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1. 发明申请

US20130018220A1 METHOD FOR ELECTROSPINNING A GRAFT LAYER 有权
标题翻译：电镀层的方法
公开(公告)号：US20130018220A1
公开(公告)日：2013-01-17
申请号：US13548956
申请日：2012-07-13
申请人： Siddharth U. Vad , Mark A. Magnuson , Mark R. Frye , Sean D. Chambers
发明人： Siddharth U. Vad , Mark A. Magnuson , Mark R. Frye , Sean D. Chambers
IPC分类号： A61F2/06
CPC分类号： A61L31/041 , A61F2/07 , B29C47/0014 , B29C47/0064 , B29C47/06 , B29K2075/00 , B29K2083/00 , B29L2009/00 , B29L2023/20 , B29L2031/7546 , B32B2250/03 , D01D5/0038 , D01D5/0069 , D01D5/0084 , D04H1/728 , D04H3/073
摘要： A method for making a graft layer is provided. The graft layer has at least two layers with different porosities. The two layers are applied by electrospinning. The parameters of the electrospinning may be varied when applying the first and second layers in order to achieve different porosities of the first and second layers.
摘要翻译：提供了制备接枝层的方法。接枝层具有至少两层具有不同孔隙率的层。通过静电纺丝应用两层。当施加第一和第二层以便实现第一和第二层的不同孔隙率时，静电纺丝的参数可以变化。

2. 发明授权

US09163333B2 Method for electrospinning a graft layer 有权
标题翻译：静电纺丝接枝层的方法
公开(公告)号：US09163333B2
公开(公告)日：2015-10-20
申请号：US13548956
申请日：2012-07-13
申请人： Siddharth U. Vad , Mark A. Magnuson , Mark R. Frye , Sean D. Chambers
发明人： Siddharth U. Vad , Mark A. Magnuson , Mark R. Frye , Sean D. Chambers
IPC分类号： A61F2/06 , D01D5/00 , D04H1/728 , D04H3/073 , A61F2/07
CPC分类号： A61L31/041 , A61F2/07 , B29C47/0014 , B29C47/0064 , B29C47/06 , B29K2075/00 , B29K2083/00 , B29L2009/00 , B29L2023/20 , B29L2031/7546 , B32B2250/03 , D01D5/0038 , D01D5/0069 , D01D5/0084 , D04H1/728 , D04H3/073
摘要： A method for making a graft layer is provided. The graft layer has at least two layers with different porosities. The two layers are applied by electrospinning. The parameters of the electrospinning may be varied when applying the first and second layers in order to achieve different porosities of the first and second layers.
摘要翻译：提供了制备接枝层的方法。接枝层具有至少两层具有不同孔隙率的层。通过静电纺丝应用两层。当施加第一和第二层以便实现第一和第二层的不同孔隙率时，静电纺丝的参数可以变化。

3. 发明授权

US10271974B2 Helical stent 有权
公开(公告)号：US10271974B2
公开(公告)日：2019-04-30
申请号：US13530685
申请日：2012-06-22
申请人： Siddharth U. Vad , Mark R. Frye , Sean D. Chambers
发明人： Siddharth U. Vad , Mark R. Frye , Sean D. Chambers
IPC分类号： A61F2/88 , A61F2/07 , A61F2/89
摘要： A helical stent is provided that is wound in a zig-zag pattern along a pitch angle with respect to a plane transverse to the axis of the stent. A bisecting line extending through a bend and between two adjacent angular struts is also angled with respect to the longitudinal axis of the stent.

4. 发明申请

US20120330402A1 HELICAL STENT 审中-公开
标题翻译：螺丝刀
公开(公告)号：US20120330402A1
公开(公告)日：2012-12-27
申请号：US13530685
申请日：2012-06-22
申请人： Siddharth U. Vad , Mark R. Frye , Sean D. Chambers
发明人： Siddharth U. Vad , Mark R. Frye , Sean D. Chambers
IPC分类号： A61F2/88 , A61F2/06
CPC分类号： A61F2/88 , A61F2/07 , A61F2/89 , A61F2220/0075 , A61F2240/001
摘要： A helical stent is provided that is wound in a zig-zag pattern along a pitch angle with respect to a plane transverse to the axis of the stent. A bisecting line extending through a bend and between two adjacent angular struts is also angled with respect to the longitudinal axis of the stent.
摘要翻译：提供螺旋支架，其以相对于支架的轴线的平面的俯仰角以锯齿形图案缠绕。延伸穿过弯曲部并且在两个相邻角撑杆之间的平分线也相对于支架的纵向轴线成角度。

