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1. 发明申请

US20070092867A1 Application using non-covalent bond between a cucurbituril derivative and a ligand 有权
标题翻译：在葫芦巴衍生物和配体之间使用非共价键的应用
公开(公告)号：US20070092867A1
公开(公告)日：2007-04-26
申请号：US11407143
申请日：2006-04-20
申请人： Kimoon Kim , Kangkyun Baek , Jeeyeon Kim , Iiha Hwang , Young Ko , Narayanan Selvapalam , Erumaipatty Nagarajan , Kyeng Park
发明人： Kimoon Kim , Kangkyun Baek , Jeeyeon Kim , Iiha Hwang , Young Ko , Narayanan Selvapalam , Erumaipatty Nagarajan , Kyeng Park
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/53 , C07F5/00 , C12M1/34 , C07D487/22
CPC分类号： C07D487/22 , B01D15/3804 , B01J31/0249 , B01J31/0251 , B01J31/1658 , B82Y5/00 , B82Y15/00 , C07K1/22
摘要： Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.
摘要翻译：本发明提供了一种试剂盒，其包含第一组分，其为下式结合于第一材料的式（1）化合物，第二组分为与第二材料结合的配体，其中第一和第二材料中的每一种独立地选自由固相，生物分子，抗氧化剂，化学治疗剂，抗组胺药，葫芦巴树枝状大分子，环糊精衍生物，冠醚衍生物，杯芳烃衍生物，环戊烷衍生物，环肽衍生物，金属离子，发色团，荧光材料，荧光体，放射性材料和催化剂; 并且配体可以非共价结合式（1）的化合物; 使用与固相结合的式（1）化合物分离和纯化与配体结合的材料的方法; 使用与固相结合的配体分离和纯化式（1）化合物或与化合物结合的物质的方法; 包含与第一材料结合的式（1）化合物和与第二材料结合的配体的传感器芯片; 和包含与第一材料结合的式（1）化合物和与第二材料结合的配体的固体催化剂络合物。

2. 发明授权

US07479254B2 Application using non-covalent bond between a cucurbituril derivative and a ligand 有权
标题翻译：在葫芦巴衍生物和配体之间使用非共价键的应用
公开(公告)号：US07479254B2
公开(公告)日：2009-01-20
申请号：US11407143
申请日：2006-04-20
申请人： Kimoon Kim , Kangkyun Baek , Jeeyeon Kim , Iiha Hwang , Young Ho Ko , Narayanan Selvapalam , Erumaipatty R. Nagarajan , Kyeng Min Park
发明人： Kimoon Kim , Kangkyun Baek , Jeeyeon Kim , Iiha Hwang , Young Ho Ko , Narayanan Selvapalam , Erumaipatty R. Nagarajan , Kyeng Min Park
IPC分类号： B01L3/00 , A61K9/36 , A61K45/00 , C12Q1/68 , G01N15/06 , G01N33/53
CPC分类号： C07D487/22 , B01D15/3804 , B01J31/0249 , B01J31/0251 , B01J31/1658 , B82Y5/00 , B82Y15/00 , C07K1/22
摘要： Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.
摘要翻译：本发明提供了一种试剂盒，其包含第一组分，其为下式结合于第一材料的式（1）化合物，第二组分为与第二材料结合的配体，其中第一和第二材料中的每一种独立地选自由固相，生物分子，抗氧化剂，化学治疗剂，抗组胺药，葫芦巴树枝状大分子，环糊精衍生物，冠醚衍生物，杯芳烃衍生物，环戊烷衍生物，环肽衍生物，金属离子，发色团，荧光材料，荧光体，放射性材料和催化剂; 并且配体可以非共价结合式（1）的化合物; 使用与固相结合的式（1）化合物分离和纯化与配体结合的材料的方法; 使用与固相结合的配体分离和纯化式（1）化合物或与化合物结合的物质的方法; 包含与第一材料结合的式（1）化合物和与第二材料结合的配体的传感器芯片; 和包含与第一材料结合的式（1）化合物和与第二材料结合的配体的固体催化剂络合物。

