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1. 发明申请

US20100145437A1 Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface 审中-公开
标题翻译：支架设计允许药物的扩展释放和/或增强的聚合物粘附到OD表面
公开(公告)号：US20100145437A1
公开(公告)日：2010-06-10
申请号：US12706881
申请日：2010-02-17
申请人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuchling
发明人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuchling
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2210/0076 , A61F2220/0066 , A61F2220/0083 , A61F2250/0067 , A61F2250/0068
摘要： The invention is directed to mechanisms and methods that reduce the delamination of a therapeutic agent from a stent. The mechanisms include holes (channels, wells, and other hole configurations), protrusions, sintered metal cores, clamps/staples, pins, and stainless steel shields.
摘要翻译：本发明涉及减少治疗剂从支架分层的机制和方法。这些机构包括孔（通道，孔和其他孔构造），突起，烧结金属芯，夹/钉，销和不锈钢屏蔽。

2. 发明申请

US20090076591A1 Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface 审中-公开
标题翻译：支架设计允许药物的扩展释放和/或增强的聚合物粘附到OD表面
公开(公告)号：US20090076591A1
公开(公告)日：2009-03-19
申请号：US11857736
申请日：2007-09-19
申请人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuehling
发明人： Timothy S. Girton , Jeffrey S. Lindquist , David M. Knapp , Matt Heidner , Daniel Gregorich , Umang Anand , Peter Edelman , Matthew J. Miller , Raed Rizq , Jan Weber , Tracee Eidenschink , John J. Chen , Jaykeep Y. Kokate , Aparna Bhave , Kent D. Harrison , Graig L. Kveen , Benjamin Arcand , Michael Kuehling
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2210/0076 , A61F2220/0066 , A61F2220/0083 , A61F2250/0067 , A61F2250/0068
摘要： The invention is directed to mechanisms and methods that reduce the delamination of a therapeutic agent from a stent. The mechanisms include holes (channels, wells, and other hole configurations), protrusions, sintered metal cores, clamps/staples, pins, and stainless steel shields.
摘要翻译：本发明涉及减少治疗剂从支架分层的机制和方法。这些机构包括孔（通道，孔和其他孔构造），突起，烧结金属芯，夹/钉，销和不锈钢屏蔽。

3. 发明申请

US20090118812A1 ENDOPROSTHESIS COATING 审中-公开
标题翻译：内部涂层
公开(公告)号：US20090118812A1
公开(公告)日：2009-05-07
申请号：US11934288
申请日：2007-11-02
申请人： Jaydeep Y. Kokate , Raed Rizq , Jay Rassat , Derek Sutermeister , Samuel Robaina , Peter Edelman , Tom Holman , Michael Kuehling , Yixin Xu
发明人： Jaydeep Y. Kokate , Raed Rizq , Jay Rassat , Derek Sutermeister , Samuel Robaina , Peter Edelman , Tom Holman , Michael Kuehling , Yixin Xu
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61L31/088 , A61L31/146 , A61L31/16 , A61L2300/00 , C23C14/06 , C23C14/3464
摘要： A method includes: providing a substrate, depositing a ceramic and an extractable material onto the substrate, forming a porous structure in the ceramic by removing the extractable material, and utilizing the ceramic in an endoprosthesis. An endoprosthesis, such as a stent, including a coating formed of a ceramic and an extractable material that can be removed from the coating to form voids is also disclosed.
摘要翻译：一种方法包括：提供衬底，将陶瓷和可提取材料沉积到衬底上，通过去除可提取材料在陶瓷中形成多孔结构，并在内置假体中利用陶瓷。还公开了一种内置假体，例如支架，包括由陶瓷形成的涂层和可从涂层中除去以形成空隙的可提取材料。

4. 发明申请

US20140005772A1 PROSTHETIC HEART VALVE FORMATION 有权
标题翻译：先天性心脏瓣膜形成
公开(公告)号：US20140005772A1
公开(公告)日：2014-01-02
申请号：US13932968
申请日：2013-07-01
申请人： Peter Edelman , Horng-Ban Lin , Scott Fisher , Jeffrey S. Lindquist , Huisun Wang , Richard C. Gunderson
发明人： Peter Edelman , Horng-Ban Lin , Scott Fisher , Jeffrey S. Lindquist , Huisun Wang , Richard C. Gunderson
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/24 , A61F2/2415 , A61F2/2418 , A61F2210/0076 , A61F2250/0014 , A61F2250/0018 , A61F2250/0028 , A61F2250/0036 , A61F2250/0037 , A61L27/18 , A61L27/34 , A61L2430/20 , B05B7/0408 , B05B7/0416 , B05B7/0433 , B05B7/0466 , B05B12/00 , B05B12/1454 , B05B13/0207 , B05B13/0627 , B05D1/02 , B05D7/222 , B05D2254/02 , B33Y80/00 , Y10T29/49405 , C08L75/04 , C08L83/04
摘要： A prosthetic heart valve includes a base and a plurality of polymeric leaflets. Each leaflet has a root portion coupled to the base, and each leaflet has an edge portion substantially opposite the root portion and movable relative to the root portion to coapt with a respective edge portion of at least one of the other leaflets of the plurality of leaflets. Each leaflet includes) at least two polymers along at least one portion of the leaflet, and each leaflet has a composition gradient of each of the at least two polymers along at least one portion of the leaflet.
摘要翻译：假体心脏瓣膜包括基部和多个聚合单张。每个小叶具有连接到基部的根部分，并且每个小叶具有基本上与根部相对的边缘部分，并且相对于根部部分可移动以与多个传单中的至少一个其他传单中的至少一个的相应边缘部分配合。每个小叶包括）沿着小叶的至少一部分的至少两种聚合物，并且每个小叶具有沿着小叶的至少一部分的每种至少两种聚合物的组成梯度。

