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1. 发明授权

US07252674B2 Expandable ablation burr 失效
标题翻译：可扩展消融毛刺
公开(公告)号：US07252674B2
公开(公告)日：2007-08-07
申请号：US10770336
申请日：2004-02-02
申请人： Mark H. Wyzgala , Eric B. Hamilton , Tom J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
发明人： Mark H. Wyzgala , Eric B. Hamilton , Tom J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
IPC分类号： A61B17/32
CPC分类号： A61B17/320725 , A61B17/320758 , A61B2017/00557 , A61B2017/00867 , A61B2017/320004 , A61B2017/320733
摘要： An atherectomy burr has an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include an expandable polymeric balloon having a partially abrasive exterior surface. The maximum expansion of the burr is controlled by an expansion mechanism. Various mechanisms are disclosed for controlling the maximum diameter of the burr thus preventing the burr from over expanding. In addition, the present invention includes systems that are pulled proximally to remove portions of a lesion located in a patient's vasculature. The system includes an ablation burr that has abrasive disposed on the proximal end. The burr may create a seal when expanded to block the ablated particulate so that an aspiration system can remove the particulate from the vasculature. Alternatively, the burr system may include a self expanding seal that is deployed out of the aspiration sheath.
摘要翻译：粥样斑块切除术毛刺的操作直径大于其中布置毛刺的导管的直径。毛刺可以包括具有部分研磨外表面的可膨胀聚合气囊。毛刺的最大膨胀由膨胀机构控制。公开了用于控制毛刺的最大直径的各种机构，从而防止毛刺过度膨胀。另外，本发明还包括向近侧拉动以去除位于病人脉管系统中的病变部分的系统。该系统包括具有设置在近端的磨料的消融毛刺。当膨胀时，毛刺可以产生密封，以阻止消融的颗粒，使得吸气系统可以从脉管系统中除去颗粒。或者，毛刺系统可以包括从抽吸鞘部署出来的自膨胀密封件。

2. 发明授权

US06685718B1 Expandable ablation burr 失效
标题翻译：可扩展消融毛刺
公开(公告)号：US06685718B1
公开(公告)日：2004-02-03
申请号：US09629771
申请日：2000-07-31
申请人： Mark H. Wyzgala , Eric B. Hamilton , Thomas J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
发明人： Mark H. Wyzgala , Eric B. Hamilton , Thomas J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
IPC分类号： A61B1732
CPC分类号： A61B17/320725 , A61B17/320758 , A61B2017/00557 , A61B2017/00867 , A61B2017/320004 , A61B2017/320733
摘要： An atherectomy burr has an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include a polymeric balloon that is coated with an abrasive and that expands when the burr is rotated. When the burr is rotated, the polymeric tube expands by centrifugal force. The maximum expansion of the burr is controlled by an expansion mechanism. Various mechanisms are disclosed for controlling the maximum diameter of the burr thus preventing the burr from over expanding. In addition, the present invention includes a system for preventing the loose ablated particulate from reembolizing in the distal vasculature. The system includes an ablation burr that has abrasive disposed on the proximal end that is pulled back toward the guide catheter to ablate the lesion. The burr creates a seal when expanded to block the ablated particulate so that the aspiration system can remove the particulate from the patient vessel or stent. Alternatively, the burr system may include a self expanding seal that is deployed out of the aspiration sheath so that a slight vacuum can remove the large loose particulate form, the patient's vessel or stent.
摘要翻译：粥样斑块切除术毛刺的操作直径大于其中布置毛刺的导管的直径。毛刺可以包括涂覆有磨料的聚合物气球，并且当毛刺旋转时膨胀。当毛刺旋转时，聚合物管通过离心力膨胀。毛刺的最大膨胀由膨胀机构控制。公开了用于控制毛刺的最大直径的各种机构，从而防止毛刺过度膨胀。此外，本发明还包括一种用于防止松散的消融颗粒在远端脉管系统中再栓塞的系统。该系统包括消融毛刺，其具有设置在近端上的磨料，其被拉回导向导管以烧蚀病变。当膨胀时，毛刺产生密封以阻挡消融的颗粒，使得吸气系统可以从患者的血管或支架中移除颗粒。或者，毛刺系统可以包括从抽吸鞘部署出来的自膨胀密封，使得轻微的真空可以从患者的血管或支架中移除大的松散颗粒。

