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1. 再颁专利

USRE36386E Cardioplegia delivery system 失效
标题翻译：心脏停搏分娩系统
公开(公告)号：USRE36386E
公开(公告)日：1999-11-09
申请号：US800090
申请日：1997-02-12
申请人： Martyn S. Abbott , Thomas C. Thompson , Kenneth A. Jones , Albert M. Davis , Andrew P. Mattson
发明人： Martyn S. Abbott , Thomas C. Thompson , Kenneth A. Jones , Albert M. Davis , Andrew P. Mattson
IPC分类号： F04B43/00 , A61M1/36 , A61M5/168 , A61M5/44 , A61M19/00 , A61M37/00 , A61M1/00 , A61M31/00
CPC分类号： A61M5/16827 , A61M1/3664 , A61M5/44 , A61M2205/12 , A61M2205/3344 , A61M2205/3355 , A61M2205/3606 , A61M2205/366 , Y10S128/03
摘要： A cardioplegia system for delivering cardioplegic solution to the heart during open heart surgery in cooperation with an extracorporeal blood circuit employing a heart/lung machine, includes a conduit diverting a portion of the blood flow from the heart/lung machine to a cardioplegia delivery line. A heat exchanger for controlling fluid temperature is provided in the cardioplegia delivery line. A flat pump combines the blood from the conduit with a second fluid and delivery the combined flow into the delivery line leading to the heat exchanger. A control panel is operatively connected for adjusting the ratio of blood and second fluid delivered by the first pump and for adjusting the total volumetric rate of flow from the first pump.
摘要翻译：一种心脏停搏系统，用于在开心心脏手术期间与使用心脏/肺机的体外血液回路相结合，将心脏停搏液提供给心脏，包括导管将一部分血流从心脏/肺机转移到心麻痹输送管线。用于控制流体温度的热交换器设置在心麻痹输送管线中。扁平泵将来自导管的血液与第二流体结合，并将组合的流输送到通向热交换器的输送管线。控制面板可操作地连接，用于调节由第一泵输送的血液和第二流体的比例，并用于调节来自第一泵的总体积流速。

2. 发明授权

US5385540A Cardioplegia delivery system 失效
标题翻译：心脏停搏分娩系统
公开(公告)号：US5385540A
公开(公告)日：1995-01-31
申请号：US67683
申请日：1993-05-26
申请人： Martyn S. Abbott , Thomas C. Thompson , Kenneth A. Jones , Albert M. Davis , Andrew P. Mattson
发明人： Martyn S. Abbott , Thomas C. Thompson , Kenneth A. Jones , Albert M. Davis , Andrew P. Mattson
IPC分类号： F04B43/00 , A61M1/36 , A61M5/168 , A61M5/44 , A61M19/00 , A61M37/00 , A61M1/00 , A61M31/00
CPC分类号： A61M5/16827 , A61M1/3664 , A61M5/44 , A61M2205/12 , A61M2205/3344 , A61M2205/3355 , A61M2205/3606 , A61M2205/366 , Y10S128/03
摘要： A cardioplegia system for delivering cardioplegic solution to the heart during open heart surgery in cooperation with an extracorporeal blood circuit employing a heart/lung machine, includes a conduit diverting a portion of the blood flow from the heart/lung machine to a cardioplegia delivery line. A heat exchanger for controlling fluid temperature is provided in the cardioplegia delivery line. A first pump combines the blood from the conduit with a second fluid and delivers the combined flow into the delivery line leading to the heat exchanger. A control panel is operatively connected for adjusting the ratio of blood and second fluid delivered by the first pump and for adjusting the total volumetric rate of flow from the first pump.
摘要翻译：一种心脏停搏系统，用于在开心心脏手术期间与使用心脏/肺机的体外血液回路相结合，将心脏停搏液提供给心脏，包括导管将一部分血流从心脏/肺机转移到心麻痹输送管线。用于控制流体温度的热交换器设置在心麻痹输送管线中。第一泵将来自导管的血液与第二流体结合，并将组合的流输送到通向热交换器的输送管线。控制面板可操作地连接，用于调节由第一泵输送的血液和第二流体的比例，并用于调节来自第一泵的总体积流速。

