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1. 发明申请

US20110158288A1 Apparatus With Temperature Self-Compensation And Method Thereof 有权
标题翻译：带温度自补偿装置及其方法
公开(公告)号：US20110158288A1
公开(公告)日：2011-06-30
申请号：US12789289
申请日：2010-05-27
申请人： Long-Sun Huang , Yu-Fu Ku , Yi-Kuang Yen , Shu Kuan , Kuang-Chong Wu , Shiming Lin , Ping-Yen Lin
发明人： Long-Sun Huang , Yu-Fu Ku , Yi-Kuang Yen , Shu Kuan , Kuang-Chong Wu , Shiming Lin , Ping-Yen Lin
IPC分类号： G01K7/16
CPC分类号： G01N29/022
摘要： A system for compensating a thermal effect is provided and includes a substrate structure and a microcantilever. The substrate structure includes a first piezoresistor. The first piezoresistor is buried in the substrate structure and has a first piezoresistance having a first relation to a first variable temperature. The microcantilever has the thermal effect and a second piezoresistance having a second relation to the first variable temperature, wherein the thermal effect is compensated based on the first and the second relations.
摘要翻译：提供了用于补偿热效应的系统，并且包括衬底结构和微悬臂梁。衬底结构包括第一压电电阻器。第一压电电阻器被埋在衬底结构中，并且具有与第一可变温度具有第一关系的第一压电阻。微悬臂梁具有热效应和与第一可变温度具有第二关系的第二压阻，其中基于第一和第二关系补偿热效应。

2. 发明授权

US08419271B2 Apparatus with temperature self-compensation and method thereof 有权
标题翻译：具有温度自补偿的装置及其方法
公开(公告)号：US08419271B2
公开(公告)日：2013-04-16
申请号：US12789289
申请日：2010-05-27
申请人： Long-Sun Huang , Yu-Fu Ku , Yi-Kuang Yen , Shu Kuan , Kuang-Chong Wu , Shiming Lin , Ping-Yen Lin
发明人： Long-Sun Huang , Yu-Fu Ku , Yi-Kuang Yen , Shu Kuan , Kuang-Chong Wu , Shiming Lin , Ping-Yen Lin
IPC分类号： G01K7/16
CPC分类号： G01N29/022
摘要： A system for compensating a thermal effect is provided and includes a substrate structure and a microcantilever. The substrate structure includes a first piezoresistor. The first piezoresistor is buried in the substrate structure and has a first piezoresistance having a first relation to a first variable temperature. The microcantilever has the thermal effect and a second piezoresistance having a second relation to the first variable temperature, wherein the thermal effect is compensated based on the first and the second relations.
摘要翻译：提供了用于补偿热效应的系统，并且包括衬底结构和微悬臂梁。衬底结构包括第一压电电阻器。第一压电电阻器被埋在衬底结构中，并且具有与第一可变温度具有第一关系的第一压电阻。微悬臂梁具有热效应和与第一可变温度具有第二关系的第二压阻，其中基于第一和第二关系补偿热效应。

3. 发明授权

US06661520B1 Sensor system of surface plasmon resonance (SPR) and measuring method thereof 有权
标题翻译：表面等离子体共振（SPR）传感器系统及其测量方法
公开(公告)号：US06661520B1
公开(公告)日：2003-12-09
申请号：US10153459
申请日：2002-05-22
申请人： Chu-Wann Lin , Chi-Yu Huang , Jyh-Perng Chiu , Ying-Tsuen Liou , Shuen-Chen Shiue , Te-Son Kuo , Long-Sun Huang , Pei-Zen Chang , Lung-Jieh Yang , Chau-Chung Wu , Shiming Lin , Chih-Kung Lee
发明人： Chu-Wann Lin , Chi-Yu Huang , Jyh-Perng Chiu , Ying-Tsuen Liou , Shuen-Chen Shiue , Te-Son Kuo , Long-Sun Huang , Pei-Zen Chang , Lung-Jieh Yang , Chau-Chung Wu , Shiming Lin , Chih-Kung Lee
IPC分类号： G01N2155
CPC分类号： G01N21/553
摘要： A sensor system of a surface plasmon resonance (SPR) for analyzing a characteristic of a substance and the measuring method thereof are provided. The system includes an optical device for generating a first light beam and a second light beam in sequence; a sensor device for respectively generating a first plasmon wave and a second plasmon wave in response to an optical characteristic change of the first light beam and the second light beam with respective to the substance, in which a resonance is generated from the first plasmon wave and the second plasmon wave respectively generating a first reflective signal and a second reflective signal; and a measuring device for measuring spectra of the first reflective signal and the second reflective signal and obtaining the measured value which is substituted into an operational formula to calculate a reference value used for analyzing the characteristic of the substance.
摘要翻译：提供了用于分析物质的特性的表面等离子体共振（SPR）的传感器系统及其测量方法。该系统包括依次产生第一光束和第二光束的光学装置; 传感器装置，用于响应于所述第一光束和所述第二光束的光学特性变化分别产生第一等离子体激元波和第二等离子体波，所述第一等离子体波和所述第二等离子体波相对于从所述物质产生的所述物质的光学特性变化，所述第二等离子体波分别产生第一反射信号和第二反射信号; 以及测量装置，用于测量第一反射信号和第二反射信号的光谱，并获得被代入操作公式的测量值，以计算用于分析物质特征的参考值。

