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1. 发明授权

US07490605B2 High efficiency liquid oxygen system 有权
标题翻译：高效液氧系统
公开(公告)号：US07490605B2
公开(公告)日：2009-02-17
申请号：US10658793
申请日：2003-09-10
申请人： Mark R. Frye , Leonardo S. Toma , Richard A. Davis
发明人： Mark R. Frye , Leonardo S. Toma , Richard A. Davis
IPC分类号： A62B7/06
CPC分类号： F17C7/02 , F17C2201/0114 , F17C2201/0119 , F17C2201/058 , F17C2203/0391 , F17C2205/0146 , F17C2205/0332 , F17C2221/011 , F17C2223/0123 , F17C2223/0153 , F17C2223/033 , F17C2250/043 , F17C2250/072 , F17C2270/025 , Y10S128/27
摘要： A high-efficiency liquid oxygen (LOX) storage/delivery system utilizes a portable LOX/delivery apparatus with a portable LOX container. A portable-unit LOX transfer connector is connected to the portable LOX container and is connectable to a main source of LOX in a primary reservoir LOX container. A portable-unit oxygen gas transfer connector is provided for transferring oxygen gas from the portable LOX container to an oxygen gas delivery device for delivering oxygen gas to a patient. An inter-unit oxygen gas transfer connector also is provided for connecting the portable apparatus to a stationary source of oxygen gas in the primary reservoir container, for transferring oxygen gas to the portable apparatus. A portable-unit primary relief valve is connected to the portable LOX container for venting oxygen gas out of the portable LOX container when pressure in the portable LOX container reaches a predetermined level.
摘要翻译：高效液氧（LOX）储存/输送系统利用便携式LOX /输送装置与便携式LOX容器。便携式单元LOX传输连接器连接到便携式LOX容器，并且可连接到主容器LOX容器中的主要LOX源。提供便携式氧气输送连接器，用于将氧气从便携式LOX容器转移到用于将氧气输送给患者的氧气输送装置。还提供一种单元间氧气传输连接器，用于将便携式设备连接到主储存容器中的固定的氧气源，用于将氧气输送到便携式设备。便携式主安全阀连接到便携式LOX容器，用于在便携式LOX容器中的压力达到预定水平时将氧气排出便携式LOX容器。

2. 发明授权

US06742517B1 High efficiency liquid oxygen system 有权
标题翻译：高效液氧系统
公开(公告)号：US06742517B1
公开(公告)日：2004-06-01
申请号：US09696170
申请日：2000-10-26
申请人： Mark R. Frye , Leonardo S. Toma , Richard A. Davis
发明人： Mark R. Frye , Leonardo S. Toma , Richard A. Davis
IPC分类号： A62B706
CPC分类号： F17C7/02 , F17C2201/0114 , F17C2201/0119 , F17C2201/058 , F17C2203/0391 , F17C2205/0146 , F17C2205/0332 , F17C2221/011 , F17C2223/0123 , F17C2223/0153 , F17C2223/033 , F17C2250/043 , F17C2250/072 , F17C2270/025 , Y10S128/27
摘要： A high-efficiency liquid oxygen, (LOX) storage/delivery system utilizes a portable LOX/delivery apparatus with a portable LOX container. A portable-unit LOX transfer connector is connected to the portable LOX container and is connectable to a main source of LOX in a primary reservoir LOX container. A portable-unit oxygen gas transfer connector is provided for transferring oxygen gas from the portable LOX container to an oxygen gas delivery device for delivering oxygen gas to a patient. An inter-unit oxygen gas transfer connector also is provided for connecting the portable apparatus to a stationary source of oxygen gas in the primary reservoir container, for transferring oxygen gas to the portable apparatus. A portable-unit primary relief valve is connected to the portable LOX container for venting oxygen gas out of the portable LOX container when pressure in the portable LOX container reaches a predetermined level. When the inter-unit oxygen gas transfer connector of the portable container is connected to the stationary source of oxygen in the primary reservoir container, oxygen gas can be transferred to the oxygen gas delivery device for delivery to the patient from the portable LOX container while oxygen gas is transferred to the portable container from the stationary source of gas in the primary reservoir LOX container.
摘要翻译：高效液氧（LOX）储存/输送系统利用便携式LOX /输送装置与便携式LOX容器。便携式单元LOX传输连接器连接到便携式LOX容器，并且可连接到主容器LOX容器中的主要LOX源。提供便携式氧气输送连接器，用于将氧气从便携式LOX容器转移到用于将氧气输送给患者的氧气输送装置。还提供一种单元间氧气传输连接器，用于将便携式设备连接到主储存容器中的固定的氧气源，用于将氧气输送到便携式设备。便携式主安全阀连接到便携式LOX容器，用于在便携式LOX容器中的压力达到预定水平时将氧气排出便携式LOX容器。当便携式容器的单元间氧气传输连接器连接到主储存容器中的固定的氧气源时，可以将氧气转移到氧气输送装置，以从便携式LOX容器输送到患者，同时氧气气体从主容器LOX容器中的固定气体源转移到便携式容器。

