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1. 发明申请

US20060170925A1 Biomolecular sensor system utilizing a transverse propagation wave of surface plasmon Resonance (SPR) 有权
标题翻译：利用表面等离振子共振（SPR）的横向传播波的生物分子传感器系统
公开(公告)号：US20060170925A1
公开(公告)日：2006-08-03
申请号：US11049085
申请日：2005-02-02
申请人： Chii-Wann Lin , Chih Kung Lee , Zhi-Hsiang Sung , Shiming Lin
发明人： Chii-Wann Lin , Chih Kung Lee , Zhi-Hsiang Sung , Shiming Lin
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： A biomolecular sensor system utilizing a transverse propagation wave of surface plasmon resonance (SPR) is described. The system comprises: a substrate; a dielectric layer, having a groove therein and standing on top of the substrate; a sensing film layer, sitting at the groove; a pair of prism devices, each resting on one side of the groove and both separating a tunable distance. Besides, the sensor system further comprises a light source, a light detector (a frontend of which connecting to a spectrometer and a backend connecting to a differential amplifier) and a channel with a cover forming inside the groove for the acquisition of the reflected light from the prism devices. Since the sensor system is constructed by exploiting the SPR technique on the transverse propagation, a whole contact surface is under detection (parallel detection) which differentiates it from the traditional method of single-area SPR detection. The sensor system is applicable not only for the far-infrared remote sensing with a transverse distance of several centimeters, but further for the biomedical sensing applications in the miniature sizing and high throughput.
摘要翻译：描述了利用表面等离子体共振（SPR）的横向传播波的生物分子传感器系统。该系统包括：基板; 介电层，其中具有凹槽并站立在所述基板的顶部上; 位于凹槽处的感测膜层; 一对棱镜装置，每个棱镜装置分别搁置在凹槽的一侧并且两者分离可调距离。此外，传感器系统还包括光源，光检测器（其前端连接到光谱仪和连接到差分放大器的后端）以及形成在凹槽内的盖的通道，用于获取反射光的反射光棱镜装置。由于传感器系统是通过利用SPR技术在横向传播中构建的，因此整个接触面被检测（并行检测），与传统的单区域SPR检测方法相区分。传感器系统不仅适用于横向距离为几厘米的远红外遥感，而且适用于微型尺寸和高通量的生物医学传感应用。

2. 发明授权

US07271914B2 Biomolecular sensor system utilizing a transverse propagation wave of surface plasmon resonance (SPR) 有权
标题翻译：利用表面等离子体共振（SPR）的横向传播波的生物分子传感器系统
公开(公告)号：US07271914B2
公开(公告)日：2007-09-18
申请号：US11049085
申请日：2005-02-02
申请人： Chii-Wann Lin , Chih Kung Lee , Zhi-Hsiang Sung , Shiming Lin
发明人： Chii-Wann Lin , Chih Kung Lee , Zhi-Hsiang Sung , Shiming Lin
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： A biomolecular sensor system utilizing a transverse propagation wave of surface plasmon resonance (SPR) is described. The system comprises: a substrate; a dielectric layer, having a groove therein and standing on top of the substrate; a sensing film layer, sitting at the groove; a pair of prism devices, each resting on one side of the groove and both separating a tunable distance. Besides, the sensor system further comprises a light source, a light detector (a frontend of which connecting to a spectrometer and a backend connecting to a differential amplifier) and a channel with a cover forming inside the groove for the acquisition of the reflected light from the prism devices. Since the sensor system is constructed by exploiting the SPR technique on the transverse propagation, a whole contact surface is under detection (parallel detection) which differentiates it from the traditional method of single-area SPR detection. The sensor system is applicable not only for the far-infrared remote sensing with a transverse distance of several centimeters, but further for the biomedical sensing applications in the miniature sizing and high throughput.
摘要翻译：描述了利用表面等离子体共振（SPR）的横向传播波的生物分子传感器系统。该系统包括：基板; 介电层，其中具有凹槽并站立在所述基板的顶部上; 位于凹槽处的感测膜层; 一对棱镜装置，每个棱镜装置分别搁置在凹槽的一侧并且两者分离可调距离。此外，传感器系统还包括光源，光检测器（其前端连接到光谱仪和连接到差分放大器的后端）以及形成在凹槽内的盖的通道，用于获取反射光的反射光棱镜装置。由于传感器系统是通过利用SPR技术在横向传播中构建的，因此整个接触面被检测（并行检测），与传统的单区域SPR检测方法相区分。传感器系统不仅适用于横向距离为几厘米的远红外遥感，而且适用于微型尺寸和高通量的生物医学传感应用。

