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1. 发明申请

US20120065482A1 DETERMINATION OF BLOOD PUMP SYSTEM PERFORMANCE AND SAMPLE DILUTION USING A PROPERTY OF FLUID BEING TRANSPORTED 审中-公开
标题翻译：使用流体输送物质确定血液泵系统性能和样品浓度
公开(公告)号：US20120065482A1
公开(公告)日：2012-03-15
申请号：US13193602
申请日：2011-07-29
申请人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Dan Welsh , Steve Bernard , John O'Mahony , Dave McMahon , Victor Gerald Grafe , Dave Tobler , William R. Patterson , Donald W. Landry , James H. Macemon , Russell Abbink
发明人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Dan Welsh , Steve Bernard , John O'Mahony , Dave McMahon , Victor Gerald Grafe , Dave Tobler , William R. Patterson , Donald W. Landry , James H. Macemon , Russell Abbink
IPC分类号： A61B5/145
CPC分类号： A61B5/150221 , A61B5/0215 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61M2005/1588 , A61M2039/0009
摘要： The present invention provides methods and apparatuses related to measurement of analytes, including measurements of analytes in samples withdrawn from a patient.
摘要翻译：本发明提供了与分析物的测量相关的方法和装置，包括从患者抽出的样品中的分析物的测量。

2. 发明申请

US20110060199A1 DETERMINATION OF BLOOD PUMP SYSTEM PERFORMANCE AND SAMPLE DILUTION USING A PROPERTY OF FLUID BEING TRANSPORTED 审中-公开
标题翻译：使用流体输送物质确定血液泵系统性能和样品浓度
公开(公告)号：US20110060199A1
公开(公告)日：2011-03-10
申请号：US12884175
申请日：2010-09-16
申请人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Greg Knipstein , Dan Welsh
发明人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Greg Knipstein , Dan Welsh
IPC分类号： A61B5/157
CPC分类号： A61B5/14557 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150946 , A61B5/150961 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M1/1692 , A61M1/34 , A61M1/341 , A61M1/3621 , A61M1/3639 , A61M1/3663 , A61M5/16831 , A61M2005/1404 , A61M2205/3306 , A61M2205/331 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2230/201
摘要： The use of an optical or other measurement in a blood access system enables the determination of a fluid sample appropriate for measurement on a real time basis. This information can be used to control the blood access system and related measurement processes. The determination can be based on, for example, at least one of: optical density, optical scatter, analyte level, temperature, the absolute level of any of the preceding, the stability of any of the preceding, the rate of change of any of the preceding, or the value of any of the preceding relative to another determination. The determination can be made using, for example, at least one of: electrochemical sensor, ion specific electrode, capacitance measurement, impedance measurement, inductance measurement, conductivity measurement, optical measurement, and ultrasound measurement. The present invention relates to determination of the quality of a biological sample in which determination of an analyte concentration is to be made, and various methods and apparatuses related thereto. An evaluation of sample quality can be made by monitoring the temporal changes in the sample properties or characteristics as the biological sample is procured or measured. The methods and apparatuses described herein can be used to evaluate the temporal characteristics of a sample during sample acquisition and/or during determination of the sample analyte or parameter of interest. The sample quality assurance methods and apparatuses described herein can thus be used to ensure that a valid sample has been procured by or presented to an instrument or measurement system for analyte determination, thereby preventing the measurement and reporting of analyte values for a sample that is unstable or otherwise non-representative of the biological system from which the sample was obtained.
摘要翻译：在血液存取系统中使用光学或其他测量能够实时地确定适于测量的流体样品。该信息可用于控制血液存取系统和相关测量过程。该测定可以基于例如光密度，光学散度，分析物水平，温度，前述任一项的绝对水平，前述任一项的稳定性，任何变化率前一个或前一个相对于另一个确定的任何值的值。可以使用例如电化学传感器，离子专用电极，电容测量，阻抗测量，电感测量，电导率测量，光学测量和超声测量中的至少一个来进行确定。本发明涉及要进行测定分析物浓度的生物样品的质量的确定以及与其相关的各种方法和装置。通过监测采购或测量生物样品的样品性质或特性的时间变化，可以对样品质量进行评估。本文描述的方法和装置可以用于在样品获取期间和/或在样品分析物或感兴趣的参数的确定期间评估样品的时间特征。因此，本文所述的样品质量保证方法和装置可以用于确保有效样品已经由用于分析物测定的仪器或测量系统获得或呈现给样品，从而防止对不稳定的样品的分析物值的测量和报告或以其他方式代表获得样品的生物系统。

