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1. 发明授权

US09707535B2 Microfluidic reactors for oligonucleotide synthesis 有权
公开(公告)号：US09707535B2
公开(公告)日：2017-07-18
申请号：US14334497
申请日：2014-07-17
申请人： Lance Amate Larka , John D. Williams , Randy Gaillard
发明人： Lance Amate Larka , John D. Williams , Randy Gaillard
IPC分类号： B01L3/00 , B01J19/00 , C07H21/00
CPC分类号： B01J19/0093 , B01J2219/00831 , B01J2219/0093 , B01L3/502715 , C07H21/00
摘要： The present disclosure generally pertains to systems and methods for the chemical synthesis of micro-quantities of oligonucleotides or other chemical molecules. The system includes a reusable glass micro-reactor containing a paramagnetic solid support, a magnet, an electronic drive controller and an optical spectroscopy system capable of driving a plurality individual reactors. The system utilizes the electroosmotic movement of reactants through microfluidic channels. Spectrophotometric monitoring of the reaction products allows for the real-time determination of synthesis yield.

2. 发明申请

US20150087820A1 MICROFLUIDIC REACTORS FOR OLIGONUCLEOTIDE SYNTHESIS 有权
标题翻译：寡核苷酸合成的微流化反应器
公开(公告)号：US20150087820A1
公开(公告)日：2015-03-26
申请号：US14334497
申请日：2014-07-17
申请人： Lance Amate Larka , John D. Williams , Randy Gaillard
发明人： Lance Amate Larka , John D. Williams , Randy Gaillard
IPC分类号： B01J19/00 , B01J19/08 , C07H21/00
CPC分类号： B01J19/0093 , B01J2219/00831 , B01J2219/0093 , B01L3/502715 , C07H21/00
摘要： The present disclosure generally pertains to systems and methods for the chemical synthesis of micro-quantities of oligonucleotides or other chemical molecules. The system includes a reusable glass micro-reactor containing a paramagnetic solid support, a magnet, an electronic drive controller and an optical spectroscopy system capable of driving a plurality individual reactors. The system utilizes the electroosmotic movement of reactants through microfluidic channels. Spectrophotometric monitoring of the reaction products allows for the real-time determination of synthesis yield.
摘要翻译：本公开通常涉及用于化学合成微量寡核苷酸或其它化学分子的系统和方法。该系统包括可重复使用的玻璃微反应器，其包含顺磁性固体支持体，磁体，电子驱动控制器和能够驱动多个单个反应器的光谱系统。该系统利用反应物通过微流体通道的电渗运动。反应产物的分光光度监测允许实时测定合成产率。

3. 发明授权

US08922301B1 High quality-factor resonator 有权
标题翻译：高质量因子谐振器
公开(公告)号：US08922301B1
公开(公告)日：2014-12-30
申请号：US13283138
申请日：2011-10-27
申请人： John D. Williams , Reza Kamali-Sarvestani
发明人： John D. Williams , Reza Kamali-Sarvestani
IPC分类号： H03H7/01
CPC分类号： H03H7/175 , H05K1/16 , H05K1/162 , H05K1/165
摘要： A high-Q factor resonator comprises a solenoid having an embedded capacitor assembled in a machineable high-frequency dielectric printed circuit board (“PCB”), or other substrate. The solenoid comprises a plurality of surface conductors positioned on upper and lower surfaces of the PCB. The solenoid further comprises a plurality of conductive vias extending through the PCB between the surface conductors, and at least two aligned vias are separated by a capacitive gap. The device can therefore be described as a coupled circuit having a 1.5 or more turn inductor with an embedded capacitor along the length of the conductive path. Accordingly, a resonator having a high-Q factor is provided which is relatively inexpensive and easy to fabricate.
摘要翻译：高Q因子谐振器包括具有组装在可加工的高频电介质印刷电路板（“PCB”）或其它基板中的嵌入式电容器的螺线管。螺线管包括位于PCB的上表面和下表面上的多个表面导体。螺线管还包括在表面导体之间延伸穿过PCB的多个导电通孔，并且至少两个对准的通孔被电容间隙分开。因此，该装置可以被描述为具有沿着导电路径的长度的具有嵌入式电容器的1.5或更多转向电感器的耦合电路。因此，提供了具有高Q因子的谐振器，其相对便宜并且易于制造。

