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1. 发明授权

US11375911B2 Carotid physiological parameter monitoring system 有权
公开(公告)号：US11375911B2
公开(公告)日：2022-07-05
申请号：US16630355
申请日：2018-07-10
申请人： Shiming Lin , BIV MEDICAL, LTD.
发明人： Shiming Lin
IPC分类号： A61B5/0245 , A61B5/021 , A61B5/024 , A61B5/00 , A61B5/0507 , A61B8/04 , A61B5/02 , A61B7/04
摘要： The present invention provides a carotid physiological parameter monitoring system, comprising: an electrocardiographic (ECG) monitoring device, a carotid pulse wave detector, and at least one controller. The ECG monitoring device is disposed on a user's left and right wrists or on the user's chest to obtain ECG waveforms. The carotid pulse wave detector is disposed on the user's neck at a position corresponding to the user's carotid arteries for obtaining carotid pulse waveforms. The controller is provided in at least one of the ECG monitoring device, the carotid pulse wave detector, and a mobile device, wherein the controller is configured to obtain the user's carotid physiological parameter(s) (which may include carotid pulse wave velocity or carotid blood pressure) by calculating with the ECG waveforms and/or the carotid pulse waveforms.

2. 发明申请

US20200085319A1 WEARABLE DEVICE CAPABLE OF BLOOD PRESSURE MEASUREMENT 审中-公开
公开(公告)号：US20200085319A1
公开(公告)日：2020-03-19
申请号：US16465504
申请日：2017-11-29
申请人： Shiming LIN , BIV MEDICAL, LTD.
发明人： Shiming LIN
IPC分类号： A61B5/0225 , A61B5/021 , A61B5/00 , F04B43/02 , F04B53/10
摘要： The present invention provides a wearable device capable of blood pressure measurement, comprising a wrist band assembly, a display unit provided on the wrist band assembly, and a detachable bladder provided on a backside of the wrist band assembly, wherein the wrist band assembly is provided with a micro air pump connected to the detachable bladder, an air pressure sensor provided on a side of the detachable bladder, and a processor connected to the micro air pump and the air pressure sensor, and the processor activates the micro air pump according to a trigger signal in order for the micro air pump to inflate the detachable bladder and for a user's blood pressure parameters to be derived from data sent by the air pressure sensor to the processor.

3. 发明申请

US20200000350A1 DYNAMIC MEASUREMENT DEVICE WITH A BLOOD PRESSURE DETERMINATION FUNCTION 审中-公开
公开(公告)号：US20200000350A1
公开(公告)日：2020-01-02
申请号：US16465379
申请日：2017-11-30
申请人： Shiming LIN , BIV MEDICAL, LTD.
发明人： Shiming LIN , Shih-Wei CHIANG , Cheng-Yan GUO , Tai-Cun LIN , Wei-Chih HUANG , Chun-Nan CHEN , Ya-Ting CHANG
IPC分类号： A61B5/022 , A61B5/021 , A61B7/04 , A61B5/00 , A61B5/024
摘要： The present invention provides a dynamic measurement device with a blood pressure determination function, comprising: a heartbeat sensing module disposed on the chest area of a user wherein the heartbeat sensing module comprising a heart sound sensor for obtaining heartbeat signals; a pulse sensing module disposed on a limb area of the user, the pulse sensing module comprising a pulse wave sensor for obtaining pulse signals; and a data calculating module for calculating a mean arterial pressure and a value of systolic blood pressure and diastolic blood pressure based on the heartbeat signals and pulse signals. In addition to dynamically monitoring the blood pressure of a user for 24 hours, the present invention can dynamically monitor the heart sounds of the user for 24 hours individually in order to monitor user's physical condition. Therefore, the present invention has important medical meanings.

4. 发明申请

US20100172800A1 ELECTROSENSING ANTIBODY-PROBE DETECTION AND MEASUREMENT SENSOR HAVING CONDUCTIVITY PROMOTION MOLECULES 审中-公开
标题翻译：具有电导率促销分子的静电抗体检测和测量传感器
公开(公告)号：US20100172800A1
公开(公告)日：2010-07-08
申请号：US12652419
申请日：2010-01-05
申请人： Shiming Lin , Shih-Yuan Lee , Bor-ching Sheu , Chih-chen Lin , Panchien Lin
发明人： Shiming Lin , Shih-Yuan Lee , Bor-ching Sheu , Chih-chen Lin , Panchien Lin
IPC分类号： G01N30/00
CPC分类号： G01N33/5438
摘要： A sensor for electrosensing an antigen in a test sample is disclosed. The sensor has two electrodes electrically disconnected and physically separated from each other, a layer of antibody immobilized on the surface of at least one of said electrodes. The antibody has specific binding reactivity with the antigen. Conductivity promotion molecules are conjugated with the antibody to improve electrical conductivity characteristics across the two electrodes. The antibody captures the antigen present in the test sample mixed in a buffer solution that comes into contact with the antibody-populated electrodes. This alters the electrical conductivity characteristic across the two electrodes in which an amount representative of the altering provides an indication for electrosensing of the antigen.
摘要翻译：公开了一种用于在测试样品中电敏感抗原的传感器。该传感器具有彼此电隔离并物理分离的两个电极，一层抗体固定在至少一个所述电极的表面上。抗体与抗原具有特异性结合活性。电导率促进分子与抗体缀合以改善两个电极之间的导电特性。抗体捕获与在与抗体填充的电极接触的缓冲溶液中混合的测试样品中存在的抗原。这改变了跨越两个电极的电导率特征，其中代表改变的量提供了抗原电感应的指示。

