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1. 发明申请

US20110060199A1 DETERMINATION OF BLOOD PUMP SYSTEM PERFORMANCE AND SAMPLE DILUTION USING A PROPERTY OF FLUID BEING TRANSPORTED 审中-公开
标题翻译：使用流体输送物质确定血液泵系统性能和样品浓度
公开(公告)号：US20110060199A1
公开(公告)日：2011-03-10
申请号：US12884175
申请日：2010-09-16
申请人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Greg Knipstein , Dan Welsh
发明人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Greg Knipstein , Dan Welsh
IPC分类号： A61B5/157
CPC分类号： A61B5/14557 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150946 , A61B5/150961 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M1/1692 , A61M1/34 , A61M1/341 , A61M1/3621 , A61M1/3639 , A61M1/3663 , A61M5/16831 , A61M2005/1404 , A61M2205/3306 , A61M2205/331 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2230/201
摘要： The use of an optical or other measurement in a blood access system enables the determination of a fluid sample appropriate for measurement on a real time basis. This information can be used to control the blood access system and related measurement processes. The determination can be based on, for example, at least one of: optical density, optical scatter, analyte level, temperature, the absolute level of any of the preceding, the stability of any of the preceding, the rate of change of any of the preceding, or the value of any of the preceding relative to another determination. The determination can be made using, for example, at least one of: electrochemical sensor, ion specific electrode, capacitance measurement, impedance measurement, inductance measurement, conductivity measurement, optical measurement, and ultrasound measurement. The present invention relates to determination of the quality of a biological sample in which determination of an analyte concentration is to be made, and various methods and apparatuses related thereto. An evaluation of sample quality can be made by monitoring the temporal changes in the sample properties or characteristics as the biological sample is procured or measured. The methods and apparatuses described herein can be used to evaluate the temporal characteristics of a sample during sample acquisition and/or during determination of the sample analyte or parameter of interest. The sample quality assurance methods and apparatuses described herein can thus be used to ensure that a valid sample has been procured by or presented to an instrument or measurement system for analyte determination, thereby preventing the measurement and reporting of analyte values for a sample that is unstable or otherwise non-representative of the biological system from which the sample was obtained.
摘要翻译：在血液存取系统中使用光学或其他测量能够实时地确定适于测量的流体样品。该信息可用于控制血液存取系统和相关测量过程。该测定可以基于例如光密度，光学散度，分析物水平，温度，前述任一项的绝对水平，前述任一项的稳定性，任何变化率前一个或前一个相对于另一个确定的任何值的值。可以使用例如电化学传感器，离子专用电极，电容测量，阻抗测量，电感测量，电导率测量，光学测量和超声测量中的至少一个来进行确定。本发明涉及要进行测定分析物浓度的生物样品的质量的确定以及与其相关的各种方法和装置。通过监测采购或测量生物样品的样品性质或特性的时间变化，可以对样品质量进行评估。本文描述的方法和装置可以用于在样品获取期间和/或在样品分析物或感兴趣的参数的确定期间评估样品的时间特征。因此，本文所述的样品质量保证方法和装置可以用于确保有效样品已经由用于分析物测定的仪器或测量系统获得或呈现给样品，从而防止对不稳定的样品的分析物值的测量和报告或以其他方式代表获得样品的生物系统。