4. 发明申请

US20140142134A1 INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM 有权
标题翻译：细菌III型分泌系统的抑制剂
公开(公告)号：US20140142134A1
公开(公告)日：2014-05-22
申请号：US14232445
申请日：2012-07-13
申请人： Donald T. Moir , Daniel Aiello , Norton P. Peet , John D. Williams , Matthew Torhan
发明人： Donald T. Moir , Daniel Aiello , Norton P. Peet , John D. Williams , Matthew Torhan
IPC分类号： C07D491/056 , A61K31/36 , C07D405/12 , A61K45/06 , C07C235/34 , A61K31/165 , A61K31/4355 , C07D317/50 , A61K31/443
CPC分类号： C07D491/056 , A61K31/165 , A61K31/36 , A61K31/381 , A61K31/4355 , A61K31/443 , A61K31/53 , A61K45/06 , C07C235/34 , C07D317/50 , C07D405/12 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Psendomonas spp., Yersinia spp., en tero pathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.
摘要翻译：公开了显示抑制由细菌III型分泌系统介导的效应物毒素分泌或易位的能力的有机化合物。公开的III型分泌系统抑制剂化合物可用于抵抗革兰氏阴性细菌如沙门氏菌属，志贺氏菌属（Psigomonas spp。），耶尔森菌属（Yersinia spp。），肠道致病性和肠内侵袭性大肠杆菌以及衣原体属（Chlamydia spp）的感染。具有这种III型分泌系统。

5. 发明申请

US20130331456A1 INHIBITORS OF VIRAL ENTRY INTO MAMMALIAN CELLS 有权
标题翻译：病毒进入马马里亚细胞的抑制剂
公开(公告)号：US20130331456A1
公开(公告)日：2013-12-12
申请号：US13821682
申请日：2011-09-13
申请人： Arnab Basu , Debra M. Mills , John D. Williams , Bing Li , Norton P. Peet , Terry L. Bowlin
发明人： Arnab Basu , Debra M. Mills , John D. Williams , Bing Li , Norton P. Peet , Terry L. Bowlin
IPC分类号： C07C311/44
CPC分类号： C07C311/44 , A61K31/18
摘要： The present invention is related to the development of compounds and methods for inhibiting viral infection in a mammal. A pseudotype virus was developed for use in a high throughput assay for identifying nonpeptidic small molecule inhibitors that prevent viral entry into a host cell.
摘要翻译：本发明涉及抑制哺乳动物中病毒感染的化合物和方法的开发。开发了一种假型病毒用于高通量测定，用于鉴定预防病毒进入宿主细胞的非肽小分子抑制剂。

6. 发明授权

US5924277A Ion thruster with long-lifetime ion-optics system 失效
标题翻译：离子推进器具有长寿命离子光学系统
公开(公告)号：US5924277A
公开(公告)日：1999-07-20
申请号：US767920
申请日：1996-12-17
申请人： John R. Beattie , John D. Williams , Jesse N. Matossian
发明人： John R. Beattie , John D. Williams , Jesse N. Matossian
IPC分类号： B64G1/24 , F03H1/00 , H05H1/00
CPC分类号： F03H1/0043
摘要： Ion erosion of grids is reduced in an ion thruster with a multiple-grid ion-optics system. The thruster has an array of aperture sets in which aperture areas change in a perimeter region of the array. In one ion-optics system embodiment, a screen aperture area is reduced and a decelerator aperture area is increased in aperture sets that are proximate to the perimeter of the array. Prototype tests of this embodiment have illustrated significant reduction of ion erosion.
摘要翻译：使用多栅离子光学系统的离子推进器减小了栅格的离子侵蚀。推进器具有一组孔径组，其中孔径区域在阵列的周边区域中变化。在一个离子光学系统实施例中，屏幕孔径面积减小，并且靠近阵列周边的孔径组中的减速器孔径面积增加。该实施例的原型测试表明离子侵蚀显着减少。

7. 发明授权

US5833918A Heat treatment by plasma electron heating and solid/gas jet cooling 失效
公开(公告)号：US5833918A
公开(公告)日：1998-11-10
申请号：US672133
申请日：1996-06-27
申请人： Jesse N. Matossian , John D. Williams , Wilfried Krone-Schmidt
发明人： Jesse N. Matossian , John D. Williams , Wilfried Krone-Schmidt
IPC分类号： C21D1/09 , C21D1/18 , C21D1/28 , C21D1/38 , C21D1/613 , C21D1/773 , C21D9/32 , C23C8/36 , C21D1/06
CPC分类号： C21D1/38 , C21D1/09 , C21D9/32 , C23C8/36 , C21D1/28 , C21D1/613 , C21D1/773
摘要： A workpiece is heated by first forming an ionized gas plasma around the workpiece. A positive potential is applied to the workpiece to accelerate electrons from the plasma into the workpiece. The workpiece is uniformly surface heated by the energy directed into the workpiece by the electrons. The workpiece is cooled by providing a flow of a pressurized liquid material such as carbon dioxide having a triple point. The liquid material is expanded through a nozzle to form solid particles that contact the surface of the workpiece and remove heat from it by subliming.

