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1. 发明申请

US20100145437A1 Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface 审中-公开
标题翻译：支架设计允许药物的扩展释放和/或增强的聚合物粘附到OD表面
公开(公告)号：US20100145437A1
公开(公告)日：2010-06-10
申请号：US12706881
申请日：2010-02-17
申请人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuchling
发明人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuchling
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2210/0076 , A61F2220/0066 , A61F2220/0083 , A61F2250/0067 , A61F2250/0068
摘要： The invention is directed to mechanisms and methods that reduce the delamination of a therapeutic agent from a stent. The mechanisms include holes (channels, wells, and other hole configurations), protrusions, sintered metal cores, clamps/staples, pins, and stainless steel shields.
摘要翻译：本发明涉及减少治疗剂从支架分层的机制和方法。这些机构包括孔（通道，孔和其他孔构造），突起，烧结金属芯，夹/钉，销和不锈钢屏蔽。

2. 发明申请

US20090076591A1 Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface 审中-公开
标题翻译：支架设计允许药物的扩展释放和/或增强的聚合物粘附到OD表面
公开(公告)号：US20090076591A1
公开(公告)日：2009-03-19
申请号：US11857736
申请日：2007-09-19
申请人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuehling
发明人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuehling
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2210/0076 , A61F2220/0066 , A61F2220/0083 , A61F2250/0067 , A61F2250/0068
摘要： The invention is directed to mechanisms and methods that reduce the delamination of a therapeutic agent from a stent. The mechanisms include holes (channels, wells, and other hole configurations), protrusions, sintered metal cores, clamps/staples, pins, and stainless steel shields.
摘要翻译：本发明涉及减少治疗剂从支架分层的机制和方法。这些机构包括孔（通道，孔和其他孔构造），突起，烧结金属芯，夹/钉，销和不锈钢屏蔽。

3. 发明申请

US20100207291A1 Method of Making a Tubular Member 审中-公开
标题翻译：制造管状构件的方法
公开(公告)号：US20100207291A1
公开(公告)日：2010-08-19
申请号：US12370724
申请日：2009-02-13
申请人： Tracee Eidenschink , James Feng , Karl A. Jagger , Daniel Gregorich , Leonard B. Richardson , Timothy J. Mickley , James Lee Shippy , Daniel J. Horn , John J. Chen , Thomas J. Holman , David McMorrow , Jon Kolbrek , Horng-Ban Lin
发明人： Tracee Eidenschink , James Feng , Karl A. Jagger , Daniel Gregorich , Leonard B. Richardson , Timothy J. Mickley , James Lee Shippy , Daniel J. Horn , John J. Chen , Thomas J. Holman , David McMorrow , Jon Kolbrek , Horng-Ban Lin
IPC分类号： B29D23/00 , B21C23/08
CPC分类号： B29C48/05 , A61M25/0009 , B29C48/0022 , B29C48/09 , B29C48/11 , B29C48/151 , B29L2031/7542
摘要： A method of producing a tubular member which includes providing at least one micro-extruder configured to extrude at least one material and providing a surface configured to accept the material extruded from the micro-extruder.
摘要翻译：一种制造管状构件的方法，其包括提供至少一个微型挤出机，所述微型挤出机构造成挤出至少一种材料并提供构造成接受从微型挤出机挤出的材料的表面。

4. 发明授权

US09586030B2 Fugitive plasticizer balloon surface treatment for enhanced stent securement 有权
标题翻译：挥发性增塑剂气囊表面处理增强支架固定
公开(公告)号：US09586030B2
公开(公告)日：2017-03-07
申请号：US11022585
申请日：2004-12-23
申请人： Raed Rizq , John J. Chen , Stanley Nordin
发明人： Raed Rizq , John J. Chen , Stanley Nordin
IPC分类号： A61F2/06 , A61M25/10 , A61F2/958
CPC分类号： A61M25/1027 , A61F2/958 , A61F2002/9583 , A61M2025/1088
摘要： In an assembly of a balloon mounted on a catheter and a stent mounted over the deflated balloon, the balloon is provided with a fugitive plasticizer before the stent is crimped over the balloon. The fugitive plasticizer can soften the balloon surface so that molding of the balloon surface to conform to the crimped stent occurs. The fugitive plasticizer is removed before the assembly is used.
摘要翻译：在安装在导管和安装在放气气球上的支架上的气囊的组件中，气囊在支架被压接在气囊之前设置有缓冲增塑剂。短促增塑剂可以软化球囊表面，从而发生球囊表面的模制以符合卷曲的支架。在使用组装之前，除去挥发性增塑剂。

