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1. 发明授权

US09722566B1 Systems and methods for tuning resonators 有权
公开(公告)号：US09722566B1
公开(公告)日：2017-08-01
申请号：US14528644
申请日：2014-10-30
申请人： John D. Williams , Robert Lindquist
发明人： John D. Williams , Robert Lindquist
IPC分类号： H03H7/01 , H03J5/18 , H03H3/00
CPC分类号： H03H7/0153 , H01G7/06 , H03H3/00 , H03H7/0115 , H03H2001/0085 , H03H2210/015 , H03H2210/025 , H03J5/18 , H03J2200/06 , H05K1/162 , H05K1/165 , H05K2201/0187 , H05K2201/097
摘要： A high-Q factor resonator includes a solenoid having an embedded capacitor assembled in a machinable high-frequency dielectric printed circuit board (“PCB”), or other substrate. The solenoid comprises a plurality of surface conductors positioned on upper and lower surfaces of the PCB. The solenoid further comprises a plurality of conductive vias extending through the PCB between the surface conductors, and at least two aligned vias are separated by a capacitive gap. A liquid crystal dielectric is embedded within the capacitive gap in order to control the capacitance. Accordingly, a tunable capacitive filter is achieved by changing the dielectric permittivity of the liquid crystal. In one example, a nematic liquid crystal is sealed in the capacitive gap and has its permittivity changed with a low frequency bias to tune the capacitor.

2. 发明授权

US09707535B2 Microfluidic reactors for oligonucleotide synthesis 有权
公开(公告)号：US09707535B2
公开(公告)日：2017-07-18
申请号：US14334497
申请日：2014-07-17
申请人： Lance Amate Larka , John D. Williams , Randy Gaillard
发明人： Lance Amate Larka , John D. Williams , Randy Gaillard
IPC分类号： B01L3/00 , B01J19/00 , C07H21/00
CPC分类号： B01J19/0093 , B01J2219/00831 , B01J2219/0093 , B01L3/502715 , C07H21/00
摘要： The present disclosure generally pertains to systems and methods for the chemical synthesis of micro-quantities of oligonucleotides or other chemical molecules. The system includes a reusable glass micro-reactor containing a paramagnetic solid support, a magnet, an electronic drive controller and an optical spectroscopy system capable of driving a plurality individual reactors. The system utilizes the electroosmotic movement of reactants through microfluidic channels. Spectrophotometric monitoring of the reaction products allows for the real-time determination of synthesis yield.

3. 发明授权

US09340551B2 Inhibitors of bacterial type III secretion system 有权
标题翻译：细菌III型分泌系统的抑制剂
公开(公告)号：US09340551B2
公开(公告)日：2016-05-17
申请号：US14232445
申请日：2012-07-13
申请人： Donald T. Moir , Daniel Aiello , Norton P. Peet , John D. Williams , Matthew Torhan
发明人： Donald T. Moir , Daniel Aiello , Norton P. Peet , John D. Williams , Matthew Torhan
IPC分类号： C07D405/00 , A61K31/44 , C07D491/056 , A61K31/443 , A61K31/381 , A61K31/53 , A61K31/165 , A61K31/36 , A61K31/4355 , A61K45/06 , C07C235/34 , C07D317/50 , C07D405/12
CPC分类号： C07D491/056 , A61K31/165 , A61K31/36 , A61K31/381 , A61K31/4355 , A61K31/443 , A61K31/53 , A61K45/06 , C07C235/34 , C07D317/50 , C07D405/12 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Psendomonas spp., Yersinia spp., en tero pathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.
摘要翻译：公开了显示抑制由细菌III型分泌系统介导的效应物毒素分泌或易位的能力的有机化合物。公开的III型分泌系统抑制剂化合物可用于抵抗革兰氏阴性细菌如沙门氏菌属，志贺氏菌属（Psigomonas spp。），耶尔森菌属（Yersinia spp。），肠道致病性和肠内侵袭性大肠杆菌以及衣原体属（Chlamydia spp）的感染。具有这种III型分泌系统。