8. 发明授权

US5718903A Vaccine comprising Brucella abortus which has O polysaccharide antigen absent 失效
标题翻译：含有O多糖抗原的布鲁氏菌流产的疫苗不存在
公开(公告)号：US5718903A
公开(公告)日：1998-02-17
申请号：US196777
申请日：1994-02-14
申请人： Leslie Garry Adams , Richard P. Crawford , Donald S. Davis , Thomas A. Ficht , Roger Smith, III , Blair A. Sowa , Joe W. Templeton , John D. Williams , Albert M. Wu
发明人： Leslie Garry Adams , Richard P. Crawford , Donald S. Davis , Thomas A. Ficht , Roger Smith, III , Blair A. Sowa , Joe W. Templeton , John D. Williams , Albert M. Wu
IPC分类号： A61K39/00 , C07K14/23 , C12N1/21 , A61K39/10
CPC分类号： C07K14/23 , A61K39/00 , Y10S424/823 , Y10S435/822
摘要： The present invention is an improved vaccine against Brucella abortus which permits differentiation between vaccinated and field strain infected cattle. The vaccine can be administered in two different forms: (1) cell envelopes isolated from an O polysaccharide antigen deficient, stable transposon mutant of B. abortus or (2) an O polysaccharide antigen deficient, stable transposon mutant of B. abortus.
摘要翻译：本发明是针对流产布鲁杆菌的改良疫苗，其允许在接种疫苗和野外菌株感染的牛之间进行分化。疫苗可以以两种不同的形式施用：（1）从流产流产的O多糖抗原缺陷型，稳定转座子突变体分离的细胞包膜或（2）流产流产的O多糖抗原缺陷型稳定转座子突变体。

9. 发明授权

US09212134B2 Inhibitors of viral entry into mammalian cells 有权
标题翻译：病毒进入哺乳动物细胞的抑制剂
公开(公告)号：US09212134B2
公开(公告)日：2015-12-15
申请号：US13821682
申请日：2011-09-13
申请人： Arnab Basu , Debra M. Mills , John D. Williams , Bing Li , Norton P. Peet , Terry L. Bowlin
发明人： Arnab Basu , Debra M. Mills , John D. Williams , Bing Li , Norton P. Peet , Terry L. Bowlin
IPC分类号： C07C311/44 , C07C311/32 , A61K31/18 , A61P31/16
CPC分类号： C07C311/44 , A61K31/18
摘要： The present invention is related to the development of compounds and methods for inhibiting viral infection in a mammal. A pseudotype virus was developed for use in a high throughput assay for identifying nonpeptidic small molecule inhibitors that prevent viral entry into a host cell.
摘要翻译：本发明涉及抑制哺乳动物中病毒感染的化合物和方法的开发。开发了一种假型病毒用于高通量测定，用于鉴定预防病毒进入宿主细胞的非肽小分子抑制剂。

10. 发明授权

US08906945B2 Inhibitors of bacterial type III secretion system 有权
标题翻译：细菌III型分泌系统的抑制剂
公开(公告)号：US08906945B2
公开(公告)日：2014-12-09
申请号：US13263071
申请日：2010-04-06
申请人： Donald T. Moir , Daniel Aiello , Norton P. Peet , John D. Williams
发明人： Donald T. Moir , Daniel Aiello , Norton P. Peet , John D. Williams
IPC分类号： A61K31/34 , A61K31/36 , A61K31/38 , A61K31/41 , A61K31/44 , A61K31/415 , A61K31/496 , A61K31/381 , A61K31/5375 , A61K31/4245 , A61K45/06 , A61K31/407 , A61K31/216 , A61K31/427 , A61K31/16 , A61K31/4184 , A61K31/429 , A61K31/167 , A61K31/4152
CPC分类号： A61K31/4245 , A61K31/16 , A61K31/167 , A61K31/216 , A61K31/34 , A61K31/36 , A61K31/381 , A61K31/407 , A61K31/4152 , A61K31/4184 , A61K31/427 , A61K31/429 , A61K31/496 , A61K31/5375 , A61K45/06 , Y02A50/406 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.
摘要翻译：公开了显示抑制由细菌III型分泌系统介导的效应物毒素分泌或易位的能力的有机化合物。所公开的III型分泌系统抑制剂化合物可用于抵抗革兰氏阴性菌如沙门氏菌属，志贺氏菌属，假单胞菌属，耶尔森氏菌属，肠致病性肠炎和肠毒素性大肠杆菌和衣原体属的感染。具有这种III型分泌系统。

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