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1. 发明申请

US20110060199A1 DETERMINATION OF BLOOD PUMP SYSTEM PERFORMANCE AND SAMPLE DILUTION USING A PROPERTY OF FLUID BEING TRANSPORTED 审中-公开
标题翻译：使用流体输送物质确定血液泵系统性能和样品浓度
公开(公告)号：US20110060199A1
公开(公告)日：2011-03-10
申请号：US12884175
申请日：2010-09-16
申请人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Greg Knipstein , Dan Welsh
发明人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Greg Knipstein , Dan Welsh
IPC分类号： A61B5/157
CPC分类号： A61B5/14557 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150946 , A61B5/150961 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M1/1692 , A61M1/34 , A61M1/341 , A61M1/3621 , A61M1/3639 , A61M1/3663 , A61M5/16831 , A61M2005/1404 , A61M2205/3306 , A61M2205/331 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2230/201
摘要： The use of an optical or other measurement in a blood access system enables the determination of a fluid sample appropriate for measurement on a real time basis. This information can be used to control the blood access system and related measurement processes. The determination can be based on, for example, at least one of: optical density, optical scatter, analyte level, temperature, the absolute level of any of the preceding, the stability of any of the preceding, the rate of change of any of the preceding, or the value of any of the preceding relative to another determination. The determination can be made using, for example, at least one of: electrochemical sensor, ion specific electrode, capacitance measurement, impedance measurement, inductance measurement, conductivity measurement, optical measurement, and ultrasound measurement. The present invention relates to determination of the quality of a biological sample in which determination of an analyte concentration is to be made, and various methods and apparatuses related thereto. An evaluation of sample quality can be made by monitoring the temporal changes in the sample properties or characteristics as the biological sample is procured or measured. The methods and apparatuses described herein can be used to evaluate the temporal characteristics of a sample during sample acquisition and/or during determination of the sample analyte or parameter of interest. The sample quality assurance methods and apparatuses described herein can thus be used to ensure that a valid sample has been procured by or presented to an instrument or measurement system for analyte determination, thereby preventing the measurement and reporting of analyte values for a sample that is unstable or otherwise non-representative of the biological system from which the sample was obtained.
摘要翻译：在血液存取系统中使用光学或其他测量能够实时地确定适于测量的流体样品。该信息可用于控制血液存取系统和相关测量过程。该测定可以基于例如光密度，光学散度，分析物水平，温度，前述任一项的绝对水平，前述任一项的稳定性，任何变化率前一个或前一个相对于另一个确定的任何值的值。可以使用例如电化学传感器，离子专用电极，电容测量，阻抗测量，电感测量，电导率测量，光学测量和超声测量中的至少一个来进行确定。本发明涉及要进行测定分析物浓度的生物样品的质量的确定以及与其相关的各种方法和装置。通过监测采购或测量生物样品的样品性质或特性的时间变化，可以对样品质量进行评估。本文描述的方法和装置可以用于在样品获取期间和/或在样品分析物或感兴趣的参数的确定期间评估样品的时间特征。因此，本文所述的样品质量保证方法和装置可以用于确保有效样品已经由用于分析物测定的仪器或测量系统获得或呈现给样品，从而防止对不稳定的样品的分析物值的测量和报告或以其他方式代表获得样品的生物系统。

2. 发明申请

US20120065482A1 DETERMINATION OF BLOOD PUMP SYSTEM PERFORMANCE AND SAMPLE DILUTION USING A PROPERTY OF FLUID BEING TRANSPORTED 审中-公开
标题翻译：使用流体输送物质确定血液泵系统性能和样品浓度
公开(公告)号：US20120065482A1
公开(公告)日：2012-03-15
申请号：US13193602
申请日：2011-07-29
申请人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Dan Welsh , Steve Bernard , John O'Mahony , Dave McMahon , Victor Gerald Grafe , Dave Tobler , William R. Patterson , Donald W. Landry , James H. Macemon , Russell Abbink
发明人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Dan Welsh , Steve Bernard , John O'Mahony , Dave McMahon , Victor Gerald Grafe , Dave Tobler , William R. Patterson , Donald W. Landry , James H. Macemon , Russell Abbink
IPC分类号： A61B5/145
CPC分类号： A61B5/150221 , A61B5/0215 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61M2005/1588 , A61M2039/0009
摘要： The present invention provides methods and apparatuses related to measurement of analytes, including measurements of analytes in samples withdrawn from a patient.
摘要翻译：本发明提供了与分析物的测量相关的方法和装置，包括从患者抽出的样品中的分析物的测量。