2. 发明申请

US20090156975A1 Robust System and Methods for Blood Access 审中-公开
标题翻译：健壮的血液系统和方法
公开(公告)号：US20090156975A1
公开(公告)日：2009-06-18
申请号：US12325243
申请日：2008-11-30
申请人： Mark Ries Robinson , Mike Borrello , Dan Welsh
发明人： Mark Ries Robinson , Mike Borrello , Dan Welsh
IPC分类号： A61M1/14 , B01D65/02
CPC分类号： A61M1/3653 , A61B5/0215 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150946 , A61B5/150961 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3656 , A61M1/3659 , A61M2005/1588 , A61M2039/0009
摘要： Embodiments of the present invention provide robust systems for the removal and subsequent infusion of blood for measurement purposes, and embodiments of the present invention provide methods of operating such systems and providing capabilities such as predicting and avoiding occlusions and/or bubbles, managing occlusions and/or bubbles if they occur, automatic cleaning of the blood access system, and determining and managing the patency of the blood access site. Such operational challenges can occur during any of several phases of operation of a blood access system. Embodiments of the present invention can effectively incorporate a variety of inputs for the identification of trends consistent with present or pending occlusions. An embodiment of the present invention can be aware of the stage of operation, e.g., withdrawal, infusion, or cleaning, and the prior performance of the system. Embodiments of the present invention can have the ability to identify the location of the problem so that effective procedures can be used to resolve the problem.
摘要翻译：本发明的实施例提供用于去除和随后输注用于测量目的的血液的鲁棒系统，并且本发明的实施例提供了操作这样的系统并提供诸如预测和避免闭塞和/或气泡的能力的方法，管理闭塞和/ 如果发生气泡，自动清洗血液存取系统，以及确定和管理血液通道的通畅。这样的操作挑战可以在血液存取系统的几个操作阶段的任何阶段发生。本发明的实施例可以有效地结合用于识别与当前或未决遮挡一致的趋势的各种输入。本发明的实施例可以意识到操作的阶段，例如撤回，输注或清洁，以及系统的先前的执行。本发明的实施例可以具有识别问题的位置的能力，从而可以使用有效的过程来解决问题。

3. 发明申请

US20120065482A1 DETERMINATION OF BLOOD PUMP SYSTEM PERFORMANCE AND SAMPLE DILUTION USING A PROPERTY OF FLUID BEING TRANSPORTED 审中-公开
标题翻译：使用流体输送物质确定血液泵系统性能和样品浓度
公开(公告)号：US20120065482A1
公开(公告)日：2012-03-15
申请号：US13193602
申请日：2011-07-29
申请人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Dan Welsh , Steve Bernard , John O'Mahony , Dave McMahon , Victor Gerald Grafe , Dave Tobler , William R. Patterson , Donald W. Landry , James H. Macemon , Russell Abbink
发明人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Dan Welsh , Steve Bernard , John O'Mahony , Dave McMahon , Victor Gerald Grafe , Dave Tobler , William R. Patterson , Donald W. Landry , James H. Macemon , Russell Abbink
IPC分类号： A61B5/145
CPC分类号： A61B5/150221 , A61B5/0215 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61M2005/1588 , A61M2039/0009
摘要： The present invention provides methods and apparatuses related to measurement of analytes, including measurements of analytes in samples withdrawn from a patient.
摘要翻译：本发明提供了与分析物的测量相关的方法和装置，包括从患者抽出的样品中的分析物的测量。

4. 发明申请

US20070240497A1 Blood Analyte Determinations 审中-公开
公开(公告)号：US20070240497A1
公开(公告)日：2007-10-18
申请号：US11679835
申请日：2007-02-27
申请人： Mark Ries Robinson , Mike Borrello , Richard Thompson , Stephen Vanslyke , Steve Bernard , John O'Mahony
发明人： Mark Ries Robinson , Mike Borrello , Richard Thompson , Stephen Vanslyke , Steve Bernard , John O'Mahony
IPC分类号： G01N33/48 , G01N1/00
CPC分类号： A61B5/150961 , A61B5/14532 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150366 , A61B5/150992 , A61B5/153 , A61B5/155 , A61M1/1692 , A61M1/34 , A61M1/3621 , A61M1/3639 , A61M1/3663 , A61M5/16831 , A61M2005/1404 , A61M2205/3306 , A61M2205/331 , A61M2205/3331 , A61M2205/3334 , A61M2230/201
摘要： The present invention comprises methods and apparatuses that can provide measurement of glucose and other analytes with a variety of sensors without many of the performance-degrading problems of conventional approaches. An apparatus according to the present invention comprises a blood access system, adapted to remove blood from a body and infuse at least a portion of the removed blood back into the body. Such an apparatus also comprises an analyte sensor, mounted with the blood access system such that the analyte sensor measures the analyte in the blood that has been removed from the body by the blood access system. A method according to the present invention comprises removing blood from a body, using an analyte sensor to measure an analyte in the removed blood, and infusing at least a portion of the removed blood back into the body. The use of a non-contact sensor with a closed system creates a system will minimal infection risk.

