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1. 发明授权

US07912554B2 Method for treatment of aneurysms 有权
标题翻译：治疗动脉瘤的方法
公开(公告)号：US07912554B2
公开(公告)日：2011-03-22
申请号：US11119368
申请日：2005-04-29
申请人： Leonilda Capuano , Daniel Nahon , Michael Urick , Willard W. Hennemann , Patrick Chauvet , Claudia Lückge
发明人： Leonilda Capuano , Daniel Nahon , Michael Urick , Willard W. Hennemann , Patrick Chauvet , Claudia Lückge
IPC分类号： A61F2/00
CPC分类号： A61B18/02 , A61B18/22 , A61B2017/22001 , A61B2017/22051 , A61B2018/00095 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61N5/045 , A61N5/0601
摘要： A method is disclosed for treating an aneurysm or vascular defect by cooling a target tissue region of the aneurysm or vascular defect to a temperature below body temperature for a preselected time period. The method entails thickening, strengthening, or increasing the density of a blood vessel wall by cooling the blood vessel wall with a cryogenically cooled device. The method also includes irradiating the inner wall of a blood vessel around an aneurysm or vascular defect with various forms of energy to delay or halt aneurysm or vascular defect formation. An energy-emitting element is disposed on the distal end portion of a catheter device to be disposed proximate the aneurysm. Various forms of energy, including visible light energy, laser light energy, ultrasound, microwave and radiofrequency sources may be used to irradiate and treat the aneurysm. In addition, the method may include irradiating a tissue site concomitantly with other treatments, including the delivery of vaso-occlusive compounds, mechanical intravascular devices, or an endovascular graft to the target tissue region.
摘要翻译：公开了一种用于通过将动脉瘤或血管缺陷的靶组织区域冷却到低于体温的温度预处理时间段来治疗动脉瘤或血管缺陷的方法。该方法通过用低温冷却装置冷却血管壁来增加，增强或增加血管壁的密度。该方法还包括以各种形式的能量照射动脉瘤或血管缺损周围的血管内壁，以延迟或停止动脉瘤或血管缺损形成。能量发射元件设置在导管装置的远端部分上以靠近动脉瘤设置。可以使用包括可见光能量，激光能量，超声波，微波和射频源在内的各种形式的能量照射和治疗动脉瘤。此外，该方法可以包括与其它治疗伴随地照射组织部位，包括将血管闭塞化合物，机械血管内装置或血管内移植物递送至靶组织区域。

2. 发明授权

US06736809B2 Method and device for treatment of aneurysms 失效
标题翻译：用于治疗动脉瘤的方法和装置
公开(公告)号：US06736809B2
公开(公告)日：2004-05-18
申请号：US09964264
申请日：2001-09-26
申请人： Leonilda Capuano , Daniel Nahon , Michael Urick , Willard W. Hennemann , Patrick Chauvet
发明人： Leonilda Capuano , Daniel Nahon , Michael Urick , Willard W. Hennemann , Patrick Chauvet
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/22051 , A61B2018/00095 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61N5/045 , A61N5/0601
摘要： A method is disclosed for treating an aneurysm by cooling a target tissue region of the aneurysm to a temperature below temperature for a preselected time period. The method entails thickening, strengthening, or increasing the density of a blood vessel wall by cooling the blood vessel wall with a cryogenically cooled device. In particular, a device having a heat conductive cooling chamber is disposed proximate to the aneurysm site; and a cryogenic fluid coolant is directed to flow inside the chamber to create endothermic cooling relative to the aneurysm. The method also promotes the growth of collagen and elastin in vascular tissue. Tissue cooling temperatures range from +20 to −20 degrees Celsius. The duration of treatment by application of cooling ranges from 15 seconds to up to 20 minutes or more. The method includes treating the aneurysm both from inside and outside the blood vessel wall forming the aneurysm.
摘要翻译：公开了一种用于通过将动脉瘤的靶组织区域冷却到低于温度的预选时间段来治疗动脉瘤的方法。该方法通过用低温冷却装置冷却血管壁来增加，增强或增加血管壁的密度。特别地，具有导热冷却室的装置设置在动脉瘤部位附近; 并且低温流体冷却剂被引导以在腔室内流动以产生相对于动脉瘤的吸热冷却。该方法还促进血管组织中胶原和弹性蛋白的生长。组织冷却温度范围为+20至-20摄氏度。通过应用冷却治疗的持续时间为15秒至20分钟以上。该方法包括从形成动脉瘤的血管壁的内部和外部处理动脉瘤。