3. 发明授权

US07718128B2 Application using non-covalent bond between a cucurbituril derivative and a ligand 有权
标题翻译：在葫芦巴衍生物和配体之间使用非共价键的应用
公开(公告)号：US07718128B2
公开(公告)日：2010-05-18
申请号：US12339944
申请日：2008-12-19
申请人： Kimoon Kim , Kangkyun Baek , Jeeyeon Kim , Ilha Hwang , Young Ho Ko , Narayanan Selvapalam , Erumaipatty R. Nagarajan , Kyeng Min Park
发明人： Kimoon Kim , Kangkyun Baek , Jeeyeon Kim , Ilha Hwang , Young Ho Ko , Narayanan Selvapalam , Erumaipatty R. Nagarajan , Kyeng Min Park
IPC分类号： G01N15/06 , A61K9/14 , A61K45/00 , B01L3/00 , C12Q1/68 , G01N33/53
CPC分类号： C07D487/22 , B01D15/3804 , B01J31/0249 , B01J31/0251 , B01J31/1658 , B82Y5/00 , B82Y15/00 , C07K1/22
摘要： Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.
摘要翻译：本发明提供了一种试剂盒，其包含第一组分，其为下式结合于第一材料的式（1）化合物，第二组分为与第二材料结合的配体，其中第一和第二材料中的每一种独立地选自由固相，生物分子，抗氧化剂，化学治疗剂，抗组胺药，葫芦巴树枝状大分子，环糊精衍生物，冠醚衍生物，杯芳烃衍生物，环戊烷衍生物，环肽衍生物，金属离子，发色团，荧光材料，荧光体，放射性材料和催化剂; 并且配体可以非共价结合式（1）的化合物; 使用与固相结合的式（1）化合物分离和纯化与配体结合的材料的方法; 使用与固相结合的配体分离和纯化式（1）化合物或与化合物结合的物质的方法; 包含与第一材料结合的式（1）化合物和与第二材料结合的配体的传感器芯片; 和包含与第一材料结合的式（1）化合物和与第二材料结合的配体的固体催化剂络合物。

4. 发明授权

US07867391B2 Cucurbituril derivative-bonded solid substrate and biochip using the same 有权
标题翻译：葫芦素衍生物固定基质和使用其的生物芯片
公开(公告)号：US07867391B2
公开(公告)日：2011-01-11
申请号：US10563463
申请日：2004-07-05
申请人： Kimoon Kim , Jin Koo Kang , Woo Seong Jeon , Sang Yong Jon , Selvapalam Narayanan , Dong Hyun Oh , Kangkyun Baek
发明人： Kimoon Kim , Jin Koo Kang , Woo Seong Jeon , Sang Yong Jon , Selvapalam Narayanan , Dong Hyun Oh , Kangkyun Baek
IPC分类号： B01D15/08
CPC分类号： G01N33/54353 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , G01N33/551 , G01N33/552
摘要： The present disclosure provides a cucurbituril derivative-bonded solid substrate in which cucurbituril derivatives of Formula 1 are covalently bonded to a modified solid substrate of Formula 2. The cucurbituril derivative provides functional groups which can be used to link biomaterials to the substrate. Protein chips, gene chips, and sensors for biomaterial assays having the cucurbituril derivative-bonded solid substrate are also provided.
摘要翻译：本公开内容提供了一种葫芦巴衍生物结合的固体底物，其中式1的葫芦巴脲衍生物与式2的改性固体底物共价键合。葫芦巴衍生物提供可用于将生物材料与底物连接的官能团。还提供了具有葫芦巴衍生物键合的固体基质的蛋白质芯片，基因芯片和用于生物材料测定的传感器。