5. 发明申请

US20070225675A1 Blood Analyte Determinations 审中-公开
标题翻译：血液分析物测定
公开(公告)号：US20070225675A1
公开(公告)日：2007-09-27
申请号：US11679837
申请日：2007-02-28
申请人： Mark Ries Robinson , Mike Borrello , Richard Thompson , Stephen Vanslyke , Steve Bernard , John O'Mahony
发明人： Mark Ries Robinson , Mike Borrello , Richard Thompson , Stephen Vanslyke , Steve Bernard , John O'Mahony
IPC分类号： A61M37/00 , A61M31/00 , A61B5/00
CPC分类号： A61B5/150961 , A61B5/14532 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150366 , A61B5/150992 , A61B5/153 , A61B5/155 , A61M1/1692 , A61M1/34 , A61M1/3621 , A61M1/3639 , A61M1/3663 , A61M5/16831 , A61M2005/1404 , A61M2205/3306 , A61M2205/331 , A61M2205/3331 , A61M2205/3334 , A61M2230/201
摘要： The present invention comprises methods and apparatuses that can provide measurement of glucose and other analytes with a variety of sensors without many of the performance-degrading problems of conventional approaches. As apparatus according to the present invention comprises a blood access system, adapted to remove blood from a body and infuse at least a portion of the removed blood back into the body. Such an apparatus also comprises an analyte sensor, mounted with the blood access system such that the analyte sensor measures the analyte in the blood that has been removed from the body by the blood access system. A method according to the present invention comprises removing blood from a body, using an analyte sensor to measure an analyte in the removed blood, and infusing at least a portion of the removed blood back into the body. The use of a non-contact sensor with a closed system creates a system will minimal infection risk.
摘要翻译：本发明包括可以提供葡萄糖和其他分析物与各种传感器的测量而不是常规方法的许多性能降级问题的方法和装置。根据本发明的装置包括一个血液存取系统，适用于从体内去除血液，并将至少一部分去除的血液注入体内。这种装置还包括安装有血液存取系统的分析物传感器，使得分析物传感器测量已经通过血液存取系统从体内除去的血液中的分析物。根据本发明的方法包括从身体去除血液，使用分析物传感器来测量去除的血液中的分析物，并将至少一部分去除的血液输入体内。使用具有封闭系统的非接触式传感器创建的系统将会最小的感染风险。

6. 发明申请

US20090048535A1 Detecting Cross-contamination in Blood Measurements with a Multilumen Catheter 审中-公开
标题翻译：用多次导管检测血液测量中的交叉污染
公开(公告)号：US20090048535A1
公开(公告)日：2009-02-19
申请号：US11860545
申请日：2007-09-25
申请人： Mark Ries Robinson , Mike Borrello , John O'Mahony , Richard Thompson , V. Gerald Grafe
发明人： Mark Ries Robinson , Mike Borrello , John O'Mahony , Richard Thompson , V. Gerald Grafe
IPC分类号： A61B5/155
CPC分类号： A61B5/150961 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/155 , A61B5/157
摘要： The present invention comprises methods and apparatuses that can provide accurate measurement of glucose or other analytes from a multilumen catheter in the presence of infusion of substances, including glucose. Examples of “multilumen catheters” include central venous catheters having multiple lumens, midline catheters having multiple lumens, multiple catheters configured or emplaced such that their lumens are in proximity to each other, and, in the case of indwelling analyte sensors, a catheter with a lumen for infusion and an indwelling sensor spaced apart from the infusion lumen. For blood withdrawal, anti-cross contamination controls can prevent the entrainment of blood which might be contaminated with feeding fluids or medications that are administered through other lumens within the catheter and in proximity of the blood sampling port. Cross contamination can occur under various situations, and is known to occur when the patient is connected to a ventilator. The ventilator cyclically raises the intra-thoracic pressure and diminishes blood flow rate in the central veins returning to the heart. The diminished flow can increase the chances for cross-contamination when additional lumens are introducing fluids during a draw sample.
摘要翻译：本发明包括在存在输入物质（包括葡萄糖）的情况下可以提供来自多腔导管的葡萄糖或其它分析物的精确测量的方法和装置。 “多腔导管”的实例包括具有多个内腔的中心静脉导管，具有多个腔的中线导管，多个导管被配置或放置成使得它们的内腔彼此靠近，并且在留置分析物传感器的情况下，用于输注的内腔和与输液腔间隔开的留置传感器。为了取血，反交叉污染控制可以防止可能被导管内和在血液采样端口附近通过其他管腔给药液体或药物而被污染的血液夹带。交叉污染可以在各种情况下发生，并且已知当患者连接到通气机时发生交叉污染。呼吸机周期性地升高胸腔内压，并减少返回心脏的中央静脉血流量。减少的流量可以增加在抽取样品期间附加管腔引入流体时交叉污染的机会。

