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1. 发明授权

US06708505B2 Air conditioner 失效
标题翻译：冷气机
公开(公告)号：US06708505B2
公开(公告)日：2004-03-23
申请号：US10197460
申请日：2002-07-18
申请人： Hiroo Nakamura , Hidenori Yokoyama , Masayuki Nonaka , Atsushi Ohtsuka , Tsutomu Kurokawa
发明人： Hiroo Nakamura , Hidenori Yokoyama , Masayuki Nonaka , Atsushi Ohtsuka , Tsutomu Kurokawa
IPC分类号： F25B4900
CPC分类号： G06F8/65 , F24F11/30 , F24F11/58 , F24F11/62
摘要： An air conditioner and a control software updating system capable of easily updating and adding control software desired by a customer. An internet system including telephones and/or personal computers is provided between a service center and customers. Each of air conditioners is provided with a connection terminal for connection to a communication terminal. Software for controlling operation of the air conditioner is updated by using the internet or a memory card after explaining a control software to the customer and confirming the customer's desire.
摘要翻译：一种空调和控制软件更新系统，能够容易地更新和添加客户所需的控制软件。在服务中心和客户之间提供包括电话和/或个人计算机的互联网系统。每个空调设置有连接到通信终端的连接终端。用于控制空调的操作的软件在向客户解释控制软件并确认客户的愿望之后通过使用因特网或存储卡来更新。

2. 发明授权

US06221637B1 Xanthene derivatives, their production and use 失效
标题翻译：呫吨衍生物，其生产和使用
公开(公告)号：US06221637B1
公开(公告)日：2001-04-24
申请号：US08812946
申请日：1997-03-04
申请人： Tsuneaki Hida , Masahiko Hattori , Tsutomu Kurokawa , Atsushi Nakanishi
发明人： Tsuneaki Hida , Masahiko Hattori , Tsutomu Kurokawa , Atsushi Nakanishi
IPC分类号： C12P1702
CPC分类号： C07D405/12 , C07D311/82 , C07D311/86 , C07D407/04 , C07D409/04 , C07K14/70521
摘要： Xanthene compounds represented by the formula: wherein R1 is a carboxyl group which may be esterified or amidated; R2 is a hydrogen atom, a hydroxyl group, or a hydrocarbon group which may be substituted; R3 and R4 are the same or different and are a hydroxyl group which may be substituted; R5 and R6 are a hydrogen atom or a halogen atom; R7 is a hydrogen atom, a nitro group, a halogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted, or an acyl group which may be substituted; n is an integer of 0 to 2; and Y is an oxygen atom or two hydrogen atoms; and when n is 0, R2 may be a group represented by the formula: wherein the symbols have the same meanings as defined above, or a salt thereof inhibit a binding of B7-1 to CD28, prevent the B7-1-dependent activation of T cells and inhibit IL-2 production from T cells, thus being used as an immunomodulator such as a graft rejection inhibitor or a pharmaceutical composition for therapeutic treatment of allergy, rheumatoid arthritis, autoimmune disease, nephritis, diabetes mellitus and so on.
摘要翻译：由下式表示的呫吨化合物：其中R1是可被酯化或酰胺化的羧基; R2是氢原子，羟基或可被取代的烃基; R3和R4相同或不同，为可被取代的羟基; R5和R6是氢原子或卤素原子; R7是氢原子，硝基，卤素原子，可被取代的烃基，可被取代的杂环基或可被取代的酰基; n为0〜2的整数， Y是氧原子或两个氢原子; 当n为0时，R2可以是由下式表示的基团：其中符号具有与上述相同的含义，或其盐抑制B7-1与CD28的结合，防止B7-1依赖性的活化 T细胞，抑制T细胞的IL-2产生，作为免疫调节剂，例如移植排斥抑制剂或用于治疗过敏，类风湿性关节炎，自身免疫性疾病，肾炎，糖尿病等的药物组合物。