4. 发明授权

US07148057B2 Array biochip workstation 失效
标题翻译：阵列生物芯片工作站
公开(公告)号：US07148057B2
公开(公告)日：2006-12-12
申请号：US10216911
申请日：2002-08-13
申请人： Yo-Hsin Su , Hsi-Lien Lu , Hsun-Min Lung , Chung-Ho Tung , Ta-Chang Liu , Chih-Kung Lee , Su-Ming Hsu , Shiming Lin , Long-Sun Huang , Chii-Wann Lin
发明人： Yo-Hsin Su , Hsi-Lien Lu , Hsun-Min Lung , Chung-Ho Tung , Ta-Chang Liu , Chih-Kung Lee , Su-Ming Hsu , Shiming Lin , Long-Sun Huang , Chii-Wann Lin
IPC分类号： C12M1/34
CPC分类号： B01L9/527 , B01F11/0266 , B01F13/0059 , B01L2200/027 , B01L2300/0819 , G01N1/312 , G01N35/1074 , G01N2035/00158 , G01N2035/1039
摘要： A microarray biochip workstation allowing positioning of chips, immobilization of molecules, mixing of sample solution, molecular interactions and washing and processing qualitative and quantitative analyses consists of a positioning device for holding a biochip, a mixing device for acting on the sample solution applied on the biochip, a pumping device for removing the sample solution from the biochip surface that does not react, and a reading device for detecting reaction results of the biochip. The workstation thus constructed provides an integrated and effective work interface.
摘要翻译：一种微阵列生物芯片工作站，用于定位芯片，分子固定，样品溶液混合，分子相互作用以及洗涤和加工定性和定量分析，包括用于保持生物芯片的定位装置，用于作用在样品溶液上的混合装置生物芯片，用于从未反应的生物芯片表面去除样品溶液的泵送装置，以及用于检测生物芯片的反应结果的读取装置。这样构造的工作站提供了一个集成且有效的工作界面。

5. 发明授权

US06828807B2 Biological cell test method and apparatus 失效
标题翻译：生物细胞试验方法和装置
公开(公告)号：US06828807B2
公开(公告)日：2004-12-07
申请号：US10334910
申请日：2003-01-02
申请人： Yo-Hsin Su , Hsi-Lien Lu , Ta-Chang Liu , Hsun-Min Lung , Long-Sun Huang , Shiming Lin , Der-Xing Liou , Chien-Hsun Chen , Chih-Kung Lee
发明人： Yo-Hsin Su , Hsi-Lien Lu , Ta-Chang Liu , Hsun-Min Lung , Long-Sun Huang , Shiming Lin , Der-Xing Liou , Chien-Hsun Chen , Chih-Kung Lee
IPC分类号： G01R2708
CPC分类号： C12M23/12 , C12M35/02 , C12M41/46
摘要： A biological cell test method and apparatus employs a conventional perforated cell carrier which has a plurality of holes. Each hole has two metal electrodes. A cell is disposed in the hole to contact the two electrodes. The electrodes are connected to electric current or voltage. The electric current or field flows from one electrode through the cell to another electrode. Through the inherent impedance, inductance or capacitance of the cell, the presence or property reactions of the cell may be detected.
摘要翻译：生物细胞试验方法和装置采用具有多个孔的常规穿孔细胞载体。每个孔都有两个金属电极。一个电池设置在孔中以接触两个电极。电极连接电流或电压。电流或场从一个电极通过电池流到另一个电极。通过电阻的固有阻抗，电感或电容，可以检测电池的存在或性质反应。