3. 发明申请

US20090054754A1 CLINICIAN-CONTROLLED SEMI-AUTOMATED MEDICATION MANAGEMENT 审中-公开
标题翻译：临床控制的半自动药物管理
公开(公告)号：US20090054754A1
公开(公告)日：2009-02-26
申请号：US12188205
申请日：2008-08-08
申请人： Dave McMahon , Mark Ries Robinson , Mike Borrello , Richard Thompson , Shonn Hendee
发明人： Dave McMahon , Mark Ries Robinson , Mike Borrello , Richard Thompson , Shonn Hendee
IPC分类号： A61B5/145 , A61M5/00
CPC分类号： A61M5/1723 , A61M2005/14296 , A61M2230/201 , G06F19/3468
摘要： The present invention is directed to methods and apparatuses of medication management based upon active authorization of medication infusion by a clinician that can provide for effective management of an analyte in a patient's blood, reducing the opportunities for human error common with current manual systems while still placing final control of the medication management with the human clinician. For example, a semi-automated glucose management system can measure the glucose level in a patient's blood, recommend infusion parameters to a clinician who can authorize an infusion of glucose or insulin, and infuse the glucose or insulin into the patient.
摘要翻译：本发明涉及药物治疗方法和装置，其基于临床医生的药物输注的主动授权，其可以提供对患者血液中的分析物的有效管理，减少与当前手动系统共同的人为错误的机会，同时仍然放置最终控制用药管理与人体临床医师。例如，半自动葡萄糖管理系统可以测量患者血液中的葡萄糖水平，向可以授权输注葡萄糖或胰岛素的临床医生推荐输注参数，并将葡萄糖或胰岛素注入患者体内。

4. 发明申请

US20100168535A1 METHODS AND APPARATUSES RELATED TO BLOOD ANALYTE MEASUREMENT SYSTEM 审中-公开
标题翻译：与血液分析仪测量系统相关的方法和装置
公开(公告)号：US20100168535A1
公开(公告)日：2010-07-01
申请号：US12714100
申请日：2010-02-26
申请人： Mark Ries Robinson , William R. Patterson , Richard P. Thompson , Shonn Hendee , James H. Macemon
发明人： Mark Ries Robinson , William R. Patterson , Richard P. Thompson , Shonn Hendee , James H. Macemon
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150992 , A61B5/153 , A61M5/16831 , A61M2005/1404 , A61M2205/3306 , A61M2205/331 , A61M2230/201
摘要： The present invention relates to a blood analyte measurement system for the procurement of blood samples for measurement of blood properties such as analyte concentration or analyte presence. A blood access system can be coupled with a measurement system such as an electrochemical sensor, and can also be used with other measurement modalities. Embodiments of the present invention can facilitate accurate measurement of blood glucose by the clinician in a sterile manner. Embodiments of the present invention can also enable the calibration of the sensor at one or more calibration points. One desired analyte of measurement is glucose for the effective implementation of glycemic control protocols. Embodiments of the present invention can also be used for the measurement of other analytes such as arterial blood gases, lactate, hemoglobin, potassium and urea. Additionally, embodiments of the present invention can function effectively on a variety of blood access points and specifically enables glucose monitoring in an existing arterial line that is already in place for hemodynamic monitoring. The present invention does not consume a significant amount of blood. Some embodiments of the present invention can re-infuse the blood into the patient, which can facilitate operation of the system in a sterile manner.
摘要翻译：本发明涉及一种用于血液分析物测量系统，用于采血用于测量血液特性如分析物浓度或分析物存在。血液存取系统可以与诸如电化学传感器的测量系统耦合，并且还可以与其它测量模式一起使用。本发明的实施方案可以促进临床医生以无菌方式精确测量血糖。本发明的实施例还可以实现在一个或多个校准点处的传感器的校准。一个期望的测量分析物是用于有效实施血糖控制方案的葡萄糖。本发明的实施方案也可用于测量其它分析物，例如动脉血气，乳酸，血红蛋白，钾和尿素。此外，本发明的实施例可以有效地在各种血液接入点上起作用，并且具体地实现已经存在于用于血液动力学监测的现有动脉管线中的葡萄糖监测。本发明不消耗大量的血液。本发明的一些实施例可以将血液重新注入患者体内，这可以以无菌的方式促进系统的操作。

