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1. 发明申请

US20190219594A1 PREDICTIVE BIOMARKERS OF CLINICAL RESPONSE TO ANTI-LPS IMMUNOGLOBULIN TREATMENT 审中-公开
公开(公告)号：US20190219594A1
公开(公告)日：2019-07-18
申请号：US16282389
申请日：2019-02-22
申请人： JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG , IGNOVA GMBH
发明人： Günter SPROTTE , Ana Maria WAAGA-GASSER
IPC分类号： G01N33/68 , C07K16/44 , C12Q1/6876 , C12Q1/6883 , G01N33/569 , G01N33/92 , C07K16/12
CPC分类号： G01N33/6863 , A61K2039/505 , C07K16/1203 , C07K16/44 , C07K2317/11 , C07K2317/23 , C12Q1/6876 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/56911 , G01N33/6866 , G01N33/6869 , G01N33/92 , G01N2333/475 , G01N2333/4756 , G01N2333/521 , G01N2333/54 , G01N2333/5412 , G01N2333/5421 , G01N2333/5428 , G01N2333/56 , G01N2333/705 , G01N2333/70596 , G01N2333/916 , G01N2400/50 , G01N2800/125 , G01N2800/26 , G01N2800/52
摘要： The present invention relates to the biomarkers for predicting the clinical response to anti-LPS immunoglobulin treatments in patients in need thereof. In particular, the invention provides methods for predicting the clinical response to an anti-LPS immunoglobulin treatment in a patient in need thereof, said method comprising the steps of evaluating the expression of a predictive biomarker selected from the group consisting of CD14, CD68, TLR4, TLR7, IL6, IL8, IL10, IFN-alpha, IGF1, CXCL1, CXCL9, CXCL10, RAGE, GDNF, BCHE, and combination thereof, in said patient.

2. 发明申请

US20190187131A1 UNMASKING ENDOTOXINS IN SOLUTION 审中-公开
公开(公告)号：US20190187131A1
公开(公告)日：2019-06-20
申请号：US16282558
申请日：2019-02-22
申请人： HYGLOS INVEST GMBH
发明人： Johannes REICH , Holger GRALLERT
IPC分类号： G01N33/53 , G01N33/50 , G01N33/92
CPC分类号： G01N33/5306 , G01N33/50 , G01N33/92 , G01N2400/50
摘要： The invention relates to unmasking endotoxins in compositions so that previously present, but undetectable endotoxins are rendered detectable.

3. 发明授权

US10072073B2 Glycans as functional cancer targets and antibodies thereto 有权
公开(公告)号：US10072073B2
公开(公告)日：2018-09-11
申请号：US15033568
申请日：2014-10-31
申请人： The University of Nottingham
发明人： Lindy Gillian Durrant , Jiaxin Chua , Tina Rose Parsons
IPC分类号： C07K16/18 , C07K16/28 , C07K16/30 , C07H13/04 , G01N33/574 , C07K16/44 , A61K39/00
CPC分类号： C07K16/18 , A61K2039/505 , C07H13/04 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , G01N33/57492 , G01N2400/50 , G01N2440/38
摘要： A glycan having the structure galβ1-3GLcNacβ1-3Galβ1-4(Fucα1-3)GlcNAc (LecLex) which is attached to a lipid or protein backbone, and isolated binding members capable of binding thereto.

4. 发明申请

US20170145079A1 E. COLI SPECIFIC ANTIBODY SEQUENCES 审中-公开
公开(公告)号：US20170145079A1
公开(公告)日：2017-05-25
申请号：US15117360
申请日：2014-12-19
申请人： ARSANIS BIOSCIENCES GMBH
发明人： Eszter NAGY , Gabor NAGY , Valeria SZIJARTO , Luis GUACHALLA , Maximiliano VASQUEZ
IPC分类号： C07K16/12 , G01N33/92 , G01N33/569
CPC分类号： C07K16/1232 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56916 , G01N33/92 , G01N2333/245 , G01N2400/50
摘要： The invention refers to an isolated antibody that specifically binds to O25b antigen of E. coli strains comprising at least an antibody heavy chain variable region (VH), which comprises any of the CDR1 to CDR3 sequences as listed in FIG. 1, and optionally further comprising an antibody light chain variable region (VL), which comprises any of the CDR4 to CDR6 sequences as listed in FIG. 1, or functionally active CDR variants of any of the forgoing CDR 1-6 sequences.