3. 发明授权

US6116242A Oxygen-conserving regulator assembly 失效
标题翻译：保氧调节器组件
公开(公告)号：US6116242A
公开(公告)日：2000-09-12
申请号：US849417
申请日：1997-04-28
申请人： Mark R. Frye , John R. Grenaway , Richard A. Davis , Douglas R. Leithauser
发明人： Mark R. Frye , John R. Grenaway , Richard A. Davis , Douglas R. Leithauser
IPC分类号： A61M16/00 , A61M16/06 , A61M16/20 , A62B9/02
CPC分类号： A61M16/00 , A61M16/0677 , A61M16/20 , A61M16/207 , A61M2016/0021 , A61M2202/03 , A61M2205/8225
摘要： An apparatus is provided for controlling discharge of oxygen from an oxygen supply source to a patient. The apparatus includes an oxygen supply inlet, a pressure regulator coupled to the oxygen supply inlet and configured to reduce pressure of oxygen received from the oxygen supply inlet to a selected magnitude, a flow controller coupled to the pressure regulator and configured to meter oxygen received from the pressure regulator at a selected flow rate, and an oxygen distribution assembly including a pneumatic demand oxygen valve and a conduit conducting oxygen discharged from the flow controller through the pressure regulator to the pneumatic demand oxygen valve for delivery to a patient. The flow controller includes a chamber and a rotary valve for splitting oxygen discharged from the chamber into a first stream in an oxygen supply passageway for use by a patient and a second stream in a diaphragm supply passageway for controlling operation of pneumatic demand oxygen valve.
摘要翻译： PCT No.PCT / US96 / 15549 Sec。 371日期1997年04月28日 102（e）1997年4月28日PCT PCT 1996年9月27日PCT公布。公开号WO97 / 11734 日期1997年4月3日提供了一种用于控制从氧供应源向患者排出氧气的装置。该设备包括氧气供应入口，压力调节器，其耦合到氧气供应入口并且被配置为将从氧气供应入口接收的氧气的压力降低到所选择的大小;流量控制器，耦合到压力调节器并且被配置为测量从所述压力调节器以选定的流速，以及氧气分配组件，其包括气动需求氧气阀和将从所述流量控制器通过所述压力调节器排出的氧的导管传送到气动需求氧气阀以递送给患者。流量控制器包括一个腔室和一个旋转阀，用于将从腔室排出的氧气分成氧气供应通道中的第一流，以供患者使用，并在隔膜供应通道中分配第二流量，以控制气动需求氧气阀的运行。

