recombinant DNA, (4) a transformant transformed with the above vector, and (5) a process for producing the water-soluble mutein which comprises cultivating the above transformant in a culture medium, the mutein being useful as therapeutic agents or to enhance cell proliferation activity.
摘要翻译：公开了（1）具有作为成纤维细胞生长因子（FGF）蛋白的受体的活性的动物蛋白质的水溶性突变蛋白，（2）具有编码上述水溶性突变蛋白的核苷酸序列的重组DNA（3 ）含有上述重组DNA的载体，（4）用上述载体转化的转化体，和（5）一种生产水溶性突变蛋白的方法，其包括在培养基中培养上述转化体，所述突变蛋白可用作治疗药剂或增强细胞增殖活性。

7. 发明申请

US20070195133A1 LIQUID DISCHARGE RECORDING HEAD AND LIQUID DISCHARGE APPARATUS 失效
标题翻译：液体排放记录头和液体排放装置
公开(公告)号：US20070195133A1
公开(公告)日：2007-08-23
申请号：US11551299
申请日：2006-10-20
申请人： Koichi Igarashi , Shogo Ono , Manabu Tomita , Minoru Kohno
发明人： Koichi Igarashi , Shogo Ono , Manabu Tomita , Minoru Kohno
IPC分类号： B41J2/045
CPC分类号： B41J2/1404 , B41J2/14145 , B41J2/1603 , B41J2/1629 , B41J2/1631 , B41J2/1632
摘要： A liquid discharge recording head which discharges a liquid includes a substrate on which liquid-discharge-energy-generating elements are provided and which constitutes a part of a flow path for supplying the liquid; and a covering resin layer which is provided on the substrate, which constitutes a part of the flow path, and which includes orifices for discharging the liquid, wherein the covering resin layer is composed of an oxetane resin composition containing an oxetane compound having at least one oxetanyl group in its molecule and a photocationic polymerization initiator as essential components.
摘要翻译：排出液体的液体排出记录头包括其上设置有排液能量元件并构成用于供给液体的流路的一部分的基板; 以及覆盖树脂层，其设置在构成流路的一部分的基板上，并且包括用于排出液体的孔，其中，所述覆盖树脂层由含有氧杂环丁烷化合物的氧杂环丁烷树脂组合物构成，所述氧杂环丁烷树脂组合物含有至少一种氧杂环丁烷基和光阳离子聚合引发剂作为必需组分。

8. 发明申请

US20070153063A1 Method and apparatus for ejecting liquid 失效
标题翻译：用于喷射液体的方法和装置
公开(公告)号：US20070153063A1
公开(公告)日：2007-07-05
申请号：US11641577
申请日：2006-12-18
申请人： Takeo Eguchi , Masato Nakamura , Toru Tanikawa , Minoru Kohno , Koichi Igarashi , Manabu Tomita , Shogo Ono , Takaaki Miyamoto , Iwao Ushinohama
发明人： Takeo Eguchi , Masato Nakamura , Toru Tanikawa , Minoru Kohno , Koichi Igarashi , Manabu Tomita , Shogo Ono , Takaaki Miyamoto , Iwao Ushinohama
IPC分类号： B41J2/05
CPC分类号： B41J2/1404 , B41J2/055 , B41J2/1433 , B41J2002/14387 , B41J2002/14403 , B41J2002/14467 , B41J2002/14475
摘要： In a method and an apparatus for ejecting liquid, the processing accuracy of an ejection unit for ejecting ink can be easily increased and the variations in the volume of ink drops, the ejection angle thereof, etc., can be reduced even when dust is mixed in ink. In addition, a reduction in an ink-supply speed at which ink is supplied to an ink ejection unit can be prevented. An ink ejection apparatus includes a plurality of heating units (13) provided on a base member (11), ink cells for pressurizing ink with energy generated by the heating units (13), and nozzles (17) having ejection holes for ejecting the ink which is pressurized in the ink cells. Each of the nozzles (17) is disposed above each of the heating units (13). In addition, first open sides of the nozzles (17) which face the heating units (13) serve as ink inlets (17b) and second open sides of the nozzles (17) serve as the ejection holes (17a), so that inner spaces of the nozzles (17) serve as the ink cells, the ink cells not being provided separately.
摘要翻译：在用于喷射液体的方法和装置中，即使在灰尘混合的情况下也能够容易地提高用于喷射墨水的喷射单元的处理精度，并且可以降低墨水的体积变化，其喷射角度等。在墨水。此外，可以防止向墨水喷射单元供应墨水的墨水供应速度的降低。一种喷墨装置，包括：设置在基底构件（11）上的多个加热单元（13），用于通过加热单元（13）产生的能量对墨水加压的墨水池;以及具有用于喷射墨水的喷射孔的喷嘴其在墨水池中被加压。每个喷嘴（17）设置在每个加热单元（13）的上方。此外，面对加热单元（13）的喷嘴（17）的第一开口侧用作墨水入口（17b），并且喷嘴（17）的第二开口侧用作喷射孔（17a），使得喷嘴（17）的内部空间用作墨水池，而不是分开设置墨水单元。