3. 发明授权

US06870237B1 Repeated structure of nanometer thin films with symmetric or asymmetric configuration for SPR signal modulation 有权
标题翻译：用于SPR信号调制的具有对称或非对称配置的纳米薄膜的重复结构
公开(公告)号：US06870237B1
公开(公告)日：2005-03-22
申请号：US10647229
申请日：2003-08-26
申请人： Chii-Wann Lin , Chen Kung Huang , Shiming Lin , Chih Kung Lee , Peizen Chang , Shu Sheng Lee
发明人： Chii-Wann Lin , Chen Kung Huang , Shiming Lin , Chih Kung Lee , Peizen Chang , Shu Sheng Lee
IPC分类号： G01N21/55 , G01N21/75 , G01N21/77 , G02B6/122 , H01L31/00 , H01L33/00
CPC分类号： B82Y20/00 , G01N21/553 , G01N21/554 , G01N2021/757 , G01N2021/7776 , G02B6/1226 , Y10S977/719 , Y10S977/759 , Y10S977/792
摘要： A symmetric or asymmetric multilayer structure based on the technique of surface plasmon resonance (SPR) has been applied for modulation of resonant angle and wavelength. The fabrication of this invention can have nanoscale thin film layers up to several hundreds, while each layer has its own material of a high or low refractive index value, and the total layers in a thickness of tens to hundreds nanometers are grown in this single structure. This invention is intended for optimizing the scanning of mechanism by modulating SPR resonant angle and wavelength, and for developing the prospect of portable instruments.
摘要翻译：基于表面等离子体共振（SPR）技术的对称或不对称多层结构已被应用于谐振角和波长的调制。本发明的制造可以具有几百个纳米尺度的薄膜层，而每层具有其自身的具有高或低折射率值的材料，并且在该单一结构中生长厚度为数十至数百纳米的总层。本发明旨在通过调制SPR谐振角和波长来优化机构的扫描，并用于开发便携式仪器的前景。

4. 发明授权

US07148057B2 Array biochip workstation 失效
标题翻译：阵列生物芯片工作站
公开(公告)号：US07148057B2
公开(公告)日：2006-12-12
申请号：US10216911
申请日：2002-08-13
申请人： Yo-Hsin Su , Hsi-Lien Lu , Hsun-Min Lung , Chung-Ho Tung , Ta-Chang Liu , Chih-Kung Lee , Su-Ming Hsu , Shiming Lin , Long-Sun Huang , Chii-Wann Lin
发明人： Yo-Hsin Su , Hsi-Lien Lu , Hsun-Min Lung , Chung-Ho Tung , Ta-Chang Liu , Chih-Kung Lee , Su-Ming Hsu , Shiming Lin , Long-Sun Huang , Chii-Wann Lin
IPC分类号： C12M1/34
CPC分类号： B01L9/527 , B01F11/0266 , B01F13/0059 , B01L2200/027 , B01L2300/0819 , G01N1/312 , G01N35/1074 , G01N2035/00158 , G01N2035/1039
摘要： A microarray biochip workstation allowing positioning of chips, immobilization of molecules, mixing of sample solution, molecular interactions and washing and processing qualitative and quantitative analyses consists of a positioning device for holding a biochip, a mixing device for acting on the sample solution applied on the biochip, a pumping device for removing the sample solution from the biochip surface that does not react, and a reading device for detecting reaction results of the biochip. The workstation thus constructed provides an integrated and effective work interface.
摘要翻译：一种微阵列生物芯片工作站，用于定位芯片，分子固定，样品溶液混合，分子相互作用以及洗涤和加工定性和定量分析，包括用于保持生物芯片的定位装置，用于作用在样品溶液上的混合装置生物芯片，用于从未反应的生物芯片表面去除样品溶液的泵送装置，以及用于检测生物芯片的反应结果的读取装置。这样构造的工作站提供了一个集成且有效的工作界面。

