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1. 发明申请

US20100323300A1 DIGITAL OPTICAL CHEMISTRY MICROMIRROR IMAGER 有权
标题翻译：数字光学化学MICROMIRROR IMAGER
公开(公告)号：US20100323300A1
公开(公告)日：2010-12-23
申请号：US12870187
申请日：2010-08-27
申请人： Harold R. Garner
发明人： Harold R. Garner
IPC分类号： G03F7/20
CPC分类号： G03F7/70375 , B01J19/0046 , B01J2219/00439 , B01J2219/00527 , B01J2219/00529 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00704 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C40B40/06 , G01J2003/1278 , G02B26/0833 , G03F7/2002 , G03F7/2053 , G03F7/70291
摘要： An apparatus and method for catalyzing a reaction on a substrate (24) comprising, a light source (12), a micromirror (16) positioned to redirect light (14) from the light source (12) toward a substrate (24) wherein the redirected light (14) catalyzes a chemical reaction proximate a substrate (24), is disclosed. A computer (18) is connected to; and controls, the positioning of mirrors within the micromirror (16) to specifically redirect light to specific portions of a substrate. The substrate (24) can be placed in a reaction chamber (50), wherein the light (14) that is redirected by the micromirror (16) catalyzes a chemical reaction proximate a substrate (24).
摘要翻译：一种用于在衬底（24）上催化反应的装置和方法，包括光源（12），微反射镜（16），其定位成将光（14）从光源（12）重新定向到衬底（24），其中公开了重定向的光（14）催化邻近衬底（24）的化学反应。计算机（18）连接到; 并且控制微镜（16）内的反射镜的定位以将光特异性地重定向到衬底的特定部分。衬底（24）可以放置在反应室（50）中，其中由微反射镜（16）重定向的光（14）催化邻近衬底（24）的化学反应。

2. 发明授权

US06472154B1 Polymorphic repeats in human genes 失效
标题翻译：人类基因中的多态重复序列
公开(公告)号：US06472154B1
公开(公告)日：2002-10-29
申请号：US09475947
申请日：1999-12-31
申请人： Harold R. Garner , Jonathan D. Wren , John D. Minna , John W. Fondon, III
发明人： Harold R. Garner , Jonathan D. Wren , John D. Minna , John W. Fondon, III
IPC分类号： C12Q168
CPC分类号： G06F19/22 , C12Q1/6876 , C12Q2600/156
摘要： The invention provides computational methods and compositions for identifying polymorphic repeats in genes. Candidate polymorphic repeats are identified by detecting tandem repeats in a target coding sequence, scoring the repeats for polymorphic probability, and generating a dataset correlating the repeats with polymorphic probability. Actual polymorphic repeat are identified by further detecting the candidate polymorphic repeat in each of a population of different coding sequences, and determining whether the candidate polymorphic repeat is polymorphic in the population. Computationally derived polymorphic repeats are validated with phenotypic variations and these correlates are used to detect the presence or absence of such phenotypic variation in test genes. Variances at polymorphic repeats are identified by detecting in a test gene or coding region the presence or absence of variance at a disclosed unconventional polymorphic repeat.
摘要翻译：本发明提供用于鉴定基因中多态性重复序列的计算方法和组合物。通过检测目标编码序列中的串联重复序列来鉴定候选多态性重复序列，对重复序列进行多态概率评分，并生成将重复与多态概率相关联的数据集。通过进一步检测不同编码序列的群体中的候选多态性重复，并确定候选多态性重复是否在群体中是多态性，来鉴定实际多态性重复。计算得到的多态性重复序列用表型变异验证，这些相关性用于检测测试基因中这种表型变异的存在或不存在。通过在测试基因或编码区域中检测在所公开的非常规多态性重复序列中存在或不存在差异来鉴定多态性重复序列的差异。