3. 发明授权

US5573502A Display panel and controls for blood mixture delivery system 失效
标题翻译：血液混合物输送系统的显示面板和控制
公开(公告)号：US5573502A
公开(公告)日：1996-11-12
申请号：US204532
申请日：1994-03-01
申请人： Andrew D. LeCocq , Thomas C. Thompson , Kenneth A. Jones , Martyn Abbott , Albert M. Davis , Andrew P. Mattson
发明人： Andrew D. LeCocq , Thomas C. Thompson , Kenneth A. Jones , Martyn Abbott , Albert M. Davis , Andrew P. Mattson
IPC分类号： F04B43/00 , A61M1/36 , A61M5/168 , A61M5/44 , A61M19/00 , A61M37/00 , A61M1/00 , A61M31/00
CPC分类号： A61M1/3664 , A61M5/16827 , A61M5/44 , A61M2205/12 , A61M2205/3344 , A61M2205/3355 , A61M2205/3606 , A61M2205/366 , Y10S128/03
摘要： A display panel for use with a blood mixture fluid delivery system, which system has mechanisms for infusing blood mixture fluid to a patient and for controlling characteristics of the fluid delivery system. The display panel includes a visible schematic representation of a blood mixture fluid flow path through the fluid delivery system and visible displays of two or more of the controllable characteristics of the fluid delivery system, which visible displays are positioned along the schematic representation of the blood mixture fluid flow path.
摘要翻译：一种与血液混合物输送系统一起使用的显示面板，该系统具有将血液混合液注入患者体内并具有控制流体输送系统特征的机构。显示面板包括通过流体输送系统的血液混合物流体流动路径的可见示意图，以及流体输送系统的两个或更多个可控特征的可见显示器，该可视显示器沿着血液混合物的示意图流体流路。

4. 发明授权

US5899873A Biological fluid delivery system 失效
标题翻译：生物流体输送系统
公开(公告)号：US5899873A
公开(公告)日：1999-05-04
申请号：US823529
申请日：1997-03-24
申请人： Kenneth A. Jones , Martyn Abbott , Andrew P. Mattson
发明人： Kenneth A. Jones , Martyn Abbott , Andrew P. Mattson
IPC分类号： A61M1/36 , A61M37/00
CPC分类号： A61M1/3664
摘要： A cardioplegia system for delivering cardioplegic solution to the heart during open heart surgery in cooperation with an extracorporeal blood circuit employing a heart/lung machine, includes a conduit diverting a portion of the blood flow from the heart/lung machine to a cardioplegia delivery line. A heat exchanger assembly including a heat exchanger for controlling fluid temperature is provided in the cardioplegia delivery line. In addition to a heat exchanger, the heat exchanger assembly includes an integral bubble trap, filtration means and means to enable the measurement of certain physical characteristics of the circulating cardioplegia fluid and/or certain events occurring within the heat exchanger assembly.
摘要翻译：一种心脏停搏系统，用于在开心心脏手术期间与使用心脏/肺机的体外血液回路相结合，将心脏停搏液提供给心脏，包括导管将一部分血流从心脏/肺机转移到心麻痹输送管线。在心麻痹输送管线中设置有包括用于控制流体温度的热交换器的热交换器组件。除了热交换器之外，热交换器组件还包括一体式气泡阱，过滤装置和能够测量循环心麻痹液体的某些物理特性和/或在热交换器组件内发生的某些事件的装置。

5. 发明授权

US5645531A Constant pressure blood mixture delivery system and method 失效
标题翻译：恒压血液输送系统及方法
公开(公告)号：US5645531A
公开(公告)日：1997-07-08
申请号：US204530
申请日：1994-03-01
申请人： Thomas C. Thompson , Martyn Abbott , Kenneth A. Jones
发明人： Thomas C. Thompson , Martyn Abbott , Kenneth A. Jones
IPC分类号： F04B43/00 , A61M1/10 , A61M1/36 , A61M5/168 , A61M5/44 , A61M19/00 , A61M31/00
CPC分类号： A61M1/3664 , A61M1/3621 , A61M5/16827 , A61M5/44 , A61M2205/12 , A61M2205/3344 , A61M2205/3355 , A61M2205/3606 , A61M2205/366 , Y10S128/03
摘要： A system and method for blood mixture fluid delivery to a patient includes fluid delivery conduits connected to the patient for delivering blood mixture fluid, a pump for controlled pumping of blood mixture fluid through the conduits to the patient, and an automatic control mechanism operatively connected to the pump for controlling the pump so that the blood mixture fluid is continuously delivered to the patient at a defined constant pressure.
摘要翻译：用于向患者输送血液混合物的系统和方法包括连接到患者以输送血液混合物流体的流体输送管道，用于通过导管将血液混合物流体受控地泵送到患者的泵，以及可操作地连接到用于控制泵的泵，使得血液混合物流体以规定的恒定压力连续递送到患者体内。

