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1. 发明授权

US07912554B2 Method for treatment of aneurysms 有权
标题翻译：治疗动脉瘤的方法
公开(公告)号：US07912554B2
公开(公告)日：2011-03-22
申请号：US11119368
申请日：2005-04-29
申请人： Leonilda Capuano , Daniel Nahon , Michael Urick , Willard W. Hennemann , Patrick Chauvet , Claudia Lückge
发明人： Leonilda Capuano , Daniel Nahon , Michael Urick , Willard W. Hennemann , Patrick Chauvet , Claudia Lückge
IPC分类号： A61F2/00
CPC分类号： A61B18/02 , A61B18/22 , A61B2017/22001 , A61B2017/22051 , A61B2018/00095 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61N5/045 , A61N5/0601
摘要： A method is disclosed for treating an aneurysm or vascular defect by cooling a target tissue region of the aneurysm or vascular defect to a temperature below body temperature for a preselected time period. The method entails thickening, strengthening, or increasing the density of a blood vessel wall by cooling the blood vessel wall with a cryogenically cooled device. The method also includes irradiating the inner wall of a blood vessel around an aneurysm or vascular defect with various forms of energy to delay or halt aneurysm or vascular defect formation. An energy-emitting element is disposed on the distal end portion of a catheter device to be disposed proximate the aneurysm. Various forms of energy, including visible light energy, laser light energy, ultrasound, microwave and radiofrequency sources may be used to irradiate and treat the aneurysm. In addition, the method may include irradiating a tissue site concomitantly with other treatments, including the delivery of vaso-occlusive compounds, mechanical intravascular devices, or an endovascular graft to the target tissue region.
摘要翻译：公开了一种用于通过将动脉瘤或血管缺陷的靶组织区域冷却到低于体温的温度预处理时间段来治疗动脉瘤或血管缺陷的方法。该方法通过用低温冷却装置冷却血管壁来增加，增强或增加血管壁的密度。该方法还包括以各种形式的能量照射动脉瘤或血管缺损周围的血管内壁，以延迟或停止动脉瘤或血管缺损形成。能量发射元件设置在导管装置的远端部分上以靠近动脉瘤设置。可以使用包括可见光能量，激光能量，超声波，微波和射频源在内的各种形式的能量照射和治疗动脉瘤。此外，该方法可以包括与其它治疗伴随地照射组织部位，包括将血管闭塞化合物，机械血管内装置或血管内移植物递送至靶组织区域。

2. 发明授权

US06736809B2 Method and device for treatment of aneurysms 失效
标题翻译：用于治疗动脉瘤的方法和装置
公开(公告)号：US06736809B2
公开(公告)日：2004-05-18
申请号：US09964264
申请日：2001-09-26
申请人： Leonilda Capuano , Daniel Nahon , Michael Urick , Willard W. Hennemann , Patrick Chauvet
发明人： Leonilda Capuano , Daniel Nahon , Michael Urick , Willard W. Hennemann , Patrick Chauvet
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/22051 , A61B2018/00095 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61N5/045 , A61N5/0601
摘要： A method is disclosed for treating an aneurysm by cooling a target tissue region of the aneurysm to a temperature below temperature for a preselected time period. The method entails thickening, strengthening, or increasing the density of a blood vessel wall by cooling the blood vessel wall with a cryogenically cooled device. In particular, a device having a heat conductive cooling chamber is disposed proximate to the aneurysm site; and a cryogenic fluid coolant is directed to flow inside the chamber to create endothermic cooling relative to the aneurysm. The method also promotes the growth of collagen and elastin in vascular tissue. Tissue cooling temperatures range from +20 to −20 degrees Celsius. The duration of treatment by application of cooling ranges from 15 seconds to up to 20 minutes or more. The method includes treating the aneurysm both from inside and outside the blood vessel wall forming the aneurysm.
摘要翻译：公开了一种用于通过将动脉瘤的靶组织区域冷却到低于温度的预选时间段来治疗动脉瘤的方法。该方法通过用低温冷却装置冷却血管壁来增加，增强或增加血管壁的密度。特别地，具有导热冷却室的装置设置在动脉瘤部位附近; 并且低温流体冷却剂被引导以在腔室内流动以产生相对于动脉瘤的吸热冷却。该方法还促进血管组织中胶原和弹性蛋白的生长。组织冷却温度范围为+20至-20摄氏度。通过应用冷却治疗的持续时间为15秒至20分钟以上。该方法包括从形成动脉瘤的血管壁的内部和外部处理动脉瘤。