3. 发明授权

US06427126B1 Automatic sequencer/genotyper having extended spectral response 失效
标题翻译：自动定序器/ genotyper具有扩展的光谱响应
公开(公告)号：US06427126B1
公开(公告)日：2002-07-30
申请号：US09227720
申请日：1999-01-08
申请人： Ali Dabiri , Harold R. Garner
发明人： Ali Dabiri , Harold R. Garner
IPC分类号： G06E100
CPC分类号： G01N27/44721 , B01J2219/00702
摘要： An advanced imaging spectrograph system and method are provided for very high throughput identification, sequencing and/or genotyping of DNA and other molecules. The system is based on the integration of improved electrophoresis structures with an imaging spectrophotometer that records the entire emission spectra along an imaging line across a sequencing gel (or capillary array). The system includes spectral shape matching to improve dye identification allowing the use of dyes having nearly any emission spectra and allowing greater than four dye multiplexing.
摘要翻译：提供先进的成像光谱仪系统和方法，用于DNA和其他分子的非常高的通量鉴定，测序和/或基因分型。该系统基于改进的电泳结构与成像分光光度计的整合，其通过测序凝胶（或毛细管阵列）沿着成像线记录整个发射光谱。该系统包括光谱形状匹配以改善染料鉴定，允许使用具有几乎任何发射光谱并允许大于四种染料复合的染料。

4. 发明授权

US5387526A Coated capillary tube for the controlled release of reagent 失效
标题翻译：涂层毛细管用于控释试剂
公开(公告)号：US5387526A
公开(公告)日：1995-02-07
申请号：US030445
申请日：1993-03-30
申请人： Harold R. Garner , Orenda F. Tuason , Larry S. Peranich
发明人： Harold R. Garner , Orenda F. Tuason , Larry S. Peranich
IPC分类号： B01L3/00 , B01L3/02 , G01N21/03 , G01N21/29 , G01N21/59 , G01N21/64 , G01N21/77 , G01N33/52 , G01N33/543 , G01N35/00 , G01N35/10
CPC分类号： B01L3/508 , B01L3/502 , G01N21/03 , G01N33/52 , G01N33/54373 , B01L2200/16 , B01L2300/0838 , B01L2300/087 , B01L3/021 , G01N2021/0346 , G01N2035/00237 , G01N2035/1062 , G01N21/29 , Y10S436/81 , Y10T436/143333
摘要： A hollow, elongated, micropipette, which is specially adapted for use in spectrometers and which has an inner wall on which a coating containing a reagent has been deposited, is provided. The reagent is selected from among those that interact with one or more compounds in a sample solution, which is introduced into the micropipette, in order to permit the compounds to be detected by virtue of light absorption or emission by the complexes formed upon interaction of the reagent with the compound of interest in the sample.Upon introduction of the sample solution into the micropipette, a sufficient amount of the reagent in the coating dissolves in the solution and reacts, either directly or indirectly with a compound or compounds of interest in the solution to render such compound detectable and to permit quantification of the concentration of the compound in the sample. The resulting solution is held in the micropipette for analysis of the light absorption or light emission characteristics of the solution to determine the composition of the solution or the concentration of a particular constituent of the solution.In preferred embodiments, the coating on the inner surface of the micropipette includes a binding agent or adhesive that delays, preferably for about 5 to 15 sec, the dissolution of the reagent in the solution.
摘要翻译： PCT No.PCT / US91 / 06567 Sec。 371日期1993年3月30日 102（e）1993年3月30日PCT 1991年9月11日PCT。一种中空的细长的微量移液器，其特别适用于分光计，并且其内壁上已经沉积了含有试剂的涂层，被提供。该试剂选自与引入微量吸管中的样品溶液中的一种或多种化合物相互作用的试剂，以便允许通过在相互作用下形成的络合物的光吸收或发射来检测化合物试剂与样品中感兴趣的化合物。当将样品溶液引入微量移液管中时，涂层中的足量的试剂溶解在溶液中，直接或间接地与溶液中的化合物或化合物直接或间接反应，以使该化合物可检测并允许定量样品中化合物的浓度。将所得溶液保持在微量移液管中，以分析溶液的光吸收或发光特性，以确定溶液的组成或溶液的特定成分的浓度。在优选的实施方案中，微量移液管内表面上的涂层包括粘合剂或粘合剂，其优选延长试剂溶解在溶液中约5至15秒。

