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1. 发明申请

US20120065482A1 DETERMINATION OF BLOOD PUMP SYSTEM PERFORMANCE AND SAMPLE DILUTION USING A PROPERTY OF FLUID BEING TRANSPORTED 审中-公开
标题翻译：使用流体输送物质确定血液泵系统性能和样品浓度
公开(公告)号：US20120065482A1
公开(公告)日：2012-03-15
申请号：US13193602
申请日：2011-07-29
申请人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Dan Welsh , Steve Bernard , John O'Mahony , Dave McMahon , Victor Gerald Grafe , Dave Tobler , William R. Patterson , Donald W. Landry , James H. Macemon , Russell Abbink
发明人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Dan Welsh , Steve Bernard , John O'Mahony , Dave McMahon , Victor Gerald Grafe , Dave Tobler , William R. Patterson , Donald W. Landry , James H. Macemon , Russell Abbink
IPC分类号： A61B5/145
CPC分类号： A61B5/150221 , A61B5/0215 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61M2005/1588 , A61M2039/0009
摘要： The present invention provides methods and apparatuses related to measurement of analytes, including measurements of analytes in samples withdrawn from a patient.
摘要翻译：本发明提供了与分析物的测量相关的方法和装置，包括从患者抽出的样品中的分析物的测量。

2. 发明授权

US09969677B2 Histone acetyltransferase modulators and uses thereof 有权
公开(公告)号：US09969677B2
公开(公告)日：2018-05-15
申请号：US13996483
申请日：2011-12-22
申请人： Yitshak Francis , Mauro Fa , Ottavio Arancio , Jole Fiorito , Shixian Deng , Donald W. Landry , Michal Luzac , Yan Feng
发明人： Yitshak Francis , Mauro Fa , Ottavio Arancio , Jole Fiorito , Shixian Deng , Donald W. Landry , Michal Luzac , Yan Feng
IPC分类号： C07C217/22 , C07D209/48 , C07D295/088 , C07D265/14
CPC分类号： C07C217/22 , C07C217/58 , C07C235/60 , C07C235/64 , C07C251/24 , C07D209/48 , C07D265/14 , C07D265/36 , C07D295/088
摘要： The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.

3. 发明授权

US08710045B2 Agents for preventing and treating disorders involving modulation of the ryanodine receptors 有权
标题翻译：用于预防和治疗涉及调节兰诺定受体的疾病的药剂
公开(公告)号：US08710045B2
公开(公告)日：2014-04-29
申请号：US12938098
申请日：2010-11-02
申请人： Andrew Robert Marks , Donald W. Landry , Shixian Deng
发明人： Andrew Robert Marks , Donald W. Landry , Shixian Deng
IPC分类号： A61P9/00 , A61K31/553 , A61K31/554 , C07D281/02
CPC分类号： C07D281/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells.
摘要翻译：本发明提供式I化合物及其盐，水合物，溶剂合物，络合物和前药。本发明还提供了合成式I化合物的方法。本发明另外提供包含式I化合物的药物组合物和使用式I药物组合物的方法，以治疗和预防与调节钙的RyR受体相关的疾病和疾病通道在单元格中起作用。

4. 发明授权

US08685963B2 Compounds that inhibit NFκB and BACE1 activity 有权
标题翻译：抑制NF＆Kgr B和BACE1活性的化合物
公开(公告)号：US08685963B2
公开(公告)日：2014-04-01
申请号：US13094504
申请日：2011-04-26
申请人： Donald W. Landry , Shi Xian Deng , Gangli Gong , Yuli Xie , Yidong Liu , K. Alison Rinderspacher
发明人： Donald W. Landry , Shi Xian Deng , Gangli Gong , Yuli Xie , Yidong Liu , K. Alison Rinderspacher
IPC分类号： A61K31/54 , A01N43/42 , A61K31/47 , C07D215/36
CPC分类号： C07D215/40 , A61K31/47 , C07D401/12 , C07D409/12
摘要： The present invention relates to compounds with activity as BACE1 and NFκB modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease. The present invention is also directed to the treatment of diseases related to dysfunction of cell proliferation, the immune system and/or inflammation using such compounds or pharmaceutical compositions containing such candidate compounds.
摘要翻译：本发明涉及具有BACE1和NFκB调节剂活性的化合物，以及治疗，预防或改善神经变性疾病如阿尔茨海默氏病的方法。本发明还涉及使用这些化合物或包含这些候选化合物的药物组合物治疗与细胞增殖功能障碍，免疫系统和/或炎症有关的疾病。