5. 发明授权

US09138338B2 Two-stage method of compressing a stent 有权
标题翻译：压缩支架的两段方法
公开(公告)号：US09138338B2
公开(公告)日：2015-09-22
申请号：US13322091
申请日：2010-05-21
申请人： Sean D. Chambers , Mark A. Magnuson , Fred T. Parker
发明人： Sean D. Chambers , Mark A. Magnuson , Fred T. Parker
IPC分类号： B23P11/00 , A61F2/95 , A61F2/958
CPC分类号： A61F2/95 , A61F2/958 , A61F2002/9522 , Y10T29/49908
摘要： A two-stage method of compressing a stent entails providing an expandable stent (100,105) in a radially expanded state. An outward pressure is applied to an inner surface of the tubular framework to support the stent, and a diameter of the stent is reduced to a first compressed diameter (D1) while applying the outward pressure. The outward pressure is halted after reaching the first compressed diameter. According to an embodiment in which the stent is balloon-expandable, a delivery balloon catheter (130) comprising an uninflated balloon in a delivery configuration is inserted into the lumen after halting the outward pressure. The diameter of the stent is reduced to a second compressed diameter (D2) smaller than the first compressed diameter to crimp the stent onto the delivery balloon catheter.
摘要翻译：压缩支架的两级方法需要提供处于放大状态的可扩张支架（100,105）。向管状框架的内表面施加向外的压力以支撑支架，并且在施加向外的压力的同时将支架的直径减小到第一压缩直径（D1）。达到第一压缩直径后，向外的压力停止。根据其中支架是球囊可膨胀的实施例，包括具有输送构型的未膨胀气囊的输送气囊导管（130）在停止向外的压力之后插入腔内。支架的直径减小到小于第一压缩直径的第二压缩直径（D2），以将支架卷曲到输送球囊导管上。

6. 发明申请

US20120060348A1 TWO-STAGE METHOD OF COMPRESSING A STENT 有权
标题翻译：压缩方法的两阶段方法
公开(公告)号：US20120060348A1
公开(公告)日：2012-03-15
申请号：US13322091
申请日：2010-05-21
申请人： Sean D. Chambers , Mark A. Magnuson , Fred T. Parker
发明人： Sean D. Chambers , Mark A. Magnuson , Fred T. Parker
IPC分类号： B23P11/00
CPC分类号： A61F2/95 , A61F2/958 , A61F2002/9522 , Y10T29/49908
摘要： A two-stage method of compressing a stent entails providing an expandable stent (100,105) in a radially expanded state. An outward pressure is applied to an inner surface of the tubular framework to support the stent, and a diameter of the stent is reduced to a first compressed diameter (D1) while applying the outward pressure. The outward pressure is halted after reaching the first compressed diameter. According to an embodiment in which the stent is balloon-expandable, a delivery balloon catheter (130) comprising an uninflated balloon in a delivery configuration is inserted into the lumen after halting the outward pressure. The diameter of the stent is reduced to a second compressed diameter (D2) smaller than the first compressed diameter to crimp the stent onto the delivery balloon catheter.
摘要翻译：压缩支架的两级方法需要提供处于放大状态的可扩张支架（100,105）。向管状框架的内表面施加向外的压力以支撑支架，并且在施加向外的压力的同时将支架的直径减小到第一压缩直径（D1）。达到第一压缩直径后，向外的压力停止。根据其中支架是球囊可膨胀的实施例，包括具有输送构型的未膨胀气囊的输送气囊导管（130）在停止向外的压力之后插入腔内。支架的直径减小到小于第一压缩直径的第二压缩直径（D2），以将支架卷曲到输送球囊导管上。

7. 发明公开

US20240058094A1 MRI Compatible Interventional Medical Devices and Related Methods 审中-公开
公开(公告)号：US20240058094A1
公开(公告)日：2024-02-22
申请号：US18234440
申请日：2023-08-16
申请人： Ram H. Paul, Jr. , Sean D. Chambers , David Gross , Neal Fearnot , Jesse Roll , Joshua F. Krieger , Carl A. Cook
发明人： Ram H. Paul, Jr. , Sean D. Chambers , David Gross , Neal Fearnot , Jesse Roll , Joshua F. Krieger , Carl A. Cook
IPC分类号： A61B90/00 , A61B5/055 , A61L31/02 , A61L31/14
CPC分类号： A61B90/39 , A61B5/055 , A61L31/022 , A61L31/14 , A61B2090/3954 , A61M2025/09075
摘要： The disclosure relates to methods of imaging a portion of a body vessel using magnetic resonance imaging (MRI), methods of performing interventional medical treatment under MRI, interventional medical devices, such as wire guides, useful in performing treatment under MRI, and methods of making interventional medical devices. A method of imaging a portion of a body vessel of a patient using MRI includes advancing through a body vessel an end of a wire guide comprising a continuous metal core member and a continuous jacket disposed over the entire core member through a body vessel and scanning the portion of the patient that is positioned within an MRI scanner and that includes a portion of the body vessel within which the end of the wire guide is disposed. A secondary medical device, such as a catheter, can be disposed over the wire guide and manipulated in the method.