3. 发明申请

US20090156975A1 Robust System and Methods for Blood Access 审中-公开
标题翻译：健壮的血液系统和方法
公开(公告)号：US20090156975A1
公开(公告)日：2009-06-18
申请号：US12325243
申请日：2008-11-30
申请人： Mark Ries Robinson , Mike Borrello , Dan Welsh
发明人： Mark Ries Robinson , Mike Borrello , Dan Welsh
IPC分类号： A61M1/14 , B01D65/02
CPC分类号： A61M1/3653 , A61B5/0215 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150946 , A61B5/150961 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3656 , A61M1/3659 , A61M2005/1588 , A61M2039/0009
摘要： Embodiments of the present invention provide robust systems for the removal and subsequent infusion of blood for measurement purposes, and embodiments of the present invention provide methods of operating such systems and providing capabilities such as predicting and avoiding occlusions and/or bubbles, managing occlusions and/or bubbles if they occur, automatic cleaning of the blood access system, and determining and managing the patency of the blood access site. Such operational challenges can occur during any of several phases of operation of a blood access system. Embodiments of the present invention can effectively incorporate a variety of inputs for the identification of trends consistent with present or pending occlusions. An embodiment of the present invention can be aware of the stage of operation, e.g., withdrawal, infusion, or cleaning, and the prior performance of the system. Embodiments of the present invention can have the ability to identify the location of the problem so that effective procedures can be used to resolve the problem.
摘要翻译：本发明的实施例提供用于去除和随后输注用于测量目的的血液的鲁棒系统，并且本发明的实施例提供了操作这样的系统并提供诸如预测和避免闭塞和/或气泡的能力的方法，管理闭塞和/ 如果发生气泡，自动清洗血液存取系统，以及确定和管理血液通道的通畅。这样的操作挑战可以在血液存取系统的几个操作阶段的任何阶段发生。本发明的实施例可以有效地结合用于识别与当前或未决遮挡一致的趋势的各种输入。本发明的实施例可以意识到操作的阶段，例如撤回，输注或清洁，以及系统的先前的执行。本发明的实施例可以具有识别问题的位置的能力，从而可以使用有效的过程来解决问题。

4. 发明授权

US07164130B2 Signal enhancement module 有权
标题翻译：信号增强模块
公开(公告)号：US07164130B2
公开(公告)日：2007-01-16
申请号：US10782730
申请日：2004-02-18
申请人： Dan Welsh , Joel Kindem , Michael Gurley , Richard L. Conwell
发明人： Dan Welsh , Joel Kindem , Michael Gurley , Richard L. Conwell
IPC分类号： G01T1/00
CPC分类号： G01T1/1647
摘要： Events of interest are detected within a gamma ray detection system. Characteristics of undesired signals, including a multiplicity of events within the signal, a density of events within the signal, and other aspects are determined. The signal is filtered based on its expected characteristics. A signal which does not have the expected characteristics is rejected, and an image is formed that excludes those rejected signals.
摘要翻译：在伽马射线检测系统内检测感兴趣的事件。确定不需要的信号的特征，包括信号内的多个事件，信号内事件的密度以及其他方面。信号根据其预期特性进行过滤。不具有期望特性的信号被拒绝，并且形成排除那些拒绝信号的图像。

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