3. 发明申请

US20100094213A1 HIGH PERFORMANCE BALLOON CATHETER/COMPONENT 有权
标题翻译：高性能气球吸管/组件
公开(公告)号：US20100094213A1
公开(公告)日：2010-04-15
申请号：US12637490
申请日：2009-12-14
申请人： Daniel J. Horn , Jeffrey S. Lindquist , Irina Nazarova , Scott Schewe , David W. Meister , John J. Chen
发明人： Daniel J. Horn , Jeffrey S. Lindquist , Irina Nazarova , Scott Schewe , David W. Meister , John J. Chen
IPC分类号： A61M25/10
CPC分类号： A61M25/1029 , A61L29/126 , Y10T156/103 , Y10T428/13 , Y10T428/1303 , Y10T428/1352 , Y10T428/1359 , Y10T428/1362 , Y10T428/1369 , Y10T428/139
摘要： Composite fiber reinforced balloons for medical devices prepared by applying a web of fibers to the exterior of a preformed underlying balloon and encasing the web with a matrix material to form a composite balloon. The fiber web is applied to at least the cone portion of the underlying balloon form. Either the cone portion of the underlying balloon form, or the web fibers applied to said cone portion, or both, have a friction-enhancing material coated thereon.
摘要翻译：用于医疗装置的复合纤维增强气囊通过将纤维网施加到预先形成的下面的气球的外部并且用基质材料包裹纤维网以形成复合气囊而制备。至少将纤维网应用于下面的气球形式的锥形部分。下面的球囊形成的锥形部分或施加到所述锥形部分的纤维网或两者都具有涂覆在其上的摩擦增强材料。

4. 发明授权

US08481139B2 High performance balloon catheter/component 有权
公开(公告)号：US08481139B2
公开(公告)日：2013-07-09
申请号：US12637490
申请日：2009-12-14
申请人： Daniel J. Horn , Jeffrey S. Lindquist , Irina Nazarova , Scott Schewe , David W. Meister , John J. Chen
发明人： Daniel J. Horn , Jeffrey S. Lindquist , Irina Nazarova , Scott Schewe , David W. Meister , John J. Chen
IPC分类号： B32B23/00 , B32B1/08
CPC分类号： A61M25/1029 , A61L29/126 , Y10T156/103 , Y10T428/13 , Y10T428/1303 , Y10T428/1352 , Y10T428/1359 , Y10T428/1362 , Y10T428/1369 , Y10T428/139
摘要： Composite fiber reinforced balloons for medical devices prepared by applying a web of fibers to the exterior of a preformed underlying balloon and encasing the web with a matrix material to form a composite balloon. The fiber web is applied to at least the cone portion of the underlying balloon form. Either the cone portion of the underlying balloon form, or the web fibers applied to said cone portion, or both, have a friction-enhancing material coated thereon.

5. 发明授权

US07635510B2 High performance balloon catheter/component 有权
标题翻译：高性能球囊导管/部件
公开(公告)号：US07635510B2
公开(公告)日：2009-12-22
申请号：US10889574
申请日：2004-07-07
申请人： Daniel J. Horn , Jeffrey S. Lindquist , Irina Nazarova , Scott Schewe , David W. Meister , John J. Chen
发明人： Daniel J. Horn , Jeffrey S. Lindquist , Irina Nazarova , Scott Schewe , David W. Meister , John J. Chen
IPC分类号： B32B1/00 , B32B1/02 , B22B1/08
CPC分类号： A61M25/1029 , A61L29/126 , Y10T156/103 , Y10T428/13 , Y10T428/1303 , Y10T428/1352 , Y10T428/1359 , Y10T428/1362 , Y10T428/1369 , Y10T428/139
摘要： Composite fiber reinforced balloons for medical devices prepared by applying a web of fibers to the exterior of a preformed underlying balloon and encasing the web with a matrix material to form a composite balloon. The fiber web is applied to at least the cone portion of the underlying balloon form. Either the cone portion of the underlying balloon form, or the web fibers applied to said cone portion, or both, have a friction-enhancing material coated thereon.
摘要翻译：用于医疗装置的复合纤维增强气囊通过将纤维网施加到预先形成的下面的气球的外部并且用基质材料包裹纤维网以形成复合气囊而制备。至少将纤维网应用于下面的气球形式的锥形部分。下面的球囊形成的锥形部分或施加到所述锥形部分的纤维网或两者都具有涂覆在其上的摩擦增强材料。

6. 发明公开

US20240277976A1 CHEMICAL ABLATION AND METHOD OF TREATMENT FOR VARIOUS DISEASES 审中-公开
公开(公告)号：US20240277976A1
公开(公告)日：2024-08-22
申请号：US18644498
申请日：2024-04-24
申请人： Lixiao Wang , Neurotronic, Inc.
发明人： Lixiao Wang , John J. Chen , Yongxing Zhang
IPC分类号： A61M25/10 , A61B18/00 , A61B18/06 , A61K31/045 , A61M5/00 , A61M5/142 , A61M5/172 , A61M29/02
CPC分类号： A61M25/1002 , A61B18/06 , A61K31/045 , A61M5/007 , A61M5/142 , A61M5/172 , A61M25/1011 , A61M29/02 , A61B2018/00577 , A61M2025/105 , A61M2025/1052 , A61M2202/02
摘要： Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.