6. 发明授权

US09234514B2 Two-chamber blood pump 有权
标题翻译：双室血泵
公开(公告)号：US09234514B2
公开(公告)日：2016-01-12
申请号：US12199593
申请日：2008-08-27
申请人： Kenneth A. Jones
发明人： Kenneth A. Jones
IPC分类号： F04B1/02 , A61M1/00 , F04B9/04 , F04B43/02 , A61M1/10 , F04B7/00 , F04B23/06 , F04B53/14
CPC分类号： F04B43/02 , A61M1/1006 , A61M1/1037 , A61M1/1046 , A61M1/1081 , A61M1/1086 , A61M2202/047 , A61M2205/12 , F04B7/00 , F04B23/06 , F04B43/026 , F04B53/14
摘要： A fluid pump for medical applications. The pump includes a flexible cassette containing two pump chambers of differing volume, each chamber having a dedicated piston. The first piston pushes fluid from the first chamber to the second, and the second piston pushes fluid from the second chamber and out of the pump. Three valves are coordinated with the action of the pistons to control fluid flow into and out of the pump chambers by applying and releasing pressure to and from specific points of the flexible cassette. A control system controls the operation of the pistons and valves and directs the pistons to be advanced according to a time-varying velocity profile. The first pump chamber passively fills and then rapidly expels the collected fluid into the second chamber at low pressure. The second chamber, once filled, expels the fluid downstream at high pressure, producing a pulsatile pressure profile.
摘要翻译：用于医疗应用的流体泵。该泵包括一个含有两个不同体积的泵室的柔性盒，每个室具有专用的活塞。第一活塞将流体从第一腔室推动到第二活塞，第二活塞将流体从第二腔室推出泵出。三个阀门与活塞的作用协调起来，以通过向和从该软管盒的特定点施加和释放压力来控制流入和流出泵室的流体。控制系统控制活塞和阀的操作，并根据时变速度分布指示要提前的活塞。第一泵室被动填充，然后在低压下将收集的流体快速排出到第二室中。一旦装满了第二个室，高压下排出流体，产生脉动压力分布。

7. 发明授权

US07517658B2 Methods for preparing compositions using a SNORF33 receptor 失效
标题翻译：使用SNORF33受体制备组合物的方法
公开(公告)号：US07517658B2
公开(公告)日：2009-04-14
申请号：US11227855
申请日：2005-09-15
申请人： Beth E. Borowsky , Kristine L. Ogozalek , Kenneth A. Jones
发明人： Beth E. Borowsky , Kristine L. Ogozalek , Kenneth A. Jones
IPC分类号： G01N33/567 , G01N33/53 , C07K14/47
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00
摘要： This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF33 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF33 receptors, methods of isolating mammalian SNORF33 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF33 receptors, as well as methods of determining binding of compounds to mammalian SNORF33 receptors, methods of identifying agonists and antagonists of SNORF33 receptors, and agonists and antagonists so identified.
摘要翻译：本发明提供编码哺乳动物SNORF33受体的分离的核酸，纯化的哺乳动物SNORF33受体，包含编码哺乳动物SNORF33受体的核酸的载体，包含此类载体的细胞，针对哺乳动物SNORF33受体的抗体，用于检测编码哺乳动物SNORF33受体的核酸的核酸探针，与编码哺乳动物SNORF33受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变的哺乳动物SNORF33受体的DNA的转基因非人动物，分离哺乳动物SNORF33受体的方法，治疗与哺乳动物的活性相关的异常的方法 SNORF33受体以及确定化合物与哺乳动物SNORF33受体的结合的方法，识别SNORF33受体的激动剂和拮抗剂的方法，以及所鉴定的激动剂和拮抗剂。

