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1. 发明申请

US20050272046A1 Methods, apparatus and compositions for improved measurements with optical biosensors 失效
标题翻译：用于利用光学生物传感器改进测量的方法，装置和组合物
公开(公告)号：US20050272046A1
公开(公告)日：2005-12-08
申请号：US10864086
申请日：2004-06-09
申请人： Mack Schermer , Mark Bobrow , Philip Buzby , Thomas Mullinax
发明人： Mack Schermer , Mark Bobrow , Philip Buzby , Thomas Mullinax
IPC分类号： C12M1/32 , C12M1/34 , C12Q1/68 , G01N21/25
CPC分类号： G01N21/253 , B01L9/50 , G01N21/7743
摘要： The invention provides an apparatus for interrogating an optical biosensor. The apparatus includes (a) locating means for positioning one or more optical biosensors; (b) calibration means for generating a reference measurement; (c) one or more biosensors for generating one or more sample measurements, the biosensors being substantially planar and removable from the apparatus; (d) a reading means for interrogating biosensor and calibration means, and (e) a transport means for moving one or more of a biosensor, the calibration means and the reading means, whereby the reading means is positioned to interrogate the biosensor and the calibration means.
摘要翻译：本发明提供一种询问光学生物传感器的装置。该装置包括（a）用于定位一个或多个光学生物传感器的定位装置; （b）用于产生参考测量的校准装置; （c）用于产生一个或多个样品测量的一个或多个生物传感器，所述生物传感器基本上是平面的并且可从所述设备移除; （d）用于询问生物传感器和校准装置的读取装置，以及（e）用于移动生物传感器，校准装置和读取装置中的一个或多个的传送装置，由此读取装置被定位成询问生物传感器和校准手段。

2. 发明申请

US20070166810A1 METHODS AND COMPOSITIONS FOR DETECTING ENZYMATIC ACTIVITY 审中-公开
标题翻译：用于检测酶活性的方法和组合物
公开(公告)号：US20070166810A1
公开(公告)日：2007-07-19
申请号：US11615733
申请日：2006-12-22
申请人： Mark Bobrow , Karl Adler , Mack Schermer
发明人： Mark Bobrow , Karl Adler , Mack Schermer
IPC分类号： C12N9/00
CPC分类号： C12Q1/34 , C12Q1/00 , G01N33/585 , G01N2333/98 , G01N2800/04
摘要： This invention relates to methods and compositions useful in detecting enzymatic activity. Also featured are methods for diagnosing enzyme deficiencies such as metabolic disorders.
摘要翻译：本发明涉及可用于检测酶活性的方法和组合物。还有一些诊断酶缺乏症如代谢紊乱的方法。

3. 发明申请

US20060172339A1 Particle-based multiplex assay for identifying glycosylation 审中-公开
标题翻译：用于鉴定糖基化的基于粒子的多重测定
公开(公告)号：US20060172339A1
公开(公告)日：2006-08-03
申请号：US11289060
申请日：2005-11-29
申请人： Wayne Patton , Mack Schermer , Mark Bobrow
发明人： Wayne Patton , Mack Schermer , Mark Bobrow
IPC分类号： G01N33/53 , G06F19/00
CPC分类号： G01N33/585 , G01N33/6842 , G01N2400/00 , G01N2400/10 , G01N2400/40 , G01N2400/50 , G01N2405/10
摘要： The present invention provides systems, methods and kits for performing multiplexed assays for glycoproteins using encoded particles as supports for glycoprotein specific binding agents.
摘要翻译：本发明提供用于使用编码的颗粒作为糖蛋白特异性结合剂的载体进行糖蛋白多重测定的系统，方法和试剂盒。

4. 发明申请

US20070166835A1 MULTIPLEX ASSAYS USING MAGNETIC AND NON-MAGNETIC PARTICLES 审中-公开
标题翻译：使用磁性和非磁性颗粒的多重测定
公开(公告)号：US20070166835A1
公开(公告)日：2007-07-19
申请号：US11615731
申请日：2006-12-22
申请人： Mark Bobrow , Karl Adler , Mack Schermer
发明人： Mark Bobrow , Karl Adler , Mack Schermer
IPC分类号： G01N1/00
CPC分类号： C12Q1/6834 , G01N33/54313 , G01N33/54326 , G01N35/0098 , G01N35/028 , G01N2035/00564 , Y10T436/25 , C12Q2563/149 , C12Q2563/143 , C12Q2537/143
摘要： Disclosed herein are methods and compositions for multiplexed assays using magnetic and non-magnetic particles. Also disclosed are methods and compositions for performing multi-step assays within a single assay vessel.
摘要翻译：本文公开了使用磁性和非磁性颗粒的多重测定法的方法和组合物。还公开了用于在单个测定容器内进行多步测定的方法和组合物。