3. 发明申请

US20050222649A1 Method for treatment of aneurysms 有权
标题翻译：治疗动脉瘤的方法
公开(公告)号：US20050222649A1
公开(公告)日：2005-10-06
申请号：US11119368
申请日：2005-04-29
申请人： Leonilda Capuano , Daniel Nahon , Michael Urick , Willard Hennemann , Patrick Chauvet , Claudia Luckge
发明人： Leonilda Capuano , Daniel Nahon , Michael Urick , Willard Hennemann , Patrick Chauvet , Claudia Luckge
IPC分类号： A61B17/22 , A61B18/00 , A61B18/02 , A61B18/22 , A61F7/00 , A61F7/12 , A61N5/06
CPC分类号： A61B18/02 , A61B18/22 , A61B2017/22001 , A61B2017/22051 , A61B2018/00095 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61N5/045 , A61N5/0601
摘要： A method is disclosed for treating an aneurysm or vascular defect by cooling a target tissue region of the aneurysm or vascular defect to a temperature below body temperature for a preselected time period. The method entails thickening, strengthening, or increasing the density of a blood vessel wall by cooling the blood vessel wall with a cryogenically cooled device. The method also includes irradiating the inner wall of a blood vessel around an aneurysm or vascular defect with various forms of energy to delay or halt aneurysm or vascular defect formation. An energy-emitting element is disposed on the distal end portion of a catheter device to be disposed proximate the aneurysm. Various forms of energy, including visible light energy, laser light energy, ultrasound, microwave and radiofrequency sources may be used to irradiate and treat the aneurysm. In addition, the method may include irradiating a tissue site concomitantly with other treatments, including the delivery of vaso-occlusive compounds, mechanical intravascular devices, or an endovascular graft to the target tissue region.
摘要翻译：公开了一种用于通过将动脉瘤或血管缺陷的靶组织区域冷却到低于体温的温度预处理时间段来治疗动脉瘤或血管缺陷的方法。该方法通过用低温冷却装置冷却血管壁来增加，增强或增加血管壁的密度。该方法还包括以各种形式的能量照射动脉瘤或血管缺损周围的血管内壁，以延迟或停止动脉瘤或血管缺损形成。能量发射元件设置在导管装置的远端部分上以靠近动脉瘤设置。可以使用包括可见光能量，激光能量，超声波，微波和射频源在内的各种形式的能量照射和治疗动脉瘤。此外，该方法可以包括与其它治疗伴随地照射组织部位，包括将血管闭塞化合物，机械血管内装置或血管内移植物递送至靶组织区域。

4. 发明申请

US20060282016A1 GUIDE WIRE WITH HYDROPHILICALLY COATED TIP 审中-公开
标题翻译：指导线与水平涂层的提示
公开(公告)号：US20060282016A1
公开(公告)日：2006-12-14
申请号：US11467234
申请日：2006-08-25
申请人： Richard Cornelius , Anthony Kelzenberg , Michael Urick , Brian Reynolds
发明人： Richard Cornelius , Anthony Kelzenberg , Michael Urick , Brian Reynolds
IPC分类号： A61M25/00
CPC分类号： A61M25/09 , A61L31/10 , A61M2025/0046 , A61M2025/09083 , A61M2025/09091 , A61M2025/09133 , A61M2025/09175 , C08L27/18 , C08L83/04
摘要： A guide wire including a lubricous distal portion and a less lubricous intermediate portion proximal of said distal portion. One guide wire provides a highly lubricous distal portion with a hydrophilic layer and a less lubricous intermediate portion with a hydrophobic layer. Another guide wire provides a lubricous distal portion with a polymer tip that is itself hydrophilic. Yet another guide wire provides a less lubricous intermediate portion using a stainless steel coil helically wound around the tapering intermediate portion. The coil is preferably coated with a hydrophobic coating such as PTFE or silicone. The coil can either abut the distal portion proximal end or extend into the distal portion interior.
摘要翻译：导丝，其包括在所述远端部分的近侧的润滑的远侧部分和较少润滑的中间部分。一个引导线提供具有亲水层的高度润滑的远端部分和具有疏水层的较少润滑的中间部分。另一种导丝提供具有本身是亲水性的聚合物末端的润滑的远端部分。另一种导丝使用螺旋缠绕在锥形中间部分上的不锈钢线圈提供较少润滑的中间部分。线圈优选地涂覆有诸如PTFE或硅树脂的疏水涂层。线圈可以邻近远侧部分近端或延伸到远端部分内部。

