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1. 发明授权

US10131889B1 Candida antarctica lipase B mutant, and methods for making and using the same 有权
公开(公告)号：US10131889B1
公开(公告)日：2018-11-20
申请号：US15810007
申请日：2017-11-11
申请人： Liming Liu , Bin Yang
发明人： Liming Liu , Bin Yang
IPC分类号： C12N9/20 , C12N15/74 , C12N15/00 , C12P9/00
摘要： The present invention relates to the field of bioengineering. It provides a Candida antarctica lipase B mutant and its application. The mutant enzyme overcomes the limit of the parent enzyme that can exhibit high enantioselectivity towards (R)-3-TBDMSO glutaric acid methyl monoester only at temperatures below 5° C. The mutant enzyme successfully increased R-ee value at 5-70° C. The mutant D223V/A281S exhibits high R-ee value (>99%), high conversion rate (80%), and high space-time yield (107.54 g L−1 d−1). The present invention lays a foundation for industrial production of (R)-3-TBDMSO glutaric acid methyl monoester using a biosynthesis approach and provide insights into conformational dynamics-based enzyme design.

2. 发明申请

US20200270517A1 NANOCRYSTAL ASSEMBLIES AND USES THEREOF 审中-公开
公开(公告)号：US20200270517A1
公开(公告)日：2020-08-27
申请号：US16796847
申请日：2020-02-20
申请人： Satria Zulkarnaen Bisri , Thomas Kugler , Ian Johnson , Jeremy Burroughes , Yoshihiro Iwasa , Yasuhiro Ishida , Liming Liu
发明人： Satria Zulkarnaen Bisri , Thomas Kugler , Ian Johnson , Jeremy Burroughes , Yoshihiro Iwasa , Yasuhiro Ishida , Liming Liu
IPC分类号： C09K11/06 , C09K11/66 , H01L35/26 , H01L29/12
摘要： Provided herein are nanocrystal assemblies comprising quantum dots, a dopant (e.g., an organic compound dopant), and a ligand bridging the quantum dots. Also provided are methods of preparing the assemblies and devices comprising the assemblies (e.g., field effect transistors, thermoelectric generators).

3. 发明申请

US20130045218A1 FC RECEPTOR BINDING PROTEINS 审中-公开
公开(公告)号：US20130045218A1
公开(公告)日：2013-02-21
申请号：US13584221
申请日：2012-08-13
申请人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato , Malini Viswanathan
发明人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato , Malini Viswanathan
IPC分类号： C07K16/28 , A61P19/02 , A61P21/04 , G01N33/566 , A61P25/00 , A61P1/04 , A61P37/00 , A61P1/00 , A61K39/395 , A61P3/10
摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

4. 发明授权

US08273351B2 Fc receptor binding proteins 有权
标题翻译： Fc受体结合蛋白
公开(公告)号：US08273351B2
公开(公告)日：2012-09-25
申请号：US12429529
申请日：2009-04-24
申请人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato
发明人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , G01N33/53
CPC分类号： C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535
摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
摘要翻译：本公开尤其提供结合FcRn的蛋白质，例如以高亲和力和选择性抑制FcRn的免疫球蛋白。 FcRn结合蛋白可用于治疗多种疾病，包括自身免疫性疾病。

5. 发明申请

US20090324614A1 FC RECEPTOR BINDING PROTEINS 有权
标题翻译： FC受体结合蛋白
公开(公告)号：US20090324614A1
公开(公告)日：2009-12-31
申请号：US12429529
申请日：2009-04-24
申请人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato
发明人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , G01N33/53 , A61P37/00
CPC分类号： C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535
摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
摘要翻译：本公开尤其提供结合FcRn的蛋白质，例如以高亲和力和选择性抑制FcRn的免疫球蛋白。 FcRn结合蛋白可用于治疗多种疾病，包括自身免疫性疾病。

6. 发明授权

US10508279B2 Recombinant Escherichia coli for high efficiency production of fructosylated chondroitin and method for making thereof 有权
公开(公告)号：US10508279B2
公开(公告)日：2019-12-17
申请号：US15891564
申请日：2018-02-08
申请人： Jing Wu , Quan Zhang , Liming Liu , Xiulai Chen , Jia Liu , Qiuling Luo
发明人： Jing Wu , Quan Zhang , Liming Liu , Xiulai Chen , Jia Liu , Qiuling Luo
IPC分类号： C12N1/20 , C12N15/70 , C12N9/10 , C12N9/90 , C12P19/24 , C12P19/26
摘要： The present invention relates to the field of biotechnology engineering. It provides a recombinant Escherichia coli that can produce fructosylated chondroitin with high yields and the method for constructing the recombinant strain. The present invention discloses a method for constructing an expression plasmid pETM6R1-RBS-glmM-GGGS-glmS that contains a glmM and a glmS gene under regulation of ribosome binding sites. The recombinant plasmid was transformed into E. coli K4 to obtain a recombinant E. coli strain ZQ33 that can produce fructosylated chondroitin up to 3.99 g·L−1 by fed-batch fermentation in a 5-L fermentor, which was increased by 108.90% compared to that of the wild type strain.

