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1. 发明申请

US20090095677A1 APPLICATION USING NON-COVALENT BOND BETWEEN A CUCURBITURIL DERIVATIVE AND A LIGAND 有权
标题翻译：使用CUCURBITURIL衍生物和配体之间的非共价键的应用
公开(公告)号：US20090095677A1
公开(公告)日：2009-04-16
申请号：US12339944
申请日：2008-12-19
申请人： Kimoon KIM , Kangkyun Baek , Jeeyeon Kim , Ilha Hwang , Young Ho Ko , Narayanan Selvapalam , Erumaipatty R. Nagarajan , Kyeng Min Park
发明人： Kimoon KIM , Kangkyun Baek , Jeeyeon Kim , Ilha Hwang , Young Ho Ko , Narayanan Selvapalam , Erumaipatty R. Nagarajan , Kyeng Min Park
IPC分类号： B01D15/32 , C12N9/96 , C12N11/14 , C12N11/08 , C12N11/10 , B01J31/12
CPC分类号： C07D487/22 , B01D15/3804 , B01J31/0249 , B01J31/0251 , B01J31/1658 , B82Y5/00 , B82Y15/00 , C07K1/22
摘要： Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.
摘要翻译：本发明提供了一种试剂盒，其包含第一组分，其为下式结合于第一材料的式（1）化合物，第二组分为与第二材料结合的配体，其中第一和第二材料中的每一种独立地选自由固相，生物分子，抗氧化剂，化学治疗剂，抗组胺药，葫芦巴树枝状大分子，环糊精衍生物，冠醚衍生物，杯芳烃衍生物，环戊烷衍生物，环肽衍生物，金属离子，发色团，荧光材料，荧光体，放射性材料和催化剂; 并且配体可以非共价结合式（1）的化合物; 使用与固相结合的式（1）化合物分离和纯化与配体结合的材料的方法; 使用与固相结合的配体分离和纯化式（1）化合物或与化合物结合的物质的方法; 包含与第一材料结合的式（1）化合物和与第二材料结合的配体的传感器芯片; 和包含与第一材料结合的式（1）化合物和与第二材料结合的配体的固体催化剂络合物。

2. 发明授权

US07479254B2 Application using non-covalent bond between a cucurbituril derivative and a ligand 有权
标题翻译：在葫芦巴衍生物和配体之间使用非共价键的应用
公开(公告)号：US07479254B2
公开(公告)日：2009-01-20
申请号：US11407143
申请日：2006-04-20
申请人： Kimoon Kim , Kangkyun Baek , Jeeyeon Kim , Iiha Hwang , Young Ho Ko , Narayanan Selvapalam , Erumaipatty R. Nagarajan , Kyeng Min Park
发明人： Kimoon Kim , Kangkyun Baek , Jeeyeon Kim , Iiha Hwang , Young Ho Ko , Narayanan Selvapalam , Erumaipatty R. Nagarajan , Kyeng Min Park
IPC分类号： B01L3/00 , A61K9/36 , A61K45/00 , C12Q1/68 , G01N15/06 , G01N33/53
CPC分类号： C07D487/22 , B01D15/3804 , B01J31/0249 , B01J31/0251 , B01J31/1658 , B82Y5/00 , B82Y15/00 , C07K1/22
摘要： Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.
摘要翻译：本发明提供了一种试剂盒，其包含第一组分，其为下式结合于第一材料的式（1）化合物，第二组分为与第二材料结合的配体，其中第一和第二材料中的每一种独立地选自由固相，生物分子，抗氧化剂，化学治疗剂，抗组胺药，葫芦巴树枝状大分子，环糊精衍生物，冠醚衍生物，杯芳烃衍生物，环戊烷衍生物，环肽衍生物，金属离子，发色团，荧光材料，荧光体，放射性材料和催化剂; 并且配体可以非共价结合式（1）的化合物; 使用与固相结合的式（1）化合物分离和纯化与配体结合的材料的方法; 使用与固相结合的配体分离和纯化式（1）化合物或与化合物结合的物质的方法; 包含与第一材料结合的式（1）化合物和与第二材料结合的配体的传感器芯片; 和包含与第一材料结合的式（1）化合物和与第二材料结合的配体的固体催化剂络合物。