5. 发明授权

US06844935B2 Multi-function opto-electronic detection apparatus 有权
标题翻译：多功能光电检测仪
公开(公告)号：US06844935B2
公开(公告)日：2005-01-18
申请号：US10761116
申请日：2004-01-20
申请人： Chih-Kung Lee , Shuen-Chen Shiue , Shu-Sheng Lee , Jiun-Yan Wu , Chii-Wann Lin , Shiming Lin
发明人： Chih-Kung Lee , Shuen-Chen Shiue , Shu-Sheng Lee , Jiun-Yan Wu , Chii-Wann Lin , Shiming Lin
IPC分类号： G01B11/00 , G01B9/02
CPC分类号： G01B11/00
摘要： A multi-function opto-electronic detection apparatus for detecting molecular characteristics of a test sample. The appratuses comprises functional mode subsystems including a detecting light source subsystem for generating sampling beams for illuminating the test sample; a manipulation optics subsystem for aligning the sampling beam onto the test sample; a target signal processing subsystem for analyzing target beams emerging from the test sample resulting from the illuminating of the sampling beam; and a sample fixation subsystem for holding the test sample. The detecting light source subsystem, manipulation optics subsystem and target signal processing subsystem are assembled into one of several possible optical sampling setups for the detection characteristics of the test sample. The functional mode setups include at least ellispometer, confocal image scanner, photon tunneling scanning microscope and interferometer.
摘要翻译：一种用于检测试样的分子特性的多功能光电检测装置。该装置包括功能模式子系统，包括用于产生用于照亮测试样本的采样光束的检测光源子系统; 用于将采样光束对准到测试样品的操纵光学子系统; 目标信号处理子系统，用于分析从采样光束的照明产生的从测试样本出射的目标光束; 以及用于保持测试样本的样本固定子系统。检测光源子系统，操作光学子系统和目标信号处理子系统被组合成用于测试样本的检测特性的几种可能的光学采样设置之一。功能模式设置至少包括椭圆计，共焦图像扫描仪，光子隧道扫描显微镜和干涉仪。

6. 发明申请

US20050045977A1 REPEATED STRUCTURE OF NANOMETER THIN FILMS WITH SYMMETRIC OR ASYMMETRIC CONFIGURATION FOR SPR SIGNAL MODULATION 有权
标题翻译：具有SPR信号调制的对称或非对称配置的纳米薄膜的重复结构
公开(公告)号：US20050045977A1
公开(公告)日：2005-03-03
申请号：US10647229
申请日：2003-08-26
申请人： Chii-Wann Lin , Chen Huang , Shiming Lin , Chih Lee , Peizen Chang , Shu Lee
发明人： Chii-Wann Lin , Chen Huang , Shiming Lin , Chih Lee , Peizen Chang , Shu Lee
IPC分类号： G01N21/55 , G01N21/75 , G01N21/77 , G02B6/122 , H01L31/00 , H01L33/00
CPC分类号： B82Y20/00 , G01N21/553 , G01N21/554 , G01N2021/757 , G01N2021/7776 , G02B6/1226 , Y10S977/719 , Y10S977/759 , Y10S977/792
摘要： A symmetric or asymmetric multilayer structure based on the technique of surface plasmon resonance (SPR) has been applied for modulation of resonant angle and wavelength. The fabrication of this invention can have nanoscale thin film layers up to several hundreds, while each layer has its own material of a high or low refractive index value, and the total layers in a thickness of tens to hundreds nanometers are grown in this single structure. This invention is intended for optimizing the scanning of mechanism by modulating SPR resonant angle and wavelength, and for developing the prospect of portable instruments.
摘要翻译：基于表面等离子体共振（SPR）技术的对称或不对称多层结构已被应用于谐振角和波长的调制。本发明的制造可以具有几百个纳米尺度的薄膜层，而每层具有其自身的具有高或低折射率值的材料，并且在该单一结构中生长厚度为数十至数百纳米的总层。本发明旨在通过调制SPR谐振角和波长来优化机构的扫描，并用于开发便携式仪器的前景。