4. 发明授权

US09101635B2 Inhibitors of filovirus entry into host cells 有权
标题翻译：叶病毒进入宿主细胞的抑制剂
公开(公告)号：US09101635B2
公开(公告)日：2015-08-11
申请号：US13383345
申请日：2010-07-10
申请人： Arnab Basu , Debra M. Mills , Norton P. Peet , John D. Williams
发明人： Arnab Basu , Debra M. Mills , Norton P. Peet , John D. Williams
IPC分类号： A61K31/18 , A61K31/5513 , C07D213/74 , C07D215/40 , C07D243/12 , C07D249/10 , C07D307/71 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D471/04 , C07D491/22
CPC分类号： A61K31/5513 , A61K31/18 , C07D213/74 , C07D215/40 , C07D243/12 , C07D249/10 , C07D307/71 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D471/04 , C07D491/22 , A61K2300/00
摘要： Organic compounds showing the ability to inhibit viral glycoprotein (GP)-mediated entry of a filovirus into a host cell are disclosed. The disclosed filovirus entry inhibitor compounds are useful for treating, preventing, or reducing the spread of infections by filovirus including the type species Marburg virus (MARV) and Ebola virus (EBOV). Preferred inhibitors of the invention provide therapeutic agents for combating the Ivory Coast, Sudan, Zaire, Bundibugyo, and Reston Ebola virus strains.
摘要翻译：公开了显示抑制病毒糖蛋白（GP）介导的病毒入宿主细胞的能力的有机化合物。所公开的叶病毒入侵抑制剂化合物可用于治疗，预防或减少包括类型物种马尔堡病毒（MARV）和埃博拉病毒（EBOV）的病毒感染的扩散。本发明优选的抑制剂提供用于对抗科特迪瓦海岸，苏丹，扎伊尔，Bundibugyo和Reston埃博拉病毒毒株的治疗剂。

5. 发明申请

US20150087820A1 MICROFLUIDIC REACTORS FOR OLIGONUCLEOTIDE SYNTHESIS 有权
标题翻译：寡核苷酸合成的微流化反应器
公开(公告)号：US20150087820A1
公开(公告)日：2015-03-26
申请号：US14334497
申请日：2014-07-17
申请人： Lance Amate Larka , John D. Williams , Randy Gaillard
发明人： Lance Amate Larka , John D. Williams , Randy Gaillard
IPC分类号： B01J19/00 , B01J19/08 , C07H21/00
CPC分类号： B01J19/0093 , B01J2219/00831 , B01J2219/0093 , B01L3/502715 , C07H21/00
摘要： The present disclosure generally pertains to systems and methods for the chemical synthesis of micro-quantities of oligonucleotides or other chemical molecules. The system includes a reusable glass micro-reactor containing a paramagnetic solid support, a magnet, an electronic drive controller and an optical spectroscopy system capable of driving a plurality individual reactors. The system utilizes the electroosmotic movement of reactants through microfluidic channels. Spectrophotometric monitoring of the reaction products allows for the real-time determination of synthesis yield.
摘要翻译：本公开通常涉及用于化学合成微量寡核苷酸或其它化学分子的系统和方法。该系统包括可重复使用的玻璃微反应器，其包含顺磁性固体支持体，磁体，电子驱动控制器和能够驱动多个单个反应器的光谱系统。该系统利用反应物通过微流体通道的电渗运动。反应产物的分光光度监测允许实时测定合成产率。