8. 发明授权

US08881365B2 Implantable graft device having treated yarn and method for making same 有权
标题翻译：具有处理纱线的可植入移植装置及其制造方法
公开(公告)号：US08881365B2
公开(公告)日：2014-11-11
申请号：US13457949
申请日：2012-04-27
申请人： Shyam S V Kuppurathanam , Sean D. Chambers , David P. Biggs , Scott E. Eells
发明人： Shyam S V Kuppurathanam , Sean D. Chambers , David P. Biggs , Scott E. Eells
IPC分类号： B23P11/00 , A61F2/89 , A61F2/07 , A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/065 , A61F2002/075 , A61F2250/0067 , Y10T29/49849
摘要： An implantable graft device having treated yarn is disclosed. The device comprises a graft body forming a lumen defining a longitudinal axis and comprising proximal and distal ends. The graft body comprises a woven fabric having warp yarns aligned in a first direction and a weft yarns aligned in a second direction. At least one of the weft yarns and the warp yarns has an agent applied thereto defining treated yarns of the graft body.
摘要翻译：公开了一种具有经处理的纱线的可植入移植装置。该装置包括形成限定纵向轴线并包括近端和远端的内腔的移植物主体。移植物主体包括具有沿第一方向排列的经纱和沿第二方向排列的纬纱的机织织物。纬纱和经纱中的至少一个具有施加到其上的试剂，其限定了移植物体的经处理的纱线。

9. 发明授权

US08870816B2 Device for treating hardened lesions 有权
标题翻译：治疗硬化病变的装置
公开(公告)号：US08870816B2
公开(公告)日：2014-10-28
申请号：US13130420
申请日：2008-12-01
申请人： Sean D. Chambers , Steen Aggerholm , Joe Horn
发明人： Sean D. Chambers , Steen Aggerholm , Joe Horn
IPC分类号： A61M31/00 , A61M37/00 , A61B17/22 , A61B17/32 , A61D1/02 , A61M25/10 , A61B17/3207 , A61B17/00 , A61M25/00
CPC分类号： A61M25/104 , A61B17/320725 , A61B2017/00539 , A61B2017/00778 , A61B2017/22061 , A61M2025/0057 , A61M2025/1013 , A61M2025/105 , A61M2025/1061 , A61M2025/1086 , A61M2025/109
摘要： A balloon catheter is provided that may be used to dilate hardened regions of a stenosis on a vessel wall. The balloon catheter is provided with cutting elements that extend along a surface of a balloon. At least one bioactive is present, either on the cutting element, within the interior of the balloon, within the material of the balloon or on an outside surface of the balloon. The bioactive is delivered to the vessel wall upon dilation of the balloon.
摘要翻译：提供了可用于扩张血管壁上的狭窄硬化区域的球囊导管。气囊导管设置有沿气球表面延伸的切割元件。在切割元件上，在球囊的内部，气囊的材料内或气球的外表面上存在至少一种生物活性物质。气球膨胀后，生物活性物质被传送到血管壁。

10. 发明申请

US20130079867A1 Valve Frame 审中-公开
公开(公告)号：US20130079867A1
公开(公告)日：2013-03-28
申请号：US13681362
申请日：2012-11-19
申请人： Grant T. Hoffman , Sean D. Chambers , Ram H. Paul
发明人： Grant T. Hoffman , Sean D. Chambers , Ram H. Paul
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/24 , A61F2/2418 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058
摘要： The disclosure relates to support frames for prosthetic implantable valves. The support frames may include a plurality of symmetrically arrayed interconnected U-shaped member structures. Preferred support frames are tubular structures enclosing a longitudinal axis and including a plurality of U-shaped member structures facing a distal or a proximal end of the support frame. Each U-shaped member structure may be connected to a single longitudinally adjacent U-shaped member facing in an opposite longitudinal direction, as well as two laterally adjacent U-shaped members.

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