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1. 发明申请

US20080264433A1 Cucurbituril Added Cigarettes and Manufacturing Method Thereof 审中-公开
标题翻译：葫芦巴添加香烟及其制造方法
公开(公告)号：US20080264433A1
公开(公告)日：2008-10-30
申请号：US12091557
申请日：2006-03-09
申请人： Kimoon Kim , Kyeng-Min Park , Young-Ho Ko , Narayanan Selvapalam
发明人： Kimoon Kim , Kyeng-Min Park , Young-Ho Ko , Narayanan Selvapalam
IPC分类号： A24C5/00 , A24D3/14 , A24B1/00 , A24F7/04
CPC分类号： A24D1/002 , A24D3/14
摘要： Provided is a cucurbituril-containing tobacco. The cucurbituril-containing tobacco includes a cucurbituril represented by Formula 1. The cucurbituril-containing tobacco can produce a reduced amount of harmful substances.
摘要翻译：提供含有葫芦素的烟草。含葫芦素的烟草包括由式1表示的葫芦巴脲。含葫芦素的烟草可以产生减少量的有害物质。

2. 发明申请

US20070154553A1 CUCURBITURIL-CONTAINING GEL AND METHOD OF PREPARING THE SAME 失效
标题翻译：含有凝血素的凝胶及其制备方法
公开(公告)号：US20070154553A1
公开(公告)日：2007-07-05
申请号：US11552624
申请日：2006-10-25
申请人： Kimoon KIM , Il Ha HWANG , Woo Sung JEON , Hee Joon KIM , Dongwoo KIM , Narayanan SELVAPALAM , Erumaipatty R. NAGARAJAN
发明人： Kimoon KIM , Il Ha HWANG , Woo Sung JEON , Hee Joon KIM , Dongwoo KIM , Narayanan SELVAPALAM , Erumaipatty R. NAGARAJAN
IPC分类号： A61K38/28 , A61K38/31 , A61K38/27 , A61K38/25 , A61K38/26 , A61K38/24 , A61K38/22 , A61K38/21 , A61K38/19 , A61K31/573 , A61K9/14
CPC分类号： A61K9/06 , A61K31/573 , A61K38/00 , A61K41/0042 , A61K47/16
摘要： Provided are a gel including a compound represented by Formula 1 below and a method of preparing the same: wherein n, X, A1, and A2 are as defined in the specification.
摘要翻译：提供一种凝胶，其包含由下述通式1表示的化合物及其制备方法：其中n，X，A 1和A 2如在规范。

3. 发明申请

US20070092867A1 Application using non-covalent bond between a cucurbituril derivative and a ligand 有权
标题翻译：在葫芦巴衍生物和配体之间使用非共价键的应用
公开(公告)号：US20070092867A1
公开(公告)日：2007-04-26
申请号：US11407143
申请日：2006-04-20
申请人： Kimoon Kim , Kangkyun Baek , Jeeyeon Kim , Iiha Hwang , Young Ko , Narayanan Selvapalam , Erumaipatty Nagarajan , Kyeng Park
发明人： Kimoon Kim , Kangkyun Baek , Jeeyeon Kim , Iiha Hwang , Young Ko , Narayanan Selvapalam , Erumaipatty Nagarajan , Kyeng Park
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/53 , C07F5/00 , C12M1/34 , C07D487/22
CPC分类号： C07D487/22 , B01D15/3804 , B01J31/0249 , B01J31/0251 , B01J31/1658 , B82Y5/00 , B82Y15/00 , C07K1/22
摘要： Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.
摘要翻译：本发明提供了一种试剂盒，其包含第一组分，其为下式结合于第一材料的式（1）化合物，第二组分为与第二材料结合的配体，其中第一和第二材料中的每一种独立地选自由固相，生物分子，抗氧化剂，化学治疗剂，抗组胺药，葫芦巴树枝状大分子，环糊精衍生物，冠醚衍生物，杯芳烃衍生物，环戊烷衍生物，环肽衍生物，金属离子，发色团，荧光材料，荧光体，放射性材料和催化剂; 并且配体可以非共价结合式（1）的化合物; 使用与固相结合的式（1）化合物分离和纯化与配体结合的材料的方法; 使用与固相结合的配体分离和纯化式（1）化合物或与化合物结合的物质的方法; 包含与第一材料结合的式（1）化合物和与第二材料结合的配体的传感器芯片; 和包含与第一材料结合的式（1）化合物和与第二材料结合的配体的固体催化剂络合物。

