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1. 发明申请

US20120065482A1 DETERMINATION OF BLOOD PUMP SYSTEM PERFORMANCE AND SAMPLE DILUTION USING A PROPERTY OF FLUID BEING TRANSPORTED 审中-公开
标题翻译：使用流体输送物质确定血液泵系统性能和样品浓度
公开(公告)号：US20120065482A1
公开(公告)日：2012-03-15
申请号：US13193602
申请日：2011-07-29
申请人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Dan Welsh , Steve Bernard , John O'Mahony , Dave McMahon , Victor Gerald Grafe , Dave Tobler , William R. Patterson , Donald W. Landry , James H. Macemon , Russell Abbink
发明人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Dan Welsh , Steve Bernard , John O'Mahony , Dave McMahon , Victor Gerald Grafe , Dave Tobler , William R. Patterson , Donald W. Landry , James H. Macemon , Russell Abbink
IPC分类号： A61B5/145
CPC分类号： A61B5/150221 , A61B5/0215 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61M2005/1588 , A61M2039/0009
摘要： The present invention provides methods and apparatuses related to measurement of analytes, including measurements of analytes in samples withdrawn from a patient.
摘要翻译：本发明提供了与分析物的测量相关的方法和装置，包括从患者抽出的样品中的分析物的测量。

2. 发明申请

US20100168535A1 METHODS AND APPARATUSES RELATED TO BLOOD ANALYTE MEASUREMENT SYSTEM 审中-公开
标题翻译：与血液分析仪测量系统相关的方法和装置
公开(公告)号：US20100168535A1
公开(公告)日：2010-07-01
申请号：US12714100
申请日：2010-02-26
申请人： Mark Ries Robinson , William R. Patterson , Richard P. Thompson , Shonn Hendee , James H. Macemon
发明人： Mark Ries Robinson , William R. Patterson , Richard P. Thompson , Shonn Hendee , James H. Macemon
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150992 , A61B5/153 , A61M5/16831 , A61M2005/1404 , A61M2205/3306 , A61M2205/331 , A61M2230/201
摘要： The present invention relates to a blood analyte measurement system for the procurement of blood samples for measurement of blood properties such as analyte concentration or analyte presence. A blood access system can be coupled with a measurement system such as an electrochemical sensor, and can also be used with other measurement modalities. Embodiments of the present invention can facilitate accurate measurement of blood glucose by the clinician in a sterile manner. Embodiments of the present invention can also enable the calibration of the sensor at one or more calibration points. One desired analyte of measurement is glucose for the effective implementation of glycemic control protocols. Embodiments of the present invention can also be used for the measurement of other analytes such as arterial blood gases, lactate, hemoglobin, potassium and urea. Additionally, embodiments of the present invention can function effectively on a variety of blood access points and specifically enables glucose monitoring in an existing arterial line that is already in place for hemodynamic monitoring. The present invention does not consume a significant amount of blood. Some embodiments of the present invention can re-infuse the blood into the patient, which can facilitate operation of the system in a sterile manner.
摘要翻译：本发明涉及一种用于血液分析物测量系统，用于采血用于测量血液特性如分析物浓度或分析物存在。血液存取系统可以与诸如电化学传感器的测量系统耦合，并且还可以与其它测量模式一起使用。本发明的实施方案可以促进临床医生以无菌方式精确测量血糖。本发明的实施例还可以实现在一个或多个校准点处的传感器的校准。一个期望的测量分析物是用于有效实施血糖控制方案的葡萄糖。本发明的实施方案也可用于测量其它分析物，例如动脉血气，乳酸，血红蛋白，钾和尿素。此外，本发明的实施例可以有效地在各种血液接入点上起作用，并且具体地实现已经存在于用于血液动力学监测的现有动脉管线中的葡萄糖监测。本发明不消耗大量的血液。本发明的一些实施例可以将血液重新注入患者体内，这可以以无菌的方式促进系统的操作。