3. 发明申请

US20050222649A1 Method for treatment of aneurysms 有权
标题翻译：治疗动脉瘤的方法
公开(公告)号：US20050222649A1
公开(公告)日：2005-10-06
申请号：US11119368
申请日：2005-04-29
申请人： Leonilda Capuano , Daniel Nahon , Michael Urick , Willard Hennemann , Patrick Chauvet , Claudia Luckge
发明人： Leonilda Capuano , Daniel Nahon , Michael Urick , Willard Hennemann , Patrick Chauvet , Claudia Luckge
IPC分类号： A61B17/22 , A61B18/00 , A61B18/02 , A61B18/22 , A61F7/00 , A61F7/12 , A61N5/06
CPC分类号： A61B18/02 , A61B18/22 , A61B2017/22001 , A61B2017/22051 , A61B2018/00095 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61N5/045 , A61N5/0601
摘要： A method is disclosed for treating an aneurysm or vascular defect by cooling a target tissue region of the aneurysm or vascular defect to a temperature below body temperature for a preselected time period. The method entails thickening, strengthening, or increasing the density of a blood vessel wall by cooling the blood vessel wall with a cryogenically cooled device. The method also includes irradiating the inner wall of a blood vessel around an aneurysm or vascular defect with various forms of energy to delay or halt aneurysm or vascular defect formation. An energy-emitting element is disposed on the distal end portion of a catheter device to be disposed proximate the aneurysm. Various forms of energy, including visible light energy, laser light energy, ultrasound, microwave and radiofrequency sources may be used to irradiate and treat the aneurysm. In addition, the method may include irradiating a tissue site concomitantly with other treatments, including the delivery of vaso-occlusive compounds, mechanical intravascular devices, or an endovascular graft to the target tissue region.
摘要翻译：公开了一种用于通过将动脉瘤或血管缺陷的靶组织区域冷却到低于体温的温度预处理时间段来治疗动脉瘤或血管缺陷的方法。该方法通过用低温冷却装置冷却血管壁来增加，增强或增加血管壁的密度。该方法还包括以各种形式的能量照射动脉瘤或血管缺损周围的血管内壁，以延迟或停止动脉瘤或血管缺损形成。能量发射元件设置在导管装置的远端部分上以靠近动脉瘤设置。可以使用包括可见光能量，激光能量，超声波，微波和射频源在内的各种形式的能量照射和治疗动脉瘤。此外，该方法可以包括与其它治疗伴随地照射组织部位，包括将血管闭塞化合物，机械血管内装置或血管内移植物递送至靶组织区域。

4. 发明授权

US06283959B1 Endovascular cryotreatment catheter 有权
公开(公告)号：US06283959B1
公开(公告)日：2001-09-04
申请号：US09378972
申请日：1999-08-23
申请人： Jean Pierre Lalonde , Robert Martin , Claudia Lueckge , Leonilda Capuano , John W. Lehmann , Daniel Nahon
发明人： Jean Pierre Lalonde , Robert Martin , Claudia Lueckge , Leonilda Capuano , John W. Lehmann , Daniel Nahon
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： A catheter is attached to an elongated catheter body adapted for endovascular insertion with a balloon assembly at its distal end. Coolant injected through the catheter body may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. A valve may regulate back pressure in the return passage to coordinate the flow of coolant into and out of the balloon so as to both inflate the balloon and achieve cryogenic cooling at the surface of the balloon. The coolant is biologically safe, and may be liquid carbon dioxide. Plural balloons may be provided adjacent the cooling segment, and one balloon may be shaped to treat the ostium of a vessel. Preferably, thermal conductivity of the balloon wall is enhanced by inclusion of thermally conductive material, such as metal, which may be introduced as a component of a composite elastomer material, or as a patterned metal layer that defines a pattern of thermally conductive treatment regions of the balloon surface. Patterns formed by printing, lithography or other means with copper, silver or other highly thermally conductive material enhance through-conduction characteristics of the wall so icing preferentially occurs to stimulate tissue destruction and vascular regeneration. Suitable patterns include spirals, dots, arrays of separated segments, or meandering curves which allow expansion of the balloon body without introducing delamination, localized stress cracking or separation of the balloon material. The conductive patterns may include patterns such as waffle-iron or other arrays of small lesions that are effective to treat the endovascular wall. When separate media are used for cooling and for balloon expansion, the cooling chamber may have a large diameter, and the balloon may form a thin shell or cuff. In that case, the balloon may be quickly inflated with a medium such as a saline to provide a quickly deployed and compliant contact structure of excellent conductivity.

5. 发明授权

US07648497B2 Endovascular cryotreatment catheter 有权
标题翻译：血管内冷冻治疗导管
公开(公告)号：US07648497B2
公开(公告)日：2010-01-19
申请号：US11244710
申请日：2005-10-06
申请人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
发明人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.
摘要翻译：具有远端球囊组件的细长导管装置适于血管内插入。在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。在第一种情况下，冷却剂还使气囊膨胀，并且废弃的冷却剂经由延伸穿过导管主体的返回通道返回到手柄。可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置，冷却室周围的绝热体。可以采用各种构造，例如球囊界面的表面改性，或者在气球界面中放置颗粒，涂层或可膨胀的网孔或线圈，以实现该功能。