5. 发明授权

US09572836B2 Methods for assessing the suitability of transduced T cells for administration 有权
标题翻译：评估转导性T细胞给药适应性的方法
公开(公告)号：US09572836B2
公开(公告)日：2017-02-21
申请号：US14412844
申请日：2013-07-12
申请人： The Trustees of the University of Pennsylvania
发明人： Carl H. June , Bruce L. Levine , Michael D. Kalos
IPC分类号： C12Q1/04 , A61K35/17 , C12Q1/70 , G01N33/569 , G01N33/92 , C07K16/28
CPC分类号： A61K35/17 , C07K16/2803 , C07K2317/622 , C12Q1/04 , C12Q1/701 , C12Q2600/158 , G01N33/569 , G01N33/56933 , G01N33/56983 , G01N33/92 , G01N2333/195 , G01N2333/37 , G01N2400/50
摘要： The invention relates to of analyzing vector supernatants useful for transducing T cells destined for administration to a human subject. The invention also related to methods of analyzing transduced T cells destined for administration to a human subject.
摘要翻译：本发明涉及分析用于转导注射给人受试者的T细胞的载体上清液。本发明还涉及分配用于给予受试者的转导性T细胞的方法。

6. 发明申请

US20160264652A1 GLYCANS AS FUNCTIONAL CANCER TARGETS AND ANTIBODIES THERETO 审中-公开
标题翻译： GLYCANS作为功能性癌症目标和抗体
公开(公告)号：US20160264652A1
公开(公告)日：2016-09-15
申请号：US15033568
申请日：2014-10-31
申请人： THE UNIVERSITY OF NOTTINGHAM
发明人： Lindy Gillian Durrant , Jiaxin Chua , Tina Rose Parsons
IPC分类号： C07K16/18 , C07H13/04 , G01N33/574 , C07K16/30
CPC分类号： C07K16/18 , A61K2039/505 , C07H13/04 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , G01N33/57492 , G01N2400/50 , G01N2440/38
摘要： A glycan having the structure galβ1-3GLcNacβ1-3Galβ1-4(Fucα1-3)GlcNAc (LecLex) which is attached to a lipid or protein backbone, and isolated binding members capable of binding thereto.
摘要翻译：具有结合于脂质或蛋白质主链的结构galβ1-3GLcNacβ1-3Galβ1-4（Fucα1-3）GlcNAc（LecLex）的聚糖以及能与其结合的分离的结合成员。

7. 发明授权

US09229002B2 Nucleic acids encoding bacteriophage tail proteins 有权
标题翻译：核酸编码噬菌体尾蛋白
公开(公告)号：US09229002B2
公开(公告)日：2016-01-05
申请号：US14445327
申请日：2014-07-29
申请人： Hyglos Invest GmbH
发明人： Stefan Miller , Roman Meyer , Renate Grassl , Manfred Biebl , Holger Grallert
IPC分类号： C12N7/00 , B01D15/08 , C07K14/005 , G01N33/566 , G01N33/569 , G01N33/92 , G01N30/00 , C07K1/13 , C07K1/22
CPC分类号： G01N33/566 , B01D15/08 , C07K1/13 , C07K1/22 , C07K14/005 , C12N7/00 , C12N2795/00022 , C12N2795/00031 , G01N30/00 , G01N33/56911 , G01N33/92 , G01N2333/005 , G01N2400/50
摘要： The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
摘要翻译：本发明涉及在没有二价阳离子，特别是Ca 2+或Mg 2+的情况下能够结合内毒素的噬菌体尾蛋白及其衍生物和片段。此外，本发明涉及使用根据本发明的噬菌体尾蛋白从溶液和样品中消耗内毒素的方法以及内毒素的检测方法。