5. 发明申请

US20080275426A1 Flexible and Durable Tip 审中-公开
标题翻译：灵活和耐用的提示
公开(公告)号：US20080275426A1
公开(公告)日：2008-11-06
申请号：US11743753
申请日：2007-05-03
申请人： Thomas J. HOLMAN , Tracee Eidenschink , John J. Chen , Daniel J. Horn
发明人： Thomas J. HOLMAN , Tracee Eidenschink , John J. Chen , Daniel J. Horn
IPC分类号： A61M25/16
CPC分类号： A61M25/104 , A61M25/001 , A61M25/0069 , A61M25/1006 , A61M2025/1093
摘要： A method of making a flexible, durable catheter tip is achieved by providing a catheter tip, and in some embodiments, applying heat energy only to the distal portion of a catheter tip. In other embodiments, the method includes ablating a portion of the outer diameter of the proximal region material. In at least one embodiment, the method includes manufacturing a catheter tip with a layer of a harder material disposed about a first layer of a relatively softer material and then ablating at least a portion of the harder material. In some embodiments, the method includes dipping at least a portion of the distal region of the catheter tip into a chemical bath. In some embodiments, the method includes providing a catheter tip made of a tip material, adding a curable adhesive to at least a portion of the distal region, and then applying heat energy to cure the curable adhesive.
摘要翻译：通过提供导管尖端来实现制造柔性，耐久的导管尖端的方法，并且在一些实施例中，仅将热能施加到导管尖端的远端部分。在其他实施例中，该方法包括烧蚀近端区域材料的外径的一部分。在至少一个实施例中，该方法包括制造具有设置在相对较软材料的第一层周围的较硬材料层的导管末端，然后再烧蚀至少一部分较硬的材料。在一些实施例中，该方法包括将导管尖端的远端区域的至少一部分浸入化学浴中。在一些实施例中，该方法包括提供由尖端材料制成的导管末端，将可固化粘合剂添加到远侧区域的至少一部分，然后施加热能以固化可固化粘合剂。

6. 发明申请

US20100094213A1 HIGH PERFORMANCE BALLOON CATHETER/COMPONENT 有权
标题翻译：高性能气球吸管/组件
公开(公告)号：US20100094213A1
公开(公告)日：2010-04-15
申请号：US12637490
申请日：2009-12-14
申请人： Daniel J. Horn , Jeffrey S. Lindquist , Irina Nazarova , Scott Schewe , David W. Meister , John J. Chen
发明人： Daniel J. Horn , Jeffrey S. Lindquist , Irina Nazarova , Scott Schewe , David W. Meister , John J. Chen
IPC分类号： A61M25/10
CPC分类号： A61M25/1029 , A61L29/126 , Y10T156/103 , Y10T428/13 , Y10T428/1303 , Y10T428/1352 , Y10T428/1359 , Y10T428/1362 , Y10T428/1369 , Y10T428/139
摘要： Composite fiber reinforced balloons for medical devices prepared by applying a web of fibers to the exterior of a preformed underlying balloon and encasing the web with a matrix material to form a composite balloon. The fiber web is applied to at least the cone portion of the underlying balloon form. Either the cone portion of the underlying balloon form, or the web fibers applied to said cone portion, or both, have a friction-enhancing material coated thereon.
摘要翻译：用于医疗装置的复合纤维增强气囊通过将纤维网施加到预先形成的下面的气球的外部并且用基质材料包裹纤维网以形成复合气囊而制备。至少将纤维网应用于下面的气球形式的锥形部分。下面的球囊形成的锥形部分或施加到所述锥形部分的纤维网或两者都具有涂覆在其上的摩擦增强材料。

7. 发明授权

US08481139B2 High performance balloon catheter/component 有权
公开(公告)号：US08481139B2
公开(公告)日：2013-07-09
申请号：US12637490
申请日：2009-12-14
申请人： Daniel J. Horn , Jeffrey S. Lindquist , Irina Nazarova , Scott Schewe , David W. Meister , John J. Chen
发明人： Daniel J. Horn , Jeffrey S. Lindquist , Irina Nazarova , Scott Schewe , David W. Meister , John J. Chen
IPC分类号： B32B23/00 , B32B1/08
CPC分类号： A61M25/1029 , A61L29/126 , Y10T156/103 , Y10T428/13 , Y10T428/1303 , Y10T428/1352 , Y10T428/1359 , Y10T428/1362 , Y10T428/1369 , Y10T428/139
摘要： Composite fiber reinforced balloons for medical devices prepared by applying a web of fibers to the exterior of a preformed underlying balloon and encasing the web with a matrix material to form a composite balloon. The fiber web is applied to at least the cone portion of the underlying balloon form. Either the cone portion of the underlying balloon form, or the web fibers applied to said cone portion, or both, have a friction-enhancing material coated thereon.

