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    • 1. 发明申请
    • Biomolecular sensor system utilizing a transverse propagation wave of surface plasmon Resonance (SPR)
    • 利用表面等离振子共振(SPR)的横向传播波的生物分子传感器系统
    • US20060170925A1
    • 2006-08-03
    • US11049085
    • 2005-02-02
    • Chii-Wann LinChih Kung LeeZhi-Hsiang SungShiming Lin
    • Chii-Wann LinChih Kung LeeZhi-Hsiang SungShiming Lin
    • G01N21/55
    • G01N21/553
    • A biomolecular sensor system utilizing a transverse propagation wave of surface plasmon resonance (SPR) is described. The system comprises: a substrate; a dielectric layer, having a groove therein and standing on top of the substrate; a sensing film layer, sitting at the groove; a pair of prism devices, each resting on one side of the groove and both separating a tunable distance. Besides, the sensor system further comprises a light source, a light detector (a frontend of which connecting to a spectrometer and a backend connecting to a differential amplifier) and a channel with a cover forming inside the groove for the acquisition of the reflected light from the prism devices. Since the sensor system is constructed by exploiting the SPR technique on the transverse propagation, a whole contact surface is under detection (parallel detection) which differentiates it from the traditional method of single-area SPR detection. The sensor system is applicable not only for the far-infrared remote sensing with a transverse distance of several centimeters, but further for the biomedical sensing applications in the miniature sizing and high throughput.
    • 描述了利用表面等离子体共振(SPR)的横向传播波的生物分子传感器系统。 该系统包括:基板; 介电层,其中具有凹槽并站立在所述基板的顶部上; 位于凹槽处的感测膜层; 一对棱镜装置,每个棱镜装置分别搁置在凹槽的一侧并且两者分离可调距离。 此外,传感器系统还包括光源,光检测器(其前端连接到光谱仪和连接到差分放大器的后端)以及形成在凹槽内的盖的通道,用于获取反射光的反射光 棱镜装置。 由于传感器系统是通过利用SPR技术在横向传播中构建的,因此整个接触面被检测(并行检测),与传统的单区域SPR检测方法相区分。 传感器系统不仅适用于横向距离为几厘米的远红外遥感,而且适用于微型尺寸和高通量的生物医学传感应用。
    • 2. 发明授权
    • Biomolecular sensor system utilizing a transverse propagation wave of surface plasmon resonance (SPR)
    • 利用表面等离子体共振(SPR)的横向传播波的生物分子传感器系统
    • US07271914B2
    • 2007-09-18
    • US11049085
    • 2005-02-02
    • Chii-Wann LinChih Kung LeeZhi-Hsiang SungShiming Lin
    • Chii-Wann LinChih Kung LeeZhi-Hsiang SungShiming Lin
    • G01N21/55
    • G01N21/553
    • A biomolecular sensor system utilizing a transverse propagation wave of surface plasmon resonance (SPR) is described. The system comprises: a substrate; a dielectric layer, having a groove therein and standing on top of the substrate; a sensing film layer, sitting at the groove; a pair of prism devices, each resting on one side of the groove and both separating a tunable distance. Besides, the sensor system further comprises a light source, a light detector (a frontend of which connecting to a spectrometer and a backend connecting to a differential amplifier) and a channel with a cover forming inside the groove for the acquisition of the reflected light from the prism devices. Since the sensor system is constructed by exploiting the SPR technique on the transverse propagation, a whole contact surface is under detection (parallel detection) which differentiates it from the traditional method of single-area SPR detection. The sensor system is applicable not only for the far-infrared remote sensing with a transverse distance of several centimeters, but further for the biomedical sensing applications in the miniature sizing and high throughput.
    • 描述了利用表面等离子体共振(SPR)的横向传播波的生物分子传感器系统。 该系统包括:基板; 介电层,其中具有凹槽并站立在所述基板的顶部上; 位于凹槽处的感测膜层; 一对棱镜装置,每个棱镜装置分别搁置在凹槽的一侧并且两者分离可调距离。 此外,传感器系统还包括光源,光检测器(其前端连接到光谱仪和连接到差分放大器的后端)以及形成在凹槽内的盖的通道,用于获取反射光的反射光 棱镜装置。 由于传感器系统是通过利用SPR技术在横向传播中构建的,因此整个接触面被检测(并行检测),与传统的单区域SPR检测方法相区分。 传感器系统不仅适用于横向距离为几厘米的远红外遥感,而且适用于微型尺寸和高通量的生物医学传感应用。
    • 5. 发明授权
    • Multi-function opto-electronic detection apparatus
    • 多功能光电检测仪
    • US06844935B2
    • 2005-01-18
    • US10761116
    • 2004-01-20
    • Chih-Kung LeeShuen-Chen ShiueShu-Sheng LeeJiun-Yan WuChii-Wann LinShiming Lin
    • Chih-Kung LeeShuen-Chen ShiueShu-Sheng LeeJiun-Yan WuChii-Wann LinShiming Lin
    • G01B11/00G01B9/02
    • G01B11/00
    • A multi-function opto-electronic detection apparatus for detecting molecular characteristics of a test sample. The appratuses comprises functional mode subsystems including a detecting light source subsystem for generating sampling beams for illuminating the test sample; a manipulation optics subsystem for aligning the sampling beam onto the test sample; a target signal processing subsystem for analyzing target beams emerging from the test sample resulting from the illuminating of the sampling beam; and a sample fixation subsystem for holding the test sample. The detecting light source subsystem, manipulation optics subsystem and target signal processing subsystem are assembled into one of several possible optical sampling setups for the detection characteristics of the test sample. The functional mode setups include at least ellispometer, confocal image scanner, photon tunneling scanning microscope and interferometer.
    • 一种用于检测试样的分子特性的多功能光电检测装置。 该装置包括功能模式子系统,包括用于产生用于照亮测试样本的采样光束的检测光源子系统; 用于将采样光束对准到测试样品的操纵光学子系统; 目标信号处理子系统,用于分析从采样光束的照明产生的从测试样本出射的目标光束; 以及用于保持测试样本的样本固定子系统。 检测光源子系统,操作光学子系统和目标信号处理子系统被组合成用于测试样本的检测特性的几种可能的光学采样设置之一。 功能模式设置至少包括椭圆计,共焦图像扫描仪,光子隧道扫描显微镜和干涉仪。