7. 发明申请

US20070244382A1 Blood Analyte Determinations 审中-公开
标题翻译：血液分析物测定
公开(公告)号：US20070244382A1
公开(公告)日：2007-10-18
申请号：US11679839
申请日：2007-02-28
申请人： Mark Ries Robinson , Mike Borrello , Richard Thompson , Stephen Vanslyke , Steve Bernard , John O'Mahony
发明人： Mark Ries Robinson , Mike Borrello , Richard Thompson , Stephen Vanslyke , Steve Bernard , John O'Mahony
IPC分类号： A61B5/157
CPC分类号： A61B5/150961 , A61B5/14532 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150366 , A61B5/150992 , A61B5/153 , A61B5/155 , A61M1/1692 , A61M1/34 , A61M1/3621 , A61M1/3639 , A61M1/3663 , A61M5/16831 , A61M2005/1404 , A61M2205/3306 , A61M2205/331 , A61M2205/3331 , A61M2205/3334 , A61M2230/201
摘要： The present invention comprises methods and apparatuses that can provide measurement of glucose and other analytes with a variety of sensors without many of the performance-degrading problems of conventional approaches. An apparatus according to the present invention comprises a blood access system, adapted to remove blood from a body and infuse at least a portion of the removed blood back into the body. Such an apparatus also comprises an analyte sensor, mounted with the blood access system such that the analyte sensor measures the analyte in the blood that has been removed from the body by the blood access system. A method according to the present invention comprises removing blood from a body, using an analyte sensor to measure an analyte in the removed blood, and infusing at least a portion of the removed blood back into the body. The use of a non-contact sensor with a closed system creates a system will minimal infection risk.
摘要翻译：本发明包括可以提供葡萄糖和其他分析物与各种传感器的测量而不是常规方法的许多性能降级问题的方法和装置。根据本发明的装置包括血液存取系统，其适于从身体去除血液并且将至少一部分去除的血液注入体内。这种装置还包括安装有血液存取系统的分析物传感器，使得分析物传感器测量已经通过血液存取系统从体内除去的血液中的分析物。根据本发明的方法包括从身体去除血液，使用分析物传感器来测量去除的血液中的分析物，并将至少一部分去除的血液输入体内。使用具有封闭系统的非接触式传感器创建的系统将会最小的感染风险。

8. 发明申请

US20100094113A1 HEMODYNAMIC MONITORING DURING AUTOMATED MEASUREMENT OF BLOOD CONSTITUENTS 审中-公开
标题翻译：血液自动测量期间的血液动力学监测
公开(公告)号：US20100094113A1
公开(公告)日：2010-04-15
申请号：US12576121
申请日：2009-10-08
申请人： Mark Ries Robinson , Mike Borrello , William R. Patterson
发明人： Mark Ries Robinson , Mike Borrello , William R. Patterson
IPC分类号： A61B5/1473 , A61B5/02 , A61B5/021
CPC分类号： A61B5/0215 , A61B5/14532 , A61B5/14546
摘要： The present invention provides methods and apparatuses that can provide measurement of analytes such as glucose with a variety of sensors in connection with hemodynamic monitoring. Some embodiments of the present invention enable the use of a single arterial access site for automated blood glucose measurement as well as hemodynamic monitoring. Some embodiments of the present invention can reduce or eliminate nuisance hemodynamic alarms. Some embodiments of the present invention can provide hemodynamic monitoring during an automated analyte measurement process. An example apparatus according to the present invention comprises a blood access system, adapted to remove blood from a body and infuse at least a portion of the blood back into the body. Such an apparatus also comprises an analyte sensor, mounted with or integrated into the blood access system such that the analyte sensor measures the analyte in the blood that has been removed from the body by the blood access system.
摘要翻译：本发明提供了可以提供诸如葡萄糖等分析物与血液动力学监测相结合的各种传感器的测量方法和装置。本发明的一些实施例使得能够使用单个动脉进入部位进行自动血糖测量以及血液动力学监测。本发明的一些实施例可以减少或消除麻烦的血液动力学警报。本发明的一些实施方案可以在自动分析物测量过程中提供血液动力学监测。根据本发明的示例性装置包括血液存取系统，其适于从身体去除血液并将至少一部分血液注入体内。这样的装置还包括安装有或集成到血液存取系统中的分析物传感器，使得分析物传感器测量血液中已被血液存取系统从体内除去的分析物。

