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    • 5. 发明授权
    • Coated capillary tube for the controlled release of reagent
    • 涂层毛细管用于控释试剂
    • US5387526A
    • 1995-02-07
    • US030445
    • 1993-03-30
    • Harold R. GarnerOrenda F. TuasonLarry S. Peranich
    • Harold R. GarnerOrenda F. TuasonLarry S. Peranich
    • B01L3/00B01L3/02G01N21/03G01N21/29G01N21/59G01N21/64G01N21/77G01N33/52G01N33/543G01N35/00G01N35/10
    • B01L3/508B01L3/502G01N21/03G01N33/52G01N33/54373B01L2200/16B01L2300/0838B01L2300/087B01L3/021G01N2021/0346G01N2035/00237G01N2035/1062G01N21/29Y10S436/81Y10T436/143333
    • A hollow, elongated, micropipette, which is specially adapted for use in spectrometers and which has an inner wall on which a coating containing a reagent has been deposited, is provided. The reagent is selected from among those that interact with one or more compounds in a sample solution, which is introduced into the micropipette, in order to permit the compounds to be detected by virtue of light absorption or emission by the complexes formed upon interaction of the reagent with the compound of interest in the sample.Upon introduction of the sample solution into the micropipette, a sufficient amount of the reagent in the coating dissolves in the solution and reacts, either directly or indirectly with a compound or compounds of interest in the solution to render such compound detectable and to permit quantification of the concentration of the compound in the sample. The resulting solution is held in the micropipette for analysis of the light absorption or light emission characteristics of the solution to determine the composition of the solution or the concentration of a particular constituent of the solution.In preferred embodiments, the coating on the inner surface of the micropipette includes a binding agent or adhesive that delays, preferably for about 5 to 15 sec, the dissolution of the reagent in the solution.
    • PCT No.PCT / US91 / 06567 Sec。 371日期1993年3月30日 102(e)1993年3月30日PCT 1991年9月11日PCT。一种中空的细长的微量移液器,其特别适用于分光计,并且其内壁上已经沉积了含有试剂的涂层, 被提供。 该试剂选自与引入微量吸管中的样品溶液中的一种或多种化合物相互作用的试剂,以便允许通过在相互作用下形成的络合物的光吸收或发射来检测化合物 试剂与样品中感兴趣的化合物。 当将样品溶液引入微量移液管中时,涂层中的足量的试剂溶解在溶液中,直接或间接地与溶液中的化合物或化合物直接或间接反应,以使该化合物可检测并允许定量 样品中化合物的浓度。 将所得溶液保持在微量移液管中,以分析溶液的光吸收或发光特性,以确定溶液的组成或溶液的特定成分的浓度。 在优选的实施方案中,微量移液管内表面上的涂层包括粘合剂或粘合剂,其优选延长试剂溶解在溶液中约5至15秒。
    • 10. 发明授权
    • Cystic fibrosis tester
    • 囊性纤维化检测仪
    • US5525521A
    • 1996-06-11
    • US490820
    • 1995-06-15
    • Larry S. Peranich
    • Larry S. Peranich
    • G01N22/00G01N23/02
    • G01N22/00Y10T436/193333
    • A device and method for testing for Cystic Fibrosis includes a sample cell having a capillary tube with a lumen that will hold approximately five microliters of sweat. The capillary tube has metallic rings around each end of the tube with an RF oscillator attached to one ring and a microprocessor attached to the other. An RF signal, which is transmitted from the RF oscillator through the sweat in the sample cell, is subsequently analyzed at the microprocessor by comparing the transmitted signal to a reference. In accordance with the comparison made by the microprocessor, the presence of Cystic Fibrosis may be detected.
    • 用于囊性纤维化测试的装置和方法包括具有毛细管的样品池,其具有将保持约5微升汗液的内腔。 毛细管在管的每一端具有金属环,RF振荡器连接到一个环上,微处理器连接到另一个环。 随后通过将所发送的信号与参考值进行比较,在微处理器中分析从RF振荡器通过样本单元中的汗液发送的RF信号。 根据微处理器的比较,可以检测到囊性纤维化的存在。