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1. 发明授权

US07300433B2 Endovascular cryotreatment catheter 有权
标题翻译：血管内冷冻治疗导管
公开(公告)号：US07300433B2
公开(公告)日：2007-11-27
申请号：US10397619
申请日：2003-03-26
申请人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
发明人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.
摘要翻译：具有远端球囊组件的细长导管装置适于血管内插入。在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。在第一种情况下，冷却剂还使气囊膨胀，并且废弃的冷却剂经由延伸穿过导管主体的返回通道返回到手柄。可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置，冷却室周围的绝热体。可以采用各种构造，例如球囊界面的表面改性，或者在气球界面中放置颗粒，涂层或可膨胀的网孔或线圈，以实现该功能。

2. 发明授权

US07648497B2 Endovascular cryotreatment catheter 有权
标题翻译：血管内冷冻治疗导管
公开(公告)号：US07648497B2
公开(公告)日：2010-01-19
申请号：US11244710
申请日：2005-10-06
申请人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
发明人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.
摘要翻译：具有远端球囊组件的细长导管装置适于血管内插入。在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。在第一种情况下，冷却剂还使气囊膨胀，并且废弃的冷却剂经由延伸穿过导管主体的返回通道返回到手柄。可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置，冷却室周围的绝热体。可以采用各种构造，例如球囊界面的表面改性，或者在气球界面中放置颗粒，涂层或可膨胀的网孔或线圈，以实现该功能。

3. 发明授权

US06575966B2 Endovascular cryotreatment catheter 有权
公开(公告)号：US06575966B2
公开(公告)日：2003-06-10
申请号：US09945319
申请日：2001-08-31
申请人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
发明人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.

4. 发明申请

US20060030843A1 Endovascular cryotreatment catheter 有权
公开(公告)号：US20060030843A1
公开(公告)日：2006-02-09
申请号：US11244710
申请日：2005-10-06
申请人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Luckge , Jean-Luc Pageard , Marwan Abboud , Johnny Asmar , Abderrahim Benrabah , Ken Chen , John Lehmann , Philippe Marchand , Robert Martin , Fredric Milder , Daniel Nahon
发明人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Luckge , Jean-Luc Pageard , Marwan Abboud , Johnny Asmar , Abderrahim Benrabah , Ken Chen , John Lehmann , Philippe Marchand , Robert Martin , Fredric Milder , Daniel Nahon
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.

5. 发明授权

US06283959B1 Endovascular cryotreatment catheter 有权
公开(公告)号：US06283959B1
公开(公告)日：2001-09-04
申请号：US09378972
申请日：1999-08-23
申请人： Jean Pierre Lalonde , Robert Martin , Claudia Lueckge , Leonilda Capuano , John W. Lehmann , Daniel Nahon
发明人： Jean Pierre Lalonde , Robert Martin , Claudia Lueckge , Leonilda Capuano , John W. Lehmann , Daniel Nahon
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： A catheter is attached to an elongated catheter body adapted for endovascular insertion with a balloon assembly at its distal end. Coolant injected through the catheter body may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. A valve may regulate back pressure in the return passage to coordinate the flow of coolant into and out of the balloon so as to both inflate the balloon and achieve cryogenic cooling at the surface of the balloon. The coolant is biologically safe, and may be liquid carbon dioxide. Plural balloons may be provided adjacent the cooling segment, and one balloon may be shaped to treat the ostium of a vessel. Preferably, thermal conductivity of the balloon wall is enhanced by inclusion of thermally conductive material, such as metal, which may be introduced as a component of a composite elastomer material, or as a patterned metal layer that defines a pattern of thermally conductive treatment regions of the balloon surface. Patterns formed by printing, lithography or other means with copper, silver or other highly thermally conductive material enhance through-conduction characteristics of the wall so icing preferentially occurs to stimulate tissue destruction and vascular regeneration. Suitable patterns include spirals, dots, arrays of separated segments, or meandering curves which allow expansion of the balloon body without introducing delamination, localized stress cracking or separation of the balloon material. The conductive patterns may include patterns such as waffle-iron or other arrays of small lesions that are effective to treat the endovascular wall. When separate media are used for cooling and for balloon expansion, the cooling chamber may have a large diameter, and the balloon may form a thin shell or cuff. In that case, the balloon may be quickly inflated with a medium such as a saline to provide a quickly deployed and compliant contact structure of excellent conductivity.

