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1. 发明授权

US08815246B2 Fc receptor binding proteins 有权
标题翻译： Fc受体结合蛋白
公开(公告)号：US08815246B2
公开(公告)日：2014-08-26
申请号：US13617498
申请日：2012-09-14
申请人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron K. Sato , Malini Viswanathan
发明人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron K. Sato , Malini Viswanathan
IPC分类号： C07K16/28 , G01N33/68
CPC分类号： C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535
摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
摘要翻译：本公开尤其提供结合FcRn的蛋白质，例如以高亲和力和选择性抑制FcRn的免疫球蛋白。 FcRn结合蛋白可用于治疗多种疾病，包括自身免疫性疾病。

2. 发明申请

US20130078262A1 FC RECEPTOR BINDING PROTEINS 有权
公开(公告)号：US20130078262A1
公开(公告)日：2013-03-28
申请号：US13617498
申请日：2012-09-14
申请人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato , Malini Viswanathan
发明人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato , Malini Viswanathan
IPC分类号： C07K16/28 , G01N33/68
CPC分类号： C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535
摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

3. 发明申请

US20100101111A1 MULTISTRUCTURAL SUPPORT SYSTEM FOR A SOLE IN A RUNNING SHOE 审中-公开
标题翻译：运动鞋上单身多用途支援系统
公开(公告)号：US20100101111A1
公开(公告)日：2010-04-29
申请号：US12258069
申请日：2008-10-24
申请人： Kevin McDonnell
发明人： Kevin McDonnell
IPC分类号： A43B13/20 , A43B13/12 , A43B23/00
CPC分类号： A43B13/181 , A43B1/0054 , A43B3/0015 , A43B13/12 , A43B13/189 , A43B13/20 , A43B13/206 , A43B17/026 , A43B17/03
摘要： A shoe structure for foot strike energy dissipation employs compressible members each having an internal void containing a first working fluid. A set of mating compressible members are each connected to a related one of the first compressible members through a fluid conduit such that the first working fluid is transferred from the related compressible member to the mating compressible member responsive to compression induced by foot strike. A sole pad and a foot bed intermediately constrain the compressible members. Resilient structural members are placed intermediate the compressible members to deform responsive to compression of the foot bed induced by foot strike provide both energy dissipation and resilient recovery of the compression cylinders to their uncompressed state. The sole pad and foot bed are interconnected by a peripheral wall forming a cavity which contains a second working fluid that is transmissible between the compressible members responsive to compression of the foot bed. Cooling tubes are provided for energy dissipation of the second working fluid which bathes the compressible members, conduits and resilient elements. A buoyant magnet carried within the void of at least one compressible member is displaced within the compressible member responsive to foot strike. An induction coil encircling the compressible member is operatively connected to a resistive element for energy dissipation responsive to electromagnetically generated current resulting from relative motion of the buoyant magnet. A repelling magnet having opposite polarity to the buoyant magnet is mounted in the compressible member to prevent bottoming out of the buoyant magnet during compression.
摘要翻译：用于脚踏能量耗散的鞋结构采用可压缩构件，每个都具有包含第一工作流体的内部空隙。一组配合的可压缩构件各自通过流体导管连接到第一可压缩构件中相关的一个，使得第一工作流体响应于由脚踏引起的压缩而从相关的可压缩构件传递到配合的可压缩构件。鞋底垫和脚床中间限制可压缩构件。弹性结构构件放置在可压缩构件之间，以响应于由脚蹬引起的脚床的压缩而变形，从而提供压缩气缸的能量耗散和弹性恢复到其未压缩状态。鞋底垫和脚床通过形成空腔的周边壁相互连接，所述空腔包含第二工作流体，该第二工作流体可响应于脚底的压缩在可压缩构件之间传播。提供冷却管用于第二工作流体的能量耗散，该第二工作流体沐浴可压缩构件，管道和弹性元件。承载在至少一个可压缩构件的空隙内的浮力磁体响应脚踏而在可压缩构件内移动。围绕可压缩构件的感应线圈可操作地连接到电阻元件，用于响应于由浮力磁体的相对运动而产生的电磁产生的电流的能量耗散。具有与浮力磁体相反极性的排斥磁体安装在可压缩构件中，以防止在压缩期间从漂浮磁体触底。