7. 发明授权

US06661520B1 Sensor system of surface plasmon resonance (SPR) and measuring method thereof 有权
标题翻译：表面等离子体共振（SPR）传感器系统及其测量方法
公开(公告)号：US06661520B1
公开(公告)日：2003-12-09
申请号：US10153459
申请日：2002-05-22
申请人： Chu-Wann Lin , Chi-Yu Huang , Jyh-Perng Chiu , Ying-Tsuen Liou , Shuen-Chen Shiue , Te-Son Kuo , Long-Sun Huang , Pei-Zen Chang , Lung-Jieh Yang , Chau-Chung Wu , Shiming Lin , Chih-Kung Lee
发明人： Chu-Wann Lin , Chi-Yu Huang , Jyh-Perng Chiu , Ying-Tsuen Liou , Shuen-Chen Shiue , Te-Son Kuo , Long-Sun Huang , Pei-Zen Chang , Lung-Jieh Yang , Chau-Chung Wu , Shiming Lin , Chih-Kung Lee
IPC分类号： G01N2155
CPC分类号： G01N21/553
摘要： A sensor system of a surface plasmon resonance (SPR) for analyzing a characteristic of a substance and the measuring method thereof are provided. The system includes an optical device for generating a first light beam and a second light beam in sequence; a sensor device for respectively generating a first plasmon wave and a second plasmon wave in response to an optical characteristic change of the first light beam and the second light beam with respective to the substance, in which a resonance is generated from the first plasmon wave and the second plasmon wave respectively generating a first reflective signal and a second reflective signal; and a measuring device for measuring spectra of the first reflective signal and the second reflective signal and obtaining the measured value which is substituted into an operational formula to calculate a reference value used for analyzing the characteristic of the substance.
摘要翻译：提供了用于分析物质的特性的表面等离子体共振（SPR）的传感器系统及其测量方法。该系统包括依次产生第一光束和第二光束的光学装置; 传感器装置，用于响应于所述第一光束和所述第二光束的光学特性变化分别产生第一等离子体激元波和第二等离子体波，所述第一等离子体波和所述第二等离子体波相对于从所述物质产生的所述物质的光学特性变化，所述第二等离子体波分别产生第一反射信号和第二反射信号; 以及测量装置，用于测量第一反射信号和第二反射信号的光谱，并获得被代入操作公式的测量值，以计算用于分析物质特征的参考值。