3. 发明授权

US07850992B2 Cucurbituril-containing gel and method of preparing the same 失效
标题翻译：含有葫芦素的凝胶及其制备方法
公开(公告)号：US07850992B2
公开(公告)日：2010-12-14
申请号：US11552624
申请日：2006-10-25
申请人： Kimoon Kim , II Ha Hwang , Woo Sung Jeon , Hee Joon Kim , Dongwoo Kim , Narayanan Selvapalam , Erumaipatty R. Nagarajan
发明人： Kimoon Kim , II Ha Hwang , Woo Sung Jeon , Hee Joon Kim , Dongwoo Kim , Narayanan Selvapalam , Erumaipatty R. Nagarajan
IPC分类号： A61K9/14
CPC分类号： A61K9/06 , A61K31/573 , A61K38/00 , A61K41/0042 , A61K47/16
摘要： Provided are a gel including a compound represented by Formula 1 below and a method of preparing the same: wherein n, X, A1, and A2 are as defined in the specification.
摘要翻译：提供一种凝胶，其包含下述通式1所示的化合物及其制备方法：其中n，X，A1和A2如说明书中所定义。

4. 发明授权

US07718128B2 Application using non-covalent bond between a cucurbituril derivative and a ligand 有权
标题翻译：在葫芦巴衍生物和配体之间使用非共价键的应用
公开(公告)号：US07718128B2
公开(公告)日：2010-05-18
申请号：US12339944
申请日：2008-12-19
申请人： Kimoon Kim , Kangkyun Baek , Jeeyeon Kim , Ilha Hwang , Young Ho Ko , Narayanan Selvapalam , Erumaipatty R. Nagarajan , Kyeng Min Park
发明人： Kimoon Kim , Kangkyun Baek , Jeeyeon Kim , Ilha Hwang , Young Ho Ko , Narayanan Selvapalam , Erumaipatty R. Nagarajan , Kyeng Min Park
IPC分类号： G01N15/06 , A61K9/14 , A61K45/00 , B01L3/00 , C12Q1/68 , G01N33/53
CPC分类号： C07D487/22 , B01D15/3804 , B01J31/0249 , B01J31/0251 , B01J31/1658 , B82Y5/00 , B82Y15/00 , C07K1/22
摘要： Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.
摘要翻译：本发明提供了一种试剂盒，其包含第一组分，其为下式结合于第一材料的式（1）化合物，第二组分为与第二材料结合的配体，其中第一和第二材料中的每一种独立地选自由固相，生物分子，抗氧化剂，化学治疗剂，抗组胺药，葫芦巴树枝状大分子，环糊精衍生物，冠醚衍生物，杯芳烃衍生物，环戊烷衍生物，环肽衍生物，金属离子，发色团，荧光材料，荧光体，放射性材料和催化剂; 并且配体可以非共价结合式（1）的化合物; 使用与固相结合的式（1）化合物分离和纯化与配体结合的材料的方法; 使用与固相结合的配体分离和纯化式（1）化合物或与化合物结合的物质的方法; 包含与第一材料结合的式（1）化合物和与第二材料结合的配体的传感器芯片; 和包含与第一材料结合的式（1）化合物和与第二材料结合的配体的固体催化剂络合物。