7. 发明申请

US20110092999A1 MEDICAL DEVICE EMPLOYING LIQUID CRYSTAL BLOCK COPOLYMERS AND METHOD OF MAKING THE SAME 有权
标题翻译：使用液晶块式共聚物的医疗装置及其制造方法
公开(公告)号：US20110092999A1
公开(公告)日：2011-04-21
申请号：US12974467
申请日：2010-12-21
申请人： John J. Chen
发明人： John J. Chen
IPC分类号： A61M29/02 , C08G81/00 , C09K19/00
CPC分类号： C09K19/3852 , A61L29/049 , A61L29/126 , A61M25/1027 , C09K19/00 , C09K19/3809 , C09K19/408 , Y10T428/1352 , C08L53/00
摘要： A medical device, at least a portion of which is formed from a polymer composition including at least one liquid crystal block copolymer having at least one A block and at least one B block wherein the A block is formed of mesogenic repeat units and the B block is a soft block.
摘要翻译：一种医疗装置，其至少一部分由聚合物组合物形成，所述聚合物组合物包含至少一种具有至少一个A嵌段和至少一个B嵌段的液晶嵌段共聚物，其中A嵌段由介晶重复单元形成，B嵌段是一个软块。

8. 发明授权

US07914485B2 Medical device employing liquid crystal block copolymers and method of making the same 有权
标题翻译：采用液晶嵌段共聚物的医疗器械及其制造方法
公开(公告)号：US07914485B2
公开(公告)日：2011-03-29
申请号：US12549743
申请日：2009-08-28
申请人： John J. Chen , Joseph Delaney, Jr.
发明人： John J. Chen , Joseph Delaney, Jr.
IPC分类号： A61M25/10 , B29D22/00 , C09K19/38
CPC分类号： A61M25/1027 , A61L29/049 , C09K19/00 , C09K19/3809 , C09K19/3852 , C09K19/408 , Y10T428/1352
摘要： A medical device, at least a portion of which is formed from a polymer composition including at least one liquid crystal block copolymer having at least one A block and at least one B block wherein the A block is a liquid crystal polymer block formed of repeating units comprising mesogenic groups and the B block is a non-liquid crystal polymer block.
摘要翻译：一种医疗装置，其至少一部分由包含至少一种具有至少一个A嵌段和至少一个B嵌段的至少一种液晶嵌段共聚物的聚合物组合物形成，其中A嵌段是由重复单元形成的液晶聚合物嵌段包括介晶基团，B嵌段是非液晶聚合物嵌段。

9. 发明申请

US20100145437A1 Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface 审中-公开
标题翻译：支架设计允许药物的扩展释放和/或增强的聚合物粘附到OD表面
公开(公告)号：US20100145437A1
公开(公告)日：2010-06-10
申请号：US12706881
申请日：2010-02-17
申请人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuchling
发明人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuchling
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2210/0076 , A61F2220/0066 , A61F2220/0083 , A61F2250/0067 , A61F2250/0068
摘要： The invention is directed to mechanisms and methods that reduce the delamination of a therapeutic agent from a stent. The mechanisms include holes (channels, wells, and other hole configurations), protrusions, sintered metal cores, clamps/staples, pins, and stainless steel shields.
摘要翻译：本发明涉及减少治疗剂从支架分层的机制和方法。这些机构包括孔（通道，孔和其他孔构造），突起，烧结金属芯，夹/钉，销和不锈钢屏蔽。

10. 发明申请

US20100145269A1 MEDICAL DEVICE EMPLOYING LIQUID CRYSTAL BLOCK COPOLYMERS AND METHOD OF MAKING THE SAME 有权
标题翻译：使用液晶块式共聚物的医疗装置及其制造方法
公开(公告)号：US20100145269A1
公开(公告)日：2010-06-10
申请号：US12706463
申请日：2010-02-16
申请人： John J. Chen
发明人： John J. Chen
IPC分类号： A61M25/10
CPC分类号： C09K19/3852 , A61L29/049 , A61L29/126 , A61M25/1027 , C09K19/00 , C09K19/3809 , C09K19/408 , Y10T428/1352 , C08L53/00
摘要： A medical device, at least a portion of which is formed from a polymer composition including at least one liquid crystal block copolymer having at least one A block and at least one B block wherein the A block is formed of mesogenic repeat units and the B block is a soft block.
摘要翻译：一种医疗装置，其至少一部分由聚合物组合物形成，所述聚合物组合物包含至少一种具有至少一个A嵌段和至少一个B嵌段的液晶嵌段共聚物，其中A嵌段由介晶重复单元形成，B嵌段是一个软块。

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