5. 发明申请

US20090018633A1 PROTECTOR FOR AN INSERTABLE OR IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于无插入或可植入医疗器械的保护器
公开(公告)号：US20090018633A1
公开(公告)日：2009-01-15
申请号：US11775324
申请日：2007-07-10
申请人： Jeffrey S. Lindquist , Peter Edelman
发明人： Jeffrey S. Lindquist , Peter Edelman
IPC分类号： A61B19/02 , A61F2/06 , A61M25/10
CPC分类号： A61F2/0095 , A61F2/95 , A61L29/04 , A61L29/14 , A61M25/002
摘要： A protector for a medical device including a tubular member, the tubular member including a polymer matrix material and a scavenger for moisture, oxygen or a combination thereof dispersed in the polymer matrix material.
摘要翻译：一种用于包括管状构件的医疗装置的保护器，所述管状构件包括分散在聚合物基质材料中的聚合物基质材料和用于水分，氧气或其组合的清除剂。

6. 发明授权

US08444669B2 Embolic filter delivery system and method 有权
标题翻译：栓塞过滤器输送系统及方法
公开(公告)号：US08444669B2
公开(公告)日：2013-05-21
申请号：US12563758
申请日：2009-09-21
申请人： Peter Edelman , Lawrence Wasicek , Nayan Ashar , Husnija Mujkanovic , Eddie Sucgang
发明人： Peter Edelman , Lawrence Wasicek , Nayan Ashar , Husnija Mujkanovic , Eddie Sucgang
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2250/0048
摘要： The disclosure pertains to a medical device deployment system comprising a restraint member which holds the embolic protection filter in a restrained, or partially collapsed, state for insertion into a lumen and transit to a desired deployment site. The restraint member comprises two or more portions which differ in their mechanical ability to resist the radial forces exerted by various portions of the medical device when it is in a restrained, or partially collapsed, state. The restraint member is maintained in a restraint configuration by an actuation member which engages portions of the restraint member lying on opposite sides of a generally axial gap until deployment of the medical device is desired. Withdrawal of the actuation member allows the restraint member to release the medical device which may then return to a deployed state. The invention also provides a method for assembling a medical device deployment system.
摘要翻译：本公开涉及一种医疗装置展开系统，其包括限制构件，该限制构件将栓塞保护过滤器保持在限制或部分折叠的状态，用于插入管腔并且转运到期望的部署位置。约束构件包括两个或更多个部分，其在机械能力方面不同，以抵抗由医疗装置的各部分施加的径向力在其处于受限制或部分塌缩状态时。约束构件通过致动构件保持在约束构造中，所述致动构件接合位于大致轴向间隙的相对侧上的限制构件的部分，直到需要部署医疗装置。致动构件的抽出允许约束构件释放医疗装置，然后可以返回到展开状态。本发明还提供了一种用于组装医疗装置展开系统的方法。

7. 发明申请

US20090149942A1 ENDOPROSTHESIS HAVING A NON-FOULING SURFACE 有权
标题翻译：具有非表面表面的底物
公开(公告)号：US20090149942A1
公开(公告)日：2009-06-11
申请号：US12174752
申请日：2008-07-17
申请人： Peter Edelman , Samuel Robaina
发明人： Peter Edelman , Samuel Robaina
IPC分类号： A61F2/06
CPC分类号： C08G65/3322 , A61L31/088 , A61L31/10 , A61L31/14 , C08G65/33337 , C08L71/02 , C08L2203/02
摘要： An endoprosthesis, e.g., a stent, that includes a pro-healing surface and a temporary non-fouling material attached to the surface, and a method of making the same are disclosed.
摘要翻译：公开了一种内置假体，例如支架，其包括附着于表面的前恢复表面和临时非结垢材料及其制造方法。