3. 再颁专利

USRE30712E System and apparatus for contour plotting the total luminescence spectrum of a sample 失效
标题翻译：用于轮廓绘制样品总发光光谱的系统和装置
公开(公告)号：USRE30712E
公开(公告)日：1981-08-18
申请号：US45420
申请日：1979-06-04
申请人： James H. Macemon
发明人： James H. Macemon
IPC分类号： G01J3/44
CPC分类号： G01J3/4406
摘要： A system for plotting the total luminescence spectrum of a sample comprises a spectrofluorometer including excitation and emission monochromator stages having operating wavelengths dependent on applied stepping pulses, and an X-Y plotter having a marking pen synchronized for movement along X and Y axis with changes in the wavelengths of the monochromators. A control circuit generates pulses to incrementally step the emission monochromator and horizontally scan the marking pen. A level detection circuit monitors the output of the spectroflourometer and activates the pen upon attainment of a desired contour level. Limit circuitry incorporated in the control circuit momentarily actuates the excitation monochromator following each horizontal scan to increase the excitation wavelength for the subsequent emission scan to complete the plot.

4. 发明授权

US4090789A Cuvette positioning device for optical analytical apparatus 失效
标题翻译：用于光学分析仪器的比色杯定位装置
公开(公告)号：US4090789A
公开(公告)日：1978-05-23
申请号：US702473
申请日：1976-07-06
申请人： James H. Macemon , Charles Soodak
发明人： James H. Macemon , Charles Soodak
IPC分类号： G01N21/13 , G01N21/25 , G01J3/30
CPC分类号： G01N21/253 , G01N2201/0415
摘要： Cuvette positioning apparatus for use in a spectrophotometer adapted for comparing first and second material samples includes a carrier in which cuvettes to be alternately analyzed are arranged end-to-end. The carrier is reciprocated along a vertical axis to expose the cuvettes in alternation to the monochromatic beam of the apparatus. The rate of reciprocation is selected to avoid cavitation of the samples, and a sinusoidal drive arrangement increases the exposure time of the samples to the light beam and minimizes transit time for optimum measurement efficiency. Circuitry responsive to synchronizing signals derived from the drive arrangement is utilized to form an output signal indicative of the difference in measured characteristics between the samples.
摘要翻译：用于比较第一和第二材料样品的分光光度计中的比色杯定位装置包括载体，其中交替分析的比色杯端对端地排列。载体沿着垂直轴线往复运动，以使试管与设备的单色光束交替地暴露。选择往复运动的速率以避免样品的气蚀，并且正弦驱动装置增加了样品对光束的曝光时间，并将传播时间最小化以获得最佳的测量效率。利用响应于从驱动装置导出的同步信号的电路来形成指示样本之间的测量特性差异的输出信号。

5. 发明授权

US06969419B1 Method for removing gas bubbles from a fluid-containing chamber 有权
标题翻译：从流体容纳室除去气泡的方法
公开(公告)号：US06969419B1
公开(公告)日：2005-11-29
申请号：US10474101
申请日：2000-05-05
申请人： James H. Macemon
发明人： James H. Macemon
IPC分类号： B01D19/00 , B01D19/02
CPC分类号： B01D19/0005
摘要： A method for removing bubbles adhering to the interior wall of a fluid-filled chamber through which a fluid flows, and a related method and apparatus for removing bubbles from a chamber having medical sensory equipment such as a blood gas and chemistry analyzer. The method includes drawing a quantity of gas into the chamber to empty the chamber of fluid, maintaining the chamber in an empty state for a predetermined period of time, and then refilling the chamber with fluid at a rate low enough to remove remaining bubbles and to prevent the formation and trapping of new bubbles within the chamber.
摘要翻译：用于去除附着在流体流过的流体填充室的内壁上的气泡的方法以及用于从具有诸如血液气体和化学分析仪的医学感觉设备的室中除去气泡的相关方法和装置。该方法包括将一定数量的气体抽入腔室以清空流体室，将腔室保持在空的状态一段预定的时间，然后以足够低的速率用流体重新填充腔室以除去剩余的气泡，并且防止在室内形成和捕获新的气泡。