8. 发明申请

US20150241456A1 METHODS FOR USING LIPID PARTICLES 审中-公开
标题翻译：使用脂质颗粒的方法
公开(公告)号：US20150241456A1
公开(公告)日：2015-08-27
申请号：US14429908
申请日：2013-09-19
申请人： Manas K. HALDAR , NDSU RESEARCH FOUNDATION
发明人： Erin Nyren-Erickson , Sanku Mallik , D.K. Srivastava , Manas K. Haldar
IPC分类号： G01N33/92 , C07H21/00
CPC分类号： G01N33/92 , C07H21/00 , G01N33/5308 , G01N33/68 , G01N33/84 , G01N2400/40 , G01N2400/50 , Y10T436/143333
摘要： Provided herein are methods for using lipid particles. In one embodiment, lipid particles are used for determining whether a composition includes a charged contaminant. The method includes combining a test composition that includes an analyte with lipid particles to form a mixture, and determining whether there is any change in zeta potential of the mixture and/or average aggregate diameter of liposome aggregates in the mixture. In one embodiment, lipid particles are used for enriching an analyte. The method includes combining a test composition that includes an analyte with lipid particles and multivalent cations to form a mixture, incubating the mixture under conditions suitable for forming a complex that includes the analyte bound to the lipid particle, and separating the complex from the contaminant present in the mixture.
摘要翻译：本文提供了使用脂质颗粒的方法。在一个实施方案中，脂质颗粒用于确定组合物是否包含带电荷的污染物。该方法包括将包括分析物的测试组合物与脂质颗粒组合以形成混合物，以及确定混合物中混合物的ζ电位是否有任何变化和/或脂质体聚集体的平均聚集体直径。在一个实施方案中，脂质颗粒用于富集分析物。该方法包括将包含分析物的测试组合物与脂质颗粒和多价阳离子组合以形成混合物，在适于形成包含与脂质颗粒结合的分析物的复合物的条件下温育该混合物，以及将该复合物与存在的污染物分离在混合物中。

9. 发明申请

US20150241424A1 MULTI-ANALYTE ASSAY 审中-公开
标题翻译：多分析测定
公开(公告)号：US20150241424A1
公开(公告)日：2015-08-27
申请号：US14433370
申请日：2013-10-07
申请人： Gregory M. LAWRENCE , Lisa SHINEFELD , VERAX BIOMEDICAL INCORPORATED
发明人： Gregory M. Lawrence , Lisa Shinefeld
IPC分类号： G01N33/543 , G01N33/569 , G01N33/553
CPC分类号： G01N33/54353 , G01N33/553 , G01N33/558 , G01N33/56911 , G01N33/585 , G01N2333/195 , G01N2400/50 , G01N2405/04
摘要： The present invention is directed to devices and methods using pan-generic antibodies to detect bacteria in a sample.
摘要翻译：本发明涉及使用泛泛型抗体检测样品中细菌的装置和方法。

10. 发明申请

US20150233917A1 SENSITIVE AND RAPID METHOD FOR DETECTION OF LOW LEVELS OF LAL-REACTIVE SUBSTANCES 有权
标题翻译：用于检测低反应物质水平的敏感和快速检测方法
公开(公告)号：US20150233917A1
公开(公告)日：2015-08-20
申请号：US14434364
申请日：2013-10-07
申请人： GENERAL ELECTRIC COMPANY
发明人： Paul Charles Melanson , Vidyasankar Sundaresan , Richard Douglas Godec , Shouquan Deng
IPC分类号： G01N33/569 , G01N21/17
CPC分类号： G01N33/56911 , B01L3/5027 , B01L3/502715 , B01L3/5085 , B01L2200/0605 , B01L2200/0684 , B01L2300/021 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/16 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B01L2400/0688 , B01L2400/0694 , G01N21/17 , G01N33/579 , G01N2400/10 , G01N2400/50 , Y10T436/2575
摘要： Methods and systems for measuring the concentration of LAL-reactive substances in fluid samples is provided. They include contacting an aqueous sample with a detection reagent to form a prepared sample. A physical property of the prepared sample may be measured to obtain at least one sample measurement characteristic of the prepared sample. Curve fitting may then be used to forecast a concentration of the LAL-reactive substance the aqueous sample will have at a specified time in the future based on the sample measurement and a correlation developed between at least one standard measurement of a physical quality of a solution with a known concentration of a LAL-reactive substance therein. The quality of the sample measurement may be validated using historical data and/or the standard measurement.
摘要翻译：提供了测量流体样品中LAL反应物质浓度的方法和系统。它们包括使水样品与检测试剂接触以形成制备的样品。可以测量制备的样品的物理性质以获得所制备样品的至少一个样品测量特性。然后可以使用曲线拟合来预测水样品将来在特定时间将具有的LAL反应物质的浓度，基于样品测量，并且在溶液的物理质量的至少一个标准测量之间产生相关性其中已知浓度的LAL反应物质。可以使用历史数据和/或标准测量来验证样品测量的质量。

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