5. 发明申请

US20050027212A1 Guide wire with stranded tip 有权
标题翻译：导丝与绞合
公开(公告)号：US20050027212A1
公开(公告)日：2005-02-03
申请号：US10632145
申请日：2003-07-31
申请人： Garland Segner , Kent Anderson , Douglas Molland , Thomas Clubb , Michael Urick
发明人： Garland Segner , Kent Anderson , Douglas Molland , Thomas Clubb , Michael Urick
IPC分类号： A61M25/01 , A61M25/09
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09175 , A61M2025/09191
摘要： The invention provides a guide wire comprising an elongate, flexible core having a proximal region, a proximal end, a distal region, and a distal end, and the distal region having a tapered portion; a plurality of wire strands wrapped helically parallel to one another and disposed on at least a portion of the tapered distal region of the core; a polymer tie layer disposed on at least a portion of the plurality of wire strands; and a lubricious polymer layer disposed on the polymer tie layer.
摘要翻译：本发明提供了一种导丝，其包括具有近端区域，近端，远侧区域和远端的细长的柔性芯，并且远端区域具有锥形部分; 多个线股螺旋地并行地包裹并设置在芯的锥形远端区域的至少一部分上; 聚合物粘结层，设置在所述多根金属丝股线的至少一部分上; 以及设置在聚合物粘结层上的润滑聚合物层。

6. 发明申请

US20050182365A1 Method and apparatus for locating and detecting vascular plaque via impedence and conductivity measurements, and for cryogenically passivating vascular plaque and inhibiting vascular plaque progression and rupture 审中-公开
标题翻译：用于通过阻抗和电导率测量定位和检测血管斑块的方法和装置，以及用于低温钝化血管斑块和抑制血管斑块进展和破裂
公开(公告)号：US20050182365A1
公开(公告)日：2005-08-18
申请号：US11107271
申请日：2005-04-15
申请人： Willard Hennemann , Michael Urick , Domenic Santoianni , Claudia Luckge , Sean Carroll , Dan Wittenberger , Teresa Mihalik
发明人： Willard Hennemann , Michael Urick , Domenic Santoianni , Claudia Luckge , Sean Carroll , Dan Wittenberger , Teresa Mihalik
IPC分类号： A61B5/053 , A61B17/00 , A61B18/02 , A61B5/00 , A61F7/12 , H05B1/00
CPC分类号： A61B5/6853 , A61B5/02007 , A61B5/053 , A61B18/02 , A61B2017/00026 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： A method and apparatus for detecting plaque proximate an area of a human body is described, the method comprising the steps of moving one or more electrically sensitive sensors substantially near an area where plaque may be present, obtaining electrical signal readings from the sensors, and determining the presence or absence of plaque. The presence or absence of the plaque corresponds to the electrical signal readings. Another aspect of the invention provides a method for inhibiting plaque formation and passivating plaque formed on a lumenal surface of a body lumen. A cooling device is positioned at the lumenal surface at a point proximate to a plaque formation. The lumenal surface is cooled at the point proximate to the plaque formation to inhibit the progression of plaque formation in which the lumenal surface is cooled to a temperature of less than about zero degrees Celsius. As another aspect, a method is provided for reducing the risk of plaque rupture in a vessel. A catheter is inserted into a patient's vessel. The catheter is manipulated to a region of the vessel proximate to a plaque formation such that an outer surface of the catheter is positioned at tissue proximate to the plaque formation. The catheter is activated such that the outer surface of the catheter cools the contacting tissue to a temperature of less than about zero degrees Celsius.
摘要翻译：描述了一种用于在人体区域附近检测斑块的方法和装置，该方法包括以下步骤：基本上靠近可能存在斑块的区域移动一个或多个电敏感传感器，从传感器获得电信号读数，并确定斑块的存在或不存在。斑块的存在或不存在对应于电信号读数。本发明的另一方面提供了一种抑制形成在体腔内腔表面上的斑块形成和钝化斑块的方法。冷却装置位于靠近斑块形成的点处的内腔表面。腔表面在靠近斑块形成的点处被冷却，以抑制斑块形成的进展，其中腔表面被冷却到小于约零摄氏度的温度。另一方面，提供了一种减少血管中斑块破裂风险的方法。将导管插入病人的血管。导管被操纵到容器的靠近斑块形成的区域，使得导管的外表面位于靠近斑块形成的组织处。导管被激活，使得导管的外表面将接触组织冷却至小于约零摄氏度的温度。