6. 发明授权

US3967113A Wavelength-corrected spectrofluorometer 失效
标题翻译：波长校正分光荧光计
公开(公告)号：US3967113A
公开(公告)日：1976-06-29
申请号：US530053
申请日：1974-12-05
申请人： Charles Soodak , James H. Macemon
发明人： Charles Soodak , James H. Macemon
IPC分类号： G01J3/443 , G01J3/44 , G01N21/64 , H01J39/12
CPC分类号： G01J3/4406
摘要： A spectrofluorometer providing wavelength correction by means of an arbitrary function generator driven by a wavelength scanning element of the spectrofluorometer. The arbitrary function generator may be driven by the emission scanning monochromator to derive a wavelength-dependent voltage signal which is combined with the measure photomultiplier output to thereby provide a base-line compensated resultant output signal. Alternatively, the arbitrary function generator may be driven by the excitation scanning monochromator to derive a wavelength-dependent voltage signal which is combined with the output of a reference photomultiplier tube receiving part of the output of the excitation monochromator to derive an excitation-corrected reference signal which is in turn combined with the measure photomultiplier tube output signal to thereby provide an energy-corrected resultant output signal. An analog divider may be employed to divide this last-named resultant output signal by said excitation wavelength-dependent voltage signal to thereby derive a quantum-corrected fluorescence emission output signal. The arbitrary function generator has successive incremental wavelength range segments provided respectively with independently adjustable potentiometers to suitably shape the wavelength-dependent voltage signal curve.
摘要翻译：一种分光荧光计，其通过由分光荧光计的波长扫描元件驱动的任意函数发生器提供波长校正。任意函数发生器可以由发射扫描单色仪驱动，以导出与测量光电倍增管输出组合的波长相关电压信号，从而提供基线补偿的合成输出信号。或者，可以由激励扫描单色仪驱动任意函数发生器，以得到与波长相关的电压信号，该电压信号与接收激励单色仪输出的一部分的参考光电倍增管的输出相结合，以导出激励校正参考信号其结合测量光电倍增管输出信号，从而提供能量校正的结果输出信号。可以使用模拟分频器来将所述最终命名的合成输出信号除以所述激发波长相关电压信号，从而导出量子校正的荧光发射输出信号。任意函数发生器具有分别提供独立可调节的电位计的连续增量波长范围段，以适当地形成与波长相关的电压信号曲线。

7. 发明授权

US5511880A Method and apparatus for storing and mixing a plurality of fluids and body fluid sampling cartridge using same 失效
标题翻译：用于储存和混合使用其的多种流体和体液采样盒的方法和装置
公开(公告)号：US5511880A
公开(公告)日：1996-04-30
申请号：US312766
申请日：1994-09-27
申请人： James H. Macemon
发明人： James H. Macemon
IPC分类号： B01F9/00 , B01F11/00 , B01L9/06
CPC分类号： B01F9/002 , B01F11/0002 , B01L9/06
摘要： A mixing device includes a plurality of elongated ampules mounted on a rotatable support with the longitudinal axis of each ampule inclined inwardly toward the rotational axis of the rotatable support. When the mixing device rotates about the rotational support, centrifugal force causes fluid in each ampule to move toward the end farthest away from the rotatable support. A bubble in each ampule then moves toward the opposite end. In one embodiment, the rotational support is inclined so that the end of each ampule positioned farthest from the rotational support is positioned sufficiently above the other end so that the bubble rises to the end farther from the support in at least one position as the support rotates. As a result, a bubble in each ampule moves back and forth between the ends of the ampule as the rotatable support rotates to mix respective fluids in the ampules. In another embodiment, the ampules are pivotably mounted on the elongated support so that opposite ends are alternately positioned farthest from the support, thereby causing a bubble to move back and forth in each ampule. A chamber for collecting a blood sampling may be positioned on the rotatable support for subsequent analysis by an analysis machine that uses the fluids in the ampules for calibrating and washing purposes.
摘要翻译：混合装置包括安装在可旋转支撑件上的多个细长安瓿，每个安瓿的纵向轴线朝向可旋转支撑件的旋转轴线向内倾斜。当混合装置围绕旋转支撑件旋转时，离心力使得每个安瓿中的流体朝向远离可旋转支撑件最远的一端移动。每个安瓿中的气泡然后向另一端移动。在一个实施例中，旋转支撑件是倾斜的，使得位于最远离旋转支撑件的每个安瓿的端部被充分地定位在另一端的上方，使得当支撑件旋转时，气泡在至少一个位置中从支撑件上升到更远的一端。结果，随着可旋转支撑件旋转以混合安瓿中的各个流体，每个安瓿中的气泡在安瓿的端部之间来回移动。在另一个实施例中，安瓿可枢转地安装在细长支撑件上，使得相对的端部交替地定位成离支撑件最远，从而使气泡在每个安瓿中来回移动。用于收集血液取样的腔室可以定位在可旋转的支撑件上，以便由使用安瓿中的流体进行校准和洗涤目的的分析机进行随后的分析。