3. 发明授权

US5858779A Monoclonal antibody, hybridoma, their production and use thereof 失效
标题翻译：单克隆抗体，杂交瘤，其生产和使用
公开(公告)号：US5858779A
公开(公告)日：1999-01-12
申请号：US567748
申请日：1995-12-05
申请人： Makoto Iwane , Tsutomu Kurokawa , Koichi Igarashi
发明人： Makoto Iwane , Tsutomu Kurokawa , Koichi Igarashi
IPC分类号： A61K38/00 , C07K14/50 , C07K14/55 , C07K16/22 , C12N5/12 , C07K16/18 , C07K16/26
CPC分类号： C07K16/22 , C07K14/503 , C07K14/55 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/75
摘要： A monoclonal antibody is produced from a cloned hybridoma, and the monoclonal antibody combines specifically with basic fibroblast growth factor (bFGF). Therefore, the monoclonal antibody can be advantageously used for assay reagents on bFGF or for purification of bFGF.
摘要翻译：由克隆的杂交瘤产生单克隆抗体，单克隆抗体与碱性成纤维细胞生长因子（bFGF）特异性结合。因此，单克隆抗体可有利地用于bFGF上的测定试剂或用于纯化bFGF。

4. 发明授权

US5656435A Antibodies to peptides having NGF-like activity, said antibodies having no substantial cross-reactivity with NGF, and use thereof 失效
标题翻译：具有NGF样活性的肽的抗体，所述抗体与NGF无相当的交叉反应性及其用途
公开(公告)号：US5656435A
公开(公告)日：1997-08-12
申请号：US350214
申请日：1994-12-06
申请人： Kazuo Nakahama , Tsunehiko Fukuda , Tsutomu Kurokawa , Ken-ichi Kuroshima
发明人： Kazuo Nakahama , Tsunehiko Fukuda , Tsutomu Kurokawa , Ken-ichi Kuroshima
IPC分类号： C07K14/48 , C07K16/22 , C12P21/08 , G01N33/53 , C12N5/20
CPC分类号： C07K14/48 , C07K16/22
摘要： Disclosed are (A) an antibody to a peptide including at least 8 successive amino acids of an amino acid sequence represented by formulaTyrAlaGluHisLysSerHisArgGlyGluTyrSerValCys AspSerGluSerLeuTrpValThrAspLysSerSerAlaIle AspIleArgGlyHisGlnValThrValLeuGlyGluIleLys ThrGlyAsnSerProValLysGlnTyrPheTyrGluThrArg CysLysGluAlaArgProValLysAsnGlyCysArgGlyIle AspAspLysHisTrpAsnSerGlnCysLysThrSerGlnThr TyrValArgAlaLeuThrSerGluAsnAsnLysLeuValGly TrpArgTrpIleArgIleAspThrSerCysValCysAlaLeu SerArgLysIleGlyArg[1],wherein said antibody has no substantial cross-reactivity with human NGF,(B) a method for producing the antibody, (C) a cloned hybridoma which produces the antibody, (D) a method for producing the cloned hybridoma, (E) a partial peptide of a polypeptide (I) including an amino acid sequence represented by formula (1), (F) a conjugate of a peptide including at least 8 successive amino acids of formula (1) with a carrier protein, (G) a method for purifying the polypeptide (I) and (H) a method for detecting and assaying the polypeptide (I).
摘要翻译：所公开的是（A）的抗体的肽，包括由formulaTyrAlaGluHisLysSerHisArgGlyGluTyrSerValCys AspSerGluSerLeuTrpValThrAspLysSerSerAlaIle AspIleArgGlyHisGlnValThrValLeuGlyGluIleLys ThrGlyAsnSerProValLysGlnTyrPheTyrGluThrArg CysLysGluAlaArgProValLysAsnGlyCysArgGlyIle AspAspLysHisTrpAsnSerGlnCysLysThrSerGlnThr TyrValArgAlaLeuThrSerGluAsnAsnLysLeuValGly TrpArgTrpIleArgIleAspThrSerCysValCysAlaLeu SerArgLysIleGlyArg [1]表示的氨基酸序列的至少8种连续氨基酸，其中所述抗体不具有实质性的交叉反应性的人NGF，（B）产生抗体的方法，（C）产生抗体的克隆杂交瘤，（D）克隆的杂交瘤的制备方法，（E）多肽（I）的部分肽，其包含氨基酸序列通式（1），（F）包含式（1）的至少8个连续氨基酸的肽与载体蛋白的缀合物，（G）纯化多肽（I）的方法和（H）检测和测定多肽（I）。