6. 发明授权

US11375911B2 Carotid physiological parameter monitoring system 有权
公开(公告)号：US11375911B2
公开(公告)日：2022-07-05
申请号：US16630355
申请日：2018-07-10
申请人： Shiming Lin , BIV MEDICAL, LTD.
发明人： Shiming Lin
IPC分类号： A61B5/0245 , A61B5/021 , A61B5/024 , A61B5/00 , A61B5/0507 , A61B8/04 , A61B5/02 , A61B7/04
摘要： The present invention provides a carotid physiological parameter monitoring system, comprising: an electrocardiographic (ECG) monitoring device, a carotid pulse wave detector, and at least one controller. The ECG monitoring device is disposed on a user's left and right wrists or on the user's chest to obtain ECG waveforms. The carotid pulse wave detector is disposed on the user's neck at a position corresponding to the user's carotid arteries for obtaining carotid pulse waveforms. The controller is provided in at least one of the ECG monitoring device, the carotid pulse wave detector, and a mobile device, wherein the controller is configured to obtain the user's carotid physiological parameter(s) (which may include carotid pulse wave velocity or carotid blood pressure) by calculating with the ECG waveforms and/or the carotid pulse waveforms.

7. 发明申请

US20100172800A1 ELECTROSENSING ANTIBODY-PROBE DETECTION AND MEASUREMENT SENSOR HAVING CONDUCTIVITY PROMOTION MOLECULES 审中-公开
标题翻译：具有电导率促销分子的静电抗体检测和测量传感器
公开(公告)号：US20100172800A1
公开(公告)日：2010-07-08
申请号：US12652419
申请日：2010-01-05
申请人： Shiming Lin , Shih-Yuan Lee , Bor-ching Sheu , Chih-chen Lin , Panchien Lin
发明人： Shiming Lin , Shih-Yuan Lee , Bor-ching Sheu , Chih-chen Lin , Panchien Lin
IPC分类号： G01N30/00
CPC分类号： G01N33/5438
摘要： A sensor for electrosensing an antigen in a test sample is disclosed. The sensor has two electrodes electrically disconnected and physically separated from each other, a layer of antibody immobilized on the surface of at least one of said electrodes. The antibody has specific binding reactivity with the antigen. Conductivity promotion molecules are conjugated with the antibody to improve electrical conductivity characteristics across the two electrodes. The antibody captures the antigen present in the test sample mixed in a buffer solution that comes into contact with the antibody-populated electrodes. This alters the electrical conductivity characteristic across the two electrodes in which an amount representative of the altering provides an indication for electrosensing of the antigen.
摘要翻译：公开了一种用于在测试样品中电敏感抗原的传感器。该传感器具有彼此电隔离并物理分离的两个电极，一层抗体固定在至少一个所述电极的表面上。抗体与抗原具有特异性结合活性。电导率促进分子与抗体缀合以改善两个电极之间的导电特性。抗体捕获与在与抗体填充的电极接触的缓冲溶液中混合的测试样品中存在的抗原。这改变了跨越两个电极的电导率特征，其中代表改变的量提供了抗原电感应的指示。

8. 发明授权

US11800985B2 Electrocardiographic monitoring device and blood pressure monitoring system using the same 有权
公开(公告)号：US11800985B2
公开(公告)日：2023-10-31
申请号：US16465370
申请日：2017-11-30
申请人： BIV MEDICAL, LTD. , Shiming Lin
发明人： Shiming Lin , Shih-Wei Chiang , Cheng-Yan Guo , Tai-Cun Lin , Wei-Chih Huang , Chun-Nan Chen , Ya-Ting Chang
IPC分类号： A61B5/00 , A61B5/021 , A61B5/25 , A61B5/024 , A61B5/022 , A61B7/04 , A61B5/30 , A61B5/282 , A61B5/332
CPC分类号： A61B5/02108 , A61B5/0006 , A61B5/02116 , A61B5/02225 , A61B5/02438 , A61B5/02444 , A61B5/282 , A61B5/30 , A61B5/332 , A61B5/681 , A61B5/6823 , A61B5/6824 , A61B5/6841 , A61B7/04 , A61B5/02416 , A61B5/25 , A61B2562/0204 , A61B2562/0209 , A61B2562/0247
摘要： The present invention provides an electrocardiographic monitoring device comprising a device body configured to be attached to a user's chest; a plurality of electrodes provided on the device body; and a controller provided on the device body and connected to the electrodes in order to obtain the user's electrocardiographic signal waveforms. The electrocardiographic monitoring device of the invention can be applied in a blood pressure monitoring system for monitoring a user's blood pressure.