5. 发明授权

US4990858A Coaxial microwave asborption diagnostic 失效
标题翻译：同轴微波加固诊断
公开(公告)号：US4990858A
公开(公告)日：1991-02-05
申请号：US357333
申请日：1989-05-25
申请人： Harold R. Garner
发明人： Harold R. Garner
IPC分类号： G01N22/00
CPC分类号： G01N22/00
摘要： A coaxial microwave absorption diagnostic device comprises a hollow cylindrical outer layer conductor with a coaxially aligned conductor rod extending therethrough and a dielectric material which interconnects the outer layer to the conductor rod. The device is formed with a passageway which is directed perpendicular to the longitudinal axis of the device and which passed through the outer layer, the conductor rod and the dielectric material. As so formed, the passageway is positioned for receiving a sample holder, such as a small capillary tube holding a sample solution. A variable or fixed frequency oscillator is electrically connected to an input end of the conductor rod for sending microwave power through the device and a diode senses the output portion of this microwave power which has passed through the device. The absorbed power, i.e. the input microwave power less the output microwave power, is determined by a comparator and used to analyze the sample.

6. 发明申请

US20140235456A1 Methods and Compositions for Identifying Global Microsatellite Instability and for Characterizing Informative Microsatellite Loci 审中-公开
标题翻译：识别全球微卫星不稳定性和表征信息微卫星位点的方法和组合
公开(公告)号：US20140235456A1
公开(公告)日：2014-08-21
申请号：US14109548
申请日：2013-12-17
申请人： Harold R. Garner, JR. , Lauren J. McIver , Hongseok Tae
发明人： Harold R. Garner, JR. , Lauren J. McIver , Hongseok Tae
IPC分类号： G06F19/22 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , G16B30/00 , G16B35/00 , G16C20/60
摘要： The disclosure provides methods and systems for assessing microsatellites, for identifying informative microsatellite loci, and for using microsatellite data. Microsatellite information has numerous uses including, for example, to characterize disease risk, to predict responsiveness to therapy, and to non-invasively diagnose subjects.
摘要翻译：本公开提供了用于评估微卫星，识别信息微卫星位点以及使用微卫星数据的方法和系统。微卫星信息具有许多用途，包括例如表征疾病风险，预测对治疗的反应性和非侵入性诊断受试者。

7. 发明授权

US07785863B2 Digital optical chemistry micromirror imager 有权
标题翻译：数字光学化学微镜成像仪
公开(公告)号：US07785863B2
公开(公告)日：2010-08-31
申请号：US11704536
申请日：2007-02-09
申请人： Harold R. Garner
发明人： Harold R. Garner
IPC分类号： C12M1/00 , C07H21/00 , G01N15/06 , G02B26/08
CPC分类号： G03F7/70375 , B01J19/0046 , B01J2219/00439 , B01J2219/00527 , B01J2219/00529 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00704 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C40B40/06 , G01J2003/1278 , G02B26/0833 , G03F7/2002 , G03F7/2053 , G03F7/70291
摘要： An apparatus and method for catalyzing a reaction on a substrate (24) comprising, a light source (12), a micromirror (16) positioned to redirect light (14) from the light source (12) toward a substrate (24) wherein the redirected light (14) catalyzes a chemical reaction proximate a substrate (24), is disclosed. A computer (18) is connected to, and controls, the positioning of mirrors within the micromirror (16) to specifically redirect light to specific portions of a substrate. The substrate (24) can be placed in a reaction chamber (50), wherein the light (14) that is redirected by the micromirror (16) catalyzes a chemical reaction proximate a substrate (24).
摘要翻译：一种用于在衬底（24）上催化反应的装置和方法，包括光源（12），微反射镜（16），其定位成将光（14）从光源（12）重新定向到衬底（24），其中公开了重定向的光（14）催化邻近衬底（24）的化学反应。计算机（18）连接到并且控制微镜（16）内的反射镜的定位，以将光特异性地重定向到衬底的特定部分。衬底（24）可以放置在反应室（50）中，其中由微反射镜（16）重定向的光（14）催化邻近衬底（24）的化学反应。