5. 发明授权

US5622928A Glia activation factor and its production 失效
标题翻译：胶质激活因子及其生产
公开(公告)号：US5622928A
公开(公告)日：1997-04-22
申请号：US593535
申请日：1996-01-24
申请人： Ken-ichi Naruo , Chisako Seko , Tsutomu Kurokawa , Tatsuya Kondo
发明人： Ken-ichi Naruo , Chisako Seko , Tsutomu Kurokawa , Tatsuya Kondo
IPC分类号： A61K38/00 , A61P25/00 , A61P43/00 , C07K14/00 , C07K14/47 , C07K14/475 , C07K14/52 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/91 , A61K38/18
CPC分类号： C07K14/4756 , C07K14/475 , A61K38/00
摘要： Disclosed are (1) a novel glia activating factor which has glial cell growth promoting activity; (2) a glia activating factor containing a polypeptide; (3) a DNA coding for a glia activating factor; (4) a host transformed with a vector containing the DNA and (5) a method for producing the above glia activating factor which comprises cultivating the transformant described in a medium, accumulating the glia activating factor in a culture broth, and collecting the resulting glia activating factor.
摘要翻译：公开了（1）具有神经胶质细胞生长促进活性的新型神经胶质激活因子; （2）含有多肽的胶质激活因子; （3）编码神经胶质激活因子的DNA; （4）用含有DNA的载体转化的宿主（5）上述胶原激活因子的制造方法，其特征在于，培养介质中记载的转化体，在培养液中积聚神经胶质细胞活化因子，收集所得到的胶质细胞激活因子。

6. 发明授权

US07133852B2 Electricity generation equipment management system 失效
公开(公告)号：US07133852B2
公开(公告)日：2006-11-07
申请号：US09976259
申请日：2001-10-12
申请人： Tsutomu Kurokawa , Shigeaki Sato , Yoshiteru Misumi
发明人： Tsutomu Kurokawa , Shigeaki Sato , Yoshiteru Misumi
IPC分类号： G06Q99/00
CPC分类号： G06Q50/06 , H04Q9/00 , H04Q2209/50 , H04Q2209/60 , Y02E40/76 , Y04S10/54 , Y04S10/545 , Y04S10/60
摘要： A generator unit is installed locally to supply power to an electricity consumer. A management center monitors operation status of the generator unit and monitors the amount of electricity supplied to the electricity consumer by the generator unit. A service company performs maintenance and management for the generator unit based on instructions from the management center or the operation status of the generator unit. An electricity provider operating the generator unit bills the electricity consumer for an electricity supply service fee based on information sent to the management center. The resulting electricity generation equipment management system maintains and manages a generator unit without placing a burden on an electricity consumer, allowing efficient billing and payment of electricity supply service fees.

7. 发明授权

US5852177A Basic fibroblast growth factor (bFGF) muteins 失效
标题翻译：碱性成纤维细胞生长因子（bFGF）突变蛋白
公开(公告)号：US5852177A
公开(公告)日：1998-12-22
申请号：US301460
申请日：1989-01-24
申请人： Masaharu Senoo , Reiko Sasada , Tsutomu Kurokawa , Koichi Igarashi
发明人： Masaharu Senoo , Reiko Sasada , Tsutomu Kurokawa , Koichi Igarashi
IPC分类号： A61K38/00 , C07K14/50 , C07K14/55 , C07K16/22
CPC分类号： C07K16/22 , C07K14/503 , C07K14/55 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/75
摘要： A mutein of basic fibroblast growth factors (bFGF) possesses fibroblast growth promoting activity, growth stimulating activity of capillary endothelial cells and angiogenic activity, has high stability and is low toxicity. And therefore, the present mutein is advantageously used as a healing accelerator for burns etc., a therapeutic drug for thrombosis etc., and a cell cultivation promoter.
摘要翻译：碱性成纤维细胞生长因子（bFGF）的突变蛋白具有成纤维细胞生长促进活性，毛细血管内皮细胞生长刺激活性和血管生成活性，稳定性高，毒性低。因此，本发明的突变蛋白有利地用作燃烧等的愈合促进剂，血栓形成治疗药等，以及细胞培养促进剂。