8. 发明授权

US08110605B2 Compound for inactivating viruses and bacteria and method of making same 有权
标题翻译：用于灭活病毒和细菌的化合物及其制备方法
公开(公告)号：US08110605B2
公开(公告)日：2012-02-07
申请号：US12710460
申请日：2010-02-23
申请人： Shiming Lin , Chih-Kung Lee , Shih-Yuan Lee , Jim-Tong Hong , Ming-Chu Cheng , Chih-Chen Lin , Rong-Sin Wu , Shu-Fang Chu , Yu-Ting Chang , Wen-Ching Ko
发明人： Shiming Lin , Chih-Kung Lee , Shih-Yuan Lee , Jim-Tong Hong , Ming-Chu Cheng , Chih-Chen Lin , Rong-Sin Wu , Shu-Fang Chu , Yu-Ting Chang , Wen-Ching Ko
IPC分类号： A61K31/20 , B32B5/12
CPC分类号： C07C323/52 , A01N1/0215 , D01F1/103 , D06M13/252 , D06M16/00 , Y10T442/20
摘要： The invention discloses a novel compound effective in inactivating viruses and bacteria. The compound, 2-(10-mercaptodecyl)-propanedioic acid or salts thereof, is shown to disrupt, break down or inactivate viruses and bacteria, thus suppressing infection and proliferation thereof in host cells. A method of chemically synthesizing the novel compound is also disclosed.
摘要翻译：本发明公开了一种有效灭活病毒和细菌的新型化合物。化合物2-（10-巯基癸基） - 丙二酸或其盐显示破坏，分解或灭活病毒和细菌，从而抑制宿主细胞的感染和增殖。还公开了一种化学合成该新化合物的方法。

9. 发明授权

US06828807B2 Biological cell test method and apparatus 失效
标题翻译：生物细胞试验方法和装置
公开(公告)号：US06828807B2
公开(公告)日：2004-12-07
申请号：US10334910
申请日：2003-01-02
申请人： Yo-Hsin Su , Hsi-Lien Lu , Ta-Chang Liu , Hsun-Min Lung , Long-Sun Huang , Shiming Lin , Der-Xing Liou , Chien-Hsun Chen , Chih-Kung Lee
发明人： Yo-Hsin Su , Hsi-Lien Lu , Ta-Chang Liu , Hsun-Min Lung , Long-Sun Huang , Shiming Lin , Der-Xing Liou , Chien-Hsun Chen , Chih-Kung Lee
IPC分类号： G01R2708
CPC分类号： C12M23/12 , C12M35/02 , C12M41/46
摘要： A biological cell test method and apparatus employs a conventional perforated cell carrier which has a plurality of holes. Each hole has two metal electrodes. A cell is disposed in the hole to contact the two electrodes. The electrodes are connected to electric current or voltage. The electric current or field flows from one electrode through the cell to another electrode. Through the inherent impedance, inductance or capacitance of the cell, the presence or property reactions of the cell may be detected.
摘要翻译：生物细胞试验方法和装置采用具有多个孔的常规穿孔细胞载体。每个孔都有两个金属电极。一个电池设置在孔中以接触两个电极。电极连接电流或电压。电流或场从一个电极通过电池流到另一个电极。通过电阻的固有阻抗，电感或电容，可以检测电池的存在或性质反应。

10. 发明授权

US11375911B2 Carotid physiological parameter monitoring system 有权
公开(公告)号：US11375911B2
公开(公告)日：2022-07-05
申请号：US16630355
申请日：2018-07-10
申请人： Shiming Lin , BIV MEDICAL, LTD.
发明人： Shiming Lin
IPC分类号： A61B5/0245 , A61B5/021 , A61B5/024 , A61B5/00 , A61B5/0507 , A61B8/04 , A61B5/02 , A61B7/04
摘要： The present invention provides a carotid physiological parameter monitoring system, comprising: an electrocardiographic (ECG) monitoring device, a carotid pulse wave detector, and at least one controller. The ECG monitoring device is disposed on a user's left and right wrists or on the user's chest to obtain ECG waveforms. The carotid pulse wave detector is disposed on the user's neck at a position corresponding to the user's carotid arteries for obtaining carotid pulse waveforms. The controller is provided in at least one of the ECG monitoring device, the carotid pulse wave detector, and a mobile device, wherein the controller is configured to obtain the user's carotid physiological parameter(s) (which may include carotid pulse wave velocity or carotid blood pressure) by calculating with the ECG waveforms and/or the carotid pulse waveforms.

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