4. 发明授权

US08419783B2 Graft deployment assist tool 有权
标题翻译：移植部署辅助工具
公开(公告)号：US08419783B2
公开(公告)日：2013-04-16
申请号：US12831725
申请日：2010-07-07
申请人： Mark R. Frye , William F. Moore
发明人： Mark R. Frye , William F. Moore
IPC分类号： A61F2/84 , A61M5/00
CPC分类号： A61F2/95 , A61F2002/9517
摘要： A delivery system for a medical device may include a sheath, a catheter slideably disposed within the sheath, and a hemostatic device comprising a housing disposed around and sealingly engaged with the sheath by a first seal. A sleeve is slideably coupled to the catheter and comprises a second seal sealingly engaging the catheter. The sleeve is movable between a first position, in which the sleeve is disposed outside of the housing and the first seal is sealingly engaged with an outer surface of the catheter, and a second position in which at least a portion of the sleeve is disposed within the housing between an inner surface of the housing and the outer surface of the catheter, wherein, in the second position, the first seal is sealingly engaged with an outer surface of the sleeve and the second seal is sealingly engaged with the outer surface of the catheter.
摘要翻译：用于医疗装置的递送系统可以包括护套，可滑动地设置在护套内的导管和止血装置，其包括通过第一密封件设置在护套周围并与护套密封接合的壳体。套筒可滑动地联接到导管并且包括密封地接合导管的第二密封件。套筒可以在第一位置和第二位置之间移动，在该第一位置，套筒设置在壳体的外部，并且第一密封件与导管的外表面密封地接合，以及第二位置，其中套筒的至少一部分设置在其中所述壳体的内表面与所述导管的外表面之间的所述壳体，其中在所述第二位置中所述第一密封件与所述套筒的外表面密封地接合，并且所述第二密封件与所述第二密封件的外表面密封接合导管。

5. 发明授权

US10271974B2 Helical stent 有权
公开(公告)号：US10271974B2
公开(公告)日：2019-04-30
申请号：US13530685
申请日：2012-06-22
申请人： Siddharth U. Vad , Mark R. Frye , Sean D. Chambers
发明人： Siddharth U. Vad , Mark R. Frye , Sean D. Chambers
IPC分类号： A61F2/88 , A61F2/07 , A61F2/89
摘要： A helical stent is provided that is wound in a zig-zag pattern along a pitch angle with respect to a plane transverse to the axis of the stent. A bisecting line extending through a bend and between two adjacent angular struts is also angled with respect to the longitudinal axis of the stent.

6. 发明授权

US07828839B2 Flexible barb for anchoring a prosthesis 有权
标题翻译：用于锚定假体的柔性倒钩
公开(公告)号：US07828839B2
公开(公告)日：2010-11-09
申请号：US11849858
申请日：2007-09-04
申请人： William A. Cook , Michael P. DeBruyne , Mark R. Frye , Benjamin Nickless , Thomas A. Osborne , Ronan T. Young
发明人： William A. Cook , Michael P. DeBruyne , Mark R. Frye , Benjamin Nickless , Thomas A. Osborne , Ronan T. Young
IPC分类号： A61F2/06
CPC分类号： A61F2/86 , A61B2017/0412 , A61B2017/0437 , A61F2002/8483 , A61F2220/0016
摘要： A system for anchoring an endoluminal prosthesis comprises a barb. The barb comprises a base, a retractable body extending distally from the base towards a distal anchor, and a hinge disposed between the base and the anchor and spaced apart from the base. The anchor pivots about the hinge between a retracted configuration and an extended configuration. Additional devices, systems, and methods are disclosed.
摘要翻译：用于锚定内腔假体的系统包括倒钩。倒钩包括基部，从基部朝向远侧锚定件向远侧延伸的可伸缩体，以及设置在基部和锚固件之间并与基部间隔开的铰链。锚固件在缩回配置和延伸配置之间绕铰链枢转。公开了附加设备，系统和方法。