8. 发明授权

US07738151B2 Holographic projector 失效
标题翻译：全息投影仪
公开(公告)号：US07738151B2
公开(公告)日：2010-06-15
申请号：US11100855
申请日：2005-04-07
申请人： Harold R. Garner , Bala Nagendra Raja Munjuluri , Michael L. Huebschman
发明人： Harold R. Garner , Bala Nagendra Raja Munjuluri , Michael L. Huebschman
IPC分类号： G03H1/08 , G03H1/22
CPC分类号： G03H1/08 , G03H1/02 , G03H1/2205 , G03H1/2249 , G03H1/2294 , G03H2001/0216 , G03H2001/0833 , G03H2001/2213 , G03H2001/2218 , G03H2001/2231 , G03H2001/2271 , G03H2001/2297 , G03H2001/303 , G03H2210/30 , G03H2210/33 , G03H2210/454 , G03H2210/562 , G03H2222/18 , G03H2223/14 , G03H2225/24 , G03H2225/60 , G03H2226/02 , G03H2240/56
摘要： A projection device having a coherent light beam-generator that generates a light beam and a beam expander disposed to receive the light beam and to emit an expanded light beam. The projection device also includes a digital micro-mirror device disposed to receive a holographic transform of an original image and to display the holographic transform for illumination by the expanded light beam into a holographic light beam with a convergent or focusing lens disposed to receive and modulate the holographic light beam and a liquid crystal plate volumetric image reconstructor that receives the focused holographic light beam and emits a 3-dimensional holographic image of the original image.
摘要翻译：具有产生光束的相干光束发生器和设置成接收光束并发射扩展光束的光束扩展器的投影装置。投影装置还包括数字微镜装置，其被设置为接收原始图像的全息变换，并且显示全息变换，用于通过扩展的光束照射到具有聚光或聚焦透镜的全息光束中，所述会聚或聚焦透镜被设置为接收和调制全息光束和液晶板体积图像重建器，其接收聚焦全息光束并发射原始图像的3维全息图像。

9. 发明授权

US06646773B2 Digital micro-mirror holographic projection 失效
公开(公告)号：US06646773B2
公开(公告)日：2003-11-11
申请号：US09864124
申请日：2001-05-23
申请人： Harold R. Garner
发明人： Harold R. Garner
IPC分类号： G03H104
CPC分类号： G03H1/22 , G03H1/08 , G03H1/2249 , G03H1/2294 , G03H2001/0268 , G03H2210/30 , G03H2210/562 , G03H2260/54
摘要： The present invention relates to a method and apparatus for display of three-dimensional images and production of mega-channel phase-encoded optical communications. In certain embodiments, the device of the present invention allows for the creation and display of real-time, three-dimensional moving holograms. In the present invention, a computed image or virtual model of a real object is stored in a computer or dedicated digital signal processor (DSP). The stored image or model is then converted by the computer or DSP into its Fourier, or holographic, transform. The holographic transform is displayed on a light modulation device that is illuminated by a one portion of a laser emission. The remaining portion of the same laser emission is combined with the holographic transform at a plane to create a three-dimensional image.

10. 发明授权

US06337472B1 Light imaging microscope having spatially resolved images 失效
标题翻译：具有空间分辨图像的光成像显微镜
公开(公告)号：US06337472B1
公开(公告)日：2002-01-08
申请号：US09174938
申请日：1998-10-19
申请人： Harold R. Garner , Roger A. Schultz
发明人： Harold R. Garner , Roger A. Schultz
IPC分类号： G02B704
CPC分类号： G02B7/04 , G02B21/0012 , G02B21/365
摘要： A filter-less imaging microscope and method for analyzing samples on a slide at multiple wavelengths of light comprising, a microscope (12), a light dispersive element (28) positioned to receive images from the microscope (12) at multiple wavelengths, the light dispersive element (28) producing an array of light from the image and a camera (30) positioned to detect the light array produced by the light dispersive element (28), wherein the camera (30) detects the light array dispersed by the light dispersive element (28) at multiple wavelengths, is disclosed. The camera (30) can detect the entire spectrum of light produced by the light dispersive element (28).
摘要翻译：一种无过滤器成像显微镜和用于分析多个波长光的载玻片上的样品的方法，包括：显微镜（12），定位成以多个波长从显微镜（12）接收图像的光分散元件（28），所述光产生来自图像的光阵列的分散元件（28）和定位成检测由光分散元件（28）产生的光阵列的相机（30），其中相机（30）检测由光色散分散的光阵列公开了多个波长的元件（28）。相机（30）可以检测由光色散元件（28）产生的整个光谱。

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