6. 发明授权

US07992381B2 Method for improving regeneration of a catalytic diesel particulate filter 有权
标题翻译：改善催化柴油颗粒过滤器再生的方法
公开(公告)号：US07992381B2
公开(公告)日：2011-08-09
申请号：US12011530
申请日：2008-01-28
申请人： Tanto Sugiarto , John D. Williams , Thomas M. Harris
发明人： Tanto Sugiarto , John D. Williams , Thomas M. Harris
IPC分类号： F01N3/00
CPC分类号： F01N3/023 , F01N9/002 , Y02T10/47
摘要： A method for regeneration of a CDPF disposed in the exhaust stream of a diesel engine. The method includes a second phase operation following a first phase substantially as disclosed in the prior art. As the first phase ends, as indicated by a temperature sensor at the exit end of the CDPF, the temperature and oxygen content of the exhaust gas are increased at the entrance to the CDPF in an ensuing second stage. These increases cause oxidation of the soot remaining near the entrance and the sides of the CDPF, resulting in a cleaner and higher-capacity CDPF than is produced by a single-phase regeneration in the prior art. The sequential stages are implemented via an algorithm programmed into an Engine Control Module (ECM). A CDPF regenerated in accordance with the invention can have approximately 95% of its filtration capacity restored.
摘要翻译：一种设置在柴油发动机的排气流中的CDPF的再生方法。该方法包括基本上如现有技术中所公开的第一阶段之后的第二阶段操作。当第一相结束时，如在CDPF的出口端处的温度传感器所示，随后的第二阶段，排气的温度和氧含量在CDPF的入口处增加。这些增加导致残留在CDPF的入口和侧面附近的烟灰的氧化，导致比现有技术中的单相再生产生的更清洁和更高容量的CDPF。顺序阶段通过编程到发动机控制模块（ECM）中的算法来实现。根据本发明再生的CDPF可以恢复约95％的过滤能力。

7. 发明申请

US20110098323A1 INHIBITORS OF BACTERIAL BIOFILM FORMATION 审中-公开
标题翻译：细菌生物膜形成抑制剂
公开(公告)号：US20110098323A1
公开(公告)日：2011-04-28
申请号：US12991675
申请日：2009-05-19
申请人： Timothy J. Opperman , John D. Williams , Norton P. Peet , Atiyya R. Khan , Steven M. Kwasny
发明人： Timothy J. Opperman , John D. Williams , Norton P. Peet , Atiyya R. Khan , Steven M. Kwasny
IPC分类号： A01N43/40 , A01N43/78 , A01N43/08 , A01N43/50 , A01P1/00
CPC分类号： A01N43/78 , A01N43/50
摘要： Organic compounds are described for use in inhibiting or preventing formation of bacterial biofilms.
摘要翻译：描述了用于抑制或预防细菌生物膜形成的有机化合物。

8. 发明授权

US07587817B2 Method of making electrical connector on a flexible carrier 有权
标题翻译：在柔性载体上制作电连接器的方法
公开(公告)号：US07587817B2
公开(公告)日：2009-09-15
申请号：US11491160
申请日：2006-07-24
申请人： John D. Williams
发明人： John D. Williams
IPC分类号： H01R43/00 , H01R43/04
CPC分类号： H05K1/118 , H01R12/526 , H01R13/2407 , H05K3/202 , H05K3/326 , H05K3/4092 , H05K3/42 , H05K2201/0311 , H05K2201/0397 , H05K2201/10378 , H05K2203/1572 , Y10T29/49156 , Y10T29/49204 , Y10T29/49218 , Y10T29/49222
摘要： A compliant, scalable, thermal-electrical-mechanical, flexible electrical connector. In one configuration, the flexible electrical connector comprises a flexible substrate, a first and second conductive layer, and a plating contiguously applied over the conductive layers and holes through the substrate. The first and second conductive layers are adhered to opposite sides of the flexible substrate and have a plurality of raised contact elements in registration with at least a subset of the holes. At least some contact elements on the first and second conductive layers that oppose each other are in electrical communication with one another by way of the plating.
摘要翻译：兼容，可扩展，热电机械，柔性电连接器。在一种配置中，柔性电连接器包括柔性基板，第一和第二导电层以及连续施加在导电层上的电镀层和通过基板的孔。第一和第二导电层粘附到柔性基板的相对侧上，并且具有多个与至少一个孔的子集对准的凸起接触元件。在第一和第二导电层上彼此相对的至少一些接触元件通过电镀彼此电连通。