4. 发明授权

US08058451B2 Hydroxycucurbituril derivatives, their preparation methods and uses 有权
标题翻译：羟基葫芦脲衍生物，其制备方法和用途
公开(公告)号：US08058451B2
公开(公告)日：2011-11-15
申请号：US12138883
申请日：2008-06-13
申请人： Ki-Moon Kim , Sang-Yong Jon , Narayanan Selvapalam , Dong-Hyun Oh
发明人： Ki-Moon Kim , Sang-Yong Jon , Narayanan Selvapalam , Dong-Hyun Oh
IPC分类号： C07D403/02
CPC分类号： C07D487/22 , Y02C10/08
摘要： Provided are hydroxycucurbituril derivatives, their preparation methods and uses. The hydroxycucurbituril derivative is easy to further functionalize with enhanced solubility in common solvents, thereby providing wider applications.
摘要翻译：提供羟ucurituril衍生物，其制备方法和用途。羟基葫芦脲衍生物易于进一步官能化，在普通溶剂中的溶解度增加，从而提供更广泛的应用。

5. 发明授权

US07850992B2 Cucurbituril-containing gel and method of preparing the same 失效
标题翻译：含有葫芦素的凝胶及其制备方法
公开(公告)号：US07850992B2
公开(公告)日：2010-12-14
申请号：US11552624
申请日：2006-10-25
申请人： Kimoon Kim , II Ha Hwang , Woo Sung Jeon , Hee Joon Kim , Dongwoo Kim , Narayanan Selvapalam , Erumaipatty R. Nagarajan
发明人： Kimoon Kim , II Ha Hwang , Woo Sung Jeon , Hee Joon Kim , Dongwoo Kim , Narayanan Selvapalam , Erumaipatty R. Nagarajan
IPC分类号： A61K9/14
CPC分类号： A61K9/06 , A61K31/573 , A61K38/00 , A61K41/0042 , A61K47/16
摘要： Provided are a gel including a compound represented by Formula 1 below and a method of preparing the same: wherein n, X, A1, and A2 are as defined in the specification.
摘要翻译：提供一种凝胶，其包含下述通式1所示的化合物及其制备方法：其中n，X，A1和A2如说明书中所定义。

6. 发明授权

US07718128B2 Application using non-covalent bond between a cucurbituril derivative and a ligand 有权
标题翻译：在葫芦巴衍生物和配体之间使用非共价键的应用
公开(公告)号：US07718128B2
公开(公告)日：2010-05-18
申请号：US12339944
申请日：2008-12-19
申请人： Kimoon Kim , Kangkyun Baek , Jeeyeon Kim , Ilha Hwang , Young Ho Ko , Narayanan Selvapalam , Erumaipatty R. Nagarajan , Kyeng Min Park
发明人： Kimoon Kim , Kangkyun Baek , Jeeyeon Kim , Ilha Hwang , Young Ho Ko , Narayanan Selvapalam , Erumaipatty R. Nagarajan , Kyeng Min Park
IPC分类号： G01N15/06 , A61K9/14 , A61K45/00 , B01L3/00 , C12Q1/68 , G01N33/53
CPC分类号： C07D487/22 , B01D15/3804 , B01J31/0249 , B01J31/0251 , B01J31/1658 , B82Y5/00 , B82Y15/00 , C07K1/22
摘要： Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.
摘要翻译：本发明提供了一种试剂盒，其包含第一组分，其为下式结合于第一材料的式（1）化合物，第二组分为与第二材料结合的配体，其中第一和第二材料中的每一种独立地选自由固相，生物分子，抗氧化剂，化学治疗剂，抗组胺药，葫芦巴树枝状大分子，环糊精衍生物，冠醚衍生物，杯芳烃衍生物，环戊烷衍生物，环肽衍生物，金属离子，发色团，荧光材料，荧光体，放射性材料和催化剂; 并且配体可以非共价结合式（1）的化合物; 使用与固相结合的式（1）化合物分离和纯化与配体结合的材料的方法; 使用与固相结合的配体分离和纯化式（1）化合物或与化合物结合的物质的方法; 包含与第一材料结合的式（1）化合物和与第二材料结合的配体的传感器芯片; 和包含与第一材料结合的式（1）化合物和与第二材料结合的配体的固体催化剂络合物。