5. 发明申请

US20120295853A1 NEURONAL PAIN PATHWAY 有权
标题翻译：神经痛痛途径
公开(公告)号：US20120295853A1
公开(公告)日：2012-11-22
申请号：US13569510
申请日：2012-08-08
申请人： Richard Ambron , Ying-Ju Sung , Donald W. Landry , Shi-Xian Deng
发明人： Richard Ambron , Ying-Ju Sung , Donald W. Landry , Shi-Xian Deng
IPC分类号： A61K31/55 , A61P25/00 , A61P25/04 , A61K38/02
CPC分类号： A61K38/06 , A61K9/0014 , A61K9/7023 , A61K31/352 , A61K31/4422 , A61K31/55 , A61K38/02 , A61K38/07 , A61K38/465 , A61K47/64 , C12N9/1205 , C12Y301/04017
摘要： The present invention relates to the discovery of a novel molecular pathway involved in long-term hyperexcitability of sensory neurons, which, in higher animals, is associated with persistent pain. It is based on the discovery that, following injury to an axon of a neuron, an increase in nitric oxide synthase activity results in increased nitric oxide production, which, in turn, activates guanylyl cyclase, thereby increasing levels of cGMP. Increased cGMP results in activation of protein kinase G (“PKG”), which then is retrogradely transported along the axon to the neuron cell body, where it phosphorylates MAPKerk.
摘要翻译：本发明涉及发现涉及感觉神经元的长期兴奋性的新型分子途径，其在高等动物中与持续性疼痛相关。基于这样的发现，在神经元轴突损伤之后，一氧化氮合酶活性的增加导致一氧化氮产生增加，这反过来激活鸟苷酸环化酶，从而增加cGMP的水平。增加的cGMP导致蛋白激酶G（PKG）的激活，其然后沿着轴突逆行转运到神经元细胞体，其中磷酸化MAPKerk。

6. 发明申请

US20110294800A1 HYPOGLYCEMIC DIHYDROPYRIDONES 有权
标题翻译：高分子二氢吡啶
公开(公告)号：US20110294800A1
公开(公告)日：2011-12-01
申请号：US13058142
申请日：2009-08-07
申请人： Yuli Xie , Shixian Deng , Donald W. Landry , Paul Harris , Antonella Maffei
发明人： Yuli Xie , Shixian Deng , Donald W. Landry , Paul Harris , Antonella Maffei
IPC分类号： A61K31/4418 , C07D211/46 , C07D455/06 , C07D413/14 , C07D309/32 , A61P3/08 , A61K31/451 , A61K31/473 , A61K31/5377 , A61K31/366 , A61P3/10 , C07D211/86 , C07D211/76
CPC分类号： C07D211/94 , C07D211/76 , C07D211/88 , C07D309/32 , C07D471/04
摘要： The present invention provides, inter alia, a compound of formula I: wherein the substituent designations are indicated in the Specification. The present invention also provides pharmaceutical compositions comprising a compound of formula I, and methods of treatment or prevention of diabetes or hyperglycemia in a patient, and of normalizing blood glucose levels in a subject, by administering an effective amount of a compound of formula I.
摘要翻译：本发明尤其提供式I化合物：其中取代基名称在说明书中指出。本发明还提供了包含式I化合物的药物组合物，以及通过施用有效量的式I化合物来治疗或预防患者中的糖尿病或高血糖并使受试者血糖水平正常化的方法。

7. 发明申请

US20110142816A1 THERMOSTABILIZATION OF PROTEINS 失效
标题翻译：蛋白质的热稳定性
公开(公告)号：US20110142816A1
公开(公告)日：2011-06-16
申请号：US12667895
申请日：2008-07-10
申请人： Donald W. Landry , James H. Woods , Roger K. Sunahara , Diwahar L. Narasimhan , Joanne MacDonald , Milan N. Stojanovich , John J. Tesmer , Remy L. Brim
发明人： Donald W. Landry , James H. Woods , Roger K. Sunahara , Diwahar L. Narasimhan , Joanne MacDonald , Milan N. Stojanovich , John J. Tesmer , Remy L. Brim
IPC分类号： A61K38/46 , C12N9/96 , C12Q1/44 , A61K31/7088 , C07H21/00 , A61P25/30
CPC分类号： A61K38/465 , A61K9/0019 , A61K31/505 , A61K45/06 , A61K47/12 , A61K47/18 , A61K47/22 , A61K47/542 , A61K47/545 , A61K47/60 , C12N9/18 , C12Q1/44 , C12Y301/01084 , G01N2333/918 , A61K2300/00
摘要： Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal under-going a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition.
摘要翻译：提供了包含可卡因酯酶（CocE）和使CocE稳定化合物的组合物。还提供了热稳定可卡因酯酶的方法。另外提供了治疗可卡因诱导病症的哺乳动物的方法。还提供了确定化合物是否是蛋白质的热稳定剂的方法。另外提供了上述用于治疗可卡因诱导病症的组合物的用途。另外提供了编码具有取代L169K和G173Q的CocE多肽和由该核酸编码的CocE多肽的分离的核酸及其药物组合物。还提供了该组合物用于制备用于治疗可卡因诱导的病症和用于治疗可卡因诱导病症的药物的用途。