9. 发明授权

US07216420B2 Method of manufacturing print head 失效
标题翻译：制造打印头的方法
公开(公告)号：US07216420B2
公开(公告)日：2007-05-15
申请号：US10393200
申请日：2003-03-20
申请人： Manabu Tomita , Koichi Igarashi
发明人： Manabu Tomita , Koichi Igarashi
IPC分类号： H05B3/00
CPC分类号： B41J2/1603 , B41J2/1629 , B41J2/1631 , B41J2/1639 , B41J2/1645 , Y10T29/42 , Y10T29/49002 , Y10T29/49083 , Y10T29/49172 , Y10T29/49401 , Y10T29/49798 , Y10T29/49812
摘要： A print head manufacturing method in which satisfactory precision can be obtained by simple processes are provided. Projecting objects having a predetermined shape are formed on a substrate, and a setting resin is applied on the substrate and is set. Then, the projecting objects are removed so that ink cells and nozzles are formed. The thickness of the setting resin is determined such that tip portions of the projecting objects project above the setting resin and ink cells can be formed.
摘要翻译：提供了通过简单的工艺可以获得令人满意的精度的打印头制造方法。在基板上形成具有预定形状的投影物体，并将设定树脂施加在基板上并设定。然后，移除投影物体，从而形成墨盒和喷嘴。确定设定树脂的厚度，使得突出物体的末端部分突出于固化树脂上方，并且可以形成墨水池。

10. 发明授权

US07150515B2 Liquid delivering device and liquid delivering method 失效
标题翻译：液体输送装置和液体输送方法
公开(公告)号：US07150515B2
公开(公告)日：2006-12-19
申请号：US10469185
申请日：2002-12-18
申请人： Takeo Eguchi , Masato Nakamura , Toru Tanikawa , Minoru Kohno , Koichi Igarashi , Manabu Tomita , Shogo Ono , Takaai Miyamoto , Iwao Ushinohama
发明人： Takeo Eguchi , Masato Nakamura , Toru Tanikawa , Minoru Kohno , Koichi Igarashi , Manabu Tomita , Shogo Ono , Takaai Miyamoto , Iwao Ushinohama
IPC分类号： B41J2/05
CPC分类号： B41J2/1404 , B41J2/055 , B41J2/1433 , B41J2002/14387 , B41J2002/14403 , B41J2002/14467 , B41J2002/14475
摘要： In a method and an apparatus for ejecting liquid, the processing accuracy of an ejection unit for ejecting ink can be easily increased and the variations in the volume of ink drops, the ejection angle thereof, etc., can be reduced even when dust is mixed in ink. In addition, a reduction in an ink-supply speed at which ink is supplied to an ink ejection unit can be prevented. An ink ejection apparatus includes a plurality of heating units (13) provided on a base member (11), ink cells for pressurizing ink with energy generated by the heating units (13), and nozzles (17) having ejection holes for ejecting the ink which is pressurized in the ink cells. Each of the nozzles (17) is disposed above each of the heating units (13). In addition, first open sides of the nozzles (17) which face the heating units (13) serve as ink inlets (17b) and second open sides of the nozzles (17) serve as the ejection holes (17a), so that inner spaces of the nozzles (17) serve as the ink cells, the ink cells not being provided separately.
摘要翻译：在用于喷射液体的方法和装置中，即使在灰尘混合的情况下也能够容易地提高用于喷射墨水的喷射单元的处理精度，并且可以降低墨水的体积变化，其喷射角度等。在墨水。此外，可以防止向墨水喷射单元供应墨水的墨水供应速度的降低。一种喷墨装置，包括：设置在基底构件（11）上的多个加热单元（13），用于通过加热单元（13）产生的能量对墨水加压的墨水池;以及具有用于喷射墨水的喷射孔的喷嘴其在墨水池中被加压。每个喷嘴（17）设置在每个加热单元（13）的上方。此外，面对加热单元（13）的喷嘴（17）的第一开口侧用作墨水入口（17b），并且喷嘴（17）的第二开口侧用作喷射孔（17a），使得喷嘴（17）的内部空间用作墨水池，而不是分开设置墨水单元。

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