5. 发明申请

US20070142720A1 Apparatus and methods for mitigating the effects of foreign interferents on analyte measurements in spectroscopy 有权
标题翻译：用于减轻外来干扰物对光谱学中分析物测量的影响的装置和方法
公开(公告)号：US20070142720A1
公开(公告)日：2007-06-21
申请号：US11305964
申请日：2005-12-19
申请人： Trent Ridder , Shonn Hendee
发明人： Trent Ridder , Shonn Hendee
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/7264
摘要： The present invention includes apparatuses and methods for mitigating the effects of foreign interferents on analyte measurements. The present invention comprises several interferent mitigation steps. Examples include sample cleaning procedures, detection of the presence of interferents, determination of the identity of interferents, and modification or selection of a multivariate calibration model to mitigate the effects of one or more interferents on analyte measurements. The interferent mitigation steps of the present invention can be applied individually, and in some embodiments can be applied in combination. Some examples of relevant analyte measurements include the noninvasive determination of the presence or concentration of alcohol, glucose, urea, byproducts of alcohol metabolism, and substances of abuse.
摘要翻译：本发明包括用于减轻外来干扰物对分析物测量的影响的装置和方法。本发明包括几个干扰减轻步骤。实例包括样品清洗程序，检测干扰物的存在，确定干扰物的身份，以及修改或选择多变量校准模型以减轻一种或多种干扰物对分析物测量的影响。本发明的干扰减缓步骤可以单独应用，并且在一些实施方案中可以组合应用。相关分析物测量的一些实例包括无创测定酒精，葡萄糖，尿素，酒精代谢副产物和滥用物质的存在或浓度。

6. 发明授权

US07756558B2 Apparatus and methods for mitigating the effects of foreign interferents on analyte measurements in spectroscopy 有权
标题翻译：用于减轻外来干扰物对光谱学中分析物测量的影响的装置和方法
公开(公告)号：US07756558B2
公开(公告)日：2010-07-13
申请号：US11305964
申请日：2005-12-19
申请人： Trent Ridder , Shonn Hendee
发明人： Trent Ridder , Shonn Hendee
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/7264
摘要： The present invention includes apparatuses and methods for mitigating the effects of foreign interferents on analyte measurements. The present invention comprises several interferent mitigation steps. Examples include sample cleaning procedures, detection of the presence of interferents, determination of the identity of interferents, and modification or selection of a multivariate calibration model to mitigate the effects of one or more interferents on analyte measurements. The interferent mitigation steps of the present invention can be applied individually, and in some embodiments can be applied in combination. Some examples of relevant analyte measurements include the noninvasive determination of the presence or concentration of alcohol, glucose, urea, byproducts of alcohol metabolism, and substances of abuse.
摘要翻译：本发明包括用于减轻外来干扰物对分析物测量的影响的装置和方法。本发明包括几个干扰减轻步骤。实例包括样品清洗程序，检测干扰物的存在，确定干扰物的身份，以及修改或选择多变量校准模型以减轻一种或多种干扰物对分析物测量的影响。本发明的干扰减缓步骤可以单独应用，并且在一些实施方案中可以组合应用。相关分析物测量的一些实例包括无创测定酒精，葡萄糖，尿素，酒精代谢副产物和滥用物质的存在或浓度。

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