8. 发明授权

US5696314A Multilayer enzyme electrode membranes and methods of making same 失效
标题翻译：多层酶电极膜及其制备方法
公开(公告)号：US5696314A
公开(公告)日：1997-12-09
申请号：US679089
申请日：1996-07-12
申请人： Robert McCaffrey , Bonnie Dalzell , Katarina Tkacik , Susan Holbert , Mark Boden , James Flaherty , Michael Flanagan , Josef Brown , Kimiya Takeshita , Peter Edelman
发明人： Robert McCaffrey , Bonnie Dalzell , Katarina Tkacik , Susan Holbert , Mark Boden , James Flaherty , Michael Flanagan , Josef Brown , Kimiya Takeshita , Peter Edelman
IPC分类号： G01N27/327 , C12Q1/00 , G01N27/26 , G01N33/535 , G01N33/66 , H01L29/78
CPC分类号： C12Q1/002 , Y10S435/817
摘要： An electrochemical sensor is designed for use in detecting a concentration of an analyte in a sample solution. The sensor to have a longer useful lifetime, improved stability and improved response time for single or multiple use applications. In one aspect, some of these goals are achieved by providing the multilayer enzyme electrode membrane having both nonporous and microporous layers. The microporous layer is formed from a polymer binder, a polymer powder, a surfactant and a mineral powder. In another aspect, certain of these goals are achieved by the use of a layer comprised of an enzyme disposed within a polymer matrix. In certain embodiments, the multilayer enzyme electrode membrane includes an outermost layer which is capable of dissolving in the sample solution such that the interface between the multilayer enzyme electrode membrane and the sample solution is continually renewed. The sensor provides an electrical current output proportional to the reagent chemical interaction of the analyte with an immobilized enzyme layer during exposure of the sensor in such solution.
摘要翻译：电化学传感器设计用于检测样品溶液中分析物的浓度。该传感器具有更长的使用寿命，提高了单个或多个使用应用的稳定性和改进的响应时间。在一个方面，通过提供具有无孔和多孔层的多层酶电极膜来实现这些目标中的一些。微孔层由聚合物粘合剂，聚合物粉末，表面活性剂和矿物粉末形成。在另一方面，这些目标中的某些通过使用由置于聚合物基质内的酶构成的层来实现。在某些实施方案中，多层酶电极膜包括能够溶解在样品溶液中的最外层，使得多层酶电极膜和样品溶液之间的界面不断更新。传感器在这种溶液中曝光期间，传感器提供与分析物与固定化酶层的试剂化学相互作用成比例的电流输出。

9. 发明申请

US20060147409A1 Biocompatible crosslinked polymers with visualization agents 有权
公开(公告)号：US20060147409A1
公开(公告)日：2006-07-06
申请号：US11293892
申请日：2005-12-02
申请人： Chandrashekhar Pathak , Amarpreet Sawhney , Peter Edelman
发明人： Chandrashekhar Pathak , Amarpreet Sawhney , Peter Edelman
IPC分类号： A61K31/74
CPC分类号： A61K47/34 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K31/74 , A61K47/42 , A61L24/106 , A61L27/18 , A61L27/50 , A61L31/06 , C07K14/75 , C08G63/08 , C08G63/912 , C08L89/00 , G06K7/10831 , G06K2207/1016 , C08L2666/02
摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.

10. 发明申请

US20050215901A1 Interface for use between medical instrumentation and a patient 审中-公开
标题翻译：医疗仪器与病人之间使用的界面
公开(公告)号：US20050215901A1
公开(公告)日：2005-09-29
申请号：US11038351
申请日：2005-01-18
申请人： Thomas Anderson , Nathan Dale , Peter Edelman , John Stiggelbout , David Perozek , Lee Weng , Jimin Zhang , Robert Hubler , Paul Leonard
发明人： Thomas Anderson , Nathan Dale , Peter Edelman , John Stiggelbout , David Perozek , Lee Weng , Jimin Zhang , Robert Hubler , Paul Leonard
IPC分类号： A61B8/00 , A61B8/12 , A61B17/22
CPC分类号： A61B8/4281 , A61B8/12 , A61B2017/2253
摘要： Disclosed herein are methods, devices, compositions, and systems for providing an interface between medical instrumentation and a patient. In various embodiments, the interface provides a sterile barrier, acoustic coupler, and thermal insulator between the patient and a medical instrument. In some embodiments, an acoustic coupler interface is used between an ultrasound instrument and a patient. In some embodiments, the acoustic coupler comprises a thermoplastic elastomer (“TPE”) and in particular oil-enhanced or gelatinous TPEs that can be used in diagnostic and therapeutic (HIFU) ultrasound procedures.
摘要翻译：本文公开了用于在医疗仪器和患者之间提供界面的方法，装置，组合物和系统。在各种实施例中，界面在患者和医疗器械之间提供无菌屏障，声耦合器和热绝缘体。在一些实施例中，在超声仪器和患者之间使用声耦合器接口。在一些实施方案中，声学耦合器包括热塑性弹性体（“TPE”），特别是可用于诊断和治疗（HIFU）超声程序的油增强或凝胶状TPE。

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