5. 发明申请

US20070166739A1 COMPARATIVE GENOMIC HYBRIDIZATION ON ENCODED MULTIPLEX PARTICLES 审中-公开
标题翻译：编码多重粒子的比较基因组杂交
公开(公告)号：US20070166739A1
公开(公告)日：2007-07-19
申请号：US11615739
申请日：2006-12-22
申请人： Mark Bobrow , Karl Adler , Mack Schermer
发明人： Mark Bobrow , Karl Adler , Mack Schermer
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： C12Q1/6809 , C12Q1/6834 , C12Q1/6841 , C12Q2565/518 , C12Q2563/149
摘要： Disclosed herein are methods and compositions for evaluating genomic content using encoded particles to evaluate multiple samples in parallel.
摘要翻译：本文公开了使用编码的颗粒来评估基因组含量以平行评估多个样品的方法和组合物。

6. 发明申请

US20060228735A1 Multiplex assay systems 审中-公开
标题翻译：多重测定系统
公开(公告)号：US20060228735A1
公开(公告)日：2006-10-12
申请号：US11394673
申请日：2006-03-31
申请人： Mark Bobrow , Mack Schermer
发明人： Mark Bobrow , Mack Schermer
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6818 , C12Q1/6834 , G01N33/585 , C12Q2565/537 , C12Q2563/149 , C12Q2563/103 , C12Q2565/1015 , C12Q2565/525 , C12Q2537/143 , C12Q2525/301 , C12Q2565/101 , C12Q2525/186 , C12Q2525/161 , C12Q2537/1373 , C12Q2533/101
摘要： The methods described herein can be used, e.g., for detecting at least two target molecules in a sample (e.g., a single sample). Exemplary methods include using a target-specific switch probe attached to a substrate and using zip codes to associate holographically encoded particles with a target-specific probe.
摘要翻译：本文描述的方法可以用于例如检测样品中的至少两个靶分子（例如单个样品）。示例性的方法包括使用连接到基板的目标特异性开关探针并使用邮政编码将全息编码的粒子与目标特异性探针相关联。

7. 发明申请

US20060177850A1 Particle-based multiplex assay system with three or more assay reporters 审中-公开
标题翻译：具有三个或更多测定记录的基于粒子的多重测定系统
公开(公告)号：US20060177850A1
公开(公告)日：2006-08-10
申请号：US11321374
申请日：2005-12-29
申请人： Mack Schermer , Mark Bobrow , Wayne Patton
发明人： Mack Schermer , Mark Bobrow , Wayne Patton
IPC分类号： C12Q1/68 , C12M1/34 , G01N33/551
CPC分类号： G01N33/54313 , B01J19/0046 , B01J2219/005 , B01J2219/00502 , B01J2219/00504 , B01J2219/00545 , B01J2219/00547 , B01J2219/00576 , B01J2219/00592 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00702 , B01J2219/00722 , C12Q1/6827 , G01N33/54333 , G01N33/54366 , G01N2035/00772 , C12Q2565/102 , C12Q2563/107 , C12Q2537/143 , C12Q2563/149
摘要： A system and method for developing and utilizing particle-based n-multiplexed assays that include three or more reporters utilizes n particle sets that are associated with particle identification images or labels (IDs) that differ between sets. The encoded particles for a given set are coated with a specific binding member, or in the case of the sandwich assay with coupled capture and detector binding pair members, to form particle types. The sets of particle types are then pooled, and aliquots of the particle types are removed to assay vessels. Next, samples with three or four reporter molecules are supplied to the respective vessels. After one or more incubation periods, the particles are supplied to a reader system, which determines the particle IDs to identify the particle types and also detects the reporter signals. The reader system includes multiple excitation lasers that excite the various reporters in sequence or in parallel, to supply associated signals to one or more detectors. Emission filters and wavelength discriminators are included such that a given detector receives at a given time the signals associated with a single assay binding label. The system further develops greater capacity sandwich assays by assigning subsets of capture and detector antibody pairings to the three or four reporters, respectively. The system performs greater numbers of differential RNA expressions based on the use of the three or more reporters, with one or more reporters assigned to the reference sample and the other reporters assigned to respective test samples. The system and method are also capable of performing greater numbers of SNPs utilizing primer extension reactions, by assigning different color reporters to the respective nucleotides or terminators.
摘要翻译：用于开发和利用包括三个或更多个记录器的基于粒子的n多元化测定的系统和方法利用与在组之间不同的粒子识别图像或标签（ID）相关联的n个粒子集。给定组的编码颗粒用特异性结合成员涂覆，或者在使用偶联捕获和检测器结合对成员的夹心测定的情况下，形成颗粒类型。然后将这些颗粒类型集合，并将等分的颗粒类型移除到测定容器中。接下来，将具有三个或四个报告分子的样品供应到各个容器。在一个或多个孵育期后，颗粒被提供给读取器系统，其确定颗粒ID以识别颗粒类型并且还检测报告信号。读取器系统包括多个激发激光器，其按顺序或并联激励各种报告器，以将相关信号提供给一个或多个检测器。包括发射滤波器和波长鉴别器，使得给定检测器在给定时间接收与单个测定结合标签相关联的信号。该系统通过分别将三个或四个记录者的捕获和检测抗体配对分组进一步开发更大容量的夹心测定。该系统基于使用三个或更多个记者，分配给参考样本的一个或多个记者和分配给各个测试样品的其他记者，来执行更多数量的差异RNA表达。通过将不同的颜色记录分配给各个核苷酸或终止子，该系统和方法还能够利用引物延伸反应来进行更多数量的SNP。