6. 发明授权

US07300433B2 Endovascular cryotreatment catheter 有权
标题翻译：血管内冷冻治疗导管
公开(公告)号：US07300433B2
公开(公告)日：2007-11-27
申请号：US10397619
申请日：2003-03-26
申请人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
发明人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.
摘要翻译：具有远端球囊组件的细长导管装置适于血管内插入。在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。在第一种情况下，冷却剂还使气囊膨胀，并且废弃的冷却剂经由延伸穿过导管主体的返回通道返回到手柄。可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置，冷却室周围的绝热体。可以采用各种构造，例如球囊界面的表面改性，或者在气球界面中放置颗粒，涂层或可膨胀的网孔或线圈，以实现该功能。

7. 发明申请

US20060030843A1 Endovascular cryotreatment catheter 有权
公开(公告)号：US20060030843A1
公开(公告)日：2006-02-09
申请号：US11244710
申请日：2005-10-06
申请人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Luckge , Jean-Luc Pageard , Marwan Abboud , Johnny Asmar , Abderrahim Benrabah , Ken Chen , John Lehmann , Philippe Marchand , Robert Martin , Fredric Milder , Daniel Nahon
发明人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Luckge , Jean-Luc Pageard , Marwan Abboud , Johnny Asmar , Abderrahim Benrabah , Ken Chen , John Lehmann , Philippe Marchand , Robert Martin , Fredric Milder , Daniel Nahon
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.

8. 发明授权

US06575966B2 Endovascular cryotreatment catheter 有权
公开(公告)号：US06575966B2
公开(公告)日：2003-06-10
申请号：US09945319
申请日：2001-08-31
申请人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
发明人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.

9. 发明授权

US09937332B2 Cryo-perfusion balloon device 有权
公开(公告)号：US09937332B2
公开(公告)日：2018-04-10
申请号：US11347854
申请日：2006-02-06
申请人： Daniel Nahon , Willard W. Hennemann
发明人： Daniel Nahon , Willard W. Hennemann
IPC分类号： A61M25/10 , A61B18/00 , A61B18/02
CPC分类号： A61M25/104 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M25/1011 , A61M2025/1095 , A61M2025/1097 , A61M2202/03
摘要： The present invention provides a method and apparatus for treating a vascular occlusion and preventing or reducing ischemic consequences of such an obstruction. The medical device of the present invention may include an elongate body defining a proximal end and a distal end, where the elongate body may also define an injection lumen, an exhaust lumen, and a guidewire lumen. A first expandable element may be coupled to the elongate body, where the first expandable element is in fluid communication with the injection lumen and the exhaust lumen. Further, a perfusion path may be disposed within the elongate body, and a sheath may be movably disposed about at least a portion of the elongate body. The medical device may further include a second expandable element disposed about the elongate body, as well as second inflation and exhaust lumens.

10. 发明授权

US08672988B2 Method and device for local cooling within an organ using an intravascular device 有权
标题翻译：使用血管内装置的器官内局部冷却的方法和装置
公开(公告)号：US08672988B2
公开(公告)日：2014-03-18
申请号：US11257331
申请日：2005-10-24
申请人： Willard W. Hennemann , Daniel Nahon , Fredric Milder
发明人： Willard W. Hennemann , Daniel Nahon , Fredric Milder
IPC分类号： A61F7/12
CPC分类号： A61F7/123 , A61B2017/22001 , A61F2007/126
摘要： A method is disclosed for cooling a limited portion of a body organ by placing a cooling device into a blood vessel within a target organ; and activating the cooling device to cool tissue proximate the cooling device to a temperature below +34 degrees Centigrade. The blood vessel can be a vein or an artery and the cooling device can be a fixed diameter catheter or it can include a balloon. More particularly, the method of cooling can provide a method for treating injured ischemic and infarcted tissue by placing a device capable of passage through the vasculature into a target organ, wherein the device is capable of providing sufficient thermal exchange at a working region thereof to cool adjacent tissue; and activating the device to cool adjacent tissue to a temperature in the range of 0 degrees Centigrade to +36 degrees Centigrade. The method can further include placement of a second device capable of passage through the vasculature into the target organ, wherein the second device is capable of at least partially removing a blockage from a blood vessel.
摘要翻译：公开了一种通过将冷却装置放置在目标器官内的血管中来冷却身体器官的有限部分的方法; 并且激活冷却装置以将冷却装置附近的组织冷却至低于+ 34摄氏度的温度。血管可以是静脉或动脉，并且冷却装置可以是固定直径的导管，也可以包括气囊。更具体地，冷却方法可以提供一种通过将能够通过脉管系统通过脉管系统的装置放置到靶器官中来治疗受伤的缺血和梗死组织的方法，其中该装置能够在其工作区域提供足够的热交换以冷却相邻组织; 并激活该装置以将相邻组织冷却至0摄氏度至+36摄氏度的温度。该方法还可以包括能够穿过脉管系统进入目标器官的第二装置的放置，其中第二装置能够至少部分地从血管中去除堵塞物。

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