5. 发明授权

US11800985B2 Electrocardiographic monitoring device and blood pressure monitoring system using the same 有权
公开(公告)号：US11800985B2
公开(公告)日：2023-10-31
申请号：US16465370
申请日：2017-11-30
申请人： BIV MEDICAL, LTD. , Shiming Lin
发明人： Shiming Lin , Shih-Wei Chiang , Cheng-Yan Guo , Tai-Cun Lin , Wei-Chih Huang , Chun-Nan Chen , Ya-Ting Chang
IPC分类号： A61B5/00 , A61B5/021 , A61B5/25 , A61B5/024 , A61B5/022 , A61B7/04 , A61B5/30 , A61B5/282 , A61B5/332
CPC分类号： A61B5/02108 , A61B5/0006 , A61B5/02116 , A61B5/02225 , A61B5/02438 , A61B5/02444 , A61B5/282 , A61B5/30 , A61B5/332 , A61B5/681 , A61B5/6823 , A61B5/6824 , A61B5/6841 , A61B7/04 , A61B5/02416 , A61B5/25 , A61B2562/0204 , A61B2562/0209 , A61B2562/0247
摘要： The present invention provides an electrocardiographic monitoring device comprising a device body configured to be attached to a user's chest; a plurality of electrodes provided on the device body; and a controller provided on the device body and connected to the electrodes in order to obtain the user's electrocardiographic signal waveforms. The electrocardiographic monitoring device of the invention can be applied in a blood pressure monitoring system for monitoring a user's blood pressure.

6. 发明申请

US20200000349A1 PULSE DETECTION MODULE AND USE-AS-YOU-NEED BLOOD PRESSURE MEASUREMENT DEVICE COMPRISING THE SAME 审中-公开
公开(公告)号：US20200000349A1
公开(公告)日：2020-01-02
申请号：US16465446
申请日：2017-11-30
申请人： Shiming LIN , BIV MEDICAL, LTD.
发明人： Shiming LIN , Shih-Wei CHIANG , Cheng-Yan GUO , Tai-Cun LIN , Wei-Chih HUANG , Chun-Nan CHEN , Ya-Ting CHANG
IPC分类号： A61B5/021 , A61B5/00
摘要： The present invention provides a pulse detection module and a use-as-you-need blood pressure measurement device comprising the pulse detection module. The pulse detection module is characterized by comprising a plurality of sensors and a controller linked to the sensors, wherein the sensors are arranged horizontally on the wrist watch in a direction parallel to a user's limb on which the wrist watch is worn, and the controller obtains the user's pulse signals through the sensors.

7. 发明申请

US20190387984A1 ELECTROCARDOGRAPHIC MONITORING DEVICE AND BLOOD PRESSURE MONITORING SYSTEM USING THE SAME 审中-公开
公开(公告)号：US20190387984A1
公开(公告)日：2019-12-26
申请号：US16465370
申请日：2017-11-30
申请人： Shiming LIN , BIV MEDICAL, LTD.
发明人： Shiming LIN , Shih-Wei CHIANG , Cheng-Yan GUO , Tai-Cun LIN , Wei-Chih HUANG , Chun-Nan CHEN , Ya-Ting CHANG
IPC分类号： A61B5/021 , A61B5/00 , A61B5/0408 , A61B5/024 , A61B5/0404 , A61B5/0428
摘要： The present invention provides an electrocardiographic monitoring device comprising a device body configured to be attached to a user's chest; a plurality of electrodes provided on the device body; and a controller provided on the device body and connected to the electrodes in order to obtain the user's electrocardiographic signal waveforms. The electrocardiographic monitoring device of the invention can be applied in a blood pressure monitoring system for monitoring a user's blood pressure.