8. 发明授权

US07381531B2 Displacement assay for detection of small molecules 有权
公开(公告)号：US07381531B2
公开(公告)日：2008-06-03
申请号：US11123648
申请日：2005-05-06
申请人： Milan N. Stojanovic , Donald W. Landry
发明人： Milan N. Stojanovic , Donald W. Landry
IPC分类号： C12Q1/68
CPC分类号： G01N33/566 , Y10T436/143333
摘要： Complex of an anti-cocaine aptamer and the dye diethylthiotricarbocyanine behaves as a calorimetric sensor with attenuation in absorbance at 760 nm for cocaine in the concentration range of 2-5000 μM. Mechanistic studies indicate an intermolecular displacement of the dye as the mechanism of action of the sensor. As the dye is insoluble in buffer, cocaine binding can be detected as displaced dye precipitates and supernatant decolorizes.

9. 发明授权

US06280987B1 Anti-cocaine catalytic antibody 失效
标题翻译：抗可卡因催化抗体
公开(公告)号：US06280987B1
公开(公告)日：2001-08-28
申请号：US09214095
申请日：1999-07-19
申请人： Donald W. Landry
发明人： Donald W. Landry
IPC分类号： C12N900
CPC分类号： C12N9/0002 , A61K38/00
摘要： This invention provides a polypeptide comprising a light chain domain which comprises a complementarity determining region 1 having the amino acid sequence RSSXGTITXXNYAN (Seq ID No: 73), a complementarity determining region 2 having the amino acid sequence XNNYRPP (Seq ID No: 74) and a complementarity determining region 3 having the amino acid sequence ALWYSNHWV (Seq ID No: 75), interposed between appropriate framework regions, and linked to said light chain domain a heavy chain domain which comprises a complementarity determining region 1 having the amino acid sequence DYNMY (Seq ID No: 76), a complementarity determining region 2 having the amino acid sequence YIDPXNGXIFYNQKFXG (Seq ID No: 77) and a complementarity determining region 3 having the amino acid sequence GGGLFAX (Seq ID No: 78) interposed between appropriate framework regions, said polypeptide having a conformation suitable for degrading cocaine.
摘要翻译：本发明提供了包含轻链结构域的多肽，其包含具有氨基酸序列RSSXGTITXXNYAN（Seq ID No：73）的互补决定区域1，具有氨基酸序列XNNYRPP（Seq ID No：74）的互补决定区域2和具有氨基酸序列ALWYSNHWV（Seq ID No：75）的互补决定区3，插入在适当的框架区之间，并连接到所述轻链结构域，重链结构域包含具有氨基酸序列DYNMY的互补决定区1（ Seq ID No：76），具有氨基酸序列YIDPXNGXIFYNQKFXG（Seq ID No：77）的互补决定区域2和插入适当框架区域之间具有氨基酸序列GGGLFAX（Seq ID No：78）的互补决定区域3，所述多肽具有适于降解可卡因的构象。

10. 发明授权

US06184013B2 Catalytic antibodies against cocaine and methods of using and producing same 失效
标题翻译：针对可卡因的催化抗体及其使用和生产方法
公开(公告)号：US06184013B2
公开(公告)日：2001-02-06
申请号：US08313291
申请日：1994-10-03
申请人： Donald W. Landry , Kang Zhao
发明人： Donald W. Landry , Kang Zhao
IPC分类号： C07K1600
CPC分类号： C07D451/02 , A61K38/00 , A61K47/6803 , C07F9/6561 , C07F9/657172 , C07F9/6584 , C07K16/44 , C12N9/0002
摘要： This invention provides compounds which are analogs to the hydrolysis transition-state of a cocaine benzoyl ester group. This invention also provides such analogs linked to carrier proteins, and antibodies thereto. This invention further provides pharmaceutical composition for decreasing concentration in a subject using the antibodies produced.
摘要翻译：本发明提供了类似于可卡因苯甲酰酯基的水解转变状态的化合物。本发明还提供了与载体蛋白质及其抗体连接的类似物。本发明还提供了使用所产生的抗体降低受试者浓度的药物组合物。

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