4. 发明授权

US08635238B2 Appratus, system and method for an automated stock ledger 有权
标题翻译：自动化库存分类帐的应用程序，系统和方法
公开(公告)号：US08635238B2
公开(公告)日：2014-01-21
申请号：US12685130
申请日：2010-01-11
申请人： Arthur Tisi , Kevin McDonnell , Oleg Margolin , Oleg Alshansky
发明人： Arthur Tisi , Kevin McDonnell , Oleg Margolin , Oleg Alshansky
IPC分类号： G06F17/30
CPC分类号： G06F17/30286 , G06Q10/087 , G06Q20/203 , G06Q30/0601 , G06Q40/12 , Y10S707/99942
摘要： An inventory stock ledger system, apparatus and method including a process by which one can track inventory efficiently, but can also utilize to perform inventory analysis on a dynamic level. The method includes recording inventory snapshots across various dimensions of a retail business and tracking the inventory levels for select products in to provide real time reports. Central to the apparatus is the idea that inventory can be viewed from a central starting point, and then examined among various dimensions. Inventory management is readily modified and dynamic. The method includes a build capability for examining the inventory levels and snapshots of inventory for a retail market franchise.
摘要翻译：库存库存分类帐系统，装置和方法包括可以有效地跟踪库存的过程，但也可以利用来在动态层面上执行库存分析。该方法包括在零售业务的各个维度上记录库存快照，并跟踪选定产品的库存水平以提供实时报告。该设备的核心在于可以从中心起点查看库存，然后在各种维度之间进行检查。库存管理易于修改和动态。该方法包括用于检查零售市场特许经营的库存水平和库存快照的构建功能。

5. 发明申请

US20130045218A1 FC RECEPTOR BINDING PROTEINS 审中-公开
公开(公告)号：US20130045218A1
公开(公告)日：2013-02-21
申请号：US13584221
申请日：2012-08-13
申请人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato , Malini Viswanathan
发明人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato , Malini Viswanathan
IPC分类号： C07K16/28 , A61P19/02 , A61P21/04 , G01N33/566 , A61P25/00 , A61P1/04 , A61P37/00 , A61P1/00 , A61K39/395 , A61P3/10
摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

6. 发明授权

US08273351B2 Fc receptor binding proteins 有权
标题翻译： Fc受体结合蛋白
公开(公告)号：US08273351B2
公开(公告)日：2012-09-25
申请号：US12429529
申请日：2009-04-24
申请人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato
发明人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , G01N33/53
CPC分类号： C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535
摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
摘要翻译：本公开尤其提供结合FcRn的蛋白质，例如以高亲和力和选择性抑制FcRn的免疫球蛋白。 FcRn结合蛋白可用于治疗多种疾病，包括自身免疫性疾病。

7. 发明申请

US20090324614A1 FC RECEPTOR BINDING PROTEINS 有权
标题翻译： FC受体结合蛋白
公开(公告)号：US20090324614A1
公开(公告)日：2009-12-31
申请号：US12429529
申请日：2009-04-24
申请人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato
发明人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , G01N33/53 , A61P37/00
CPC分类号： C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535
摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
摘要翻译：本公开尤其提供结合FcRn的蛋白质，例如以高亲和力和选择性抑制FcRn的免疫球蛋白。 FcRn结合蛋白可用于治疗多种疾病，包括自身免疫性疾病。

8. 发明申请

US20070069161A1 Repeatable heat-treating methods and apparatus 有权
标题翻译：可重复的热处理方法和装置
公开(公告)号：US20070069161A1
公开(公告)日：2007-03-29
申请号：US11521074
申请日：2006-09-14
申请人： David Camm , Sergiy Dets , Kevin McDonnell , Greg Stuart , Tilman Thrum , Igor Rudic , Ljubomir Kaludjercic
发明人： David Camm , Sergiy Dets , Kevin McDonnell , Greg Stuart , Tilman Thrum , Igor Rudic , Ljubomir Kaludjercic
IPC分类号： G01J3/10
CPC分类号： F27B17/0025 , H01L21/67115 , H01L21/67248 , H01L22/20
摘要： A first heat-treating method involves monitoring at least one thermal efficiency parameter associated with an irradiance system configured to produce an irradiance flash incident on a surface of a workpiece, and automatically updating control information used by the irradiance system to produce the irradiance flash, in response to the monitoring of the thermal efficiency parameter. A second method involves predicting a heating effect of an irradiance flash to be incident upon a surface of a workpiece, in response to a measurement of a heating parameter of the surface, and pre-adjusting the irradiance flash, in response to the predicted heating effect. A third method involves measuring a temperature of a surface of a workpiece during an initial portion of an irradiance flash incident on the surface, and controlling a power of a remaining portion of the irradiance flash, in response to the temperature.
摘要翻译：第一热处理方法包括监测与被配置为产生入射在工件表面上的辐照闪光相关联的辐射系统的至少一个热效率参数，并且自动更新由辐照系统使用的控制信息以产生辐照闪光，响应于热效率参数的监测。第二种方法包括响应于表面的加热参数的测量以及响应于预测的加热效应来预先调节辐照度闪光来预测辐射闪光的加热效应入射到工件的表面上。第三种方法包括测量在入射到表面上的辐照闪光的初始部分期间工件表面的温度，以及响应于温度来控制辐照闪光的剩余部分的功率。