6. 发明授权

US06280439B1 Adjustable position injection tubing 有权
标题翻译：可调节位置注射管
公开(公告)号：US06280439B1
公开(公告)日：2001-08-28
申请号：US09352021
申请日：1999-07-12
申请人： Robert Martin , Claudia Lueckge , Leonilda Capuano , Miriam Lane
发明人： Robert Martin , Claudia Lueckge , Leonilda Capuano , Miriam Lane
IPC分类号： A61B1802
CPC分类号： A61B18/02 , A61B2017/00092 , A61B2018/00196 , A61B2018/0212 , A61B2018/0262
摘要： A cryogenic catheter includes an outer flexible member having a cryogenic fluid path defined by an injection tube disposed in the outer flexible member. The injection tube is slidably disposed within the outer flexible member. A guide member may be provided to support the injection tube within the outer flexible member. A wire is attached to the injection tube at one end and further attached to a spool to provide for take-up of the wire.
摘要翻译：低温导管包括具有由设置在外部柔性构件中的注射管限定的低温流体路径的外部柔性构件。注射管可滑动地设置在外部柔性构件内。可以设置引导构件以将注射管支撑在外部柔性构件内。电线在一端连接到注射管，并进一步连接到线轴以提供线的卷绕。

7. 发明申请

US20060270981A1 Coiled injection tube 审中-公开
标题翻译：螺旋注射管
公开(公告)号：US20060270981A1
公开(公告)日：2006-11-30
申请号：US11129044
申请日：2005-05-13
申请人： Leonilda Capuano , Robert Martin , Teresa Mihalik
发明人： Leonilda Capuano , Robert Martin , Teresa Mihalik
IPC分类号： A61F7/12 , A61M29/00
CPC分类号： A61B18/02 , A61B2017/22038 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： A medical device includes a catheter having a proximal end and a distal end, the catheter defining a lumen. A passage for a guide wire is disposed within the lumen so as to be coaxial with the lumen. The passage has an open proximal end that is substantially coterminous with the proximal end of the catheter and an open distal end that is substantially coterminous with the distal end of the catheter. A fluid injection tube is wound around the passage for the guide wire and is provided with radially spaced fluid injection ports.
摘要翻译：医疗装置包括具有近端和远端的导管，所述导管限定内腔。用于引导线的通道设置在内腔内以与内腔同轴。通道具有与导管的近端基本相邻的开放近端，以及与导管的远端基本上相邻的开口远端。流体注入管缠绕在用于导丝的通道周围，并且设置有径向间隔开的流体注入口。

8. 发明授权

US06575933B1 Mechanical support for an expandable membrane 有权
标题翻译：可膨胀膜的机械支撑
公开(公告)号：US06575933B1
公开(公告)日：2003-06-10
申请号：US09491239
申请日：2000-01-25
申请人： Dan Wittenberger , Claudia Lueckge , Robert Martin , Sean Carroll , Leonilda Capuano , Margaret Yoklavich
发明人： Dan Wittenberger , Claudia Lueckge , Robert Martin , Sean Carroll , Leonilda Capuano , Margaret Yoklavich
IPC分类号： A61M2900
CPC分类号： A61B18/02 , A61B2017/00867 , A61B2017/22002 , A61B2017/22051 , A61B2018/0022 , A61B2018/00404 , A61B2018/00422 , A61B2018/0212 , A61B2018/025 , A61B2018/0262 , A61B2018/0281 , A61F2007/126 , A61M25/10 , A61M2025/1084 , A61M2205/3606
摘要： A medical implement that employs a mechanically supported expandable element. In one embodiment, the mechanically supported expandable element is a balloon. In another embodiment, the mechanically supported expandable membrane is a balloon disposed within a cryogenic catheter usable to treat tissue. A variety of illustrative mechanical support schemes are possible.
摘要翻译：一种采用机械支撑的可扩张元件的医疗器具。在一个实施例中，机械支撑的可膨胀元件是气球。在另一个实施方案中，机械支撑的可膨胀膜是设置在可用于治疗组织的低温导管内的球囊。各种说明性的机械支持方案是可能的。