8. 发明授权

US5981197A Monoclonal antibody, hybridoma, their production and use thereof 失效
公开(公告)号：US5981197A
公开(公告)日：1999-11-09
申请号：US27655
申请日：1998-02-23
申请人： Makoto Iwane , Tsutomu Kurokawa , Koichi Igarashi
发明人： Makoto Iwane , Tsutomu Kurokawa , Koichi Igarashi
IPC分类号： A61K38/00 , C07K14/50 , C07K14/55 , C07K16/22 , G01N33/53 , C12N5/06
CPC分类号： C07K16/22 , C07K14/503 , C07K14/55 , A61K38/00 , C07K2319/00 , C07K2319/02
摘要： A monoclonal antibody is produced from a cloned hybridoma, and the monoclonal antibody combines specifically with basic fibroblast growth factor (bFGF). Therefore, the monoclonal antibody can be advantageously used for assay reagents on bFGF or for purification of bFGF.

9. 发明授权

US5559093A N-terminally truncated hst-1 is a platelet-increasing factor 失效
标题翻译： N-末端截短的hst-1是血小板增加因子
公开(公告)号：US5559093A
公开(公告)日：1996-09-24
申请号：US102691
申请日：1993-08-05
申请人： Sumie Yoshitomi , Tsutomu Kurokawa , Koichi Igarashi
发明人： Sumie Yoshitomi , Tsutomu Kurokawa , Koichi Igarashi
IPC分类号： A61K38/00 , C07K14/50 , A61K38/18 , C07K14/495 , C07K14/53 , C12P21/06
CPC分类号： C07K14/50 , A61K38/00
摘要： A method of increasing platelets in mammals which comprises administering to mammals an effective amount of a heparin-binding secretory transforming factor 1 protein (hst-1) having an N-terminal deletion of 27 amino acids.
摘要翻译：一种增加哺乳动物血小板的方法，其包括向哺乳动物施用有效量的具有27个氨基酸的N-末端缺失的肝素结合分泌转化因子1蛋白（hst-1）。

10. 发明授权

US5512460A Glia activating factor and its production 失效
标题翻译：胶质激活因子及其生产
公开(公告)号：US5512460A
公开(公告)日：1996-04-30
申请号：US340820
申请日：1994-11-17
申请人： Ken-ichi Nauro , Chisako Seko , Tsutomu Kurokawa , Tatsuya Kondo
发明人： Ken-ichi Nauro , Chisako Seko , Tsutomu Kurokawa , Tatsuya Kondo
IPC分类号： A61K38/00 , A61P25/00 , A61P43/00 , C07K14/00 , C07K14/47 , C07K14/475 , C07K14/52 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/91 , C12P21/06
CPC分类号： C07K14/4756 , C07K14/475 , A61K38/00
摘要： Disclosed are (1) a novel glia activating factor which has glial cell growth promoting activity; (2) a glia activating factor containing a polypeptide represented by SEQ ID NO: 1 or a mutein thereof having activity of the factor; (3) a DNA containing a polynucleotide coding for a glia activating factor represented by SEQ ID NO: 10; (4) a host transformed with a vector containing the DNA described in (3); and (5) a method for producing the above glia activating factor which comprises cultivating the transformant described in (4) in a medium accumulating the glia activating factor in a culture broth, and collecting the resulting glia activating factor.
摘要翻译：公开了（1）具有神经胶质细胞生长促进活性的新型神经胶质激活因子; （2）含有由SEQ ID NO：1表示的多肽或具有该因子活性的突变蛋白的胶质激活因子; （3）含有编码由SEQ ID NO：10表示的神经胶质激活因子的多核苷酸的DNA; （4）用含有（3）所述DNA的载体转化的宿主; （5）上述胶原激活因子的制造方法，其特征在于，在培养液中培养上述（4）所述的转化体后，在培养液中积聚神经胶质细胞活化因子，收集所形成的神经胶质细胞活化因子。

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