9. 发明申请

US20070244381A1 Blood Analyte Determinations 审中-公开
公开(公告)号：US20070244381A1
公开(公告)日：2007-10-18
申请号：US11679826
申请日：2007-02-27
申请人： Mark Ries Robinson , Mike Borrello , Richard Thompson , Stephen Vanslyke , Steve Bernard , John O'Mahony
发明人： Mark Ries Robinson , Mike Borrello , Richard Thompson , Stephen Vanslyke , Steve Bernard , John O'Mahony
IPC分类号： A61B5/157
CPC分类号： A61B5/150961 , A61B5/14532 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150366 , A61B5/150992 , A61B5/153 , A61B5/155 , A61M1/1692 , A61M1/34 , A61M1/3621 , A61M1/3639 , A61M1/3663 , A61M5/16831 , A61M2005/1404 , A61M2205/3306 , A61M2205/331 , A61M2205/3331 , A61M2205/3334 , A61M2230/201
摘要： The present invention comprises methods and apparatuses that can provide measurement of glucose and other analytes with a variety of sensors without many of the performance-degrading problems of conventional approaches. An apparatus according to the present invention comprises a blood access system, adapted to remove blood from a body and infuse at least a portion of the removed blood back into the body. Such an apparatus also comprises an analyte sensor, mounted with the blood access system such that the analyte sensor measures the analyte in the blood that has been removed from the body by the blood access system. A method according to the present invention comprises removing blood from a body, using an analyte sensor to measure an analyte in the removed blood, and infusing at least a portion of the removed blood back into the body. The use of a non-contact sensor with a closed system creates a system will minimal infection risk.

10. 发明申请

US20090054754A1 CLINICIAN-CONTROLLED SEMI-AUTOMATED MEDICATION MANAGEMENT 审中-公开
标题翻译：临床控制的半自动药物管理
公开(公告)号：US20090054754A1
公开(公告)日：2009-02-26
申请号：US12188205
申请日：2008-08-08
申请人： Dave McMahon , Mark Ries Robinson , Mike Borrello , Richard Thompson , Shonn Hendee
发明人： Dave McMahon , Mark Ries Robinson , Mike Borrello , Richard Thompson , Shonn Hendee
IPC分类号： A61B5/145 , A61M5/00
CPC分类号： A61M5/1723 , A61M2005/14296 , A61M2230/201 , G06F19/3468
摘要： The present invention is directed to methods and apparatuses of medication management based upon active authorization of medication infusion by a clinician that can provide for effective management of an analyte in a patient's blood, reducing the opportunities for human error common with current manual systems while still placing final control of the medication management with the human clinician. For example, a semi-automated glucose management system can measure the glucose level in a patient's blood, recommend infusion parameters to a clinician who can authorize an infusion of glucose or insulin, and infuse the glucose or insulin into the patient.
摘要翻译：本发明涉及药物治疗方法和装置，其基于临床医生的药物输注的主动授权，其可以提供对患者血液中的分析物的有效管理，减少与当前手动系统共同的人为错误的机会，同时仍然放置最终控制用药管理与人体临床医师。例如，半自动葡萄糖管理系统可以测量患者血液中的葡萄糖水平，向可以授权输注葡萄糖或胰岛素的临床医生推荐输注参数，并将葡萄糖或胰岛素注入患者体内。

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