9. 发明申请

US20090188243A1 Method for controlling catalyst and filter temperatures in regeneration of a catalytic diesel particulate filter 有权
标题翻译：控制催化柴油微粒过滤器再生催化剂和过滤器温度的方法
公开(公告)号：US20090188243A1
公开(公告)日：2009-07-30
申请号：US12011536
申请日：2008-01-28
申请人： John D. Williams , Tanto Sugiarto , George N. Simopoulos
发明人： John D. Williams , Tanto Sugiarto , George N. Simopoulos
IPC分类号： F01N3/023 , F01N11/00
CPC分类号： F01N3/023 , F01N9/002 , Y02T10/47
摘要： A system for managing regeneration of a CDPF in a diesel engine. The system determines volatility of the accumulated soot by a weighting/indexing method to select a regeneration control strategy that protects the CDPF from thermal damage. The system determines the mass of wet soot and dry soot accumulated over the previous driving cycle and selects a management strategy to control the rate of temperature increase and the thermal gradient imposed upon the filter. The wet soot percent is an index for setting the regeneration temperature control profile for an allowable total accumulated soot mass as a function of the accumulated wet soot. The method also scales the soot mass regeneration threshold value based upon wet soot accumulation and accumulation rate and provides an indicator of combustibility of the soot accumulation. The method provides a temperature ramp rate, total regeneration time, and exhaust oxygen level required to control regeneration.
摘要翻译：一种用于管理柴油发动机中的CDPF再生的系统。该系统通过加权/索引方法确定积累的烟灰的挥发性，以选择保护CDPF免受热损伤的再生控制策略。该系统确定在先前的驱动循环中累积的湿煤烟和干烟尘的质量，并选择管理策略来控制温度升高速率和施加在过滤器上的热梯度。湿烟灰百分比是用于将再生温度控制曲线设置为允许的总累积烟灰质量作为累积湿烟灰的函数的指标。该方法还基于湿烟灰积累和积累速率来缩放烟灰质量再生阈值，并提供烟灰积聚的可燃性指标。该方法提供了控制再生所需的温度升高速率，总再生时间和排气氧气水平。

10. 发明申请

US20090188241A1 Method for improving regeneration of a catalytic diesel particulate filter 有权
标题翻译：改善催化柴油颗粒过滤器再生的方法
公开(公告)号：US20090188241A1
公开(公告)日：2009-07-30
申请号：US12011530
申请日：2008-01-28
申请人： Tanto Sugiarto , John D. Williams , Thomas M. Harris
发明人： Tanto Sugiarto , John D. Williams , Thomas M. Harris
IPC分类号： F01N3/023 , F01N11/00
CPC分类号： F01N3/023 , F01N9/002 , Y02T10/47
摘要： A method for regeneration of a CDPF disposed in the exhaust stream of a diesel engine. The method includes a second phase operation following a first phase substantially as disclosed in the prior art. As the first phase ends, as indicated by a temperature sensor at the exit end of the CDPF, the temperature and oxygen content of the exhaust gas are increased at the entrance to the CDPF in an ensuing second stage. These increases cause oxidation of the soot remaining near the entrance and the sides of the CDPF, resulting in a cleaner and higher-capacity CDPF than is produced by a single-phase regeneration in the prior art. The sequential stages are implemented via an algorithm programmed into an Engine Control Module (ECM). A CDPF regenerated in accordance with the invention can have approximately 95% of its filtration capacity restored.
摘要翻译：一种设置在柴油发动机的排气流中的CDPF的再生方法。该方法包括基本上如现有技术中所公开的第一阶段之后的第二阶段操作。当第一相结束时，如在CDPF的出口端处的温度传感器所示，随后的第二阶段，排气的温度和氧含量在CDPF的入口处增加。这些增加导致残留在CDPF的入口和侧面附近的烟灰的氧化，导致比现有技术中的单相再生产生的更清洁和更高容量的CDPF。顺序阶段通过编程到发动机控制模块（ECM）中的算法来实现。根据本发明再生的CDPF可以恢复约95％的过滤能力。

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