7. 发明申请

US20100076543A1 Multi-strand helical stent 有权
标题翻译：多股螺旋支架
公开(公告)号：US20100076543A1
公开(公告)日：2010-03-25
申请号：US12584176
申请日：2009-08-31
申请人： Jeffry S. Melsheimer , Kurt J. Tekulve , Mark R. Frye , James M. Carlson , Richard J. Godlewski , Michael W. Hardert , Jessica L. Burke
发明人： Jeffry S. Melsheimer , Kurt J. Tekulve , Mark R. Frye , James M. Carlson , Richard J. Godlewski , Michael W. Hardert , Jessica L. Burke
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： A61F2/07 , A61F2/89 , A61F2/90 , A61F2002/072 , A61F2002/075 , A61F2220/0075
摘要： A stent including a stent wire comprising a plurality of filaments twisted into a bundle having a helix, the stent wire bent into a pattern having a plurality of substantially straight wire sections separated by a plurality of bends. The pattern of the stent wire is spirally wound about a central axis in the same direction as the helix formed by the plurality of filaments. Each of the filaments in a bend have a cylindrical cross-section where at least one of the plurality of filaments is displaced and spaced from an immediately adjacent filament in the bend.
摘要翻译：一种支架，其包括支架线，所述支架线包括扭曲成具有螺旋线的多个细丝，所述支架线弯曲成具有由多个弯曲部分开的多个基本上直的线部分的图案。支架丝线的图案围绕中心轴线以与由多个细丝形成的螺旋线相同的方向螺旋卷绕。弯曲中的每个细丝具有圆柱形横截面，其中多个细丝中的至少一个丝线与弯曲部中紧邻的细丝位移并间隔开。

8. 发明授权

US09163333B2 Method for electrospinning a graft layer 有权
标题翻译：静电纺丝接枝层的方法
公开(公告)号：US09163333B2
公开(公告)日：2015-10-20
申请号：US13548956
申请日：2012-07-13
申请人： Siddharth U. Vad , Mark A. Magnuson , Mark R. Frye , Sean D. Chambers
发明人： Siddharth U. Vad , Mark A. Magnuson , Mark R. Frye , Sean D. Chambers
IPC分类号： A61F2/06 , D01D5/00 , D04H1/728 , D04H3/073 , A61F2/07
CPC分类号： A61L31/041 , A61F2/07 , B29C47/0014 , B29C47/0064 , B29C47/06 , B29K2075/00 , B29K2083/00 , B29L2009/00 , B29L2023/20 , B29L2031/7546 , B32B2250/03 , D01D5/0038 , D01D5/0069 , D01D5/0084 , D04H1/728 , D04H3/073
摘要： A method for making a graft layer is provided. The graft layer has at least two layers with different porosities. The two layers are applied by electrospinning. The parameters of the electrospinning may be varied when applying the first and second layers in order to achieve different porosities of the first and second layers.
摘要翻译：提供了制备接枝层的方法。接枝层具有至少两层具有不同孔隙率的层。通过静电纺丝应用两层。当施加第一和第二层以便实现第一和第二层的不同孔隙率时，静电纺丝的参数可以变化。