8. 发明授权

US06709831B1 DNA encoding mammalian neuropeptide FF (NPFF) receptors and uses thereof 失效
标题翻译：编码哺乳动物神经肽FF（NPFF）受体的DNA及其用途
公开(公告)号：US06709831B1
公开(公告)日：2004-03-23
申请号：US09405558
申请日：1999-09-24
申请人： Christophe P. G. Gerald , Kenneth A. Jones , James A. Bonini , Beth E. Borowsky , Douglas A. Craig
发明人： Christophe P. G. Gerald , Kenneth A. Jones , James A. Bonini , Beth E. Borowsky , Douglas A. Craig
IPC分类号： G01N33566
CPC分类号： C07K14/70571 , A01K2217/075
摘要： This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.
摘要翻译：本发明提供编码哺乳动物NPFF受体的分离的核酸，纯化的哺乳动物NPFF受体，包含编码哺乳动物NPFF受体的核酸的载体，包含该载体的细胞，针对哺乳动物NPFF受体的抗体，用于检测编码哺乳动物NPFF受体的核酸的核酸探针，与编码哺乳动物NPFF受体的核酸的独特序列互补的反义寡核苷酸，其表达编码正常或突变型哺乳动物NPFF受体的DNA的转基因非人动物，分离哺乳动物NPFF受体的方法，治疗与哺乳动物活性相关的异常的方法 NPFF受体，以及确定化合物与哺乳动物NPFF受体的结合的方法，识别NPFF受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。

9. 发明授权

US06262246B1 DNA encoding mammalian neuropeptides FF (NPFF) receptors and uses thereof 失效
标题翻译：编码哺乳动物神经肽FF（NPFF）受体的DNA及其用途
公开(公告)号：US06262246B1
公开(公告)日：2001-07-17
申请号：US09255368
申请日：1999-02-22
申请人： Christophe P. G. Gerald , Kenneth A. Jones , James A. Bonini , Beth Borowsky
发明人： Christophe P. G. Gerald , Kenneth A. Jones , James A. Bonini , Beth Borowsky
IPC分类号： C07H2104
CPC分类号： C07K14/70571 , A01K2217/075
摘要： This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.
摘要翻译：本发明提供编码哺乳动物NPFF受体的分离的核酸，纯化的哺乳动物NPFF受体，包含编码哺乳动物NPFF受体的核酸的载体，包含该载体的细胞，针对哺乳动物NPFF受体的抗体，用于检测编码哺乳动物NPFF受体的核酸的核酸探针，与编码哺乳动物NPFF受体的核酸的独特序列互补的反义寡核苷酸，其表达编码正常或突变型哺乳动物NPFF受体的DNA的转基因非人动物，分离哺乳动物NPFF受体的方法，治疗与哺乳动物活性相关的异常的方法 NPFF受体，以及确定化合物与哺乳动物NPFF受体的结合的方法，识别NPFF受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。

10. 发明授权

US5346856A Method of making a selective compositional disordering of a GaAs based heterostructure by the in-diffusion of Au through a single crystal, epitaxially grown Ge film 失效
标题翻译：通过单晶，外延生长的Ge膜通过Au的扩散形成GaAs基异质结构的选择性组成失调的方法
公开(公告)号：US5346856A
公开(公告)日：1994-09-13
申请号：US60073
申请日：1993-05-10
申请人： Kenneth A. Jones , Howard S. Lee
发明人： Kenneth A. Jones , Howard S. Lee
IPC分类号： H01L21/18 , H01S5/042 , H01S5/20 , H01L21/20
CPC分类号： H01L21/182 , H01S5/20 , H01S5/0421 , H01S5/0425 , H01S5/2059
摘要： A method for producing a buried heterostructure active devices and a passive waveguide by providing a heterostructure substrate such as a superlattice having at least one planar GaAs layer and at least one AlGaAs layer adjacent to it. A single crystal germanium layer is epitaxially deposited on the superlattice substrate. A layer of gold is deposited on the germanium layer. The gold and germanium layers are imagewise patterned and selected portions etched away. The patterned substrate is encapsulated in a compatible, heat resistant encapsulating material. The encapsulated substrate is then annealed at a temperature of up to about 350.degree. C.
摘要翻译：通过提供具有至少一个平面GaAs层和与其邻近的至少一个AlGaAs层的超晶格等异质结构衬底来制造掩埋异质结构有源器件和无源波导的方法。单晶锗层外延沉积在超晶格基底上。一层金沉积在锗层上。金和锗层是成像图案的，并且选择的部分被蚀刻掉。图案化衬底被封装在相容的耐热封装材料中。然后将封装的衬底在高达约350℃的温度下退火

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