9. 发明授权

US06721740B1 Method and apparatus of performing active update notification 失效
标题翻译：执行主动更新通知的方法和装置
公开(公告)号：US06721740B1
公开(公告)日：2004-04-13
申请号：US09092356
申请日：1998-06-05
申请人： Brian Skinner , Andy Kittridge Turk , Kevin McDonnell , Vanessa McDonnell
发明人： Brian Skinner , Andy Kittridge Turk , Kevin McDonnell , Vanessa McDonnell
IPC分类号： G06F1700
CPC分类号： G06F9/542 , G06F17/30368 , G06F2209/544 , Y10S707/99931 , Y10S707/99943 , Y10S707/99944
摘要： A method and apparatus of performing active update notification. Components of an application are able to specify interest in a data object or set of data objects by registering an interest object with an update management component of the application. The interest object specifies the interested application component, as well as the identity of one or more data objects or an attribute value or range of values to associate with data objects. When modifications are made to data objects corresponding to the registered interest objects, the interested application component or components receive an update notification from the update management component. In one embodiment, active update notification is performed within a multi-tier application. An update management component exists at the application server on the application tier, as well as at each client in the client tier. In the application tier, the update management component maintains, with respect to clients and servers, a registry of interest objects of sufficient depth to determine which clients or other servers may be interested in changes to data objects. Update notifications are then sent only to the interested clients or servers. The interest registry of the update management component in the interested client is used to resolve the interested application component, and to forward the update notification appropriately.
摘要翻译：一种执行主动更新通知的方法和装置。应用程序的组件能够通过将兴趣对象与应用程序的更新管理组件注册来指定对数据对象或数据对象集的兴趣。兴趣对象指定感兴趣的应用程序组件，以及一个或多个数据对象的身份或与数据对象关联的属性值或值的范围。当对与注册的兴趣对象相对应的数据对象进行修改时，感兴趣的应用组件或组件从更新管理组件接收更新通知。在一个实施例中，在多层应用程序中执行活动更新通知。更新管理组件存在于应用程序层上的应用程序服务器以及客户层中的每个客户端。在应用层中，更新管理组件针对客户端和服务器维护足够深度的兴趣对象的注册表，以确定哪些客户端或其他服务器可能对数据对象的更改感兴趣。然后，更新通知仅发送给感兴趣的客户端或服务器。感兴趣的客户端的更新管理组件的兴趣注册表用于解决感兴趣的应用程序组件，并适当地转发更新通知。

10. 发明授权

US5402270A Method of duplicating data on a magnetic disk with reduced duplication time 失效
标题翻译：以减少复制时间在磁盘上复制数据的方法
公开(公告)号：US5402270A
公开(公告)日：1995-03-28
申请号：US296451
申请日：1994-08-26
申请人： Kevin McDonnell , George Barker, deceased
发明人： Kevin McDonnell , George Barker, deceased
IPC分类号： G11B5/016 , G11B5/86 , G11B20/10 , G11B20/12 , G11B27/10
CPC分类号： G11B20/10 , G11B20/1217 , G11B5/016 , G11B5/86
摘要： A method for duplicating data on a rotating magnetic disk in sectors on concentric tracks so that the sectors are aligned with each other from track to track and referenced to an index mark. The index mark is sensed as the disk rotates. The time elapsed between sensed index marks is counted to define the angular displacement of the disk. A magnetic head is moved successively to the tracks on the disk. Data to be duplicated is recorded in sequence, sector by sector, on the respective tracks beginning at different offsets from the index mark such that recording begins with the next sector encountered after the head arrives at the respective tracks.
摘要翻译：一种用于在同心轨道上的扇区中的旋转磁盘上复制数据的方法，使得扇区彼此对准，从轨到轨并以索引标记为参考。当磁盘旋转时，感测到索引标记。计算感测的索引标记之间经过的时间以限定盘的角位移。磁头依次移动到磁盘上的轨道上。将要复制的数据按扇区逐个地按照不同的轨迹从与索引标记不同的偏移开始记录，这样记录开始于在磁头到达相应磁迹之后所遇到的下一个扇区。

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