9. 发明授权

US07753918B2 Medical grasping device 有权
标题翻译：医疗夹具
公开(公告)号：US07753918B2
公开(公告)日：2010-07-13
申请号：US11725944
申请日：2007-03-20
申请人： David Ernest Hartley , Krasnodar Ivancev , Werner D. Ducke , Michael P. DeBruyne , Jarett Diamond , Mark R. Frye
发明人： David Ernest Hartley , Krasnodar Ivancev , Werner D. Ducke , Michael P. DeBruyne , Jarett Diamond , Mark R. Frye
IPC分类号： A61B17/08
CPC分类号： A61B17/221 , A61B2017/00867 , A61B2017/22035 , A61B2017/22038 , A61B2017/2215 , A61B2090/08021 , A61F2/95
摘要： A medical grasping device (1) has an elongate control member (9) with a grasping member (17) proximal to its distal tip. An outer sheath (3) with a passageway therethrough surrounds the elongate control member and is relatively movable with respect to the control member. A control assembly (2) disposed at a proximal end of said outer sheath has a fixed handle (5) and a sliding handle (7) and the proximal end of the elongate control member is fixed to the sliding handle to move the control member. The grasping member (17) has a plurality of pre-formed wire loops (50, 52, 54, 56) which self-deploy transversely upon emerging from said distal end of said outer sheath. Each wire loop is fastened to substantially opposite sides of the elongate control member so that each of said wire loops is substantially semi-circular upon full deployment and the respective ends (27, 29) of each wire loop extend substantially in opposite directions from the elongate control member.
摘要翻译：医疗把持装置（1）具有细长的控制构件（9），其具有靠近其远端的抓握构件（17）。具有穿过其的通道的外护套（3）围绕细长控制构件并且可相对于控制构件相对移动。设置在所述外护套的近端处的控制组件（2）具有固定手柄（5）和滑动手柄（7），细长控制构件的近端固定到滑动手柄以移动控制构件。抓握构件（17）具有多个预先形成的线环（50,52,54,56），其从所述外护套的所述远端出现时横向自动展开。每个线环被紧固到细长控制构件的基本相对的两侧，使得每个线环在完全展开时基本上是半圆形的，并且每个导线环的相应端部（27,29）从细长的控制成员。

10. 发明授权

US06394088B1 Oxygen-delivery system with portable oxygen meter 失效
标题翻译：带有便携式氧气计的氧气输送系统
公开(公告)号：US06394088B1
公开(公告)日：2002-05-28
申请号：US09435174
申请日：1999-11-05
申请人： Mark R. Frye , J. Fred Brown , Douglas R. Leithauser
发明人： Mark R. Frye , J. Fred Brown , Douglas R. Leithauser
IPC分类号： A61M1600
CPC分类号： A61M16/20 , A61M16/0677 , A61M16/0841 , A61M16/207 , A61M2016/0027 , A61M2202/0208 , A61M2202/03 , A61M2202/0007
摘要： An oxygen-delivery system comprises a portable oxygen meter including a low-pressure oxygen inlet, a low-pressure oxygen outlet, and an exhale-inhale sensing port, an oxygen-supply source including a discharge outlet and configured to discharge low-pressure oxygen through the discharge outlet, a flexible supply tube arranged to conduct low-pressure oxygen from the oxygen-supply source into the portable oxygen meter through the low-pressure oxygen inlet, and a nasal cannula coupled to the low-pressure oxygen outlet and the exhale-inhale sensing port. The portable oxygen meter further includes a pneumatic demand oxygen conserver including a diaphragm valve member, control means coupled to the exhale-inhale sensing port for causing the diaphragm valve member to move to a flow-delivery position in response to inhalation of a patient and to a flow-blocking position in response to a lack of inhalation by the patient during exhalation through the nasal cannula, and an oxygen flow passage arranged to pass low-pressure oxygen through an oxygen flow-metering aperture to meter low-pressure oxygen outlet at a selected oxygen flow rate. The oxygen-delivery system further comprises a mount including a flange coupled to the portable oxygen meter and a clip adapted to be coupled to an item of clothing worn by the patient.
摘要翻译：氧气输送系统包括便携式氧气计，其包括低压氧气入口，低压氧气出口和呼出气体吸入口，供氧源包括排出口，并且被配置为排出低压氧气通过排出口，设置有柔性供应管，该供应管布置成通过低压氧气入口将氧供应源的低压氧气输送到便携式氧气计中，以及连接到低压氧气出口和呼气的鼻插管 -inhale感应端口。便携式氧气计进一步包括气动需氧保存器，其包括隔膜阀构件，联接到呼气吸入传感端口的控制装置，用于使隔膜阀构件响应于患者的吸入而移动到流动位置，并且响应于患者在通过鼻插管呼出期间不被吸入而流动阻塞位置，以及氧气流通道，其设置成使低压氧通过氧气流量计量孔以在低压氧气出口处计量选择氧气流量。氧传递系统还包括安装件，其包括联接到便携式氧气计的凸缘和适于联接到由患者佩戴的衣服的衣物的夹子。

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