9. 发明申请

US20060170925A1 Biomolecular sensor system utilizing a transverse propagation wave of surface plasmon Resonance (SPR) 有权
标题翻译：利用表面等离振子共振（SPR）的横向传播波的生物分子传感器系统
公开(公告)号：US20060170925A1
公开(公告)日：2006-08-03
申请号：US11049085
申请日：2005-02-02
申请人： Chii-Wann Lin , Chih Kung Lee , Zhi-Hsiang Sung , Shiming Lin
发明人： Chii-Wann Lin , Chih Kung Lee , Zhi-Hsiang Sung , Shiming Lin
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： A biomolecular sensor system utilizing a transverse propagation wave of surface plasmon resonance (SPR) is described. The system comprises: a substrate; a dielectric layer, having a groove therein and standing on top of the substrate; a sensing film layer, sitting at the groove; a pair of prism devices, each resting on one side of the groove and both separating a tunable distance. Besides, the sensor system further comprises a light source, a light detector (a frontend of which connecting to a spectrometer and a backend connecting to a differential amplifier) and a channel with a cover forming inside the groove for the acquisition of the reflected light from the prism devices. Since the sensor system is constructed by exploiting the SPR technique on the transverse propagation, a whole contact surface is under detection (parallel detection) which differentiates it from the traditional method of single-area SPR detection. The sensor system is applicable not only for the far-infrared remote sensing with a transverse distance of several centimeters, but further for the biomedical sensing applications in the miniature sizing and high throughput.
摘要翻译：描述了利用表面等离子体共振（SPR）的横向传播波的生物分子传感器系统。该系统包括：基板; 介电层，其中具有凹槽并站立在所述基板的顶部上; 位于凹槽处的感测膜层; 一对棱镜装置，每个棱镜装置分别搁置在凹槽的一侧并且两者分离可调距离。此外，传感器系统还包括光源，光检测器（其前端连接到光谱仪和连接到差分放大器的后端）以及形成在凹槽内的盖的通道，用于获取反射光的反射光棱镜装置。由于传感器系统是通过利用SPR技术在横向传播中构建的，因此整个接触面被检测（并行检测），与传统的单区域SPR检测方法相区分。传感器系统不仅适用于横向距离为几厘米的远红外遥感，而且适用于微型尺寸和高通量的生物医学传感应用。

10. 发明授权

US06870237B1 Repeated structure of nanometer thin films with symmetric or asymmetric configuration for SPR signal modulation 有权
标题翻译：用于SPR信号调制的具有对称或非对称配置的纳米薄膜的重复结构
公开(公告)号：US06870237B1
公开(公告)日：2005-03-22
申请号：US10647229
申请日：2003-08-26
申请人： Chii-Wann Lin , Chen Kung Huang , Shiming Lin , Chih Kung Lee , Peizen Chang , Shu Sheng Lee
发明人： Chii-Wann Lin , Chen Kung Huang , Shiming Lin , Chih Kung Lee , Peizen Chang , Shu Sheng Lee
IPC分类号： G01N21/55 , G01N21/75 , G01N21/77 , G02B6/122 , H01L31/00 , H01L33/00
CPC分类号： B82Y20/00 , G01N21/553 , G01N21/554 , G01N2021/757 , G01N2021/7776 , G02B6/1226 , Y10S977/719 , Y10S977/759 , Y10S977/792
摘要： A symmetric or asymmetric multilayer structure based on the technique of surface plasmon resonance (SPR) has been applied for modulation of resonant angle and wavelength. The fabrication of this invention can have nanoscale thin film layers up to several hundreds, while each layer has its own material of a high or low refractive index value, and the total layers in a thickness of tens to hundreds nanometers are grown in this single structure. This invention is intended for optimizing the scanning of mechanism by modulating SPR resonant angle and wavelength, and for developing the prospect of portable instruments.
摘要翻译：基于表面等离子体共振（SPR）技术的对称或不对称多层结构已被应用于谐振角和波长的调制。本发明的制造可以具有几百个纳米尺度的薄膜层，而每层具有其自身的具有高或低折射率值的材料，并且在该单一结构中生长厚度为数十至数百纳米的总层。本发明旨在通过调制SPR谐振角和波长来优化机构的扫描，并用于开发便携式仪器的前景。

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