8. 发明授权

US5143084A Disposable cartridge for sampling and analyzing body fluids 失效
标题翻译：用于取样和分析体液的一次性药筒
公开(公告)号：US5143084A
公开(公告)日：1992-09-01
申请号：US615747
申请日：1990-11-16
申请人： James H. Macemon , Mark S. Schlosser
发明人： James H. Macemon , Mark S. Schlosser
IPC分类号： A61B5/15 , A61B5/155 , B01L3/14
CPC分类号： B01L3/5082 , A61B5/15003 , A61B5/150236 , A61B5/153 , A61B5/157 , A61B5/150251 , A61B5/150259 , A61B5/150389 , A61B5/150473 , A61B5/150503
摘要： A disposable sampling cartridge for use with a blood sample analyzer. The cartridge includes a blood reservoir communicating with a hypodermic needle, a waste collection chamber adapted to receive waste fluids from the blood sample analyzer, and a plurality of ampules each containing a respective analyzing fluid adapted for use by the blood sample analyzer. Each of the ampules contain a piston, and the analyzing fluids in the ampules are expelled by forcing an actuating rod through a frangible wall of the ampule to displace the piston. In one embodiment, the analyzing fluids are withdrawn through a conduit in the actuating rod while the blood and spent analyzing fluids flow through the blood reservoir port on which the hypodermic needle is mounted. In another embodiment the waste fluid flows through an inlet port while the analyzing fluids from the ampules flow through a common port outlet port which selectively communicates with the blood reservoir and the ampules by a valve arrangement.
摘要翻译：用于血液样本分析仪的一次性取样盒。药筒包括与皮下注射针连通的血液储存器，适于接收来自血液样本分析器的废液的废物收集室，以及多个安瓿，每个安瓿含有适于由血液样本分析仪使用的各自的分析流体。每个安瓿都包含一个活塞，并且安瓿中的分析流体通过迫使致动杆穿过安瓿的易碎壁来移动活塞而排出。在一个实施例中，分析流体通过致动杆中的导管被抽出，同时血液和废分析流体流过其上安装有皮下注射针的血液储存口。在另一个实施方案中，废液流过入口，而来自安瓿的分析流体流过公共端口出口，其通过阀装置选择性地与血液储存器和安瓿连通。

9. 外观设计

USD247226S Spectrophotofluorometer 失效
公开(公告)号：USD247226S
公开(公告)日：1978-02-14
申请号：US689436
申请日：1976-05-24
申请人： James G. Bruni , Stephen G. Hauser , David L. Lessner , James H. Macemon
设计人： James G. Bruni , Stephen G. Hauser , David L. Lessner , James H. Macemon

10. 发明授权

US4105967A Automatic range selection circuit 失效
标题翻译：自动量程选择电路
公开(公告)号：US4105967A
公开(公告)日：1978-08-08
申请号：US728689
申请日：1976-10-01
申请人： James H. Macemon
发明人： James H. Macemon
IPC分类号： G01R15/09 , G01R15/08 , G01J3/30 , H03F1/36
CPC分类号： G01R15/09
摘要： The automatic range selection circuit is particularly useful with a photomultiplier tube linear microphotometer and includes an amplifier, adjustable and switchable impedances coupled between an input and an output of the amplifier for adjusting the gain thereof, two comparators for comparing the output from the amplifier with upper and lower reference voltage levels, an integrator for integrating the output of the comparators, and an analog control circuit responsive to the output signal level at the output of the integrator for controlling the amount of impedance coupled between the input and output of the amplifier thereby to automatically adjust the gain thereof.
摘要翻译：自动量程选择电路对于光电倍增管线性微光度计特别有用，并且包括放大器，耦合在用于调节其增益的放大器的输入和输出之间的可调节和可切换阻抗，两个比较器，用于将来自放大器的输出与上和较低的参考电压电平，用于对比较器的输出进行积分的积分器和响应于积分器输出处的输出信号电平的模拟控制电路，用于控制耦合在放大器的输入和输出之间的阻抗量，从而自动调整其增益。

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