9. 发明授权

US06270493B1 Cryoablation structure 有权
标题翻译：冷冻消融结构
公开(公告)号：US06270493B1
公开(公告)日：2001-08-07
申请号：US09356433
申请日：1999-07-19
申请人： Jean-Pierre Lalonde , Cristian Petre , Robert Martin , Claudia Lueckge , Sean Carroll , Dan Wittenberger , George Klein
发明人： Jean-Pierre Lalonde , Cristian Petre , Robert Martin , Claudia Lueckge , Sean Carroll , Dan Wittenberger , George Klein
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/00026 , A61B2017/00084 , A61B2018/00041 , A61B2018/0022 , A61B2018/0212 , A61B2018/0268
摘要： A cryocatheter for treatment of tissue includes a coolant line communicating with a cryochamber having a coolant receiving interior and a thermally conductive wall for contacting and conductively treating tissue. A return line returns spent coolant, and an insert or partition in the cryochamber conditions flow or channels fluid from the coolant line to the return line to enhance the rate or uniformity of cooling. The partition may extend axially to define an elongated sub-chamber which is preferentially cooled, or it may isolate one side to define an uncooled side of the cryochamber. The partition may extend axially to define a sub-chamber extending along a segmented length around a partial circumference of the catheter tip, or may channel the coolant from a central region outwardly against the peripheral wall of the cryochamber. The return line may be a vacuum return line. The catheter may include a means for warming the catheter tip to warm up or accelerate thawing of treated tissue, and the heating may be implemented by a heater in thermal contact with a fluid supply line, which may, moreover, be the coolant supply line. Alternatively, the warming fluid supply line may be distinct from the coolant line. In one embodiment, the device may connect the warming line as an additional coolant return line during cryotreatment, and switch its connection to supply warming fluid after the tissue has been cooled. The catheter may further include sensors such as thermal or impedance sensors for sensing contact orientation of the catheter against adjacent tissue. Electrodes may apply signals of two different frequencies to the two sides, and a processor may determine frequency, impedance or a differential temperature to indicate the tip contact orientation.
摘要翻译：用于治疗组织的低温灭菌器包括与具有冷却剂接收内部的冷冻箱和用于接触和导电地处理组织的导热壁连通的冷却剂管线。返回管路返回耗尽的冷却剂，冷冻箱条件中的插入物或分隔件将流体从冷却剂管路流向或返回管路，以提高冷却速度或均匀性。分隔件可以轴向延伸以限定优选冷却的细长子室，或者可以隔离一侧以限定冷冻箱的未冷却侧。分隔件可以轴向延伸以限定围绕导管尖端的部分圆周的分段长度延伸的子室，或者可以将冷却剂从中心区域向外引导抵靠冷冻箱的周壁。返回管线可以是真空回流管线。导管可以包括用于加温导管尖端以加热或加速经处理的组织的解冻的装置，并且加热可以通过与流体供应管线热接触的加热器来实现，流体供应管线还可以是冷却剂供应管线。或者，加温流体供应管线可以不同于冷却剂管线。在一个实施例中，该装置可以在冷冻处理期间将加热管线作为另外的冷却剂返回管线连接，并且在组织冷却之后将其连接切换到供应加热流体。导管还可以包括传感器，例如用于感测导管相对于相邻组织的接触取向的热传感器或阻抗传感器。电极可以将两个不同频率的信号施加到两侧，并且处理器可以确定频率，阻抗或差分温度以指示尖端接触取向。

10. 发明授权

US08481523B2 Biocide composition comprising pyrithione and pyrrole derivatives 有权
标题翻译：包含吡啶硫酮和吡咯衍生物的杀生物剂组合物
公开(公告)号：US08481523B2
公开(公告)日：2013-07-09
申请号：US12928983
申请日：2010-12-22
申请人： Craig Waldron , Robert Martin , Tina Williams
发明人： Craig Waldron , Robert Martin , Gareth Williams
IPC分类号： A01N55/02 , A61K31/555
CPC分类号： C09D5/1625 , A01N43/36 , C09D5/14 , Y10T428/31678 , Y10T428/31699 , Y10T428/31855 , Y10T428/31906 , Y10T428/31935 , Y10T428/31989 , A01N43/40 , A01N59/16 , A01N59/20 , A01N2300/00
摘要： The present invention is directed to a biocidal composition comprising a blend of one or more pyrithione compounds, and one or more pyrrole compounds of Formula I wherein said biocidal composition is copper free or low copper content.
摘要翻译：本发明涉及包含一种或多种吡啶硫酮化合物和一种或多种式I的吡咯化合物的共混物的杀生物组合物，其中所述杀生物组合物是无铜或低铜含量的。

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