8. 发明申请

US20060170925A1 Biomolecular sensor system utilizing a transverse propagation wave of surface plasmon Resonance (SPR) 有权
标题翻译：利用表面等离振子共振（SPR）的横向传播波的生物分子传感器系统
公开(公告)号：US20060170925A1
公开(公告)日：2006-08-03
申请号：US11049085
申请日：2005-02-02
申请人： Chii-Wann Lin , Chih Kung Lee , Zhi-Hsiang Sung , Shiming Lin
发明人： Chii-Wann Lin , Chih Kung Lee , Zhi-Hsiang Sung , Shiming Lin
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： A biomolecular sensor system utilizing a transverse propagation wave of surface plasmon resonance (SPR) is described. The system comprises: a substrate; a dielectric layer, having a groove therein and standing on top of the substrate; a sensing film layer, sitting at the groove; a pair of prism devices, each resting on one side of the groove and both separating a tunable distance. Besides, the sensor system further comprises a light source, a light detector (a frontend of which connecting to a spectrometer and a backend connecting to a differential amplifier) and a channel with a cover forming inside the groove for the acquisition of the reflected light from the prism devices. Since the sensor system is constructed by exploiting the SPR technique on the transverse propagation, a whole contact surface is under detection (parallel detection) which differentiates it from the traditional method of single-area SPR detection. The sensor system is applicable not only for the far-infrared remote sensing with a transverse distance of several centimeters, but further for the biomedical sensing applications in the miniature sizing and high throughput.
摘要翻译：描述了利用表面等离子体共振（SPR）的横向传播波的生物分子传感器系统。该系统包括：基板; 介电层，其中具有凹槽并站立在所述基板的顶部上; 位于凹槽处的感测膜层; 一对棱镜装置，每个棱镜装置分别搁置在凹槽的一侧并且两者分离可调距离。此外，传感器系统还包括光源，光检测器（其前端连接到光谱仪和连接到差分放大器的后端）以及形成在凹槽内的盖的通道，用于获取反射光的反射光棱镜装置。由于传感器系统是通过利用SPR技术在横向传播中构建的，因此整个接触面被检测（并行检测），与传统的单区域SPR检测方法相区分。传感器系统不仅适用于横向距离为几厘米的远红外遥感，而且适用于微型尺寸和高通量的生物医学传感应用。

9. 发明授权

US06870237B1 Repeated structure of nanometer thin films with symmetric or asymmetric configuration for SPR signal modulation 有权
标题翻译：用于SPR信号调制的具有对称或非对称配置的纳米薄膜的重复结构
公开(公告)号：US06870237B1
公开(公告)日：2005-03-22
申请号：US10647229
申请日：2003-08-26
申请人： Chii-Wann Lin , Chen Kung Huang , Shiming Lin , Chih Kung Lee , Peizen Chang , Shu Sheng Lee
发明人： Chii-Wann Lin , Chen Kung Huang , Shiming Lin , Chih Kung Lee , Peizen Chang , Shu Sheng Lee
IPC分类号： G01N21/55 , G01N21/75 , G01N21/77 , G02B6/122 , H01L31/00 , H01L33/00
CPC分类号： B82Y20/00 , G01N21/553 , G01N21/554 , G01N2021/757 , G01N2021/7776 , G02B6/1226 , Y10S977/719 , Y10S977/759 , Y10S977/792
摘要： A symmetric or asymmetric multilayer structure based on the technique of surface plasmon resonance (SPR) has been applied for modulation of resonant angle and wavelength. The fabrication of this invention can have nanoscale thin film layers up to several hundreds, while each layer has its own material of a high or low refractive index value, and the total layers in a thickness of tens to hundreds nanometers are grown in this single structure. This invention is intended for optimizing the scanning of mechanism by modulating SPR resonant angle and wavelength, and for developing the prospect of portable instruments.
摘要翻译：基于表面等离子体共振（SPR）技术的对称或不对称多层结构已被应用于谐振角和波长的调制。本发明的制造可以具有几百个纳米尺度的薄膜层，而每层具有其自身的具有高或低折射率值的材料，并且在该单一结构中生长厚度为数十至数百纳米的总层。本发明旨在通过调制SPR谐振角和波长来优化机构的扫描，并用于开发便携式仪器的前景。

10. 发明授权

US11690523B2 Carotid artery blood pressure detecting device 有权
公开(公告)号：US11690523B2
公开(公告)日：2023-07-04
申请号：US16630663
申请日：2018-07-10
申请人： Shiming Lin , BIV MEDICAL, LTD.
发明人： Shiming Lin
IPC分类号： A61B5/00 , A61B5/0245 , A61B5/021 , A61B5/024 , A61B8/04 , A61B7/04 , A61B5/0507 , A61B5/02
CPC分类号： A61B5/0245 , A61B5/002 , A61B5/0004 , A61B5/02007 , A61B5/02108 , A61B5/02125 , A61B5/02438 , A61B5/0507 , A61B5/684 , A61B5/6823 , A61B5/6824 , A61B5/6833 , A61B5/7275 , A61B7/04 , A61B8/04 , A61B5/02416 , A61B2562/0247
摘要： The present invention provides a carotid blood pressure detection device, comprising: a first sensing unit, a second sensing unit, and a controller connected or coupled to the first sensing unit and the second sensing unit. The first sensing unit is disposed on a subject's neck and adjacent to a first position of the subject's carotid arteries. The second sensing unit is disposed on the subject's neck and adjacent to a second position of the subject's carotid arteries. The controller derives a mean arterial pressure of a section of the subject's carotid arteries that lies between the first position and the second position of the subject's carotid arteries from pulse wave data measured and obtained by the first sensing unit and pulse wave data measured and obtained by the second sensing unit.

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