5. 发明申请

US20080264433A1 Cucurbituril Added Cigarettes and Manufacturing Method Thereof 审中-公开
标题翻译：葫芦巴添加香烟及其制造方法
公开(公告)号：US20080264433A1
公开(公告)日：2008-10-30
申请号：US12091557
申请日：2006-03-09
申请人： Kimoon Kim , Kyeng-Min Park , Young-Ho Ko , Narayanan Selvapalam
发明人： Kimoon Kim , Kyeng-Min Park , Young-Ho Ko , Narayanan Selvapalam
IPC分类号： A24C5/00 , A24D3/14 , A24B1/00 , A24F7/04
CPC分类号： A24D1/002 , A24D3/14
摘要： Provided is a cucurbituril-containing tobacco. The cucurbituril-containing tobacco includes a cucurbituril represented by Formula 1. The cucurbituril-containing tobacco can produce a reduced amount of harmful substances.
摘要翻译：提供含有葫芦素的烟草。含葫芦素的烟草包括由式1表示的葫芦巴脲。含葫芦素的烟草可以产生减少量的有害物质。

6. 发明申请

US20120045516A1 COMPOSITION FOR PHOTODYNAMIC THERAPY COMPRISING A MACROMOLECULAR CAPSULE 审中-公开
标题翻译：用于包含大分子胶囊的光化疗法的组合物
公开(公告)号：US20120045516A1
公开(公告)日：2012-02-23
申请号：US13264427
申请日：2009-10-20
申请人： Kimoon Kim , Kangkyun Baek , Gyeongwon Yun , Youngkook Kim , Raghunandan Hota , Kyeng Min Park , Hyuntae Jung
发明人： Kimoon Kim , Kangkyun Baek , Gyeongwon Yun , Youngkook Kim , Raghunandan Hota , Kyeng Min Park , Hyuntae Jung
IPC分类号： A61K9/51 , A61K31/506 , A61P35/00 , B32B27/00 , A61K31/337 , A61K31/704 , B82Y5/00
CPC分类号： A61K9/4816 , A61K9/5146 , A61K31/337 , A61K31/506 , A61K31/704 , A61K41/0071 , A61K47/34 , A61K47/58 , A61N5/062 , Y10T428/2982
摘要： A composition for photodynamic therapy including a polymer capsule having a diameter of about 10 nm to about 2000 nm synthesized by copolymerization of a flat aromatic compound represented by Formula 1 (see the specification) and an organic compound represented by Formula 2 (see the specification).
摘要翻译：一种用于光动力学治疗的组合物，其包括通过由式1（参见说明书）表示的平坦芳族化合物与由式2表示的有机化合物（参见说明书）共聚合的直径约10nm至约2000nm的聚合物胶囊，。

7. 发明授权

US07611888B2 Rotaxane compound, rotaxane-bonded solid substrate, and biochip using the same 失效
标题翻译： Rotaxane化合物，与轮烷结合的固体基质和使用其的生物芯片
公开(公告)号：US07611888B2
公开(公告)日：2009-11-03
申请号：US10563477
申请日：2004-07-05
申请人： Kimoon Kim , Jin Koo Kang , Woo Seong Jeon , Miran Noh , Dongwoo Kim , Kangkyun Baek
发明人： Kimoon Kim , Jin Koo Kang , Woo Seong Jeon , Miran Noh , Dongwoo Kim , Kangkyun Baek
IPC分类号： C12M1/34 , G01N33/552 , C07K1/10 , C12Q1/68 , G01N33/53 , C07D245/00
CPC分类号： C07D487/22 , C07B2200/11 , G01N33/545 , G01N2035/00158
摘要： The present disclosure provides a rotaxane compound that can be used to separate molecules within a linkage layer formed on a solid substrate of a biochip by a predetermined distance. The compound is represented by Formula 1, in which a compound of Formula 3 vertically passes through a cavity of cucurbituril or its derivative of Formula 2. It further provides gene chips, protein chips and sensors for biomaterial assays which use the rotaxane molecules to allow biomaterials to be immobilized on a linkage layer such that they are regularly spaced apart from each other by a predetermined distance.
摘要翻译：本公开提供了一种轮烷化合物，其可用于将形成在生物芯片的固体基质上的连接层内的分子分离预定距离。该化合物由式1表示，其中式3的化合物垂直通过葫芦巴或其式II的衍生物的空腔。它还提供用于生物材料测定的基因芯片，蛋白质芯片和传感器，其使用轮烷分子以允许生物材料被固定在连接层上，使得它们彼此规则地间隔开预定距离。