7. 发明申请

US20060251725A1 Nano-particles comprising cucurbituril derivatives, pharmaceutical composition containing the same, and process for the preparation thereof 审中-公开
标题翻译：包含葫芦巴衍生物的纳米颗粒，含有它们的药物组合物及其制备方法
公开(公告)号：US20060251725A1
公开(公告)日：2006-11-09
申请号：US10565834
申请日：2004-07-26
申请人： Kimoon Kim , Sang Yong Jon , Young Jin Jeon , Dong Hyun Oh , Narayanan Selvapalam
发明人： Kimoon Kim , Sang Yong Jon , Young Jin Jeon , Dong Hyun Oh , Narayanan Selvapalam
IPC分类号： A61K38/19 , A61K38/43 , A61K39/395 , A61K31/56 , A61K9/14 , A61K31/4188
CPC分类号： C07D487/22
摘要： Provided are nanoparticles prepared by the aggregation of cucurbituril derivatives and having a particle size of 1 to 1,000 nm, a pharmaceutical composition in which a pharmaceutically active substance is loaded into the nanoparticles, and preparation methods thereof.
摘要翻译：本发明提供通过葫芦素衍生物的聚集而制备的粒径为1〜1000nm的纳米颗粒，其中药物活性物质被加载到纳米颗粒中的药物组合物及其制备方法。

8. 发明申请

US20050075498A1 Hydroxycucurbituril derivatives, their preparation methods and uses 有权
标题翻译：羟基葫芦脲衍生物，其制备方法和用途
公开(公告)号：US20050075498A1
公开(公告)日：2005-04-07
申请号：US10497464
申请日：2002-11-26
申请人： Kimoon Kim , Sang Yong Jon , Narayanan Selvapalam , Dong Hyun Oh
发明人： Kimoon Kim , Sang Yong Jon , Narayanan Selvapalam , Dong Hyun Oh
IPC分类号： C07D487/22 , A61K8/49 , A61K8/72 , A61K47/22 , A61K47/34 , B01D59/28 , B01J20/26 , C02F1/00 , C02F1/58 , C02F1/62 , G01N27/333 , G01N27/416 , C07D487/20
CPC分类号： C07D487/22 , Y02C10/08
摘要： Provided are hydroxycucurbituril derivatives, their preparation methods and uses. The hydroxycucurbituril derivative is easy to further functionalize with enhanced solubility in common solvents, thereby providing wider applications.
摘要翻译：提供羟ucurituril衍生物，其制备方法和用途。羟基葫芦脲衍生物易于进一步官能化，在普通溶剂中的溶解度增加，从而提供更广泛的应用。

9. 发明授权

US08168436B2 Method for determining quantity of peptide compound having phenylalanine residue at N-terminus 失效
标题翻译：确定N-末端具有苯丙氨酸残基的肽化合物的量的方法
公开(公告)号：US08168436B2
公开(公告)日：2012-05-01
申请号：US12446718
申请日：2007-10-23
申请人： Yoshihisa Inoue , Mikhail Rekharsky , Kimoon Kim , Yong Ho Ko , Narayanan Selvapalam
发明人： Yoshihisa Inoue , Mikhail Rekharsky , Kimoon Kim , Yong Ho Ko , Narayanan Selvapalam
IPC分类号： G01N33/00
CPC分类号： G01N33/6824 , Y10S436/815
摘要： The present invention provides a method for quantifying a peptide compound having a phenylalanine residue at the N-terminal, comprising measuring the content of heat generated by mixing 1) a peptide compound having a phenylalanine residue at the N-terminal, 2) cucurbit[7]uril, and 3) a metal ion in a solution.
摘要翻译：本发明提供了一种定量在N-末端具有苯丙氨酸残基的肽化合物的方法，包括测量通过混合产生的热含量1）在N末端具有苯丙氨酸残基的肽化合物，2）葫芦[7 ]，和3）溶液中的金属离子。

10. 发明申请

US20100238969A1 METHOD FOR DETERMINING QUANTITY OF PEPTIDE COMPOUND HAVING PHENYLALANINE RESIDUE AT N-TERMINUS 失效
标题翻译：用于确定N-末端苯丙氨酸残基的肽类化合物的数量的方法
公开(公告)号：US20100238969A1
公开(公告)日：2010-09-23
申请号：US12446718
申请日：2007-10-23
申请人： Yoshihisa Inoue , Mikhail Rekharsky , Kimoon Kim , Yong Ho Ko , Narayanan Selvapalam
发明人： Yoshihisa Inoue , Mikhail Rekharsky , Kimoon Kim , Yong Ho Ko , Narayanan Selvapalam
IPC分类号： G01N25/00
CPC分类号： G01N33/6824 , Y10S436/815
摘要： The present invention provides a method for quantifying a peptide compound having a phenylalanine residue at the N-terminal, comprising measuring the content of heat generated by mixing 1) a peptide compound having a phenylalanine residue at the N-terminal, 2) cucurbit[7]uril, and 3) a metal ion in a solution.
摘要翻译：本发明提供了一种定量在N-末端具有苯丙氨酸残基的肽化合物的方法，包括测量通过混合产生的热含量1）在N末端具有苯丙氨酸残基的肽化合物，2）葫芦[7 ]，和3）溶液中的金属离子。

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