7. 发明申请

US20050075582A1 Guide wire with hydrophilically coated tip 有权
标题翻译：导丝带有亲水涂层的尖端
公开(公告)号：US20050075582A1
公开(公告)日：2005-04-07
申请号：US10680447
申请日：2003-10-07
申请人： Richard Cornelius , Anthony Kelzenberg , Michael Urick , Brian Reynolds
发明人： Richard Cornelius , Anthony Kelzenberg , Michael Urick , Brian Reynolds
IPC分类号： A61L31/10 , A61M25/00 , A61M25/09 , A61B5/00
CPC分类号： A61M25/09 , A61L31/10 , A61M2025/0046 , A61M2025/09083 , A61M2025/09091 , A61M2025/09133 , A61M2025/09175 , C08L27/18 , C08L83/04
摘要： A guide wire including a lubricous distal portion and a less lubricous intermediate portion proximal of said distal portion. One guide wire provides a highly lubricous distal portion with a hydrophilic layer and a less lubricous intermediate portion with a hydrophobic layer. Another guide wire provides a lubricous distal portion with a polymer tip that is itself hydrophilic. Yet another guide wire provides a less lubricous intermediate portion using a stainless steel coil helically wound around the tapering intermediate portion. The coil is preferably coated with a hydrophobic coating such as PTFE or silicone. The coil can either abut the distal portion proximal end or extend into the distal portion interior.
摘要翻译：导丝，其包括在所述远端部分的近侧的润滑的远侧部分和较少润滑的中间部分。一个引导线提供具有亲水层的高度润滑的远端部分和具有疏水层的较少润滑的中间部分。另一种导丝提供具有本身是亲水性的聚合物末端的润滑的远端部分。另一种导丝使用螺旋缠绕在锥形中间部分上的不锈钢线圈提供较少润滑的中间部分。线圈优选地涂覆有诸如PTFE或硅树脂的疏水涂层。线圈可以邻近远侧部分近端或延伸到远端部分内部。

8. 发明授权

US5259477A Collapsible scaffold bracket 失效
标题翻译：可折叠脚手架支架
公开(公告)号：US5259477A
公开(公告)日：1993-11-09
申请号：US834658
申请日：1992-02-12
申请人： Clois D. Fears , Michael Urick , Paul V. Furlo
发明人： Clois D. Fears , Michael Urick , Paul V. Furlo
IPC分类号： E04G5/06 , E04G5/00
CPC分类号： E04G5/06
摘要： A scaffold bracket is disclosed comprising a vertical beam of channel cross-section, a horizontal beam pivoted at its proximate end to a point between the ends of the vertical beam and adapted to nest within its channel cross-section, an angle bracket having a first and second end, the first end being connected to the proximate end of the vertical beam and the second end being connected to the middle of the horizontal beam whereby the horizontal beam is rigidly supported in a position substantially at right angles to the vertical beam, the vertical beam further having a hanger secured to its distal end, the hanger being adapted to engage a generally horizontal portion of a wall whereby the horizontal beam may be utilized to help support a scaffold along the wall.
摘要翻译：公开了一种支架支架，其包括垂直的通道横截面梁，水平梁在其近端处枢转到垂直梁的端部之间的点并且适于嵌套在其通道横截面内，具有第一和第二端，第一端连接到垂直梁的近端，并且第二端连接到水平梁的中部，由此水平梁刚性支撑在与垂直梁大致成直角的位置，垂直梁还具有固定到其远端的悬挂器，所述悬挂器适于接合壁的大致水平部分，由此可以使用水平梁来帮助沿着壁支撑支架。

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