8. 发明授权

US08168436B2 Method for determining quantity of peptide compound having phenylalanine residue at N-terminus 失效
标题翻译：确定N-末端具有苯丙氨酸残基的肽化合物的量的方法
公开(公告)号：US08168436B2
公开(公告)日：2012-05-01
申请号：US12446718
申请日：2007-10-23
申请人： Yoshihisa Inoue , Mikhail Rekharsky , Kimoon Kim , Yong Ho Ko , Narayanan Selvapalam
发明人： Yoshihisa Inoue , Mikhail Rekharsky , Kimoon Kim , Yong Ho Ko , Narayanan Selvapalam
IPC分类号： G01N33/00
CPC分类号： G01N33/6824 , Y10S436/815
摘要： The present invention provides a method for quantifying a peptide compound having a phenylalanine residue at the N-terminal, comprising measuring the content of heat generated by mixing 1) a peptide compound having a phenylalanine residue at the N-terminal, 2) cucurbit[7]uril, and 3) a metal ion in a solution.
摘要翻译：本发明提供了一种定量在N-末端具有苯丙氨酸残基的肽化合物的方法，包括测量通过混合产生的热含量1）在N末端具有苯丙氨酸残基的肽化合物，2）葫芦[7 ]，和3）溶液中的金属离子。

9. 发明申请

US20100238969A1 METHOD FOR DETERMINING QUANTITY OF PEPTIDE COMPOUND HAVING PHENYLALANINE RESIDUE AT N-TERMINUS 失效
标题翻译：用于确定N-末端苯丙氨酸残基的肽类化合物的数量的方法
公开(公告)号：US20100238969A1
公开(公告)日：2010-09-23
申请号：US12446718
申请日：2007-10-23
申请人： Yoshihisa Inoue , Mikhail Rekharsky , Kimoon Kim , Yong Ho Ko , Narayanan Selvapalam
发明人： Yoshihisa Inoue , Mikhail Rekharsky , Kimoon Kim , Yong Ho Ko , Narayanan Selvapalam
IPC分类号： G01N25/00
CPC分类号： G01N33/6824 , Y10S436/815
摘要： The present invention provides a method for quantifying a peptide compound having a phenylalanine residue at the N-terminal, comprising measuring the content of heat generated by mixing 1) a peptide compound having a phenylalanine residue at the N-terminal, 2) cucurbit[7]uril, and 3) a metal ion in a solution.
摘要翻译：本发明提供了一种定量在N-末端具有苯丙氨酸残基的肽化合物的方法，包括测量通过混合产生的热含量1）在N末端具有苯丙氨酸残基的肽化合物，2）葫芦[7 ]，和3）溶液中的金属离子。

10. 发明申请

US20060154254A1 Rotaxane compound, rotaxane-bonded solid substrate, and biochip using the same 失效
公开(公告)号：US20060154254A1
公开(公告)日：2006-07-13
申请号：US10563477
申请日：2004-07-05
申请人： Kimoon Kim , Jin Kang , Woo Jeon , Miran Noh , Dongwoo Kim , Kangkyun Baek
发明人： Kimoon Kim , Jin Kang , Woo Jeon , Miran Noh , Dongwoo Kim , Kangkyun Baek
IPC分类号： C12Q1/68 , G01N33/53 , C07D487/14
CPC分类号： C07D487/22 , C07B2200/11 , G01N33/545 , G01N2035/00158
摘要： The present disclosure provides a rotaxane compound that can be used to separate molecules within a linkage layer formed on a solid substrate of a biochip by a predetermined distance. The compound is represented by Formula 1, in which a compound of Formula 3 vertically passes through a cavity of cucurbituril or its derivative of Formula 2. It further provides gene chips, protein chips and sensors for biomaterial assays which use the rotaxane molecules to allow biomaterials to be immobilized on a linkage layer such that they are regularly spaced apart from each other by a predetermined distance.

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