5. 发明授权

US08002987B2 Stationary phase and column using cucurbituril bonded silica gel, and separation method of taxol using the column 失效
标题翻译：使用葫芦素结合硅胶固定相和柱，并用色谱柱分离紫杉醇
公开(公告)号：US08002987B2
公开(公告)日：2011-08-23
申请号：US12092663
申请日：2006-03-24
申请人： Kimoon Kim , Kyeng-Min Park , Young-Ho Ko , Narayanan Selvapalam , Erumaipatty R Nagarajan
发明人： Kimoon Kim , Kyeng-Min Park , Young-Ho Ko , Narayanan Selvapalam , Erumaipatty R Nagarajan
IPC分类号： B01D15/08
CPC分类号： C07D487/04 , B01J20/286 , C07D305/14
摘要： Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.
摘要翻译：提供了使用葫芦巴结合的硅胶的固定相和柱，以及使用该柱分离紫杉烷的方法。紫杉烷分离方法包括：制备紫杉烷分离柱，该柱用包含葫芦素结合硅胶的固定相填充，其中由式1或2表示的葫芦巴与由式3表示的改性硅胶共价结合 ; 将紫杉烷粉末溶解在溶剂中以制备含紫杉烷的溶液; 将含有紫杉烷的溶液应用于色谱柱; 向柱中提供流动相溶剂以从柱中获得紫杉烷提取物; 并从紫杉烷提取物中纯化紫杉烷。因此，高纯度的紫杉烷可以与低纯度的紫杉烷提取物分离。

6. 发明申请

US20080290028A1 Stationary Phase and Column Using Cucurbituril Bonded Silica Gel, and Separation Method of Taxol Using the Column 失效
标题翻译：使用葫芦素结合硅胶的固定相和柱，以及使用柱的紫杉醇的分离方法
公开(公告)号：US20080290028A1
公开(公告)日：2008-11-27
申请号：US12092663
申请日：2006-03-24
申请人： Kimoon Kim , Young-Ho Ko , Kyeng-Min Park , Narayanan Selvapalam , Erumaipatty R. Nagarajan
发明人： Kimoon Kim , Young-Ho Ko , Kyeng-Min Park , Narayanan Selvapalam , Erumaipatty R. Nagarajan
IPC分类号： B01D15/08
CPC分类号： C07D487/04 , B01J20/286 , C07D305/14
摘要： Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.
摘要翻译：提供了使用葫芦巴结合的硅胶的固定相和柱，以及使用该柱分离紫杉烷的方法。紫杉烷分离方法包括：制备紫杉烷分离柱，该柱用包含葫芦素结合硅胶的固定相填充，其中由式1或2表示的葫芦巴与由式3表示的改性硅胶共价结合 ; 将紫杉烷粉末溶解在溶剂中以制备含紫杉烷的溶液; 将含紫杉烷的溶液应用于色谱柱; 向柱中提供流动相溶剂以从柱中获得紫杉烷提取物; 并从紫杉烷提取物中纯化紫杉烷。因此，高纯度的紫杉烷可以与低纯度的紫杉烷提取物分离。

7. 发明申请

US20070154553A1 CUCURBITURIL-CONTAINING GEL AND METHOD OF PREPARING THE SAME 失效
标题翻译：含有凝血素的凝胶及其制备方法
公开(公告)号：US20070154553A1
公开(公告)日：2007-07-05
申请号：US11552624
申请日：2006-10-25
申请人： Kimoon KIM , Il Ha HWANG , Woo Sung JEON , Hee Joon KIM , Dongwoo KIM , Narayanan SELVAPALAM , Erumaipatty R. NAGARAJAN
发明人： Kimoon KIM , Il Ha HWANG , Woo Sung JEON , Hee Joon KIM , Dongwoo KIM , Narayanan SELVAPALAM , Erumaipatty R. NAGARAJAN
IPC分类号： A61K38/28 , A61K38/31 , A61K38/27 , A61K38/25 , A61K38/26 , A61K38/24 , A61K38/22 , A61K38/21 , A61K38/19 , A61K31/573 , A61K9/14
CPC分类号： A61K9/06 , A61K31/573 , A61K38/00 , A61K41/0042 , A61K47/16
摘要： Provided are a gel including a compound represented by Formula 1 below and a method of preparing the same: wherein n, X, A1, and A2 are as defined in the specification.
摘要翻译：提供一种凝胶，其包含由下述通式1表示的化合物及其制备方法：其中n，X，A 1和A 2如在规范。

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