7. 发明授权

US09187552B2 Method for preparing antibodies having improved properties 有权
标题翻译：制备具有改善性质的抗体的方法
公开(公告)号：US09187552B2
公开(公告)日：2015-11-17
申请号：US13699213
申请日：2011-05-25
申请人： Terrance A. Stadheim , Dongxing Zha , Liming Liu
发明人： Terrance A. Stadheim , Dongxing Zha , Liming Liu
IPC分类号： C07K1/00 , C07K16/00 , C12P21/08 , C07K16/24 , C07K16/32 , A61K39/00
CPC分类号： C12P21/005 , A61K2039/505 , C07K16/00 , C07K16/241 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K2317/14 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/71 , C07K2317/732 , C07K2317/734
摘要： The present invention is directed to methods and compositions for the production of Fc-containing polypeptides having improved properties and comprising mutations at positions 243 and 264 of the Fc region.
摘要翻译：本发明涉及用于生产具有改进性质并含有Fc区第243和264位突变的含Fc多肽的方法和组合物。

8. 发明授权

US08969755B2 Lower-power laser and arc hybrid welding method and device 有权
标题翻译：低功率激光和电弧复合焊接方法及装置
公开(公告)号：US08969755B2
公开(公告)日：2015-03-03
申请号：US13518364
申请日：2010-12-21
申请人： Liming Liu , Gang Song , Zhaodong Zhang
发明人： Liming Liu , Gang Song , Zhaodong Zhang
IPC分类号： B23K28/02 , B23K26/20 , B23K26/14 , B23K26/06 , B23K9/16
CPC分类号： B23K28/02 , B23K9/16 , B23K26/0622 , B23K26/20 , B23K26/24 , B23K26/348
摘要： A low-power laser and arc hybrid welding method includes the steps of matching laser pulses with arc phases, and inducing compress arcs by the laser pulses. A laser peak pulse is triggered from half of the positive half-wave to half of the negative half-wave of alternating arc current. The sum of laser peak pulse width and laser basic pulse width is equal to the time width from a laser pulse triggered point to a negative half-wave end point of the alternating arc current. A welding device for carrying out the method is disclosed. An angle formed by the axis of a laser beam (1) and the vertical direction is in the range of −50°-50°. An angle formed by the axis of the laser beam (1) and the axis of an arc torch (2) is in the range of 20°-120°. Arc power density is adjusted minutely in the range of 103-105 by adjusting the alternating arc current, protrusion quantity of an electrode (3) and gas flow velocity of a nozzle. The method and the device can reduce the consumption and save the cost.
摘要翻译：低功率激光和电弧混合焊接方法包括以下步骤：将激光脉冲与电弧相匹配，并通过激光脉冲引发压缩弧。激光峰值脉冲从正半波的一半触发到交变电弧电流的负半波的一半。激光峰值脉冲宽度和激光基本脉冲宽度的总和等于从激光脉冲触发点到交变电弧电流的负半波终点的时间宽度。公开了一种用于实施该方法的焊接装置。由激光束（1）的轴线和垂直方向形成的角度在-50°-50°的范围内。由激光束（1）的轴线和电弧割炬（2）的轴线形成的角度在20°-120°的范围内。通过调节交流电弧电流，电极（3）的突出量和喷嘴的气体流速，可以在103-105的范围内微调电弧功率密度。该方法和设备可以减少消耗并节省成本。

9. 发明申请

US20130071390A1 METHOD FOR PREPARING ANTIBODIES HAVING IMPROVED PROPERTIES 有权
标题翻译：用于制备具有改善性质的抗体的方法
公开(公告)号：US20130071390A1
公开(公告)日：2013-03-21
申请号：US13699213
申请日：2011-05-25
申请人： Terrance A. Stadheim , Dongxing Zha , Liming Liu
发明人： Terrance A. Stadheim , Dongxing Zha , Liming Liu
IPC分类号： C07K16/00
CPC分类号： C12P21/005 , A61K2039/505 , C07K16/00 , C07K16/241 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K2317/14 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/71 , C07K2317/732 , C07K2317/734
摘要： The present invention is directed to methods and compositions for the production of Fc-containing polypeptides having improved properties and comprising mutations at positions 243 and 264 of the Fc region.
摘要翻译：本发明涉及用于生产具有改进性质并含有Fc区第243和264位突变的含Fc多肽的方法和组合物。

10. 发明授权

US08375537B2 Process for manufacturing super-high-count ramie fabric and the fabric 有权
标题翻译：制造超高苎麻织物和织物的工艺
公开(公告)号：US08375537B2
公开(公告)日：2013-02-19
申请号：US12601921
申请日：2008-06-18
申请人： Zheng Liu , Hao Geng , Xiangqi Zhou , Liming Liu
发明人： Zheng Liu , Hao Geng , Xiangqi Zhou , Liming Liu
IPC分类号： D03D15/00 , D06B1/00 , D06C27/00
CPC分类号： D03D15/06 , D02G3/04 , D02G3/406 , D10B2201/01 , D10B2201/08
摘要： The present invention relates to a process for manufacturing a ramie fabric and the fabric. The process comprising the following steps: blend spinning a high-count ramie fiber such as a ramie fiber of 2500Nm or higher with a water-soluble fiber as carrier to form a yarn; sizing the yarn at a low temperature; weaving the yarn to form a gray fabric; then removing the water-soluble fiber from the gray fabric by deweighting the gray fabric during a printing and dyeing finishing process to obtain a super-high-count ramie fabric with a ramie yarn fineness of 160Nm or higher.
摘要翻译：本发明涉及苎麻织物和织物的制造方法。该方法包括以下步骤：将高倍数苎麻纤维如2500Nm或更高的苎麻纤维与水溶性纤维作为载体混纺以形成纱线; 在低温下定型纱线; 编织纱线形成灰色织物; 然后通过在印染整理过程中使灰色织物减重，从灰色织物中除去水溶性纤维，得到苎麻纱细度为160Nm以上的超高苎麻织物。

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