8. 发明授权

US07635510B2 High performance balloon catheter/component 有权
标题翻译：高性能球囊导管/部件
公开(公告)号：US07635510B2
公开(公告)日：2009-12-22
申请号：US10889574
申请日：2004-07-07
申请人： Daniel J. Horn , Jeffrey S. Lindquist , Irina Nazarova , Scott Schewe , David W. Meister , John J. Chen
发明人： Daniel J. Horn , Jeffrey S. Lindquist , Irina Nazarova , Scott Schewe , David W. Meister , John J. Chen
IPC分类号： B32B1/00 , B32B1/02 , B22B1/08
CPC分类号： A61M25/1029 , A61L29/126 , Y10T156/103 , Y10T428/13 , Y10T428/1303 , Y10T428/1352 , Y10T428/1359 , Y10T428/1362 , Y10T428/1369 , Y10T428/139
摘要： Composite fiber reinforced balloons for medical devices prepared by applying a web of fibers to the exterior of a preformed underlying balloon and encasing the web with a matrix material to form a composite balloon. The fiber web is applied to at least the cone portion of the underlying balloon form. Either the cone portion of the underlying balloon form, or the web fibers applied to said cone portion, or both, have a friction-enhancing material coated thereon.
摘要翻译：用于医疗装置的复合纤维增强气囊通过将纤维网施加到预先形成的下面的气球的外部并且用基质材料包裹纤维网以形成复合气囊而制备。至少将纤维网应用于下面的气球形式的锥形部分。下面的球囊形成的锥形部分或施加到所述锥形部分的纤维网或两者都具有涂覆在其上的摩擦增强材料。

9. 发明授权

US09463103B2 Medical devices comprising nanocomposites 有权
标题翻译：包含纳米复合材料的医疗器械
公开(公告)号：US09463103B2
公开(公告)日：2016-10-11
申请号：US13402141
申请日：2012-02-22
申请人： Edward Parsonage , Daniel J. Horn , John J. Chen , Paul J. Miller , Douglas A. Devens, Jr. , Jan Weber
发明人： Edward Parsonage , Daniel J. Horn , John J. Chen , Paul J. Miller , Douglas A. Devens, Jr. , Jan Weber
IPC分类号： A61L29/00 , A61F2/95 , A61F2/01 , A61F2/02 , A61F2/958 , A61L29/12 , A61L31/12
CPC分类号： A61F2/95 , A61F2/01 , A61F2/02 , A61F2/958 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61L29/126 , A61L31/125 , Y10S623/90 , Y10S977/905
摘要： The present invention provides medical devices comprising nanocomposite materials. By utilizing nanocomposites in the production thereof, the inventive medical devices can be produced with various advantageous properties. Methods of producing the inventive medical devices are also provided. Inasmuch as the inventive devices are expected to provide certain advantages in their use, there is also provided a method of medical care including methods of treatment or diagnosis, wherein the inventive devices are brought into therapeutic contact with a body to be treated or diagnosed thereby.
摘要翻译：本发明提供包含纳米复合材料的医疗装置。通过在其生产中利用纳米复合材料，本发明的医疗装置可以以各种有利的性质生产。还提供了制造本发明的医疗装置的方法。由于本发明的装置预期在使用中提供某些优点，还提供了包括治疗或诊断方法的医疗护理方法，其中本发明的装置与被治疗或被诊断的身体进行治疗接触。

10. 发明授权

US08133250B2 Medical devices comprising nanocomposites 有权
标题翻译：包含纳米复合材料的医疗器械
公开(公告)号：US08133250B2
公开(公告)日：2012-03-13
申请号：US12563780
申请日：2009-09-21
申请人： Edward Parsonage , Daniel J. Horn , John J. Chen , Paul J. Miller , Douglas A. Devens, Jr. , Jan Weber
发明人： Edward Parsonage , Daniel J. Horn , John J. Chen , Paul J. Miller , Douglas A. Devens, Jr. , Jan Weber
IPC分类号： A61M25/00 , A61M25/10
CPC分类号： A61F2/95 , A61F2/01 , A61F2/02 , A61F2/958 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61L29/126 , A61L31/125 , Y10S623/90 , Y10S977/905
摘要： The present invention provides medical devices comprising nanocomposite materials. By utilizing nanocomposites in the production thereof, the inventive medical devices can be produced with various advantageous properties. Methods of producing the inventive medical devices are also provided. Inasmuch as the inventive devices are expected to provide certain advantages in their use, there is also provided a method of medical care including methods of treatment or diagnosis, wherein the inventive devices are brought into therapeutic contact with a body to be treated or diagnosed thereby.
摘要翻译：本发明提供包含纳米复合材料的医疗装置。通过在其生产中利用纳米复合材料，本发明的医疗装置可以以各种有利的性质生产。还提供了制造本发明的医疗装置的方法。由于本发明的装置预期在使用中提供某些优点，还提供了包括治疗或诊断方法的医疗护理方法，其中本发明的装置与被治疗或被诊断的身体进行治疗接触。

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