8. 发明申请

US20070020681A1 Hydrolytic substrates for an analyte-dependent enzyme activation system 有权
公开(公告)号：US20070020681A1
公开(公告)日：2007-01-25
申请号：US10560577
申请日：2004-06-10
申请人： Mark Bobrow
发明人： Mark Bobrow
IPC分类号： G01N33/53 , C07K14/47
CPC分类号： G01N33/532 , C12Q1/34 , G01N33/542 , G01N33/58 , G01N2333/914 , G01N2333/916 , G01N2333/918 , G01N2333/924 , Y10S435/968
摘要： Disclosed are compounds of the general formulas: wherein Y is a moiety capable of being cleaved by a hydrolytic enzyme; L is a detectable label; X is a linking group; Z is a halogen; and R is hydrogen, an alkyl, or a halogen. Compounds of this general formula can be used as substrates in an analyte-dependent enzyme activation system, such as that employed in connection with catalyzed reporter depositions. Also disclosed are assays using the compounds, and kits for carrying out the assays.

9. 发明申请

US20050224354A1 Separation process and dyes for use therewith 审中-公开
标题翻译：分离方法和与其一起使用的染料
公开(公告)号：US20050224354A1
公开(公告)日：2005-10-13
申请号：US10513732
申请日：2003-05-06
申请人： Peter Jackson , Mark Bobrow , Joseph Trometer
发明人： Peter Jackson , Mark Bobrow , Joseph Trometer
IPC分类号： C07K1/107 , C07K1/13 , C07K1/26 , G01N27/447 , G01N27/453
CPC分类号： C07D311/82 , C07K1/1077 , C07K1/13 , C07K1/26 , C07K1/285 , G01N27/44726
摘要： The present invention describes rhodamine compounds particularly well-suited for pre-labeling a protein that is then subjected to two-dimensional electrophoresis. Isomeric purification and synthesis of a dye having net neutral charge or no charge precludes interference with isoelectric electrophoretic separation.
摘要翻译：本发明描述了特别适合于预先标记蛋白质的罗丹明化合物，然后进行二维电泳。具有净中性电荷或无电荷的染料的异构纯化和合成排除了对等电泳电泳分离的干扰。

10. 发明申请

US20070254308A1 AMPLIFIED ARRAY ANALYSIS METHOD AND SYSTEM 有权
标题翻译：放大阵列分析方法和系统
公开(公告)号：US20070254308A1
公开(公告)日：2007-11-01
申请号：US11741548
申请日：2007-04-27
申请人： Mark Bobrow , Karl Adler
发明人： Mark Bobrow , Karl Adler
IPC分类号： G01N33/53
CPC分类号： G01N33/54393 , G01N33/581
摘要： The present invention concerns an array-based analytical system and method having an enhanced sensitivity which allows for simple and rapid analysis of relative unmodified samples which comprises an analytical system of the type having a plurality of different first members of a specific binding pair affixed in an array thereupon, a mixture including at least one second member of a specific binding pair capable of binding to one of the first members so as to form a specific binding pair which is affixed to the support member, and a reporter system that produces a detectable signal indicative of the presence of the specific binding pair on the support member and wherein the reporter system includes an amplified reporter system that is independent of layering.
摘要翻译：本发明涉及一种基于阵列的分析系统和方法，其具有增强的灵敏度，其允许相对未修改的样品的简单和快速分析，其包括具有多个不同的第一成员的分析系统，所述第一成员固定在阵列，其包含至少一个能够结合到第一个成员之一的特异性结合对的第二个成员的混合物，以形成固定在支持部件上的特异性结合对，以及产生可检测信号的报告系统指示在支持构件上存在特异性结合对，并且其中报告系统包括独立于分层的扩增报告系统。

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